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ALLAN FERREON

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R01NS105874     (FERREON, ALLAN CHRIS)Aug 15, 2019 - Jul 31, 2024
    NIH/NINDS
    Phase Transition-Mediated Tau Function and Dysfunction
    Role: Principal Investigator
    R21NS109678     (FERREON, ALLAN CHRIS)Aug 15, 2019 - Jul 31, 2021
    NIH/NINDS
    Pharmacologic inhibition of ribonucleoprotein droplet maturation
    Role: Principal Investigator
    R21NS107792     (FERREON, ALLAN CHRIS)Apr 1, 2019 - Mar 31, 2021
    NIH/NINDS
    Mechanism of Pathologic hnRNP Droplet Maturation
    Role: Principal Investigator
    F32NS054468     (FERREON, ALLAN CHRIS)Aug 1, 2006 - Jul 31, 2009
    NIH/NINDS
    Single-Molecule Study of Synuclein Folding/Fibrillation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Quan MD, Ferreon JC, Ferreon ACM. Micropolarized to the core. Nat Chem Biol. 2024 Apr; 20(4):399-400. PMID: 38326412.
      Citations:    Fields:    
    2. Tsoi PS, Quan MD, Ferreon JC, Ferreon ACM. Aggregation of Disordered Proteins Associated with Neurodegeneration. Int J Mol Sci. 2023 Feb 08; 24(4). PMID: 36834792; PMCID: PMC9966039.
      Citations: 1     Fields:    Translation:Humans
    3. Quan MD, Liao SJ, Ferreon JC, Ferreon ACM. Fluorescence Lifetime Imaging Microscopy of Biomolecular Condensates. Methods Mol Biol. 2023; 2563:135-148. PMID: 36227471; PMCID: PMC10321152.
      Citations:    Fields:    Translation:Cells
    4. Choi KJ, Quan MD, Qi C, Lee JH, Tsoi PS, Zahabiyon M, Bajic A, Hu L, Prasad BVV, Liao SJ, Li W, Ferreon ACM, Ferreon JC. NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency. Nat Cell Biol. 2022 05; 24(5):737-747. PMID: 35484250; PMCID: PMC9106587.
      Citations:    Fields:    Translation:HumansCells
    5. Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JC. Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021 09 22; 12(1):5579. PMID: 34552088; PMCID: PMC8458463.
      Citations: 3     Fields:    Translation:HumansCells
    6. Tsoi PS, Quan MD, Choi KJ, Dao KM, Ferreon JC, Ferreon ACM. Electrostatic modulation of hnRNPA1 low-complexity domain liquid-liquid phase separation and aggregation. Protein Sci. 2021 07; 30(7):1408-1417. PMID: 33982369; PMCID: PMC8197420.
      Citations: 4     Fields:    Translation:HumansCells
    7. Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Li W, Rosen JM, Kim J, Ma L. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020 03 18; 48(5):2621-2642. PMID: 31863590; PMCID: PMC7049706.
      Citations: 25     Fields:    Translation:HumansCells
    8. Mitra S, Kumar D, Hu L, Sankaran B, Moosa MM, Rice AP, Ferreon JC, Ferreon ACM, Prasad BVV. Influenza A Virus Protein NS1 Exhibits Strain-Independent Conformational Plasticity. J Virol. 2019 11 01; 93(21). PMID: 31375595; PMCID: PMC6803261.
      Citations: 7     Fields:    Translation:Cells
    9. Moosa MM, Ferreon JC, Ferreon ACM. Single-Molecule FRET Detection of Early-Stage Conformations in a-Synuclein Aggregation. Methods Mol Biol. 2019; 1948:221-233. PMID: 30771181.
      Citations: 1     Fields:    Translation:Cells
    10. Choi KJ, Tsoi PS, Moosa MM, Paulucci-Holthauzen A, Liao SJ, Ferreon JC, Ferreon ACM. A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation. Biochemistry. 2018 12 18; 57(50):6822-6826. PMID: 30520303; PMCID: PMC6555487.
