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ROBERT F GAGEL

TitleProfessor
InstitutionMD Anderson
DepartmentEndocrine Neoplasia & HD
Address1400 Pressler St
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu H, He J, Bagheri-Yarmand R, Li Z, Liu R, Wang Z, Bach DH, Huang YH, Lin P, Guise TA, Gagel RF, Yang J. Osteocyte CIITA aggravates osteolytic bone lesions in myeloma. Nat Commun. 2022 06 27; 13(1):3684. PMID: 35760800; PMCID: PMC9237076.
      Citations:    Fields:    Translation:HumansCells
    2. Williams MD, Ma J, Grubbs EG, Gagel RF, Bagheri-Yarmand R. ATF4 loss of heterozygosity is associated with poor overall survival in medullary thyroid carcinoma. Am J Cancer Res. 2021; 11(6):3227-3239. PMID: 34249457; PMCID: PMC8263636.
      Citations: 1     
    3. Bagheri-Yarmand R, Dadu R, Ye L, Shiny Jebaraj Y, Martinez JA, Ma J, Tarapore RS, Allen JE, Sherman SI, Williams MD, Gagel RF. ONC201 Shows Potent Anticancer Activity Against Medullary Thyroid Cancer via Transcriptional Inhibition of RET, VEGFR2, and IGFBP2. Mol Cancer Ther. 2021 04; 20(4):665-675. PMID: 33536187; PMCID: PMC9484041.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Dadu R, Bagheri-Yarmand R, Ringel MD, Grubbs EG, Zafereo M, Cote G, Gagel RF, Robinson BG, Shaw KR, Hu MI. HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: The state of science in medullary thyroid carcinoma: current challenges and unmet needs. Endocr Relat Cancer. 2020 08; 27(8):T27-T39. PMID: 32580150.
      Citations: 2     Fields:    Translation:Humans
    5. Grubbs EG, Lechan RM, Edeiken-Monroe B, Cote GJ, Trotter C, Tischler AS, Gagel RF. HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: Early thyroidectomy in multiple endocrine neoplasia: a four decade experience. Endocr Relat Cancer. 2020 08; 27(8):T1-T8. PMID: 32464600.
      Citations:    Fields:    Translation:Humans
    6. Grubbs EG, Halperin DM, Waguespack SG, Gagel RF. History of the multiple endocrine neoplasia workshops and overview of MEN2019. Endocr Relat Cancer. 2020 Jun 01. PMID: 32508314.
      Citations: 2     Fields:    
    7. Jozaghi Y, Zafereo ME, Perrier ND, Wang JR, Grubbs E, Gross ND, Fisher S, Sturgis EM, Goepfert RP, Lai SY, Best C, Busaidy NL, Cabanillas ME, Dadu R, Gagel RF, Habra MA, Hu MI, Jimenez C, Sherman SI, Thosani S, Varghese J, Waguespack SG, Weitzman S, Ying AK, Graham PH. Endocrine surgery in the Coronavirus disease 2019 pandemic: Surgical Triage Guidelines. Head Neck. 2020 06; 42(6):1325-1328. PMID: 32437031; PMCID: PMC7262055.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    8. Shapiro CL, Van Poznak C, Lacchetti C, Kirshner J, Eastell R, Gagel R, Smith S, Edwards BJ, Frank E, Lyman GH, Smith MR, Mhaskar R, Henderson T, Neuner J. Management of Osteoporosis in Survivors of Adult Cancers With Nonmetastatic Disease: ASCO Clinical Practice Guideline. J Clin Oncol. 2019 11 01; 37(31):2916-2946. PMID: 31532726.
      Citations: 31     Fields:    Translation:Humans
    9. Liu H, He J, Koh SP, Zhong Y, Liu Z, Wang Z, Zhang Y, Li Z, Tam BT, Lin P, Xiao M, Young KH, Amini B, Starbuck MW, Lee HC, Navone NM, Davis RE, Tong Q, Bergsagel PL, Hou J, Yi Q, Orlowski RZ, Gagel RF, Yang J. Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. Sci Transl Med. 2019 05 29; 11(494). PMID: 31142679; PMCID: PMC6999853.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    10. Bethel MA, Patel RA, Thompson VP, Merrill P, Reed SD, Li Y, Ahmadi S, Katona BG, Gustavson SM, Ohman P, Iqbal N, Gagel RF, Hernandez AF, Buse JB, Holman RR, EXSCEL Study Group. Changes in Serum Calcitonin Concentrations, Incidence of Medullary Thyroid Carcinoma, and Impact of Routine Calcitonin Concentration Monitoring in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL). Diabetes Care. 2019 06; 42(6):1075-1080. PMID: 31010875; PMCID: PMC6973544.
      Citations: 4     Fields:    Translation:Humans
    11. Sinha KM, Bagheri-Yarmand R, Lahiri S, Lu Y, Zhang M, Amra S, Rizvi Y, Wan X, Navone N, Ozpolat B, Logothetis C, Gagel RF, Huard J. Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer. Oncogene. 2019 06; 38(25):5038-5049. PMID: 30858546.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Acharya RP, Won AM, Moon BS, Flint JH, Roubaud MS, Williams MD, Hessel AC, Murphy WA, Chambers MS, Gagel RF. Tumor-induced hypophosphatemic osteomalacia caused by a mesenchymal tumor of the mandible managed by a segmental mandibulectomy and microvascular reconstruction with a free fibula flap. Head Neck. 2019 06; 41(6):E93-E98. PMID: 30859653.
      Citations: 3     Fields:    Translation:Humans
    13. Hu MI, Elisei R, Dedecjus M, Popovtzer A, Druce M, Kapiteijn E, Pacini F, Locati L, Krajewska J, Weiss R, Gagel RF. Safety and efficacy of two starting doses of vandetanib in advanced medullary thyroid cancer. Endocr Relat Cancer. 2019 02 01; 26(2):241-250. PMID: 30557850.
      Citations: 7     Fields:    Translation:Humans
    14. Bagheri-Yarmand R, Sinha KM, Li L, Lu Y, Cote GJ, Sherman SI, Gagel RF. Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer. Mol Cancer Res. 2019 03; 17(3):751-760. PMID: 30552230; PMCID: PMC6902859.
      Citations: 7     Fields:    Translation:HumansCells
    15. Romero Arenas MA, Rich TA, Hyde SM, Busaidy NL, Cote GJ, Hu MI, Gagel RF, Gidley PW, Jimenez C, Kupferman ME, Peterson SK, Sherman SI, Ying A, Bassett RL, Waguespack SG, Perrier ND, Grubbs EG. Recontacting Patients with Updated Genetic Testing Recommendations for Medullary Thyroid Carcinoma and Pheochromocytoma or Paraganglioma. Ann Surg Oncol. 2018 May; 25(5):1395-1402. PMID: 29427212; PMCID: PMC10013431.
      Citations: 6     Fields:    Translation:Humans
    16. Edwards BJ, Sun M, Zhang X, Holmes HM, Song J, Khalil P, Karuturi M, Shah JB, Dinney CP, Gagel RF, Valero V, Champlin RE, Tripathy D, Murphy WA. Fractures frequently occur in older cancer patients: the MD Anderson Cancer Center experience. Support Care Cancer. 2018 May; 26(5):1561-1568. PMID: 29197959.
      Citations: 3     Fields:    Translation:Humans
    17. Voss RK, Feng L, Lee JE, Perrier ND, Graham PH, Hyde SM, Nieves-Munoz F, Cabanillas ME, Waguespack SG, Cote GJ, Gagel RF, Grubbs EG. Medullary Thyroid Carcinoma in MEN2A: ATA Moderate- or High-Risk RET Mutations Do Not Predict Disease Aggressiveness. J Clin Endocrinol Metab. 2017 08 01; 102(8):2807-2813. PMID: 28609830; PMCID: PMC5546858.
      Citations: 16     Fields:    Translation:Humans
    18. Bartelt A, Jeschke A, Gaziano I, Morales M, Yorgan T, Heckt T, Heine M, Gagel RF, Emeson RB, Amling M, Niemeier A, Schinke T, Keller J, M?ller B, Heeren J. Differential effects of Calca-derived peptides in male mice with diet-induced obesity. PLoS One. 2017; 12(6):e0180547. PMID: 28666011; PMCID: PMC5493411.
      Citations: 5     Fields:    Translation:Animals
    19. Long KL, Etzel C, Rich T, Hyde S, Perrier ND, Graham PH, Lee JE, Hu MI, Cote GJ, Gagel R, Grubbs EG. All in the family? Analyzing the impact of family history in addition to genotype on medullary thyroid carcinoma aggressiveness in MEN2A patients. Fam Cancer. 2017 04; 16(2):283-289. PMID: 27864651.
      Citations: 4     Fields:    Translation:Humans
    20. Bagheri-Yarmand R, Williams MD, Grubbs EG, Gagel RF. ATF4 Targets RET for Degradation and Is a Candidate Tumor Suppressor Gene in Medullary Thyroid Cancer. J Clin Endocrinol Metab. 2017 03 01; 102(3):933-941. PMID: 27935748; PMCID: PMC5460684.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    21. Lu H, Champlin RE, Popat U, Pundole X, Escalante CP, Wang X, Qiao W, Murphy WA, Gagel RF. Ibandronate for the prevention of bone loss after allogeneic stem cell transplantation for hematologic malignancies: a randomized-controlled trial. Bonekey Rep. 2016; 5:843. PMID: 28018583; PMCID: PMC5154364.
      Citations: 1     
    22. Grubbs EG, Williams MD, Scheet P, Vattathil S, Perrier ND, Lee JE, Gagel RF, Hai T, Feng L, Cabanillas ME, Cote GJ. Role of CDKN2C Copy Number in Sporadic Medullary Thyroid Carcinoma. Thyroid. 2016 11; 26(11):1553-1562. PMID: 27610696; PMCID: PMC6453497.
      Citations: 12     Fields:    Translation:Humans
    23. Xu JY, Grubbs EG, Waguespack SG, Jimenez C, Gagel RF, Sosa JA, Sellin RV, Dadu R, Hu MI, Trotter CS, Jackson M, Rich TA, Hyde SM, Sherman SI, Cote GJ. Medullary Thyroid Carcinoma Associated with Germline RETK666N Mutation. Thyroid. 2016 12; 26(12):1744-1751. PMID: 27673361; PMCID: PMC5175438.
