"TYK2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.
| Descriptor ID |
D053634
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.124.650 D12.776.476.393.650
|
| Concept/Terms |
TYK2 Kinase- TYK2 Kinase
- Kinase, TYK2
- Non-Receptor Tyrosine-Protein Kinase TYK2
- Non Receptor Tyrosine Protein Kinase TYK2
- Tyrosine Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "TYK2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "TYK2 Kinase".
This graph shows the total number of publications written about "TYK2 Kinase" by people in this website by year, and whether "TYK2 Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "TYK2 Kinase" by people in Profiles.
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TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model. Nat Neurosci. 2024 Dec; 27(12):2417-2429.
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Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk. Int J Cancer. 2022 Dec 15; 151(12):2155-2160.
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A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders. Blood. 2014 Dec 11; 124(25):3768-71.
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Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature. 2012 Sep 06; 489(7414):155-9.
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Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding. Cancer Res. 2009 Mar 01; 69(5):1958-65.
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Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-kappaB pathway and interferon-beta/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (THI 53), a new synthetic isoquinoline alkaloid. J Pharmacol Exp Ther. 2007 Feb; 320(2):782-9.
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RRR-alpha-tocopherol decreases the expression of the major scavenger receptor, CD36, in human macrophages via inhibition of tyrosine kinase (Tyk2). Atherosclerosis. 2004 Aug; 175(2):213-20.