      Citations: 16     Fields:    Translation:HumansCells
    11. Moosa MM, Tsoi PS, Choi KJ, Ferreon ACM, Ferreon JC. Direct Single-Molecule Observation of Sequential DNA Bending Transitions by the Sox2 HMG Box. Int J Mol Sci. 2018 Dec 04; 19(12). PMID: 30518054; PMCID: PMC6321608.
      Citations: 3     Fields:    Translation:Cells
    12. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, Tsoi PS, Lasanajak Y, Smith DF, Ramani S, Atmar RL, Estes MK, Ferreon JC, Prasad BVV. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018 07 06; 9(1):2631. PMID: 29980685; PMCID: PMC6035239.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    13. Moosa MM, Ferreon JC, Ferreon ACM. Ligand interactions and the protein order-disorder energetic continuum. Semin Cell Dev Biol. 2020 03; 99:78-85. PMID: 29753880.
      Citations: 4     Fields:    Translation:HumansCells
    14. Ren Z, Lee J, Moosa MM, Nian Y, Hu L, Xu Z, McCoy JG, Ferreon ACM, Im W, Zhou M. Structure of an EIIC sugar transporter trapped in an inward-facing conformation. Proc Natl Acad Sci U S A. 2018 06 05; 115(23):5962-5967. PMID: 29784777; PMCID: PMC6003338.
      Citations: 6     Fields:    Translation:Cells
    15. Ferreon JC, Jain A, Choi KJ, Tsoi PS, MacKenzie KR, Jung SY, Ferreon AC. Acetylation Disfavors Tau Phase Separation. Int J Mol Sci. 2018 May 04; 19(5). PMID: 29734651; PMCID: PMC5983838.
      Citations: 45     Fields:    Translation:HumansCells
    16. Moosa MM, Goodman AZ, Ferreon JC, Lee CW, Ferreon ACM, Deniz AA. Denaturant-specific effects on the structural energetics of a protein-denatured ensemble. Eur Biophys J. 2018 Jan; 47(1):89-94. PMID: 29080139; PMCID: PMC6588398.
      Citations: 1     Fields:    Translation:Cells
    17. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Corrigendum: Quantitative real-time imaging of glutathione. Nat Commun. 2017 10 03; 8:16163. PMID: 28972204; PMCID: PMC5628253.
      Citations: 2     Fields:    
    18. Tsoi PS, Choi KJ, Leonard PG, Sizovs A, Moosa MM, MacKenzie KR, Ferreon JC, Ferreon ACM. The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding. Angew Chem Int Ed Engl. 2017 10 02; 56(41):12590-12593. PMID: 28833982.
      Citations: 23     Fields:    Translation:HumansCells
    19. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087. PMID: 28703127; PMCID: PMC5511354.
      Citations: 47     Fields:    Translation:HumansCells
    20. Moosa MM, Ferreon AC, Deniz AA. Forced folding of a disordered protein accesses an alternative folding landscape. Chemphyschem. 2015 Jan 12; 16(1):90-4. PMID: 25345588; PMCID: PMC4286261.
      Citations: 17     Fields:    Translation:Cells
    21. Ferreon AC, Ferreon JC, Wright PE, Deniz AA. Modulation of allostery by protein intrinsic disorder. Nature. 2013 Jun 20; 498(7454):390-4. PMID: 23783631; PMCID: PMC3718496.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    22. Ferreon AC, Moosa MM, Gambin Y, Deniz AA. Counteracting chemical chaperone effects on the single-molecule a-synuclein structural landscape. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):17826-31. PMID: 22826265; PMCID: PMC3497778.
      Citations: 30     Fields:    Translation:Cells
    23. Ferreon AC, Deniz AA. Osmolyte-, binding-, and temperature-induced transitions of intrinsically disordered proteins. Methods Mol Biol. 2012; 896:257-66. PMID: 22821530.
      Citations: 2     Fields:    Translation:Cells
    24. Ferreon AC, Deniz AA. Protein folding at single-molecule resolution. Biochim Biophys Acta. 2011 Aug; 1814(8):1021-9. PMID: 21303706; PMCID: PMC3114273.