      Citations:    Fields:    Translation:Humans
    24. Xu JY, Murphy WA, Jimenez C, Rao SN, Habra MA, Waguespack SG, Dadu R, Gagel RF, Ying AK, Cabanillas ME, Weitzman SP, Busaidy NL, Sellin RV, Grubbs E, Sherman SI, Hu MI, Milton DR. Bone Metastases and Skeletal-Related Events in Medullary Thyroid Carcinoma. J Clin Endocrinol Metab. 2016 12; 101(12):4871-4877. PMID: 27662441; PMCID: PMC5155685.
      Citations: 7     Fields:    Translation:Humans
    25. Liu H, Liu Z, Du J, He J, Lin P, Amini B, Starbuck MW, Novane N, Shah JJ, Davis RE, Hou J, Gagel RF, Yang J. Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. Sci Transl Med. 2016 08 24; 8(353):353ra113. PMID: 27559096; PMCID: PMC5109917.
      Citations: 30     Fields:    Translation:HumansCells
    26. Edwards BJ, Sun M, West DP, Guindani M, Lin YH, Lu H, Hu M, Barcenas C, Bird J, Feng C, Saraykar S, Tripathy D, Hortobagyi GN, Gagel R, Murphy WA. Incidence of Atypical Femur Fractures in Cancer Patients: The MD Anderson Cancer Center Experience. J Bone Miner Res. 2016 08; 31(8):1569-76. PMID: 26896384.
      Citations: 10     Fields:    Translation:Humans
    27. Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL. Changing of the Guard. Endocr Rev. 2016 02; 2016(1):1-2. PMID: 27454359.
      Citations:    Fields:    
    28. Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL. Changing of the Guard. Endocr Rev. 2015 Aug; 36(4):345-6. PMID: 26240982.
      Citations:    Fields:    
    29. Edwards BJ, Saraykar S, Sun M, Murphy WA, Lin P, Gagel R. Resection of granulomatous tissue resolves silicone induced hypercalcemia. Bone Rep. 2016 Dec; 5:163-167. PMID: 28580383; PMCID: PMC5440967.
      Citations: 5     
    30. Grubbs EG, Gagel RF. My, How Things Have Changed in Multiple Endocrine Neoplasia Type 2A! J Clin Endocrinol Metab. 2015 Jul; 100(7):2532-5. PMID: 26151398; PMCID: PMC5393525.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    31. Wells SA, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Shah M, Waguespack SG, American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma, Schlumberger M. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. 2015 Jun; 25(6):567-610. PMID: 25810047; PMCID: PMC4490627.
      Citations: 463     Fields:    Translation:Humans
    32. Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF. A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. J Biol Chem. 2015 May 01; 290(18):11749-61. PMID: 25795775; PMCID: PMC4416875.
      Citations: 20     Fields:    Translation:HumansCells
    33. Dadu R, Hu MN, Grubbs EG, Gagel RF. Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma. Recent Results Cancer Res. 2015; 204:227-49. PMID: 26494392.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    34. Rich TA, Feng L, Busaidy N, Cote GJ, Gagel RF, Hu M, Jimenez C, Lee JE, Perrier N, Sherman SI, Waguespack SG, Ying A, Grubbs E. Prevalence by age and predictors of medullary thyroid cancer in patients with lower risk germline RET proto-oncogene mutations. Thyroid. 2014 Jul; 24(7):1096-106. PMID: 24617864; PMCID: PMC4080849.
      Citations: 13     Fields:    Translation:Humans
    35. Jain P, Baez-Vallecillo L, Huh YO, Benjamini O, Abruzzo L, O'Brien S, Pemmaraju N, Keating M, Gagel RF, Estrov Z. Atypical chronic lymphocytic leukemia with polyglandular autoimmune endocrinopathy type II: a complex profile. Leuk Lymphoma. 2014 Apr; 55(4):944-6. PMID: 23829280; PMCID: PMC4102379.
      Citations:    Fields:    Translation:Humans
    36. Santarpia L, Calin GA, Adam L, Ye L, Fusco A, Giunti S, Thaller C, Paladini L, Zhang X, Jimenez C, Trimarchi F, El-Naggar AK, Gagel RF. A miRNA signature associated with human metastatic medullary thyroid carcinoma. Endocr Relat Cancer. 2013 Dec; 20(6):809-23. PMID: 24127332.
      Citations: 39     Fields:    Translation:HumansCells
    37. Thosani S, Ayala-Ramirez M, Palmer L, Hu MI, Rich T, Gagel RF, Cote G, Waguespack SG, Habra MA, Jimenez C. The characterization of pheochromocytoma and its impact on overall survival in multiple endocrine neoplasia type 2. J Clin Endocrinol Metab. 2013 Nov; 98(11):E1813-9. PMID: 24030942; PMCID: PMC5399523.
      Citations: 26     Fields:    Translation:Humans
    38. Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar R, Litsas G, McKay R, Podoloff DA, Srinivas S, Van Poznak CH. NCCN Task Force Report: Bone Health In Cancer Care. J Natl Compr Canc Netw. 2013 Aug; 11 Suppl 3:S1-50; quiz S51. PMID: 23997241.
      Citations: 61     Fields:    Translation:Humans
    39. Tuvim MJ, Clement CG, Huang ES, Cote GJ, Evans SE, Lei X, Deftos LJ, Gagel RF, Dickey BF. Deletion of the gene encoding calcitonin and calcitonin gene-related peptide a does not affect the outcome of severe infection in mice. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):151-5. PMID: 23526213; PMCID: PMC3727888.
      Citations: 2     Fields:    Translation:AnimalsCells
    40. Handelsman Y, Leroith D, Bloomgarden ZT, Dagogo-Jack S, Einhorn D, Garber AJ, Grunberger G, Harrell RM, Gagel RF, Lebovitz HE, McGill JB, Hennekens CH. Diabetes and cancer--an AACE/ACE consensus statement. Endocr Pract. 2013 Jul-Aug; 19(4):675-93. PMID: 23978590.
      Citations: 26     Fields:    Translation:Humans
    41. Kirby BJ, Woodrow JP, Gagel RF, Rosen CJ, Sims NA, Kovacs CS, Collins JN. Lactating Ctcgrp nulls lose twice the normal bone mineral content due to fewer osteoblasts and more osteoclasts, whereas bone mass is fully restored after weaning in association with up-regulation of Wnt signaling and other novel genes. Endocrinology. 2013 Apr; 154(4):1400-13. PMID: 23462960; PMCID: PMC3678150.
      Citations: 8     Fields:    Translation:AnimalsCells
    42. Carhill AA, Cabanillas ME, Jimenez C, Waguespack SG, Habra MA, Hu M, Ying A, Vassilopoulou-Sellin R, Gagel RF, Sherman SI, Busaidy NL. The noninvestigational use of tyrosine kinase inhibitors in thyroid cancer: establishing a standard for patient safety and monitoring. J Clin Endocrinol Metab. 2013 Jan; 98(1):31-42. PMID: 23185034; PMCID: PMC3537108.
      Citations: 30     Fields:    Translation:Humans
    43. Gagel RF. Activation of G-protein-coupled receptors and thyroid malignant tumors: the jury is still out. Endocr Pract. 2011 Nov-Dec; 17(6):957-9. PMID: 22193147.
      Citations: 1     Fields:    Translation:HumansAnimals
    44. Wells SA, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, Baudin E, Elisei R, Jarzab B, Vasselli JR, Read J, Langmuir P, Ryan AJ, Schlumberger MJ. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol. 2012 Jan 10; 30(2):134-41. PMID: 22025146; PMCID: PMC3675689.
      Citations: 439     Fields:    Translation:HumansCTClinical Trials
    45. Kurzrock R, Sherman SI, Ball DW, Forastiere AA, Cohen RB, Mehra R, Pfister DG, Cohen EE, Janisch L, Nauling F, Hong DS, Ng CS, Ye L, Gagel RF, Frye J, Ratain MJ, Salgia R, M?ller T. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol. 2011 Jul 01; 29(19):2660-6. PMID: 21606412; PMCID: PMC3646303.
      Citations: 204     Fields:    Translation:HumansCTClinical Trials
    46. Jimenez C, Ayala-Ramirez M, Liu J, Nunez R, Gagel RF. Inhibition of growth hormone receptor activation by pegvisomant may increase bone density in acromegaly. Horm Metab Res. 2011 Jan; 43(1):55-61. PMID: 21104581.
      Citations: 4     Fields:    Translation:HumansCells
    47. Hoff AO, Toth B, Hu M, Hortobagyi GN, Gagel RF. Epidemiology and risk factors for osteonecrosis of the jaw in cancer patients. Ann N Y Acad Sci. 2011 Feb; 1218:47-54. PMID: 20946574.
      Citations: 28     Fields:    Translation:Humans
    48. Ye L, Santarpia L, Gagel RF. The evolving field of tyrosine kinase inhibitors in the treatment of endocrine tumors. Endocr Rev. 2010 Aug; 31(4):578-99. PMID: 20605972.
      Citations: 16     Fields:    Translation:HumansCells
    49. Hu MI, Lu H, Gagel RF. Cancer therapies and bone health. Curr Rheumatol Rep. 2010 Jun; 12(3):177-85. PMID: 20437119.
      Citations: 4     Fields:    Translation:Humans
    50. Wells SA, Gosnell JE, Gagel RF, Moley J, Pfister D, Sosa JA, Skinner M, Krebs A, Vasselli J, Schlumberger M. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol. 2010 Feb 10; 28(5):767-72. PMID: 20065189; PMCID: PMC2834392.
      Citations: 160     Fields:    Translation:HumansCTClinical Trials
    51. Hong DS, Sebti SM, Newman RA, Blaskovich MA, Ye L, Gagel RF, Moulder S, Wheler JJ, Naing A, Tannir NM, Ng CS, Sherman SI, El Naggar AK, Khan R, Trent J, Wright JJ, Kurzrock R. Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies. Clin Cancer Res. 2009 Nov 15; 15(22):7061-8. PMID: 19903778; PMCID: PMC2784003.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    52. Ye L, Santarpia L, Gagel RF. Targeted therapy for endocrine cancer: the medullary thyroid carcinoma paradigm. Endocr Pract. 2009 Sep-Oct; 15(6):597-604. PMID: 19546050.
