"Replication Origin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A unique DNA sequence of a replicon at which DNA REPLICATION is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesized, and the switch from primer RNA to DNA synthesis takes place. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D018741
|
| MeSH Number(s) |
G05.360.340.024.220.760 G05.360.340.024.745.725
|
| Concept/Terms |
Replication Origin- Replication Origin
- Origin, Replication
- Origins, Replication
- ori Region
- Region, ori
- Regions, ori
- ori Regions
- Origin of Replication
- Replication Origins
|
Below are MeSH descriptors whose meaning is more general than "Replication Origin".
Below are MeSH descriptors whose meaning is more specific than "Replication Origin".
This graph shows the total number of publications written about "Replication Origin" by people in this website by year, and whether "Replication Origin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 0 | 2 |
| 2018 | 0 | 3 | 3 |
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Below are the most recent publications written about "Replication Origin" by people in Profiles.
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Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon. BMC Biol. 2023 02 24; 21(1):41.
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Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress. Breast Cancer Res. 2019 11 27; 21(1):125.
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Minichromosome Maintenance Proteins Cooperate with LANA during the G1/S Phase of the Cell Cycle To Support Viral DNA Replication. J Virol. 2019 04 01; 93(7).
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Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks. Nature. 2018 12; 564(7735):287-290.
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Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Mol Cell. 2018 11 15; 72(4):650-660.e8.
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Mitochondrial DNA replication: clinical syndromes. Essays Biochem. 2018 07 20; 62(3):297-308.
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Origin-Dependent Inverted-Repeat Amplification: Tests of a Model for Inverted DNA Amplification. PLoS Genet. 2015 Dec; 11(12):e1005699.
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DNA Replication Initiation Is Blocked by a Distant Chromosome-Membrane Attachment. Curr Biol. 2015 Aug 17; 25(16):2143-9.
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Detection of Replication Origin Sites in Herpesvirus Genomes by Clustering and Scoring of Palindromes with Quadratic Entropy Measures. IEEE/ACM Trans Comput Biol Bioinform. 2014 Nov-Dec; 11(6):1108-18.
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Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. Genome Res. 2014 Nov; 24(11):1740-50.