"Dichloroacetic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A derivative of ACETIC ACID that contains two CHLORINE atoms attached to its methyl group.
| Descriptor ID |
D003999
|
| MeSH Number(s) |
D02.241.081.018.214.500 D02.455.526.439.196.500
|
| Concept/Terms |
Dichloroacetic Acid- Dichloroacetic Acid
- Acid, Dichloroacetic
- Bichloroacetic Acid
- Acid, Bichloroacetic
|
Below are MeSH descriptors whose meaning is more general than "Dichloroacetic Acid".
Below are MeSH descriptors whose meaning is more specific than "Dichloroacetic Acid".
This graph shows the total number of publications written about "Dichloroacetic Acid" by people in this website by year, and whether "Dichloroacetic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 2 | 3 |
| 2004 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dichloroacetic Acid" by people in Profiles.
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Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster. Age (Dordr). 2014 Jun; 36(3):9628.
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Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis. Metabolism. 2004 Aug; 53(8):1087-94.
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Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg. 1996 Jul; 224(1):97-102.
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Pyruvate dehydrogenase inactivity is not responsible for sepsis-induced insulin resistance. Crit Care Med. 1996 Apr; 24(4):566-74.
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Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate. Pediatr Neurol. 1996 Jan; 14(1):69-71.
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Mechanisms by which dichloroacetate lowers lactic acid levels: the kinetic interrelationships between lactate, pyruvate, alanine, and glucose. Proc Soc Exp Biol Med. 1994 Jan; 205(1):44-51.
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Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion. Surgery. 1991 Jul; 110(1):54-67.
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Reduction in spinal cord postischemic lactic acidosis and functional improvement with dichloroacetate. J Neurotrauma. 1990; 7(1):1-12.
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Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis. Am J Physiol. 1989 Sep; 257(3 Pt 1):E323-31.
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Evaluation of the isotopic equilibration between lactate and pyruvate. Am J Physiol. 1988 Apr; 254(4 Pt 1):E532-5.