      Citations: 3     Fields:    Translation:Humans
    53. Santarpia L, Ye L, Gagel RF. Beyond RET: potential therapeutic approaches for advanced and metastatic medullary thyroid carcinoma. J Intern Med. 2009 Jul; 266(1):99-113. PMID: 19522829.
      Citations: 14     Fields:    Translation:HumansCells
    54. Becklund BR, James BJ, Gagel RF, DeLuca HF. The calcitonin/calcitonin gene related peptide-alpha gene is not required for 1alpha,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis. Arch Biochem Biophys. 2009 Aug 15; 488(2):105-8. PMID: 19563774.
      Citations: 1     Fields:    Translation:Animals
    55. Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar RN, Shapiro CL, Shields A, Smith MR, Srinivas S, Van Poznak CH. NCCN Task Force Report: Bone Health in Cancer Care. J Natl Compr Canc Netw. 2009 Jun; 7 Suppl 3:S1-32; quiz S33-5. PMID: 19555589; PMCID: PMC3047404.
      Citations: 77     Fields:    Translation:HumansPHPublic Health
    56. American Thyroid Association Guidelines Task Force, Kloos RT, Eng C, Evans DB, Francis GL, Gagel RF, Gharib H, Moley JF, Pacini F, Ringel MD, Schlumberger M, Wells SA. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid. 2009 Jun; 19(6):565-612. PMID: 19469690.
      Citations: 319     Fields:    Translation:Humans
    57. Santarpia L, Gagel RF, Sherman SI, Sarlis NJ, Evans DB, Hoff AO. Diabetes insipidus and panhypopituitarism due to intrasellar metastasis from medullary thyroid cancer. Head Neck. 2009 Mar; 31(3):419-23. PMID: 18798312.
      Citations: 11     Fields:    Translation:Humans
    58. Habra MA, Jimenez C, Huang SC, Cote GJ, Murphy WA, Gagel RF, Hoff AO. Expression analysis of fibroblast growth factor-23, matrix extracellular phosphoglycoprotein, secreted frizzled-related protein-4, and fibroblast growth factor-7: identification of fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein as major factors involved in tumor-induced osteomalacia. Endocr Pract. 2008 Dec; 14(9):1108-14. PMID: 19158050.
      Citations: 10     Fields:    Translation:HumansCells
    59. Ye L, Santarpia L, Cote GJ, El-Naggar AK, Gagel RF. High resolution array-comparative genomic hybridization profiling reveals deoxyribonucleic acid copy number alterations associated with medullary thyroid carcinoma. J Clin Endocrinol Metab. 2008 Nov; 93(11):4367-72. PMID: 18765511; PMCID: PMC2729231.
      Citations: 17     Fields:    Translation:HumansCells
    60. Jimenez C, Burman P, Abs R, Clemmons DR, Drake WM, Hutson KR, Messig M, Thorner MO, Trainer PJ, Gagel RF. Follow-up of pituitary tumor volume in patients with acromegaly treated with pegvisomant in clinical trials. Eur J Endocrinol. 2008 Nov; 159(5):517-23. PMID: 18708436.
      Citations: 15     Fields:    Translation:Humans
    61. Santarpia L, El-Naggar AK, Sherman SI, Hymes SR, Gagel RF, Shaw S, Sarlis NJ. Four patients with cutaneous metastases from medullary thyroid cancer. Thyroid. 2008 Aug; 18(8):901-5. PMID: 18651821.
      Citations: 3     Fields:    Translation:Humans
    62. Hu MI, Gagel RF, Jim?nez C. Management of medullary thyroid carcinoma. Endocrinol Metab Clin North Am. 2008 Jun; 37(2):481-96, x-xi. PMID: 18502338.
      Citations: 27     Fields:    Translation:Humans
    63. Hoff AO, Altundag K, Johnson MM, Warneke CL, Hu M, Nooka A, Sayegh G, Guarneri V, Desrouleaux K, Cui J, Adamus A, Gagel RF, Hortobagyi GN, Toth BB. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res. 2008 Jun; 23(6):826-36. PMID: 18558816; PMCID: PMC2677083.
      Citations: 166     Fields:    Translation:Humans
    64. American Society for Bone and Mineral Research Task Force on Osteonecrosis of the Jaw, Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, McCauley LK, McGowan J, McKee MD, Mohla S, Pendrys DG, Raisz LG, Ruggiero SL, Shafer DM, Shum L, Silverman SL, Van Poznak CH, Watts N, Woo SB, Shane E. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg. 2008 Jun; 66(6):1320-1; author reply 1321-2. PMID: 18486811.
      Citations: 12     Fields:    Translation:Humans
    65. Hong D, Ye L, Gagel R, Chintala L, El Naggar AK, Wright J, Kurzrock R. Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib. Mol Cancer Ther. 2008 May; 7(5):1001-6. PMID: 18445656.
      Citations: 15     Fields:    Translation:HumansCells
    66. Grubbs EG, Rich TA, Li G, Sturgis EM, Younes MN, Myers JN, Edeiken-Monroe B, Fornage BD, Monroe DP, Staerkel GA, Williams MD, Waguespack SG, Hu MI, Cote G, Gagel RF, Cohen J, Weber RS, Anaya DA, Holsinger FC, Perrier ND, Clayman GL, Evans DB. Recent advances in thyroid cancer. In brief. Curr Probl Surg. 2008 Mar; 45(3):149-51. PMID: 18346476.
      Citations: 1     Fields:    Translation:Humans
    67. Grubbs EG, Rich TA, Li G, Sturgis EM, Younes MN, Myers JN, Edeiken-Monroe B, Fornage BD, Monroe DP, Staerkel GA, Williams MD, Waguespack SG, Hu MI, Cote G, Gagel RF, Cohen J, Weber RS, Anaya DA, Holsinger FC, Perrier ND, Clayman GL, Evans DB. Recent advances in thyroid cancer. Curr Probl Surg. 2008 Mar; 45(3):156-250. PMID: 18346477.
      Citations: 19     Fields:    Translation:Humans
    68. Hu MI, Gagel RF, Jimenez C. Bone loss in patients with breast or prostate cancer. Curr Osteoporos Rep. 2007 Dec; 5(4):170-8. PMID: 18430392.
      Citations: 6     Fields:    Translation:Humans
    69. Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, McCauley LK, McGowan J, McKee MD, Mohla S, Pendrys DG, Raisz LG, Ruggiero SL, Shafer DM, Shum L, Silverman SL, Van Poznak CH, Watts N, Woo SB, Shane E, American Society for Bone and Mineral Research. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007 Oct; 22(10):1479-91. PMID: 17663640.
      Citations: 435     Fields:    Translation:HumansAnimals
    70. Sherman SI, Angelos P, Ball DW, Byrd D, Clark OH, Daniels GH, Dilawari RA, Ehya H, Farrar WB, Gagel RF, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey J, Olson JA, Ridge JA, Shah JP, Sisson JC, Tuttle RM, Urist MM, National Comprehensive Cancer Network Thyroid Carcinoma Panel. Thyroid carcinoma. J Natl Compr Canc Netw. 2007 Jul; 5(6):568-621. PMID: 17623612.
      Citations: 21     Fields:    Translation:Humans
    71. Wood WC, Moley JF, Berchuck A, Karlan BY, Mutch DG, Gagel RF, Weitzel J, Morrow M, Weber BL, Giardiello F, Rodriguez-Bigas MA, Church J, Gruber S, Offit K, Guillem JG. ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. Ann Surg Oncol. 2006 Oct; 13(10):1296-321. PMID: 16990987.
      Citations: 11     Fields:    Translation:Humans
    72. Wood WC, Moley JF, Berchuck A, Karlan BY, Mutch DG, Gagel RF, Weitzel J, Morrow M, Weber BL, Giardiello F, Rodriguez-Bigas MA, Church J, Gruber S, Offit K, ASCO, SSO, Guillem JG. ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. J Clin Oncol. 2006 Oct 01; 24(28):4642-60. PMID: 17008706.
      Citations: 43     Fields:    Translation:Humans
    73. Cote G, Arnold A, Gagel RF, Jim?nez C. Review: Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes? J Clin Endocrinol Metab. 2006 Aug; 91(8):2851-8. PMID: 16735498.
      Citations: 33     Fields:    Translation:Humans
    74. Woodrow JP, Sharpe CJ, Fudge NJ, Hoff AO, Gagel RF, Kovacs CS. Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation. Endocrinology. 2006 Sep; 147(9):4010-21. PMID: 16675524.
      Citations: 38     Fields:    Translation:Animals
    75. Kouvaraki MA, Shapiro SE, Cote GJ, Lee JE, Yao JC, Waguespack SG, Gagel RF, Evans DB, Perrier ND. Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J Surg. 2006 May; 30(5):643-53. PMID: 16680581.
      Citations: 34     Fields:    Translation:Humans
    76. Ghori F, Polder KD, Pinter-Brown LC, Hoff AO, Gagel RF, Sherman SI, Duvic M. Thyrotoxicosis after denileukin diftitox therapy in patients with mycosis fungoides. J Clin Endocrinol Metab. 2006 Jun; 91(6):2205-8. PMID: 16595600.
      Citations: 3     Fields:    Translation:Humans
    77. Tashjian AH, Gagel RF. Teriparatide [human PTH(1-34)]: 2.5 years of experience on the use and safety of the drug for the treatment of osteoporosis. J Bone Miner Res. 2006 Mar; 21(3):354-65. PMID: 16491282.
      Citations: 50     Fields:    Translation:Humans
    78. Barkan AL, Burman P, Clemmons DR, Drake WM, Gagel RF, Harris PE, Trainer PJ, van der Lely AJ, Vance ML. Glucose homeostasis and safety in patients with acromegaly converted from long-acting octreotide to pegvisomant. J Clin Endocrinol Metab. 2005 Oct; 90(10):5684-91. PMID: 16076947.
