Pentose Phosphate Pathway
"Pentose Phosphate Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
| Descriptor ID |
D010427
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| MeSH Number(s) |
G02.111.158.875 G03.191.875 G03.295.693 G03.493.695
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| Concept/Terms |
Pentose Phosphate Pathway- Pentose Phosphate Pathway
- Pathway, Pentose Phosphate
- Pathways, Pentose Phosphate
- Pentose Phosphate Pathways
- Pentose Phosphate Shunt
- Pentose Phosphate Shunts
- Shunt, Pentose Phosphate
- Shunts, Pentose Phosphate
- Pentose Shunt
- Pentose Shunts
- Shunt, Pentose
- Shunts, Pentose
- Pentose-Phosphate Pathway
- Pathway, Pentose-Phosphate
- Pathways, Pentose-Phosphate
- Pentose-Phosphate Pathways
- Pentosephosphate Shunt
- Pentosephosphate Shunts
- Shunt, Pentosephosphate
- Shunts, Pentosephosphate
- Hexose Monophosphate Shunt
- Hexose Monophosphate Shunts
- Shunt, Hexose Monophosphate
- Shunts, Hexose Monophosphate
- Pentosephosphate Pathway
- Pathway, Pentosephosphate
- Pathways, Pentosephosphate
- Pentosephosphate Pathways
|
Below are MeSH descriptors whose meaning is more general than "Pentose Phosphate Pathway".
Below are MeSH descriptors whose meaning is more specific than "Pentose Phosphate Pathway".
This graph shows the total number of publications written about "Pentose Phosphate Pathway" by people in this website by year, and whether "Pentose Phosphate Pathway" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 3 | 2 | 5 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentose Phosphate Pathway" by people in Profiles.
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Thioredoxin reductase is a major regulator of metabolism in leukemia cells. Oncogene. 2021 Aug; 40(33):5236-5246.
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Untargeted metabolomics as an unbiased approach to the diagnosis of inborn errors of metabolism of the non-oxidative branch of the pentose phosphate pathway. Mol Genet Metab. 2020 Sep - Oct; 131(1-2):147-154.
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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 04; 22(4):476-486.
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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. Cell Rep. 2019 08 20; 28(8):1971-1980.e8.
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Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2020 10; 39(40):6265-6285.
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Inhibition of ERRa Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Rep. 2019 06 18; 27(12):3587-3601.e4.
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Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis. Cancer Commun (Lond). 2019 04 04; 39(1):17.
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Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. Nat Commun. 2018 12 21; 9(1):5442.
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Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 09 03; 8(1):13134.
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Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254.