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Deborah L. Johnson

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    R29GM040623     (JOHNSON, DEBORAH)Jul 1, 1988 - Jun 30, 1994
    NIH/NIGMS
    CHARACTERIZATION OF THE DNA BINDING FUNCTION
    Role: Principal Investigator

    R01GM045299     (JOHNSON, DEBORAH)Jul 6, 1991 - Jun 30, 1995
    NIH/NIGMS
    REGULATION OF DROSOPHILA RNA POLYMERSE I AND III
    Role: Principal Investigator

    R01CA074138     (JOHNSON, DEBORAH)May 10, 1997 - Jun 30, 2016
    NIH/NCI
    Maf1, a novel negative transcriptional regulator of the TATA binding protein
    Role: Principal Investigator

    R01CA108614     (JOHNSON, DEBORAH)Jul 1, 2004 - Mar 31, 2017
    NIH/NCI
    Novel targets that are deregulated by loss of PTEN
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang X, Rusin A, Walkey CJ, Lin JJ, Johnson DL. The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis. J Biol Chem. 2019 Dec 13; 294(50):19255-19268. PMID: 31645432.
      View in: PubMed
    2. Chen CY, Lanz RB, Walkey CJ, Chang WH, Lu W, Johnson DL. Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation. Cell Rep. 2018 08 14; 24(7):1852-1864. PMID: 30110641.
      View in: PubMed
    3. Johnson SAS, Lin JJ, Walkey CJ, Leathers MP, Coarfa C, Johnson DL. Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer. Oncotarget. 2017 Jul 25; 8(30):48832-48845. PMID: 28415573.
      View in: PubMed
    4. Johnson DL, Stiles BL. Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab. 2016 10; 27(10):742-750. PMID: 27296319.
      View in: PubMed
    5. Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles BL, Johnson DL. Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789. PMID: 25502566.
      View in: PubMed
    6. Khanna A, Johnson DL, Curran SP. Physiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014 Dec 24; 9(6):2180-91. PMID: 25497095.
      View in: PubMed
    7. Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, Stiles JW, Hou X, Medina V, Abad D, Palian BM, Al-Abdullah I, Kandeel F, Johnson DL, Stiles BL. PTEN controls ß-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell. 2013 Dec; 12(6):1000-11. PMID: 23826727.
      View in: PubMed
    8. Rohira AD, Chen CY, Allen JR, Johnson DL. Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression. J Biol Chem. 2013 Jun 28; 288(26):19288-95. PMID: 23673667.
      View in: PubMed
    9. Zhong S, Machida K, Tsukamoto H, Johnson DL. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401. PMID: 21106530.
      View in: PubMed
    10. Zhong S, Johnson DL. The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12682-7. PMID: 19620725.
      View in: PubMed
    11. Fromm JA, Johnson SA, Johnson DL. Epidermal growth factor receptor 1 (EGFR1) and its variant EGFRvIII regulate TATA-binding protein expression through distinct pathways. Mol Cell Biol. 2008 Oct; 28(20):6483-95. PMID: 18710943.
      View in: PubMed
    12. Johnson SA, Dubeau L, Johnson DL. Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. J Biol Chem. 2008 Jul 11; 283(28):19184-91. PMID: 18456653.
      View in: PubMed
    13. Johnson DL, Johnson SA. Cell biology. RNA metabolism and oncogenesis. Science. 2008 Apr 25; 320(5875):461-2. PMID: 18436765.
      View in: PubMed
    14. Woiwode A, Johnson SA, Zhong S, Zhang C, Roeder RG, Teichmann M, Johnson DL. PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol Cell Biol. 2008 Jun; 28(12):4204-14. PMID: 18391023.
      View in: PubMed
    15. Zhou D, Zhong S, Ye JJ, Quach KM, Johnson DL, Chen S. PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription. J Mol Signal. 2007 Jul 05; 2:5. PMID: 17612402.
      View in: PubMed
    16. Johnson SS, Zhang C, Fromm J, Willis IM, Johnson DL. Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases. Mol Cell. 2007 May 11; 26(3):367-79. PMID: 17499043.
      View in: PubMed
    17. Zhong S, Fromm J, Johnson DL. TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation. Mol Cell Biol. 2007 Jan; 27(1):54-64. PMID: 17074809.
      View in: PubMed
    18. Zhang C, Comai L, Johnson DL. PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. Mol Cell Biol. 2005 Aug; 25(16):6899-911. PMID: 16055704.
      View in: PubMed
    19. Zhong S, Zhang C, Johnson DL. Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity. Mol Cell Biol. 2004 Jun; 24(12):5119-29. PMID: 15169879.
      View in: PubMed
    20. Johnson SA, Dubeau L, White RJ, Johnson DL. The TATA-binding protein as a regulator of cellular transformation. Cell Cycle. 2003 Sep-Oct; 2(5):442-4. PMID: 12963838.
      View in: PubMed
    21. Crighton D, Woiwode A, Zhang C, Mandavia N, Morton JP, Warnock LJ, Milner J, White RJ, Johnson DL. p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. EMBO J. 2003 Jun 02; 22(11):2810-20. PMID: 12773395.
      View in: PubMed