      Citations: 41     Fields:    Translation:HumansCTClinical Trials
    79. Papadimitrakopoulou V, Agelaki S, Tran HT, Kies M, Gagel R, Zinner R, Kim E, Ayers G, Wright J, Khuri F. Phase I study of the farnesyltransferase inhibitor BMS-214662 given weekly in patients with solid tumors. Clin Cancer Res. 2005 Jun 01; 11(11):4151-9. PMID: 15930351.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    80. Kouvaraki MA, Shapiro SE, Perrier ND, Cote GJ, Gagel RF, Hoff AO, Sherman SI, Lee JE, Evans DB. RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. Thyroid. 2005 Jun; 15(6):531-44. PMID: 16029119.
      Citations: 56     Fields:    Translation:Humans
    81. Jimenez C, Yang Y, Kim HW, Al-Sagier F, Berry DA, El-Naggar AK, Patel S, Vassilopoulou-Sellin R, Gagel RF. Primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma. J Bone Miner Res. 2005 Sep; 20(9):1562-8. PMID: 16059628.
      Citations: 7     Fields:    Translation:Humans
    82. Sherman SI, Angelos P, Ball DW, Beenken SW, Byrd D, Clark OH, Daniels GH, Dilawari RA, Ehya H, Farrar WB, Gagel RF, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey J, Olson JA, Ridge JA, Robbins R, Shah JP, Sisson JC, Thompson NW, National Comprehensive Cancer Network. Thyroid carcinoma. J Natl Compr Canc Netw. 2005 May; 3(3):404-57. PMID: 16002006.
      Citations: 15     Fields:    Translation:Humans
    83. Hoff AO, Gagel RF. Osteoporosis in breast and prostate cancer survivors. Oncology (Williston Park). 2005 Apr; 19(5):651-8. PMID: 15945345.
      Citations: 15     Fields:    Translation:Humans
    84. Lambert LA, Shapiro SE, Lee JE, Perrier ND, Truong M, Wallace MJ, Hoff AO, Gagel RF, Evans DB. Surgical treatment of hyperparathyroidism in patients with multiple endocrine neoplasia type 1. Arch Surg. 2005 Apr; 140(4):374-82. PMID: 15841561.
      Citations: 19     Fields:    Translation:Humans
    85. Schinke T, Liese S, Priemel M, Haberland M, Schilling AF, Catala-Lehnen P, Blicharski D, Rueger JM, Gagel RF, Emeson RB, Amling M. Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide. J Bone Miner Res. 2004 Dec; 19(12):2049-56. PMID: 15537449.
      Citations: 49     Fields:    Translation:AnimalsCells
    86. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM, Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R. Parathyroid carcinoma: a 22-year experience. Head Neck. 2004 Aug; 26(8):716-26. PMID: 15287039.
      Citations: 69     Fields:    Translation:Humans
    87. Jimenez C, Habra MA, Huang SC, El-Naggar A, Shapiro SE, Evans DB, Cote G, Gagel RF. Pheochromocytoma and medullary thyroid carcinoma: a new genotype-phenotype correlation of the RET protooncogene 891 germline mutation. J Clin Endocrinol Metab. 2004 Aug; 89(8):4142-5. PMID: 15292360.
      Citations: 4     Fields:    Translation:Humans
    88. Jimenez C, Dang GT, Schultz PN, El-Naggar A, Shapiro S, Barnes EA, Evans DB, Vassilopoulou-Sellin R, Gagel RF, Cote GJ, Hoff AO. A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma. J Clin Endocrinol Metab. 2004 Jul; 89(7):3521-6. PMID: 15240641.
      Citations: 12     Fields:    Translation:HumansCells
    89. Jimenez C, Gagel RF. Genetic testing in endocrinology: lessons learned from experience with multiple endocrine neoplasia type 2 (MEN2). Growth Horm IGF Res. 2004 Jun; 14 Suppl A:S150-7. PMID: 15135800.
      Citations: 3     Fields:    Translation:HumansAnimals
    90. Yip L, Lee JE, Shapiro SE, Waguespack SG, Sherman SI, Hoff AO, Gagel RF, Arens JF, Evans DB. Surgical management of hereditary pheochromocytoma. J Am Coll Surg. 2004 Apr; 198(4):525-34; discussion 534-5. PMID: 15051000.
      Citations: 29     Fields:    Translation:Humans
    91. McDonald KR, Fudge NJ, Woodrow JP, Friel JK, Hoff AO, Gagel RF, Kovacs CS. Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis. Am J Physiol Endocrinol Metab. 2004 Aug; 287(2):E218-26. PMID: 15039145.
      Citations: 6     Fields:    Translation:Animals
    92. Yen TW, Shapiro SE, Gagel RF, Sherman SI, Lee JE, Evans DB. Medullary thyroid carcinoma: results of a standardized surgical approach in a contemporary series of 80 consecutive patients. Surgery. 2003 Dec; 134(6):890-9; discussion 899-901. PMID: 14668720.
      Citations: 10     Fields:    Translation:Humans
    93. Pederson LC, Shapiro SE, Fritsche HA, Delpassand ES, Gagel RF, Sherman SI, Vassilopoulou-Sellin R, Evans DB, Lee JE. Potential role for intraoperative gamma probe identification of normal parathyroid glands. Am J Surg. 2003 Dec; 186(6):711-7. PMID: 14672784.
      Citations: 4     Fields:    Translation:Humans
    94. Shapiro SE, Cote GC, Lee JE, Gagel RF, Evans DB. The role of genetics in the surgical management of familial endocrinopathy syndromes. J Am Coll Surg. 2003 Nov; 197(5):818-31. PMID: 14585420.
      Citations: 4     Fields:    Translation:Humans
    95. Prabhu SS, Aldape KD, Gagel RF, Benjamin RS, Trent JC, McCutcheon IE. Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma. Can J Neurol Sci. 2003 Nov; 30(4):378-83. PMID: 14672272.
      Citations: 6     Fields:    Translation:Humans
    96. Cote GJ, Gagel RF. Lessons learned from the management of a rare genetic cancer. N Engl J Med. 2003 Oct 16; 349(16):1566-8. PMID: 14561800.
      Citations: 5     Fields:    Translation:Humans
    97. Yip L, Cote GJ, Shapiro SE, Ayers GD, Herzog CE, Sellin RV, Sherman SI, Gagel RF, Lee JE, Evans DB. Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship. Arch Surg. 2003 Apr; 138(4):409-16; discussion 416. PMID: 12686527.
      Citations: 39     Fields:    Translation:Humans
    98. Huang SC, Torres-Cruz J, Pack SD, Koch CA, Vortmeyer AO, Mannan P, Lubensky IA, Gagel RF, Zhuang Z. Amplification and overexpression of mutant RET in multiple endocrine neoplasia type 2-associated medullary thyroid carcinoma. J Clin Endocrinol Metab. 2003 Jan; 88(1):459-63. PMID: 12519890.
      Citations: 15     Fields:    Translation:HumansCells
    99. Hoff AO, Catala-Lehnen P, Thomas PM, Priemel M, Rueger JM, Nasonkin I, Bradley A, Hughes MR, Ordonez N, Cote GJ, Amling M, Gagel RF. Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest. 2002 Dec; 110(12):1849-57. PMID: 12488435; PMCID: PMC151647.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    100. Royal RE, Delpassand ES, Shapiro SE, Fritsche HA, Vassilopoulou-Sellin R, Sherman SI, Gagel RF, Evans DB, Lee JE. Improving the yield of preoperative parathyroid localization: technetium Tc 99m-sestamibi imaging after thyroid suppression. Surgery. 2002 Dec; 132(6):968-74; discussion 974-5. PMID: 12490843.
      Citations: 6     Fields:    Translation:Humans
    101. Kikumori T, Cote GJ, Gagel RF. Naturally occurring heterologous trans-splicing of adenovirus RNA with host cellular transcripts during infection. FEBS Lett. 2002 Jul 03; 522(1-3):41-6. PMID: 12095616.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    102. Kouvaraki MA, Lee JE, Shapiro SE, Gagel RF, Sherman SI, Sellin RV, Cote GJ, Evans DB. Genotype-phenotype analysis in multiple endocrine neoplasia type 1. Arch Surg. 2002 Jun; 137(6):641-7. PMID: 12049533.
      Citations: 48     Fields:    Translation:Humans
    103. Gagel RF. When "The 7-Year Itch" is indicative of an endocrine malignant condition. Endocr Pract. 2002 Jan-Feb; 8(1):72-4. PMID: 11939768.
      Citations: 1     Fields:    Translation:Humans
    104. Brandi ML, Gagel RF, Angeli A, Bilezikian JP, Beck-Peccoz P, Bordi C, Conte-Devolx B, Falchetti A, Gheri RG, Libroia A, Lips CJ, Lombardi G, Mannelli M, Pacini F, Ponder BA, Raue F, Skogseid B, Tamburrano G, Thakker RV, Thompson NW, Tomassetti P, Tonelli F, Wells SA, Marx SJ. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab. 2001 Dec; 86(12):5658-71. PMID: 11739416.
      Citations: 455     Fields:    Translation:Humans
    105. Lenert JT, Barnett CC, Kudelka AP, Sellin RV, Gagel RF, Prieto VG, Skibber JM, Ross MI, Pisters PW, Curley SA, Evans DB, Lee JE. Evaluation and surgical resection of adrenal masses in patients with a history of extra-adrenal malignancy. Surgery. 2001 Dec; 130(6):1060-7. PMID: 11742339.
      Citations: 36     Fields:    Translation:Humans
    106. Solorzano CC, Lee JE, Pisters PW, Vauthey JN, Ayers GD, Jean ME, Gagel RF, Ajani JA, Wolff RA, Evans DB. Nonfunctioning islet cell carcinoma of the pancreas: survival results in a contemporary series of 163 patients. Surgery. 2001 Dec; 130(6):1078-85. PMID: 11742342.
      Citations: 77     Fields:    Translation:Humans
    107. Koch CA, Huang SC, Moley JF, Azumi N, Chrousos GP, Gagel RF, Zhuang Z, Pacak K, Vortmeyer AO. Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinoma. Oncogene. 2001 Nov 22; 20(53):7809-11. PMID: 11753660.
