"Dichloroacetic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A derivative of ACETIC ACID that contains two CHLORINE atoms attached to its methyl group.
| Descriptor ID |
D003999
|
| MeSH Number(s) |
D02.241.081.018.214.500 D02.455.526.439.196.500
|
| Concept/Terms |
Dichloroacetic Acid- Dichloroacetic Acid
- Acid, Dichloroacetic
- Bichloroacetic Acid
- Acid, Bichloroacetic
|
Below are MeSH descriptors whose meaning is more general than "Dichloroacetic Acid".
Below are MeSH descriptors whose meaning is more specific than "Dichloroacetic Acid".
This graph shows the total number of publications written about "Dichloroacetic Acid" by people in this website by year, and whether "Dichloroacetic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 2 | 2 | 4 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dichloroacetic Acid" by people in Profiles.
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Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma. JCI Insight. 2019 10 03; 4(19).
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First In Vivo Test of Thermoembolization: Turning Tissue Against Itself Using Transcatheter Chemistry in a Porcine Model. Cardiovasc Intervent Radiol. 2018 Oct; 41(10):1611-1617.
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ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer Lett. 2016 10 10; 381(1):23-30.
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Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster. Age (Dordr). 2014 Jun; 36(3):9628.
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Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy. Circ Res. 2009 Mar 27; 104(6):805-12.
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Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1. Biochem Pharmacol. 2006 May 28; 71(11):1648-61.
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Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis. Metabolism. 2004 Aug; 53(8):1087-94.
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Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg. 1996 Jul; 224(1):97-102.
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Pyruvate dehydrogenase inactivity is not responsible for sepsis-induced insulin resistance. Crit Care Med. 1996 Apr; 24(4):566-74.
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Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate. Pediatr Neurol. 1996 Jan; 14(1):69-71.