Fusion Regulatory Protein-1
"Fusion Regulatory Protein-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (FUSION REGULATORY PROTEIN 1, HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (FUSION REGULATORY PROTEIN 1, LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
| Descriptor ID |
D027261
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| MeSH Number(s) |
D12.776.157.530.200.374.750.500 D12.776.157.530.200.500.500.500 D12.776.157.530.937.313.500 D12.776.543.585.200.374.750.500 D12.776.543.585.200.500.500.500 D12.776.543.585.937.313.500
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| Concept/Terms |
Fusion Regulatory Protein-1- Fusion Regulatory Protein-1
- Fusion Regulatory Protein 1
- Regulatory Protein-1, Fusion
- 4F2-antigen
- CD98 Antigens
- FRP-1 protein
- FRP 1 protein
- CD98 Transport Proteins
- Transport Proteins, CD98
- Antigen 4F2
- Antigens, CD98
- CD98 Antigen
- Antigen, CD98
- 4F2 Antigen
Human 4F2 Antigen- Human 4F2 Antigen
- 4F2 Antigen, Human
- Human Lymphocyte Activation Antigen 4F2
- H4F2 Antigen
- Human 4F2 Cell-Surface Antigen
- Human 4F2 Cell Surface Antigen
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Below are MeSH descriptors whose meaning is more general than "Fusion Regulatory Protein-1".
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This graph shows the total number of publications written about "Fusion Regulatory Protein-1" by people in this website by year, and whether "Fusion Regulatory Protein-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fusion Regulatory Protein-1" by people in Profiles.
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Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells. J Cell Physiol. 2012 May; 227(5):1960-71.
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Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem. 2003 Feb 28; 278(9):7607-16.
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SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family. Genomics. 1999 Dec 01; 62(2):297-303.
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SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance. Nat Genet. 1999 Mar; 21(3):297-301.
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The light chain of CD98 is identified as E16/TA1 protein. J Biol Chem. 1998 Dec 11; 273(50):33127-9.
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Monocyte-dependent regulation of T lymphocyte activation through CD98. Int Immunol. 1997 Sep; 9(9):1221-31.