      Citations: 15     Fields:    Translation:HumansCells
    108. Kikumori T, Cote GJ, Gagel RF. Promiscuity of pre-mRNA spliceosome-mediated trans splicing: a problem for gene therapy? Hum Gene Ther. 2001 Jul 20; 12(11):1429-41. PMID: 11485634.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    109. Becker P, Youlton R, Cote GJ, Gagel RF, Wohllk N. [Germline mutations of the ret proto-oncogene in Chilean patients with hereditary and sporadic medullary thyroid carcinoma]. Rev Med Chil. 2001 Jul; 129(7):713-8. PMID: 11552438.
      Citations: 3     Fields:    Translation:HumansCells
    110. Dackiw AP, Lee JE, Gagel RF, Evans DB. Adrenal cortical carcinoma. World J Surg. 2001 Jul; 25(7):914-26. PMID: 11572033.
      Citations: 80     Fields:    Translation:Humans
    111. Lou H, Gagel RF. Alternative ribonucleic acid processing in endocrine systems. Endocr Rev. 2001 Apr; 22(2):205-25. PMID: 11294824.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    112. Zhang L, Hoff AO, Wimalawansa SJ, Cote GJ, Gagel RF, Westlund KN. Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity. Pain. 2001 Jan; 89(2-3):265-73. PMID: 11166483.
      Citations: 65     Fields:    Translation:AnimalsCells
    113. Thomas PM, Nasonkin I, Zhang H, Gagel RF, Cote GJ. Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes. DNA Seq. 2001; 12(2):131-5. PMID: 11761712.
      Citations: 4     Fields:    Translation:AnimalsCells
    114. Barnett CC, Varma DG, El-Naggar AK, Dackiw AP, Porter GA, Pearson AS, Kudelka AP, Gagel RF, Evans DB, Lee JE. Limitations of size as a criterion in the evaluation of adrenal tumors. Surgery. 2000 Dec; 128(6):973-82;discussion 982-3. PMID: 11114632.
      Citations: 19     Fields:    Translation:Humans
    115. Schultz PN, Ginsberg L, McCutcheon IE, Samaan N, Leavens M, Gagel RF. Quinagolide in the management of prolactinoma. Pituitary. 2000 Dec; 3(4):239-49. PMID: 11788012.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    116. Huang SC, Koch CA, Vortmeyer AO, Pack SD, Lichtenauer UD, Mannan P, Lubensky IA, Chrousos GP, Gagel RF, Pacak K, Zhuang Z. Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas. Cancer Res. 2000 Nov 15; 60(22):6223-6. PMID: 11103773.
      Citations: 19     Fields:    Translation:HumansCells
    117. Dackiw AP, Sussman JJ, Fritsche HA, Delpassand ES, Stanford P, Hoff A, Gagel RF, Evans DB, Lee JE. Relative contributions of technetium Tc 99m sestamibi scintigraphy, intraoperative gamma probe detection, and the rapid parathyroid hormone assay to the surgical management of hyperparathyroidism. Arch Surg. 2000 May; 135(5):550-5; discussion 555-7. PMID: 10807279.
      Citations: 19     Fields:    Translation:Humans
    118. McCutcheon IE, Pieper DR, Fuller GN, Benjamin RS, Friend KE, Gagel RF. Pituitary carcinoma containing gonadotropins: treatment by radical excision and cytotoxic chemotherapy: case report. Neurosurgery. 2000 May; 46(5):1233-9; discussion 1239-40. PMID: 10807257.
      Citations: 18     Fields:    Translation:Humans
    119. Yeung SJ, McCutcheon IE, Schultz P, Gagel RF. Use of long-term intravenous phosphate infusion in the palliative treatment of tumor-induced osteomalacia. J Clin Endocrinol Metab. 2000 Feb; 85(2):549-55. PMID: 10690854.
      Citations: 2     Fields:    Translation:Humans
    120. Gangula PR, Zhao H, Supowit SC, Wimalawansa SJ, Dipette DJ, Westlund KN, Gagel RF, Yallampalli C. Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. Hypertension. 2000 Jan; 35(1 Pt 2):470-5. PMID: 10642343.
      Citations: 36     Fields:    Translation:Animals
    121. Hoff AO, Cote GJ, Gagel RF. Multiple endocrine neoplasias. Annu Rev Physiol. 2000; 62:377-411. PMID: 10845096.
      Citations: 13     Fields:    Translation:HumansAnimals
    122. Dackiw AP, Cote GJ, Fleming JB, Schultz PN, Stanford P, Vassilopoulou-Sellin R, Evans DB, Gagel RF, Lee JE. Screening for MEN1 mutations in patients with atypical endocrine neoplasia. Surgery. 1999 Dec; 126(6):1097-103; discussion 1103-4. PMID: 10598193.
      Citations: 14     Fields:    Translation:Humans
    123. Hoff AO, Cote GJ, Fritsche HA, Qiu H, Schultz PN, Gagel RF. Calcium-induced activation of a mutant G-protein-coupled receptor causes in vitro transformation of NIH/3T3 cells. Neoplasia. 1999 Dec; 1(6):485-91. PMID: 10935495; PMCID: PMC1508117.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    124. Fleming JB, Lee JE, Bouvet M, Schultz PN, Sherman SI, Sellin RV, Friend KE, Burgess MA, Cote GJ, Gagel RF, Evans DB. Surgical strategy for the treatment of medullary thyroid carcinoma. Ann Surg. 1999 Nov; 230(5):697-707. PMID: 10561095; PMCID: PMC1420925.
      Citations: 20     Fields:    Translation:Humans
    125. Parthasarathy R, Cote GJ, Gagel RF. Hammerhead ribozyme-mediated inactivation of mutant RET in medullary thyroid carcinoma. Cancer Res. 1999 Aug 15; 59(16):3911-4. PMID: 10463581.
      Citations: 6     Fields:    Translation:AnimalsCells
    126. Gagel RF, McCutcheon IE. Images in clinical medicine. Pituitary gigantism. N Engl J Med. 1999 Feb 18; 340(7):524. PMID: 10021473.
      Citations: 3     Fields:    Translation:Humans
    127. Dang GT, Cote GJ, Schultz PN, Khorana S, Decker RA, Gagel RF. A codon 891 exon 15 RET proto-oncogene mutation in familial medullary thyroid carcinoma: a detection strategy. Mol Cell Probes. 1999 Feb; 13(1):77-9. PMID: 10024437.
      Citations: 5     Fields:    Translation:Humans
    128. Lou H, Helfman DM, Gagel RF, Berget SM. Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol. 1999 Jan; 19(1):78-85. PMID: 9858533; PMCID: PMC83867.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    129. Evans DB, Fleming JB, Lee JE, Cote G, Gagel RF. The surgical treatment of medullary thyroid carcinoma. Semin Surg Oncol. 1999 Jan-Feb; 16(1):50-63. PMID: 9890740.
      Citations: 7     Fields:    Translation:Humans
    130. Lou H, Gagel RF. Mechanism of tissue-specific alternative RNA processing of the calcitonin CGRP gene. Front Horm Res. 1999; 25:18-33. PMID: 10941400.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    131. Lee JE, Evans DB, Hickey RC, Sherman SI, Gagel RF, Abbruzzese MC, Abbruzzese JL. Unknown primary cancer presenting as an adrenal mass: frequency and implications for diagnostic evaluation of adrenal incidentalomas. Surgery. 1998 Dec; 124(6):1115-22. PMID: 9854592.
      Citations: 23     Fields:    Translation:Humans
    132. Lou H, Neugebauer KM, Gagel RF, Berget SM. Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol. 1998 Sep; 18(9):4977-85. PMID: 9710581; PMCID: PMC109082.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    133. Newman CB, Melmed S, George A, Torigian D, Duhaney M, Snyder P, Young W, Klibanski A, Molitch ME, Gagel R, Sheeler L, Cook D, Malarkey W, Jackson I, Vance ML, Barkan A, Frohman L, Kleinberg DL. Octreotide as primary therapy for acromegaly. J Clin Endocrinol Metab. 1998 Sep; 83(9):3034-40. PMID: 9745397.
      Citations: 59     Fields:    Translation:HumansCTClinical Trials
    134. Yeung SC, Chiu AC, Vassilopoulou-Sellin R, Gagel RF. The endocrine effects of nonhormonal antineoplastic therapy. Endocr Rev. 1998 Apr; 19(2):144-72. PMID: 9570035.
      Citations: 16     Fields:    Translation:Humans
    135. Shefelbine SE, Khorana S, Schultz PN, Huang E, Thobe N, Hu ZJ, Fox GM, Jing S, Cote GJ, Gagel RF. Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux. Hum Genet. 1998 Apr; 102(4):474-8. PMID: 9600247.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    136. Lou H, Gagel RF. Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide. J Endocrinol. 1998 Mar; 156(3):401-5. PMID: 9582495.
      Citations: 14     Fields:    Translation:HumansCells
    137. O'Brien KO, Abrams SA, Liang LK, Ellis KJ, Gagel RF. Bone turnover response to changes in calcium intake is altered in girls and adult women in families with histories of osteoporosis. J Bone Miner Res. 1998 Mar; 13(3):491-9. PMID: 9525350.
      Citations: 4     Fields:    Translation:Humans
    138. Yeung SC, Eton O, Burton DW, Deftos LJ, Vassilopoulou-Sellin R, Gagel RF. Hypercalcemia due to parathyroid hormone-related protein secretion by melanoma. Horm Res. 1998; 49(6):288-91. PMID: 9623520.
      Citations: 4     Fields:    Translation:Humans
    139. Cote GJ, Lee JE, Evans DB, Huang E, Schultz PN, Dang GT, Qiu H, Shetelbine S, Sellin RV, Gagel RF. Five novel mutations in the familial multiple endocrine neoplasia type 1 (MEN1) gene. Mutations in brief no. 188. Online. Hum Mutat. 1998; 12(3):219. PMID: 10660339.
