"Pregnanolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
| Descriptor ID |
D011280
|
| MeSH Number(s) |
D04.210.500.745.640
|
| Concept/Terms |
Pregnanolone- Pregnanolone
- 3 alpha-Hydroxy-5 beta-pregnan-20-one
- 3 alpha Hydroxy 5 beta pregnan 20 one
- alpha-Hydroxy-5 beta-pregnan-20-one, 3
- beta-pregnan-20-one, 3 alpha-Hydroxy-5
- 3-Hydroxypregnan-20-one
- 3 Hydroxypregnan 20 one
- Pregnanolone, (3alpha,5beta)-isomer
- Eltanolone
- Pregnan-3alpha-ol-20-one
- Pregnan 3alpha ol 20 one
- 3 alpha, 5 beta-Tetrahydroprogesterone
- 3 alpha, 5 beta Tetrahydroprogesterone
Sepranolone- Sepranolone
- Allopregnanolone
- 3 alpha-Hydroxy-5 alpha-pregnan-20-one
- 3 alpha Hydroxy 5 alpha pregnan 20 one
- alpha-Hydroxy-5 alpha-pregnan-20-one, 3
- alpha-pregnan-20-one, 3 alpha-Hydroxy-5
- Pregnanolone, (3alpha,5alpha)-isomer
Pregnanolone, (3beta, 5alpha)-isomer- Pregnanolone, (3beta, 5alpha)-isomer
- Allopregnan-3 beta-ol-20-one
- Allopregnan 3 beta ol 20 one
- beta-ol-20-one, Allopregnan-3
- 3beta-Hydroxy-5alpha-pregnan-20-one
- 3beta Hydroxy 5alpha pregnan 20 one
|
Below are MeSH descriptors whose meaning is more general than "Pregnanolone".
Below are MeSH descriptors whose meaning is more specific than "Pregnanolone".
This graph shows the total number of publications written about "Pregnanolone" by people in this website by year, and whether "Pregnanolone" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pregnanolone" by people in Profiles.
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Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial. Eur J Paediatr Neurol. 2024 Jul; 51:140-146.
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LC-MS/MS simultaneous analysis of allopregnanolone, epiallopregnanolone, pregnanolone, dehydroepiandrosterone and dehydroepiandrosterone 3-sulfate in human plasma. Bioanalysis. 2017 Mar; 9(6):527-539.
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The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome. Cell Cycle. 2015; 14(18):2985-95.
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Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3a,5a-THP and reduces long-term operant ethanol self-administration. J Neurosci. 2014 Apr 23; 34(17):5824-34.
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Progesterone receptors: a key for neuroprotection in experimental stroke. Endocrinology. 2012 Aug; 153(8):3747-57.
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Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors. Psychopharmacology (Berl). 2006 Jun; 186(3):312-22.
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Anxiolytic activity of progesterone in progesterone receptor knockout mice. Neuropharmacology. 2005 Jan; 48(1):14-24.
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Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J Pharmacol Exp Ther. 2004 Jul; 310(1):230-9.
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Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. J Pharmacol Exp Ther. 2004 Feb; 308(2):502-11.
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Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum. J Neurochem. 2003 Aug; 86(4):848-59.