Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
| Descriptor ID |
D019032
|
| MeSH Number(s) |
E05.196.566.755
|
| Concept/Terms |
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization
- Mass Spectrometry, Matrix Assisted Laser Desorption Ionization
- Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
- Matrix Assisted Laser Desorption Ionization Mass Spectrometry
- MALDI
- Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization
- MS-MALD
- MALD-MS
- MALDI-MS
- MALDI MS
- Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted
- Laser Desorption Ionization Mass Spectrometry, Matrix Assisted
- Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization
- Mass Spectroscopy, Matrix Assisted Laser Desorption Ionization
|
Below are MeSH descriptors whose meaning is more general than "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization".
Below are MeSH descriptors whose meaning is more specific than "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization".
This graph shows the total number of publications written about "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" by people in this website by year, and whether "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 4 | 5 |
| 2002 | 0 | 8 | 8 |
| 2003 | 1 | 14 | 15 |
| 2004 | 2 | 3 | 5 |
| 2005 | 5 | 14 | 19 |
| 2006 | 1 | 6 | 7 |
| 2007 | 1 | 10 | 11 |
| 2008 | 2 | 2 | 4 |
| 2009 | 1 | 9 | 10 |
| 2010 | 1 | 4 | 5 |
| 2011 | 0 | 6 | 6 |
| 2012 | 2 | 6 | 8 |
| 2013 | 0 | 5 | 5 |
| 2014 | 1 | 7 | 8 |
| 2015 | 1 | 4 | 5 |
| 2016 | 1 | 2 | 3 |
| 2017 | 0 | 3 | 3 |
| 2018 | 1 | 2 | 3 |
| 2019 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" by people in Profiles.
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Molecular Imaging of Human Brain Organoids Using Mass Spectrometry. J Vis Exp. 2024 Sep 27; (211).
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MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues. Drug Metab Dispos. 2024 Jun 17; 52(7):673-680.
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Application of MALDI-TOF MS and machine learning for the detection of SARS-CoV-2 and non-SARS-CoV-2 respiratory infections. Microbiol Spectr. 2024 May 02; 12(5):e0406823.
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A MALDI Mass Spectrometry Imaging Sample Preparation Method for Venous Thrombosis with Initial Lipid Characterization of Lab-Made and Murine Clots. J Am Soc Mass Spectrom. 2023 Sep 06; 34(9):1879-1889.
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Comparison of Bruker Biotyper? and Vitek? MS matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry platforms for the identification of filamentous fungi. Future Microbiol. 2023 06; 18:553-561.
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DDA-imaging with structural identification of lipid molecules on an Orbitrap Velos Pro mass spectrometer. J Mass Spectrom. 2022 Sep; 57(9):e4882.
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Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging. Biochem Pharmacol. 2022 07; 201:115080.
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Metabolic profiles of Xiao Chai Hu Tang in mouse plasma, bile and urine by the UHPLC-ESI-Q-TOF/MS technique. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Oct 01; 1128:121767.
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Susceptibility Provision Enhances Effective De-escalation (SPEED): utilizing rapid phenotypic susceptibility testing in Gram-negative bloodstream infections and its potential clinical impact. J Antimicrob Chemother. 2019 01 01; 74(Suppl 1):i16-i23.
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Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma. Nat Commun. 2018 11 21; 9(1):4904.