      Citations: 1     Fields:    Translation:Humans
    140. Lee JE, Evans DB, Sherman SI, Gagel RF. Evaluation of the incidental adrenal mass. Am J Med. 1997 Sep; 103(3):249-50. PMID: 9316558.
      Citations:    Fields:    Translation:Humans
    141. Gagel RF. Unresolved issues in the genesis and management of multiple endocrine neoplasia type 2. Horm Metab Res. 1997 Mar; 29(3):135-7. PMID: 9137984.
      Citations:    Fields:    Translation:Humans
    142. Horvit PK, Gagel RF. The goitrous patient with an elevated serum calcitonin--what to do? J Clin Endocrinol Metab. 1997 Feb; 82(2):335-7. PMID: 9024212.
      Citations: 3     Fields:    Translation:Humans
    143. Gagel RF. An overview of molecular abnormalities leading to thyroid carcinogenesis: a 1993 perspective. Stem Cells. 1997; 15 Suppl 2:7-13. PMID: 9368282.
      Citations:    Fields:    Translation:HumansCells
    144. Evans DB, Burgess MA, Goepfert H, Gagel RF. Medullary thyroid carcinoma. Curr Ther Endocrinol Metab. 1997; 6:127-32. PMID: 9174720.
      Citations: 3     Fields:    Translation:Humans
    145. Gagel RF. Multiple endocrine neoplasia type II and familial medullary thyroid carcinoma. Impact of genetic screening on management. Cancer Treat Res. 1997; 89:421-41. PMID: 9204204.
      Citations: 3     Fields:    Translation:Humans
    146. Lee JE, Curley SA, Gagel RF, Evans DB, Hickey RC. Cortical-sparing adrenalectomy for patients with bilateral pheochromocytoma. Surgery. 1996 Dec; 120(6):1064-70; discussion 1070-1. PMID: 8957496.
      Citations: 38     Fields:    Translation:Humans
    147. Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, van Amstel HK, Lips CJ, Nishisho I, Takai SI, Marsh DJ, Robinson BG, Frank-Raue K, Raue F, Xue F, Noll WW, Romei C, Pacini F, Fink M, Niederle B, Zedenius J, Komminoth P, Hendy GN, Mulligan LM, Nordenskj?ld M, et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA. 1996 Nov 20; 276(19):1575-9. PMID: 8918855.
      Citations: 262     Fields:    Translation:Humans
    148. Wohllk N, Cote GJ, Bugalho MM, Ordonez N, Evans DB, Goepfert H, Khorana S, Schultz P, Richards CS, Gagel RF. Relevance of RET proto-oncogene mutations in sporadic medullary thyroid carcinoma. J Clin Endocrinol Metab. 1996 Oct; 81(10):3740-5. PMID: 8855832.
      Citations: 29     Fields:    Translation:HumansCells
    149. Kahn MA, Cote GJ, Gagel RF. RET protooncogene mutational analysis in multiple endocrine neoplasia syndrome type 2B: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Sep; 82(3):288-94. PMID: 8884827.
      Citations: 3     Fields:    Translation:HumansCells
    150. Thomas PM, Wohllk N, Huang E, Kuhnle U, Rabl W, Gagel RF, Cote GJ. Inactivation of the first nucleotide-binding fold of the sulfonylurea receptor, and familial persistent hyperinsulinemic hypoglycemia of infancy. Am J Hum Genet. 1996 Sep; 59(3):510-8. PMID: 8751851; PMCID: PMC1914902.
      Citations: 12     Fields:    Translation:HumansCells
    151. Gagel RF, Goepfert H, Callender DL. Changing concepts in the pathogenesis and management of thyroid carcinoma. CA Cancer J Clin. 1996 Sep-Oct; 46(5):261-83. PMID: 8806393.
      Citations: 5     Fields:    Translation:Humans
    152. Lee DD, Huang JY, Wong CK, Gagel RF, Tsai SF. Genetic heterogeneity of familial primary cutaneous amyloidosis: lack of evidence for linkage with the chromosome 10 pericentromeric region in Chinese families. J Invest Dermatol. 1996 Jul; 107(1):30-3. PMID: 8752835.
      Citations: 6     Fields:    Translation:HumansCells
    153. Gagel RF. ret protooncogene mutations and endocrine neoplasia--a story intertwined with neural crest differentiation. Endocrinology. 1996 May; 137(5):1509-11. PMID: 8612478.
      Citations: 4     Fields:    Translation:HumansAnimals
    154. Payne JY, Holmes F, Cohen PR, Gagel R, Buzdar A, Dhingra K. Paclitaxel: severe mucocutaneous toxicity in a patient with hyperbilirubinemia. South Med J. 1996 May; 89(5):542-5. PMID: 8638189.
      Citations: 7     Fields:    Translation:Humans
    155. O'Brien KO, Abrams SA, Liang LK, Ellis KJ, Gagel RF. Increased efficiency of calcium absorption during short periods of inadequate calcium intake in girls. Am J Clin Nutr. 1996 Apr; 63(4):579-83. PMID: 8599323.
      Citations: 4     Fields:    Translation:HumansCells
    156. Wohllk N, Cote GJ, Evans DB, Goepfert H, Ordonez NG, Gagel RF. Application of genetic screening information to the management of medullary thyroid carcinoma and multiple endocrine neoplasia type 2. Endocrinol Metab Clin North Am. 1996 Mar; 25(1):1-25. PMID: 8907678.
      Citations: 5     Fields:    Translation:HumansCells
    157. Gagel RF. The abnormal pentagastrin test. Clin Endocrinol (Oxf). 1996 Feb; 44(2):221-2. PMID: 8849578.
      Citations: 2     Fields:    Translation:Humans
    158. Lou H, Gagel RF, Berget SM. An intron enhancer recognized by splicing factors activates polyadenylation. Genes Dev. 1996 Jan 15; 10(2):208-19. PMID: 8566754.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    159. Thomas PM, Cote GJ, Wohllk N, Mathew PM, Gagel RF. The molecular basis for familial persistent hyperinsulinemic hypoglycemia of infancy. Proc Assoc Am Physicians. 1996 Jan; 108(1):14-9. PMID: 8834059.
      Citations: 3     Fields:    Translation:Humans
    160. Lou H, Yang Y, Cote GJ, Berget SM, Gagel RF. An intron enhancer containing a 5' splice site sequence in the human calcitonin/calcitonin gene-related peptide gene. Mol Cell Biol. 1995 Dec; 15(12):7135-42. PMID: 8524281; PMCID: PMC230969.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    161. Lee JE, Berger DH, el-Naggar AK, Hickey RC, Vassilopoulou-Sellin R, Gagel RF, Burgess MA, Evans DB. Surgical management, DNA content, and patient survival in adrenal cortical carcinoma. Surgery. 1995 Dec; 118(6):1090-8. PMID: 7491528.
      Citations: 29     Fields:    Translation:Humans
    162. Garrett JE, Tamir H, Kifor O, Simin RT, Rogers KV, Mithal A, Gagel RF, Brown EM. Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology. 1995 Nov; 136(11):5202-11. PMID: 7588259.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    163. Gagel RF, Cote GJ, Martins Bugalho MJ, Boyd AE, Cummings T, Goepfert H, Evans DB, Cangir A, Khorana S, Schultz PN. Clinical use of molecular information in the management of multiple endocrine neoplasia type 2A. J Intern Med. 1995 Oct; 238(4):333-41. PMID: 7595169.
      Citations: 6     Fields:    Translation:HumansCells
    164. Mulligan LM, Marsh DJ, Robinson BG, Schuffenecker I, Zedenius J, Lips CJ, Gagel RF, Takai SI, Noll WW, Fink M, et al. Genotype-phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium. J Intern Med. 1995 Oct; 238(4):343-6. PMID: 7595170.
      Citations: 54     Fields:    Translation:Humans
    165. Newman CB, Melmed S, Snyder PJ, Young WF, Boyajy LD, Levy R, Stewart WN, Klibanski A, Molitch ME, Gagel RF. Safety and efficacy of long-term octreotide therapy of acromegaly: results of a multicenter trial in 103 patients--a clinical research center study. J Clin Endocrinol Metab. 1995 Sep; 80(9):2768-75. PMID: 7673422.
      Citations: 59     Fields:    Translation:HumansCTClinical Trials
    166. Gagel RF. Putting the bits and pieces of the RET proto-oncogene puzzle together. Bone. 1995 Aug; 17(2 Suppl):13S-16S. PMID: 8579892.
      Citations: 1     Fields:    Translation:HumansCells
    167. Yu GH, Katz RL, Raymond AK, Gagel RF, Allison A, McCutcheon I. Oncogenous osteomalacia: fine needle aspiration of a neoplasm with a unique endocrinologic presentation. Acta Cytol. 1995 Jul-Aug; 39(4):831-2. PMID: 7631565.
      Citations: 6     Fields:    Translation:Humans
    168. Cote GJ, Wohllk N, Evans D, Goepfert H, Gagel RF. RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma. Baillieres Clin Endocrinol Metab. 1995 Jul; 9(3):609-30. PMID: 7575334.
      Citations: 3     Fields:    Translation:Humans
    169. Monla YT, Peleg S, Gagel RF, Monia YT. Cell type-specific regulation of transcription by cyclic adenosine 3,'5'-monophosphate-responsive elements within the calcitonin promoter. Mol Endocrinol. 1995 Jul; 9(7):784-93. PMID: 7476962.
      Citations: 9     Fields:    Translation:HumansCells
    170. Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, Aguilar-Bryan L, Gagel RF, Bryan J. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science. 1995 Apr 21; 268(5209):426-9. PMID: 7716548.
      Citations: 187     Fields:    Translation:HumansCells
    171. Cooley LD, Elder FF, Knuth A, Gagel RF. Cytogenetic characterization of three human and three rat medullary thyroid carcinoma cell lines. Cancer Genet Cytogenet. 1995 Apr; 80(2):138-49. PMID: 7736432.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    172. Bugalho MJ, Cote GJ, Khorana S, Schultz PN, Gagel RF. Identification of a polymorphism in exon 11 of the RET protooncogene. Hum Mol Genet. 1994 Dec; 3(12):2263. PMID: 7881435.
