Complement C3 Nephritic Factor
"Complement C3 Nephritic Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
| Descriptor ID |
D003178
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| MeSH Number(s) |
D12.776.124.486.274.920.287 D12.776.124.486.485.114.323.300 D12.776.124.790.651.114.323.300 D12.776.377.715.548.114.323.300
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Complement C3 Nephritic Factor".
Below are MeSH descriptors whose meaning is more specific than "Complement C3 Nephritic Factor".
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