"Gene Products, nef" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
| Descriptor ID |
D015693
|
| MeSH Number(s) |
D12.776.964.775.362 D12.776.964.925.500
|
| Concept/Terms |
Gene Products, nef- Gene Products, nef
- Gene Product, nef
- nef Gene Product
- nef Protein
- 3'-orf Protein
- 3' orf Protein
- nef Gene Products
|
Below are MeSH descriptors whose meaning is more general than "Gene Products, nef".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, nef".
This graph shows the total number of publications written about "Gene Products, nef" by people in this website by year, and whether "Gene Products, nef" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2000 | 2 | 0 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 2 | 0 | 2 |
| 2004 | 1 | 2 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Products, nef" by people in Profiles.
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Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. J Acquir Immune Defic Syndr. 2008 Apr 01; 47(4):403-11.
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Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'. J Acquir Immune Defic Syndr. 2008 Apr 01; 47(4):412-21.
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Update on HIV-associated nephropathy. Curr Opin Nephrol Hypertens. 2006 Jul; 15(4):450-5.
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HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS. 2005 Nov 18; 19(17):1975-80.
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Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest. 2004 Sep; 114(5):643-51.
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Role of viral regulatory and accessory proteins in HIV-1 replication. Front Biosci. 2004 Sep 01; 9:2388-413.
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Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages. J Virol. 2004 Aug; 78(15):8114-9.
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HIV-1 induces complement factor C3 synthesis in astrocytes and neurons by modulation of promoter activity. Mol Immunol. 2004 Feb; 40(13):949-61.
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Critical role for Nef in HIV-1-induced podocyte dedifferentiation. Kidney Int. 2003 Nov; 64(5):1695-701.
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Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine. Immunol Lett. 2003 Oct 31; 89(2-3):207-14.