"Iduronate Sulfatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that specifically cleaves the ester sulfate of iduronic acid. Its deficiency has been demonstrated in Hunter's syndrome, which is characterized by an excess of dermatan sulfate and heparan sulfate. EC 3.1.6.13.
| Descriptor ID |
D007066
|
| MeSH Number(s) |
D08.811.277.352.827.500
|
| Concept/Terms |
Iduronate Sulfatase- Iduronate Sulfatase
- Sulfatase, Iduronate
- Iduronate Sulfate Sulfatase
- Sulfatase, Iduronate Sulfate
- Sulfate Sulfatase, Iduronate
- Sulfoiduronate Sulfatase
- Sulfatase, Sulfoiduronate
- Hunter Corrective Factor
- Corrective Factor, Hunter
- Factor, Hunter Corrective
- Iduronatesulfate Sulfohydrolase
- Sulfohydrolase, Iduronatesulfate
|
Below are MeSH descriptors whose meaning is more general than "Iduronate Sulfatase".
Below are MeSH descriptors whose meaning is more specific than "Iduronate Sulfatase".
This graph shows the total number of publications written about "Iduronate Sulfatase" by people in this website by year, and whether "Iduronate Sulfatase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Iduronate Sulfatase" by people in Profiles.
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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice. Sci Transl Med. 2020 05 27; 12(545).
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A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA. EMBO Mol Med. 2013 May; 5(5):675-90.
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Long-term, open-labeled extension study of idursulfase in the treatment of Hunter syndrome. Genet Med. 2011 Feb; 13(2):95-101.
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A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome). Genet Med. 2006 Aug; 8(8):465-73.
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Correction of Hunter syndrome in the MPSII mouse model by AAV2/8-mediated gene delivery. Hum Mol Genet. 2006 Apr 01; 15(7):1225-36.
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Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. EMBO Rep. 2005 Jul; 6(7):655-60.
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Molecular and phenotypic variation in patients with severe Hunter syndrome. Hum Mol Genet. 1997 Mar; 6(3):479-86.
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130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. Genome Res. 1995 Aug; 5(1):71-8.
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The mouse iduronate sulfatase gene: identification of a novel transcript. Biochem Biophys Res Commun. 1993 Aug 16; 194(3):1030-7.
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Cloning and characterization of the cDNA for the murine iduronate sulfatase gene. Genomics. 1993 Jun; 16(3):755-7.