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THOMAS HORVATH

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address6621 FANNIN
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jo J, Carlson TJ, Hu C, Williamson JC, Belin YT, Horvath TD, Haidacher SJ, Bass?res E, Begum K, Alam MJ, Garey KW. Faecal pharmacokinetics, microbiome, and bile acid changes in healthy subjects given intravenous followed by oral omadacycline; a Phase 1 clinical trial. J Antimicrob Chemother. 2025 Aug 12. PMID: 40796204.
      Citations:    Fields:    
    2. Eubank TA, Jo J, Alam MJ, Begum K, McPherson JK, Le TM, Horvath TD, Haidacher SJ, Poggio EC, Lin R, Yue CS, Ducharme MP, Koudssi G, Mercier J, Alder JD, Silverman MH, Garey KW, Ibezapolstat Phase 2 Investigator Group. Efficacy, safety, pharmacokinetics, and associated microbiome changes of ibezapolstat compared with vancomycin in adults with Clostridioides difficile infection: a phase 2b, randomised, double-blind, active-controlled, multicentre study. Lancet Microbe. 2025 Aug; 6(8):101126. PMID: 40516571.
      Citations:    Fields:    Translation:HumansCellsCTClinical Trials
    3. Williams MD, Sweeney TR, Trieu S, Orugunty R, Barbour A, Younesi F, Glogauer M, Hansanant N, Shin R, Lu S-E, Cao K, Tenorio A, Haidacher SJ, Haag AM, Horvath TD, Smith L. Antibiofilm properties of 4-hydroxy-3-methyl-2-alkenylquinoline, a novel Burkholderia-derived alkaloid. mSphere. 2025 May 27; 10(5):e0108124. PMID: 40338090; PMCID: PMC12108052.
      Citations:    Fields:    Translation:CellsPHPublic Health
    4. Jo J, Hu C, Horvath TD, Haidacher SJ, Begum K, Alam MJ, Garey KW. Phase I trial comparing bile acid and short-chain fatty acid alterations in stool collected from human subjects treated with omadacycline or vancomycin. Antimicrob Agents Chemother. 2025 02 13; 69(2):e0125124. PMID: 39819014; PMCID: PMC11823362.
      Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
    5. Huang X, Johnson AE, Brehm JN, Do TVT, Auchtung TA, McCullough HC, Lerma AI, Haidacher SJ, Hoch KM, Horvath TD, Sorg JA, Haag AM, Auchtung JM. Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model. mSphere. 2025 Feb 25; 10(2):e0104924. PMID: 39817755; PMCID: PMC11852769.
      Citations: 3     Fields:    Translation:HumansCells
    6. Huang X, Johnson AE, Auchtung TA, McCullough HC, Lerma AI, Haidacher SJ, Hoch KM, Horvath TD, Haag AM, Auchtung JM, Huang X, Johnson AE, Brehm JN, Thanh Do TV, Auchtung TA, McCullough HC, Lerma AI, Haidacher SJ, Hoch KM, Horvath TD, Sorg JA, Haag AM, Auchtung JM, Brehm JN, Thanh Do TV, Sorg JA. Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model. bioRxiv. 2024 Dec 11. PMID: 39071387; PMCID: PMC11275744.
      Citations:    
    7. Engevik KA, Hazzard A, Puckett B, Hoch KM, Haidacher SJ, Haag AM, Spinler JK, Versalovic J, Engevik MA, Horvath TD. Phylogenetically diverse bacterial species produce histamine. Syst Appl Microbiol. 2024 Sep; 47(5):126539. PMID: 39029335.
      Citations:    Fields:    Translation:HumansCells
    8. Kellermayer R, Carbone M, Horvath TD, Szigeti RG, Buness C, Hirschfield GM, Lewindon PJ. Identifying a therapeutic window of opportunity for people living with primary sclerosing cholangitis: Embryology and the overlap of inflammatory bowel disease with immune-mediated liver injury. Hepatology. 2025 Oct 01; 82(4):949-959. PMID: 38743006.
      Citations: 1     Fields:    
    9. Lillie IM, Booth CE, Horvath AE, Mondragon M, Engevik MA, Horvath TD. Characterizing arginine, ornithine, and putrescine pathways in enteric pathobionts. Microbiologyopen. 2024 Apr; 13(2):e1408. PMID: 38560776; PMCID: PMC10982811.
      Citations:    
    10. Horvath TD, Devaraj S. Liquid Chromatography-Tandem Mass Spectrometry-Based Therapeutic Monitoring of Plasma Atovaquone Concentrations in Pediatric Patients. Methods Mol Biol. 2024; 2737:67-77. PMID: 38036811.
