"Cyclophilin A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cyclophilin family of proteins that binds to CYCLOSPORINE.
| Descriptor ID |
D021984
|
| MeSH Number(s) |
D08.811.399.325.500.400.300.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cyclophilin A".
Below are MeSH descriptors whose meaning is more specific than "Cyclophilin A".
This graph shows the total number of publications written about "Cyclophilin A" by people in this website by year, and whether "Cyclophilin A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Cyclophilin A" by people in Profiles.
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The physical and evolutionary energy landscapes of devolved protein sequences corresponding to pseudogenes. Proc Natl Acad Sci U S A. 2024 May 21; 121(21):e2322428121.
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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing. Nat Cell Biol. 2024 Apr; 26(4):593-603.
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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science. 2023 08 18; 381(6659):794-799.
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Secreted cyclophilin A mediates G1/S phase transition of cholangiocarcinoma cells via CD147/ERK1/2 pathway. Tumour Biol. 2015 Feb; 36(2):849-59.
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CypA, a gene downstream of HIF-1a, promotes the development of PDAC. PLoS One. 2014; 9(3):e92824.
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Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer. 2011 Aug 26; 10:102.
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Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med. 2011 Jan 17; 208(1):53-66.
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Cyclophilin A: potential functions and therapeutic target for human cancer. Med Sci Monit. 2009 Nov; 15(11):RA221-32.
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Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med. 2009 Jun; 15(6):649-56.
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Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation. 2008 Jun 17; 117(24):3088-98.