Interleukin-1 Receptor Accessory Protein
"Interleukin-1 Receptor Accessory Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein that takes part in the formation of active interleukin-1 receptor complex. It binds specifically to INTERLEUKIN-1 and the INTERLEUKIN-1 RECEPTOR TYPE I at the cell surface to form a heterotrimeric complex that brings its cytoplasmic domain into contact with the cytoplasm domain of the TYPE-I INTERLEUKIN-1 RECEPTOR. Activation of intracellular signal transduction pathways from the receptor is believed to be driven by this form of cytoplasmic interaction.
| Descriptor ID |
D053577
|
| MeSH Number(s) |
D12.776.543.750.705.852.420.300.249
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor Accessory Protein".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor Accessory Protein".
This graph shows the total number of publications written about "Interleukin-1 Receptor Accessory Protein" by people in this website by year, and whether "Interleukin-1 Receptor Accessory Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Interleukin-1 Receptor Accessory Protein" by people in Profiles.
-
Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer. J Hematol Oncol. 2022 05 23; 15(1):70.
-
Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):14918-23.
-
IL-10 and IL-4 regulate type-I and type-II IL-1 receptors expression on IL-1 beta-activated mouse primary astrocytes. J Neurochem. 2001 Nov; 79(4):726-36.
-
Dexamethasone up-regulates type II IL-1 receptor in mouse primary activated astrocytes. J Neurochem. 2001 Feb; 76(3):901-9.