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Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.
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Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.
Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Rep. 2015 Mar 24; 10(11):1850-60.
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subject areas
Amino Acid Sequence
Animals
Antineoplastic Agents
Female
HEK293 Cells
Humans
Imidazoles
Jurkat Cells
Mice
Mice, Inbred C57BL
Molecular Docking Simulation
Molecular Sequence Data
Protein Binding
Protein Kinase Inhibitors
Pyridazines
Receptor-Interacting Protein Serine-Threonine Kinases
Substrate Specificity
authors with profiles
GREG D. CUNY