    22. Johnson SA, Dubeau L, Kawalek M, Dervan A, Schönthal AH, Dang CV, Johnson DL. Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis. Mol Cell Biol. 2003 May; 23(9):3043-51. PMID: 12697807.
      View in: PubMed
    23. Li J, Xu Z, Zheng Y, Johnson DL, Ou JH. Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J Virol. 2002 Jun; 76(12):5875-81. PMID: 12021320.
      View in: PubMed
    24. Modahl LE, Macnaughton TB, Zhu N, Johnson DL, Lai MM. RNA-Dependent replication and transcription of hepatitis delta virus RNA involve distinct cellular RNA polymerases. Mol Cell Biol. 2000 Aug; 20(16):6030-9. PMID: 10913185.
      View in: PubMed
    25. Johnson SA, Mandavia N, Wang HD, Johnson DL. Transcriptional regulation of the TATA-binding protein by Ras cellular signaling. Mol Cell Biol. 2000 Jul; 20(14):5000-9. PMID: 10866657.
      View in: PubMed
    26. Trivedi A, Young LS, Ouyang C, Johnson DL, Sprague KU. A TATA element is required for tRNA promoter activity and confers TATA-binding protein responsiveness in Drosophila Schneider-2 cells. J Biol Chem. 1999 Apr 16; 274(16):11369-75. PMID: 10196229.
      View in: PubMed
    27. Wang HD, Trivedi A, Johnson DL. Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein. Mol Cell Biol. 1998 Dec; 18(12):7086-94. PMID: 9819395.
      View in: PubMed
    28. Wang HD, Trivedi A, Johnson DL. Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway. Mol Cell Biol. 1997 Dec; 17(12):6838-46. PMID: 9372915.
      View in: PubMed
    29. Vilalta A, Trivedi A, Wang Z, Roeder RG, Johnson DL. An RNA polymerase III-defective mutation in TATA-binding protein disrupts its interaction with a transcription factor IIIB subunit in drosophila cells. J Biol Chem. 1997 Jul 18; 272(29):18087-92. PMID: 9218440.
      View in: PubMed
    30. Trivedi A, Vilalta A, Gopalan S, Johnson DL. TATA-binding protein is limiting for both TATA-containing and TATA-lacking RNA polymerase III promoters in Drosophila cells. Mol Cell Biol. 1996 Dec; 16(12):6909-16. PMID: 8943346.
      View in: PubMed
    31. Hong H, Kohli K, Trivedi A, Johnson DL, Stallcup MR. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4948-52. PMID: 8643509.
      View in: PubMed
    32. Gottesfeld JM, Johnson DL, Nyborg JK. Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein. Mol Cell Biol. 1996 Apr; 16(4):1777-85. PMID: 8657153.
      View in: PubMed
    33. Wang HD, Yuh CH, Dang CV, Johnson DL. The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes. Mol Cell Biol. 1995 Dec; 15(12):6720-8. PMID: 8524237.
      View in: PubMed
    34. Vilalta A, Kickhoefer VA, Rome LH, Johnson DL. The rat vault RNA gene contains a unique RNA polymerase III promoter composed of both external and internal elements that function synergistically. J Biol Chem. 1994 Nov 25; 269(47):29752-9. PMID: 7525587.
      View in: PubMed
    35. Garber ME, Vilalta A, Johnson DL. Induction of Drosophila RNA polymerase III gene expression by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is mediated by transcription factor IIIB. Mol Cell Biol. 1994 Jan; 14(1):339-47. PMID: 8264601.
      View in: PubMed
    36. Kickhoefer VA, Searles RP, Kedersha NL, Garber ME, Johnson DL, Rome LH. Vault ribonucleoprotein particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase III. J Biol Chem. 1993 Apr 15; 268(11):7868-73. PMID: 7681830.
      View in: PubMed
    37. Reynolds WF, Johnson DL. Differential expression of oocyte-type class III genes with fraction TFIIIC from immature or mature oocytes. Mol Cell Biol. 1992 Mar; 12(3):946-53. PMID: 1545826.
      View in: PubMed
    38. Garber M, Panchanathan S, Fan RS, Johnson DL. The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, induces specific transcription by RNA polymerase III in Drosophila Schneider cells. J Biol Chem. 1991 Nov 05; 266(31):20598-601. PMID: 1939109.
      View in: PubMed
    39. Johnson DL, Fan RS, Treinies ML. Analysis of the molecular mechanisms for the species-specific transcription of Drosophila and human tRNA gene transcription components. J Biol Chem. 1991 Aug 25; 266(24):16037-43. PMID: 1874746.
      View in: PubMed
    40. Johnson DL, Nichols M, Bolger MB, Wilson S. Interaction of yeast transcription factor IIIC with dimeric Schizosaccharomyces pombe tRNA(Ser)-tRNA(Met) genes. J Biol Chem. 1989 Nov 15; 264(32):19221-7. PMID: 2808421.
      View in: PubMed
    41. Johnson DL, Wilson SL. Identification of a 150-kilodalton polypeptide that copurifies with yeast TFIIIC and binds specifically to tRNA genes. Mol Cell Biol. 1989 May; 9(5):2018-24. PMID: 2664466.
      View in: PubMed
    42. DeFranco D, Dingermann T, Johnson DL, Sharp S, Söll D. Eukaryotic tRNA gene transcription is controlled by signals within and outside the mature coding sequence. Princess Takamatsu Symp. 1982; 12:63-72. PMID: 7166550.
      View in: PubMed
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