"Smad3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
| Descriptor ID |
D051900
|
| MeSH Number(s) |
D12.644.360.024.334.500.300 D12.776.157.057.170.500.300 D12.776.260.713.500.300 D12.776.476.024.428.500.300 D12.776.744.741.875 D12.776.930.806.500.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Smad3 Protein".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Smad Proteins [D12.644.360.024.334]
- Smad Proteins, Receptor-Regulated [D12.644.360.024.334.500]
- Smad3 Protein [D12.644.360.024.334.500.300]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Smad Proteins [D12.776.157.057.170]
- Smad Proteins, Receptor-Regulated [D12.776.157.057.170.500]
- Smad3 Protein [D12.776.157.057.170.500.300]
- DNA-Binding Proteins [D12.776.260]
- Smad Proteins [D12.776.260.713]
- Smad Proteins, Receptor-Regulated [D12.776.260.713.500]
- Smad3 Protein [D12.776.260.713.500.300]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Smad Proteins [D12.776.476.024.428]
- Smad Proteins, Receptor-Regulated [D12.776.476.024.428.500]
- Smad3 Protein [D12.776.476.024.428.500.300]
- Phosphoproteins [D12.776.744]
- Smad Proteins, Receptor-Regulated [D12.776.744.741]
- Smad3 Protein [D12.776.744.741.875]
- Transcription Factors [D12.776.930]
- Smad Proteins [D12.776.930.806]
- Smad Proteins, Receptor-Regulated [D12.776.930.806.500]
- Smad3 Protein [D12.776.930.806.500.300]
Below are MeSH descriptors whose meaning is more specific than "Smad3 Protein".
This graph shows the total number of publications written about "Smad3 Protein" by people in this website by year, and whether "Smad3 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 1 | 2 |
| 2009 | 3 | 2 | 5 |
| 2010 | 1 | 2 | 3 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 2 | 3 |
| 2013 | 2 | 1 | 3 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 1 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
| 2024 | 2 | 0 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Smad3 Protein" by people in Profiles.
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Fibroblast-specific TGF-? signaling mediates cardiac dysfunction, fibrosis, and hypertrophy in obese diabetic mice. Cardiovasc Res. 2024 Dec 14; 120(16):2047-2063.
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Mitral Annular Disjunction in Heritable Thoracic Aortic Disease: Insights From the Montalcino Aortic Consortium. J Am Heart Assoc. 2024 Nov 05; 13(21):e036274.
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BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML. Sci Transl Med. 2024 Sep 11; 16(764):eadp0004.
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Role of hypoxia-mediated pyroptosis?in the development of extending knee joint contracture in rats. Eur J Med Res. 2024 May 27; 29(1):298.
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Thbs1 regulates skeletal muscle mass in a TGF?-Smad2/3-ATF4-dependent manner. Cell Rep. 2024 05 28; 43(5):114149.
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Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium. J Mol Cell Cardiol. 2022 10; 171:1-15.
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Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy. Cardiovasc Res. 2021 09 28; 117(11):2377-2394.
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Heightened Crescentic Glomerulonephritis in Immune Challenged 129sv Mice Is TGF-?/Smad3 Dependent. Int J Mol Sci. 2021 Feb 19; 22(4).
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EWSR1-SMAD3 rearranged fibroblastic tumor: Case series and review. J Cutan Pathol. 2021 Feb; 48(2):255-262.
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The first reported case of Loeys-Dietz syndrome in a patient with biallelic SMAD3 variants. Am J Med Genet A. 2020 11; 182(11):2755-2760.