Multiple Sclerosis, Chronic Progressive
"Multiple Sclerosis, Chronic Progressive" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
| Descriptor ID |
D020528
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| MeSH Number(s) |
C10.114.375.500.200 C10.314.350.500.200 C20.111.258.250.500.200
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Multiple Sclerosis, Chronic Progressive".
Below are MeSH descriptors whose meaning is more specific than "Multiple Sclerosis, Chronic Progressive".
This graph shows the total number of publications written about "Multiple Sclerosis, Chronic Progressive" by people in this website by year, and whether "Multiple Sclerosis, Chronic Progressive" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Multiple Sclerosis, Chronic Progressive" by people in Profiles.
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Stool Glial Fibrillary Acidic Protein Is Elevated in Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2025 Nov; 12(6):e200466.
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Upper cervical spinal cord atrophy in MS: Sex, menopause, and neurodegeneration. Mult Scler. 2025 Mar; 31(3):278-289.
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Blood neurofilament light levels predict non-relapsing progression following anti-CD20 therapy in relapsing and primary progressive multiple sclerosis: findings from the ocrelizumab randomised, double-blind phase 3 clinical trials. EBioMedicine. 2023 Jul; 93:104662.
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Serum GFAP and NfL Levels Differentiate Subsequent Progression and Disease Activity in Patients With Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2023 01; 10(1).
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Improved relapse recovery in paediatric compared to adult multiple sclerosis. Brain. 2020 09 01; 143(9):2733-2741.
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Lower cortical gamma-aminobutyric acid level contributes to increased connectivity in sensory-motor regions in progressive MS. Mult Scler Relat Disord. 2020 Aug; 43:102183.
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Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study. Neurol Neuroimmunol Neuroinflamm. 2019 09; 6(5):e587.
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Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis. Ann Neurol. 2018 07; 84(1):51-63.
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Novel fMRI working memory paradigm accurately detects cognitive impairment in multiple sclerosis. Mult Scler. 2017 05; 23(6):836-847.
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Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 2016 Mar 12; 387(10023):1075-1084.