      Citations: 12     Fields:    Translation:Cells
    25. Gambin Y, VanDelinder V, Ferreon AC, Lemke EA, Groisman A, Deniz AA. Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing. Nat Methods. 2011 Mar; 8(3):239-41. PMID: 21297620; PMCID: PMC3071799.
      Citations: 46     Fields:    Translation:HumansCells
    26. Lee CW, Ferreon JC, Ferreon AC, Arai M, Wright PE. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19290-5. PMID: 20962272; PMCID: PMC2984141.
      Citations: 99     Fields:    Translation:Cells
    27. Ferreon AC, Moran CR, Ferreon JC, Deniz AA. Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease. Angew Chem Int Ed Engl. 2010 May 03; 49(20):3469-72. PMID: 20544898; PMCID: PMC2972640.
      Citations: 34     Fields:    Translation:Cells
    28. Ferreon AC, Moran CR, Gambin Y, Deniz AA. Single-molecule fluorescence studies of intrinsically disordered proteins. Methods Enzymol. 2010; 472:179-204. PMID: 20580965.
      Citations: 44     Fields:    Translation:HumansCells
    29. Vandelinder V, Ferreon AC, Gambin Y, Deniz AA, Groisman A. High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single F?rster resonance energy transfer image in a microfluidic device. Anal Chem. 2009 Aug 15; 81(16):6929-35. PMID: 19555081; PMCID: PMC2846235.
      Citations: 10     Fields:    Translation:HumansCells
    30. Gambin Y, Schug A, Lemke EA, Lavinder JJ, Ferreon AC, Magliery TJ, Deniz AA, Onuchic JN. Direct single-molecule observation of a protein living in two opposed native structures. Proc Natl Acad Sci U S A. 2009 Jun 23; 106(25):10153-8. PMID: 19506258; PMCID: PMC2700882.
      Citations: 33     Fields:    Translation:Cells
    31. Ferreon AC, Gambin Y, Lemke EA, Deniz AA. Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5645-50. PMID: 19293380; PMCID: PMC2667048.
      Citations: 191     Fields:    Translation:Cells
    32. Ferreon AC, Deniz AA. Alpha-synuclein multistate folding thermodynamics: implications for protein misfolding and aggregation. Biochemistry. 2007 Apr 17; 46(15):4499-509. PMID: 17378587.
      Citations: 39     Fields:    Translation:Cells
    33. Ferreon AC, Ferreon JC, Bolen DW, R?sgen J. Protein phase diagrams II: nonideal behavior of biochemical reactions in the presence of osmolytes. Biophys J. 2007 Jan 01; 92(1):245-56. PMID: 17028144; PMCID: PMC1697851.
      Citations: 8     Fields:    Translation:Cells
    34. Auton M, Ferreon AC, Bolen DW. Metrics that differentiate the origins of osmolyte effects on protein stability: a test of the surface tension proposal. J Mol Biol. 2006 Sep 01; 361(5):983-92. PMID: 16889793.
      Citations: 18     Fields:    Translation:Cells
    35. Ferreon JC, Ferreon AC, Li K, Lemon SM. Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. J Biol Chem. 2005 May 27; 280(21):20483-92. PMID: 15767257.
      Citations: 38     Fields:    Translation:Cells
    36. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Lemon SM. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2992-7. PMID: 15710891; PMCID: PMC548795.
      Citations: 423     Fields:    Translation:HumansCells
    37. Ferreon AC, Bolen DW. Thermodynamics of denaturant-induced unfolding of a protein that exhibits variable two-state denaturation. Biochemistry. 2004 Oct 26; 43(42):13357-69. PMID: 15491142.
      Citations: 23     Fields:    Translation:Cells
    38. Yang M, Ferreon AC, Bolen DW. Structural thermodynamics of a random coil protein in guanidine hydrochloride. Proteins. 2000; Suppl 4:44-9. PMID: 11013399.
      Citations: 6     Fields:    Translation:Cells
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