Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Descriptor ID |
D019032
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MeSH Number(s) |
E05.196.566.755
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Concept/Terms |
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization
- Mass Spectrometry, Matrix Assisted Laser Desorption Ionization
- Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
- Matrix Assisted Laser Desorption Ionization Mass Spectrometry
- MALDI
- Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization
- MS-MALD
- MALD-MS
- MALDI-MS
- MALDI MS
- Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted
- Laser Desorption Ionization Mass Spectrometry, Matrix Assisted
- Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization
- Mass Spectroscopy, Matrix Assisted Laser Desorption Ionization
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Below are MeSH descriptors whose meaning is more general than "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization".
Below are MeSH descriptors whose meaning is more specific than "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization".
This graph shows the total number of publications written about "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" by people in this website by year, and whether "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 |
1999 | 0 | 3 | 3 |
2000 | 0 | 1 | 1 |
2001 | 0 | 5 | 5 |
2002 | 0 | 6 | 6 |
2003 | 1 | 15 | 16 |
2004 | 2 | 3 | 5 |
2005 | 5 | 15 | 20 |
2006 | 2 | 6 | 8 |
2007 | 1 | 12 | 13 |
2008 | 2 | 3 | 5 |
2009 | 1 | 9 | 10 |
2010 | 1 | 5 | 6 |
2011 | 0 | 6 | 6 |
2012 | 2 | 6 | 8 |
2013 | 0 | 5 | 5 |
2014 | 1 | 7 | 8 |
2015 | 2 | 4 | 6 |
2016 | 1 | 2 | 3 |
2017 | 0 | 2 | 2 |
2018 | 1 | 3 | 4 |
2019 | 0 | 1 | 1 |
2022 | 0 | 2 | 2 |
2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" by people in Profiles.
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A MALDI Mass Spectrometry Imaging Sample Preparation Method for Venous Thrombosis with Initial Lipid Characterization of Lab-Made and Murine Clots. J Am Soc Mass Spectrom. 2023 Sep 06; 34(9):1879-1889.
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Comparison of Bruker Biotyper? and Vitek? MS matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry platforms for the identification of filamentous fungi. Future Microbiol. 2023 06; 18:553-561.
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DDA-imaging with structural identification of lipid molecules on an Orbitrap Velos Pro mass spectrometer. J Mass Spectrom. 2022 Sep; 57(9):e4882.
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Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging. Biochem Pharmacol. 2022 07; 201:115080.
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Susceptibility Provision Enhances Effective De-escalation (SPEED): utilizing rapid phenotypic susceptibility testing in Gram-negative bloodstream infections and its potential clinical impact. J Antimicrob Chemother. 2019 01 01; 74(Suppl 1):i16-i23.
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Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma. Nat Commun. 2018 11 21; 9(1):4904.
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Viewing the Future of IR through Molecular Histology: An Overview of Imaging Mass Spectrometry. J Vasc Interv Radiol. 2018 11; 29(11):1543-1546.e1.
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Experimental Design, Randomization, and Validation. Clin Chem. 2018 10; 64(10):1534-1535.
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Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research. J Cell Physiol. 2018 08; 233(8):5937-5948.
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Non-Native Conformational Isomers of the Catalytic Domain of PCSK9 Induce an Immune Response, Reduce Lipids and Increase LDL Receptor Levels. Int J Mol Sci. 2018 Feb 24; 19(2).