      Citations: 6     Fields:    Translation:HumansCells
    173. Lou H, Cote GJ, Gagel RF. The calcitonin exon and its flanking intronic sequences are sufficient for the regulation of human calcitonin/calcitonin gene-related peptide alternative RNA splicing. Mol Endocrinol. 1994 Dec; 8(12):1618-26. PMID: 7535892.
      Citations: 5     Fields:    Translation:HumansCells
    174. Seymour JF, Gagel RF, Hagemeister FB, Dimopoulos MA, Cabanillas F. Calcitriol production in hypercalcemic and normocalcemic patients with non-Hodgkin lymphoma. Ann Intern Med. 1994 Nov 01; 121(9):633-40. PMID: 7944070.
      Citations: 28     Fields:    Translation:HumansCTClinical Trials
    175. Khorana S, Gagel RF, Cote GJ. Direct sequencing of PCR products in agarose gel slices. Nucleic Acids Res. 1994 Aug 25; 22(16):3425-6. PMID: 7915835; PMCID: PMC523740.
      Citations: 13     Fields:    Translation:HumansCells
    176. Gagel RF. Pheochromocytoma, multiple endocrine neoplasia type 2, and von Hippel-Lindau disease. N Engl J Med. 1994 Apr 14; 330(15):1090-1. PMID: 7907397.
      Citations: 2     Fields:    Translation:Humans
    177. Evans DB, Skibber JM, Lee JE, Cleary KR, Ajani JA, Gagel RF, Sellin RV, Fenoglio CJ, Merrell RC, Hickey RC. Nonfunctioning islet cell carcinoma of the pancreas. Surgery. 1993 Dec; 114(6):1175-81; discussion 1181-2. PMID: 7903005.
      Citations: 22     Fields:    Translation:Humans
    178. Gagel RF. The role of genetic screening in the management of hereditary malignancy. Horm Metab Res. 1993 Sep; 25(9):481-3. PMID: 7901138.
      Citations:    Fields:    Translation:Humans
    179. Seymour JF, Gagel RF. Calcitriol: the major humoral mediator of hypercalcemia in Hodgkin's disease and non-Hodgkin's lymphomas. Blood. 1993 Sep 01; 82(5):1383-94. PMID: 8364192.
      Citations: 55     Fields:    Translation:Humans
    180. Nussbaum SR, Younger J, Vandepol CJ, Gagel RF, Zubler MA, Chapman R, Henderson IC, Mallette LE. Single-dose intravenous therapy with pamidronate for the treatment of hypercalcemia of malignancy: comparison of 30-, 60-, and 90-mg dosages. Am J Med. 1993 Sep; 95(3):297-304. PMID: 8368227.
      Citations: 36     Fields:    Translation:HumansCTClinical Trials
    181. Peleg S, Abruzzese RV, Cooper CW, Gagel RF. Down-regulation of calcitonin gene transcription by vitamin D requires two widely separated enhancer sequences. Mol Endocrinol. 1993 Aug; 7(8):999-1008. PMID: 8232320.
      Citations: 10     Fields:    Translation:HumansCells
    182. Gagel RF, Robinson MF, Donovan DT, Alford BR. Clinical review 44: Medullary thyroid carcinoma: recent progress. J Clin Endocrinol Metab. 1993 Apr; 76(4):809-14. PMID: 8473386.
      Citations: 3     Fields:    Translation:Humans
    183. Cote GJ, Stolow DT, Peleg S, Berget SM, Gagel RF. Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP. Nucleic Acids Res. 1992 May 11; 20(9):2361-6. PMID: 1594453; PMCID: PMC312354.
      Citations: 19     Fields:    Translation:HumansCells
    184. Robinson MF, Gagel RF, Raue F. Screening for MEN 2 with biochemical and genetic markers. Recent Results Cancer Res. 1992; 125:105-23. PMID: 1360168.
      Citations:    Fields:    Translation:HumansPHPublic Health
    185. Lichter JB, Hackleman SM, Ponder BA, Easton D, Narod SA, Lenoir GM, Gagel RF, Simpson NE, Gardner E, Goodfellow PJ, et al. A preliminary analysis of consortium data for markers tightly linked to multiple endocrine neoplasia type 2A. Henry Ford Hosp Med J. 1992; 40(3-4):205-9. PMID: 1362406.
      Citations:    Fields:    Translation:HumansCells
    186. Cote GJ, Nguyen IN, Lips CJ, Berget SM, Gagel RF. Validation of an in vitro RNA processing system for CT/CGRP precursor mRNA. Nucleic Acids Res. 1991 Jul 11; 19(13):3601-6. PMID: 1649451; PMCID: PMC328385.
      Citations: 7     Fields:    Translation:Cells
    187. Cote GJ, Nguyen IN, Berget SM, Gagel RF. Calcitonin exon sequences influence alternative RNA processing. Mol Endocrinol. 1990 Nov; 4(11):1744-9. PMID: 2280774.
      Citations: 8     Fields:    Translation:HumansCells
    188. Peleg S, Abruzzese RV, Cote GJ, Gagel RF. Transcription of the human calcitonin gene is mediated by a C cell-specific enhancer containing E-box-like elements. Mol Endocrinol. 1990 Nov; 4(11):1750-7. PMID: 2280775.
      Citations: 9     Fields:    Translation:AnimalsCells
    189. Grauer A, Raue F, Gagel RF. Changing concepts in the management of hereditary and sporadic medullary thyroid carcinoma. Endocrinol Metab Clin North Am. 1990 Sep; 19(3):613-35. PMID: 1979773.
      Citations: 4     Fields:    Translation:HumansCells
    190. Cote GJ, Abruzzese RV, Lips CJ, Gagel RF. Transfection of calcitonin gene regulatory elements into a cell culture model of the C cell. J Bone Miner Res. 1990 Feb; 5(2):165-71. PMID: 2316404.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    191. Gagel RF, Levy ML, Donovan DT, Alford BR, Wheeler T, Tschen JA. Multiple endocrine neoplasia type 2a associated with cutaneous lichen amyloidosis. Ann Intern Med. 1989 Nov 15; 111(10):802-6. PMID: 2573304.
      Citations: 25     Fields:    Translation:Humans
    192. Rogers DG, Cote GJ, Huang ES, Gagel RF. 1,25-Dihydroxyvitamin D3 silences 3',5'-cyclic adenosine monophosphate enhancement of somatostatin gene transcription in human thyroid C cells. Mol Endocrinol. 1989 Mar; 3(3):547-51. PMID: 2568585.
      Citations: 1     Fields:    Translation:HumansCells
    193. Easton DF, Ponder MA, Cummings T, Gagel RF, Hansen HH, Reichlin S, Tashjian AH, Telenius-Berg M, Ponder BA. The clinical and screening age-at-onset distribution for the MEN-2 syndrome. Am J Hum Genet. 1989 Feb; 44(2):208-15. PMID: 2563193; PMCID: PMC1715408.
      Citations: 15     Fields:    Translation:Humans
    194. Donovan DT, Levy ML, Furst EJ, Alford BR, Wheeler T, Tschen JA, Gagel RF. Familial cutaneous lichen amyloidosis in association with multiple endocrine neoplasia type 2A: a new variant. Henry Ford Hosp Med J. 1989; 37(3-4):147-50. PMID: 2576950.
      Citations: 8     Fields:    
    195. Peleg S, Cote GJ, Abruzzese RV, Gagel RF. Transcriptional regulation of the human calcitonin gene: a progress report. Henry Ford Hosp Med J. 1989; 37(3-4):194-7. PMID: 2639134.
      Citations:    Fields:    Translation:HumansCells
    196. Cote GJ, Huang ES, Gagel RF. Calcitonin production: an examination of the regulatory effects of extracellular calcium and 1,25-dihydroxyvitamin D3. Horm Metab Res Suppl. 1989; 21:15-8. PMID: 2807150.
      Citations: 1     Fields:    Translation:HumansCells
    197. Mallette LE, Kirkland JL, Gagel RF, Law WM, Heath H. Synthetic human parathyroid hormone-(1-34) for the study of pseudohypoparathyroidism. J Clin Endocrinol Metab. 1988 Nov; 67(5):964-72. PMID: 2846629.
      Citations: 3     Fields:    Translation:Humans
    198. Gagel RF, Logan C, Mallette LE. Treatment of Paget's disease of bone with salmon calcitonin nasal spray. J Am Geriatr Soc. 1988 Nov; 36(11):1010-4. PMID: 3171038.
      Citations: 2     Fields:    Translation:Humans
    199. Gagel RF, Tashjian AH, Cummings T, Papathanasopoulos N, Kaplan MM, DeLellis RA, Wolfe HJ, Reichlin S. The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a. An 18-year experience. N Engl J Med. 1988 Feb 25; 318(8):478-84. PMID: 2893259.
      Citations: 44     Fields:    Translation:Humans
    200. Ponder BA, Ponder MA, Coffey R, Pembrey ME, Gagel RF, Telenius-Berg M, Semple P, Easton DF. Risk estimation and screening in families of patients with medullary thyroid carcinoma. Lancet. 1988 Feb 20; 1(8582):397-401. PMID: 2893198.
      Citations: 25     Fields:    Translation:HumansPHPublic Health
    201. Cote GJ, Rogers DG, Huang ES, Gagel RF. The effect of 1,25-dihydroxyvitamin D3 treatment on calcitonin and calcitonin gene-related peptide mRNA levels in cultured human thyroid C-cells. Biochem Biophys Res Commun. 1987 Nov 30; 149(1):239-43. PMID: 3500723.
      Citations: 11     Fields:    Translation:HumansCells
    202. Cote GJ, Gould JA, Huang SC, Gagel RF. Studies of short-term secretion of peptides produced by alternative RNA processing. Mol Cell Endocrinol. 1987 Oct; 53(3):211-9. PMID: 2822513.
      Citations:    Fields:    Translation:Cells
    203. Cote GJ, Gagel RF. Different mechanisms of calcitonin, calcitonin gene-related peptide, and somatostatin regulation by glucocorticoids in a cell culture of human medullary thyroid carcinoma. Henry Ford Hosp Med J. 1987; 35(2-3):149-52. PMID: 2891648.
