"Ouabain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
| Descriptor ID |
D010042
|
| MeSH Number(s) |
D04.210.500.155.580.130.750.600 D09.408.180.810.600
|
| Concept/Terms |
Ouabain- Ouabain
- G-Strophanthin
- G Strophanthin
- Acocantherin
- Acolongifloroside K
|
Below are MeSH descriptors whose meaning is more general than "Ouabain".
Below are MeSH descriptors whose meaning is more specific than "Ouabain".
This graph shows the total number of publications written about "Ouabain" by people in this website by year, and whether "Ouabain" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ouabain" by people in Profiles.
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Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. Sci Rep. 2016 07 19; 6:29721.
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Intracellular calcium regulates nonsense-mediated mRNA decay. Nat Med. 2014 Aug; 20(8):961-6.
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Hypoxia limits inhibitory effects of Zn2+ on spreading depolarizations. PLoS One. 2013; 8(11):e75739.
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Modification of erythrocyte membrane proteins, enzymes and transport mechanisms in chronic alcoholics: an in vivo and in vitro study. Alcohol Alcohol. 2013 Nov-Dec; 48(6):679-86.
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Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity. Fitoterapia. 2013 Jan; 84:32-9.
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Sodium ion channel mutations in glioblastoma patients correlate with shorter survival. Mol Cancer. 2011 Feb 11; 10:17.
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An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies. J Immunol Methods. 2008 Jul 31; 336(2):142-51.
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Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. Circulation. 2003 Dec 16; 108(24):3048-53.
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Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003 Feb; 33(2):192-6.
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Insulin increases the turnover rate of Na+-K+-ATPase in human fibroblasts. Am J Physiol Cell Physiol. 2001 Apr; 280(4):C912-9.