      Citations: 1     Fields:    Translation:HumansCells
    204. Gagel RF, Tashjian AH, Cummings T, Papathanasopoulos N, Reichlin S. Impact of prospective screening for multiple endocrine neoplasia type 2. Henry Ford Hosp Med J. 1987; 35(2-3):94-8. PMID: 2891654.
      Citations:    Fields:    Translation:Humans
    205. Cote GJ, Gagel RF. Dexamethasone differentially affects the levels of calcitonin and calcitonin gene-related peptide mRNAs expressed in a human medullary thyroid carcinoma cell line. J Biol Chem. 1986 Nov 25; 261(33):15524-8. PMID: 3491070.
      Citations: 11     Fields:    Translation:HumansCells
    206. Cote GJ, Palmer WN, Leonhart K, Leong SS, Gagel RF. The regulation of somatostatin production in human medullary thyroid carcinoma cells by dexamethasone. J Biol Chem. 1986 Oct 05; 261(28):12930-5. PMID: 2875992.
      Citations: 4     Fields:    Translation:HumansCells
    207. Gagel RF, Palmer WN, Leonhart K, Chan L, Leong SS. Somatostatin production by a human medullary thyroid carcinoma cell line. Endocrinology. 1986 Apr; 118(4):1643-51. PMID: 2868883.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    208. Zeytinoglu FN, Gagel RF, DeLellis RA, Wolfe HJ, Tashjian AH, Hammer RA, Leeman SE. Clonal strains of rat medullary thyroid carcinoma cells that produce neurotensin and calcitonin. Functional and morphologic studies. Lab Invest. 1983 Oct; 49(4):453-9. PMID: 6353060.
      Citations: 1     Fields:    Translation:AnimalsCells
    209. Gagel RF, O'Briain DS, Voelkel EF, Wolfe HJ, DeLellis RA, Lee AK, Tashjian AH. Pituitary immunoreactive calcitonin-like material: lack of evidence for cross-reactivity with pro-opiomelanocortin. Metabolism. 1983 Jul; 32(7):686-96. PMID: 6191178.
      Citations:    Fields:    Translation:HumansAnimalsCells
    210. Zeytinoglu FN, Gagel RF, Tashjian AH, Hammer RA, Leeman SE. Regulation of neurotensin release by a continuous line of mammalian C-cells: the role of biogenic amines. Endocrinology. 1983 Apr; 112(4):1240-6. PMID: 6832044.
      Citations: 1     Fields:    Translation:AnimalsCells
    211. Gagel RF, Jackson CE, Block MA, Feldman ZT, Reichlin S, Hamilton BP, Tashjian AH. Age-related probability of development of hereditary medullary thyroid carcinoma. J Pediatr. 1982 Dec; 101(6):941-6. PMID: 7143171.
      Citations: 11     Fields:    Translation:Humans
    212. Spiler IJ, Kapcala LP, Graze K, Gagel RF, Feldman ZT, Biller B, Tashjian AH, Reichlin S. Effects of L-dopa and bromocriptine on calcitonin secretion in medullary thyroid carcinoma. J Clin Endocrinol Metab. 1980 Oct; 51(4):806-9. PMID: 7419666.
      Citations:    Fields:    Translation:Humans
    213. Gagel RF, Zeytinoglu FN, Voelkel EF, Tashjian AH. Establishment of a calcitonin-producing rat medullary thyroid carcinoma cell line. II. Secretory studies of the tumor and cells in culture. Endocrinology. 1980 Aug; 107(2):516-23. PMID: 7389665.
      Citations: 6     Fields:    Translation:AnimalsCells
    214. Zeytinoglu FN, DeLellis RA, Gagel RF, Wolfe HJ, Tashjian AH. Establishment of a calcitonin-producing rat medullary thyroid carcinoma cell line. I. Morphological studies of the tumor and cells in culture. Endocrinology. 1980 Aug; 107(2):509-15. PMID: 6248326.
      Citations: 8     Fields:    Translation:AnimalsCells
    215. Zeytinoglu FN, Gagel RF, Tashjian AH, Hammer RA, Leeman SE. Characterization of neurotensin production by a line of rat medullary thyroid carcinoma cells. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3741-5. PMID: 6932046; PMCID: PMC349695.
      Citations: 7     Fields:    Translation:AnimalsCells
    216. DeLellis RA, Nunnemacher G, Bitman WR, Gagel RF, Tashjian AH, Blount M, Wolfe HJ. C-cell hyperplasia and medullary thyroid carcinoma in the rat. An immunohistochemical and ultrastructural analysis. Lab Invest. 1979 Feb; 40(2):140-54. PMID: 431034.
      Citations: 7     Fields:    Translation:AnimalsCells
    217. Graze K, Spiler IJ, Tashjian AH, Melvin KE, Cervi-Skinner S, Gagel RF, Miller HH, Wolfe HJ, DeLellis RA, Leape L, Feldman ZT, Reichlin S. Natural history of familial medullary thyroid carcinoma: effect of a program for early diagnosis. N Engl J Med. 1978 Nov 02; 299(18):980-5. PMID: 692625.
      Citations: 22     Fields:    Translation:Humans
    218. Rocklin RE, Gagel R, Feldman Z, Tashjian AH. Cellular immune responses in familial medullary thyroid carcinoma. N Engl J Med. 1977 Apr 14; 296(15):835-8. PMID: 321956.
      Citations: 5     Fields:    Translation:HumansCells
    219. Gagel RF, Costanza ME, DeLellis RA, Norton RA, Bloom SR, Miller HH, Ucci A, Nathanson L. Streptozocin-treated Verner-Morrison Syndrome: plasma vasoactive intestinal peptide and tumor responses. Arch Intern Med. 1976 Dec; 136(12):1429-35. PMID: 187136.
      Citations: 6     Fields:    Translation:Humans
    220. Leape LL, Miller HH, Graze K, Feldman ZT, Gagel RF, Wolfe HJ, Delellis RA, Tashjian AH, Reichlin S. Total thyroidectomy for occult familial medullary carcinoma of the thyroid in children. J Pediatr Surg. 1976 Oct; 11(5):831-7. PMID: 993955.
      Citations: 3     Fields:    Translation:Humans
    221. DeLellis RA, Gagel RF, Kaplan MM, Curtis LE. Gastrinoma of duodenal G-cell origin. Cancer. 1976 Jul; 38(1):201-8. PMID: 181128.
      Citations: 2     Fields:    Translation:Humans
    222. DeLellis RA, Wolfe HJ, Gagel RF, Feldman ZT, Miller HH, Gang DL, Reichlin S. Adrenal medullary hyperplasia. A morphometric analysis in patients with familial medullary thyroid carcinoma. Am J Pathol. 1976 Apr; 83(1):177-96. PMID: 1275056; PMCID: PMC2032434.
      Citations: 30     Fields:    Translation:HumansAnimals
    223. Gagel RF, Melvin KE, Tashjian AH, Miller HH, Feldman ZT, Wolfe HJ, DeLellis RA, Cerviskinner S, Reichlin S. Natural history of the familial medullary thyroid carcinoma-pheochromocytoma syndrome and the identification of preneoplastic stages by screening studies: a five-year report. Trans Assoc Am Physicians. 1975; 88:177-91. PMID: 1224435.
      Citations: 9     Fields:    Translation:Humans
    224. TRH excretion and metabolism in man. Clinical Research. 23.
    225. Examination of the alternative pathways of calcitonin pre-mRNA maturation in an in vitro RNA processing system. 64-68.
    226. Erratum. Journal of Clinical Endocrinology and Metabolism. 80:3238.
    227. The JBMR goes international. Journal of Bone and Mineral Research. 17:2092-2093.
    228. Multiple endocrine neoplasia. Endocrinology and Metabolism Clinics of North America. 23.
    229. Erratum. Journal of Bone and Mineral Research. 21:807.
    230. The impact of gene mapping techniques on the management of multiple endocrine neoplasia type 2. Trends in Endocrinology and Metabolism. 2:19-25.
    231. Glucagon- and cAMP-induced phosphorylation in rat medullary thyroid carcinoma (rMTC) cells. Calcified Tissue International. 34.
    232. THYROID RESEARCH. 8-10.
    233. Adrenal medullary hyperplasia in familial medullary thyroid carcinoma. American Journal of Pathology. 78.
    234. All in the family? Analyzing the impact of family history in addition to genotype on medullary thyroid carcinoma aggressiveness in MEN2A patients. Familial Cancer. 1-7.
    235. Resection of granulomatous tissue resolves silicone induced hypercalcemia. Bone Reports. 5:163-167.
    236. Natural history of familial medullary carcinoma of the thyroid gland (MCT) pheochromocytoma syndrome and the identification of preneoplastic stages by screening tests. A five year report. Clinical Research. 23.
    237. Role of CDKN2C copy number in sporadic medullary thyroid carcinoma. Thyroid. 26:1553-1562.
    238. Advances in genetic screening for multiple endocrine neoplasia type 2 and the implications for management of children at risk. Endocrinologist. 4:140-146.
    239. Medullary Thyroid Carcinoma Associated with Germline RETK666N Mutation. Thyroid. 26:1744-1751.
    240. Bone metastases and skeletal-related events in medullary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism. 101:4871-4877.
    241. Vitamin D Control of the Calcitonin Gene in Thyroid C Cells. 687-701.
    242. Streptozocin-Treated Verner-Morrison Syndrome. Archives of Internal Medicine. 136:1429-1435.
    243. Multiple endocrine neoplasia types 1 and 2. Current Opinion in Endocrinology and Diabetes. 4:91-99.
    244. Endocrine Manifestations of Tumors. 1187-1192.
    245. Revised American thyroid association guidelines for the management of medullary thyroid carcinoma. Thyroid. 25:567-610.
    246. Reply to J.-F. Chatal et al. Journal of Clinical Oncology. 30:2166-2167.
    247. Pituitary gigantism. New England Journal of Medicine. 340:524.
    248. Multiple endocrine neoplasia type 2. 393-399.
    249. Calcitonin Gene Family of Peptides. 813-836.
    250. Molecular Diagnosis of Bone and Mineral Disorders. 193-196.
    251. Archives of Osteoporosis. 11.
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