      Citations:    Fields:    Translation:Humans
    11. Engevik MA, Thapa S, Lillie IM, Yacyshyn MB, Yacyshyn B, Percy AJ, Chace D, Horvath TD. Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples. Am J Physiol Gastrointest Liver Physiol. 2024 02 01; 326(2):G95-G106. PMID: 38014449; PMCID: PMC11208030.
      Citations:    Fields:    Translation:Humans
    12. Engevik KA, Gonzalez H, Daniels C, Stavert RK, Oezguen N, Engevik MA, Horvath TD. A high-throughput protocol for measuring solution pH of bacterial cultures using UV-Vis absorption spectrophotometry. STAR Protoc. 2023 09 15; 4(3):102540. PMID: 37682718; PMCID: PMC10493592.
      Citations: 1     Fields:    
    13. Barbour A, Smith L, Oveisi M, Williams M, Huang RC, Marks C, Fine N, Sun C, Younesi F, Zargaran S, Orugunty R, Horvath TD, Haidacher SJ, Haag AM, Sabharwal A, Hinz B, Glogauer M. Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome. Proc Natl Acad Sci U S A. 2023 05 30; 120(22):e2219392120. PMID: 37216534; PMCID: PMC10235938.
      Citations: 2     Fields:    Translation:HumansCells
    14. Hughes LD, Tsueng G, DiGiovanna J, Horvath TD, Rasmussen LV, Savidge TC, Stoeger T, Turkarslan S, Wu Q, Wu C, Su AI, Pache L, NIAID Systems Biology Data Dissemination Working Group. Addressing barriers in FAIR data practices for biomedical data. Sci Data. 2023 02 23; 10(1):98. PMID: 36823198; PMCID: PMC9950056.
      Citations: 3     Fields:    
    15. Horvath TD, Haidacher SJ, Engevik MA, Luck B, Ruan W, Ihekweazu F, Bajaj M, Hoch KM, Oezguen N, Spinler JK, Versalovic J, Haag AM. Interrogation of the mammalian gut-brain axis using LC-MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic mouse models. Nat Protoc. 2023 02; 18(2):490-529. PMID: 36352124.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Oezguen N, Yilmaz V, Horvath TD, Akbayir E, Haidacher SJ, Hoch KM, Thapa S, Palacio J, T?rkoglu R, K?rt?nc? M, Engevik MA, Versalovic J, Haag AM, T?z?n E. Serum 3-phenyllactic acid level is reduced in benign multiple sclerosis and is associated with effector B cell ratios. Mult Scler Relat Disord. 2022 Dec; 68:104239. PMID: 36279598.
      Citations:    Fields:    
    17. Horvath TD, Poventud-Fuentes I, Olayinka L, James A, Haidacher SJ, Hoch KM, Stevens AM, Haag AM, Devaraj S. Validation of atovaquone plasma levels by liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring in pediatric patients. J Mass Spectrom Adv Clin Lab. 2022 Nov; 26:23-27. PMID: 36388060; PMCID: PMC9641598.
      Citations: 1     
    18. Blackman AC, Thapa S, Venkatachalam A, Horvath TD, Runge JK, Haidacher SJ, Hoch KM, Haag AM, Luna RA, Anagnostou A. Insights into Microbiome and Metabolic Signatures of Children Undergoing Peanut Oral Immunotherapy. Children (Basel). 2022 Aug 09; 9(8). PMID: 36010081; PMCID: PMC9406383.
      Citations:    
    19. Xavier JB, Monk JM, Poudel S, Norsigian CJ, Sastry AV, Liao C, Bento J, Suchard MA, Arrieta-Ortiz ML, Peterson EJR, Baliga NS, Stoeger T, Ruffin F, Richardson RAK, Gao CA, Horvath TD, Haag AM, Wu Q, Savidge T, Yeaman MR. Mathematical models to study the biology of pathogens and the infectious diseases they cause. iScience. 2022 Apr 15; 25(4):104079. PMID: 35359802; PMCID: PMC8961237.
      Citations:    
    20. Fultz R, Ticer T, Ihekweazu FD, Horvath TD, Haidacher SJ, Hoch KM, Bajaj M, Spinler JK, Haag AM, Buffington SA, Engevik MA. Unraveling the Metabolic Requirements of the Gut Commensal Bacteroides ovatus. Front Microbiol. 2021; 12:745469. PMID: 34899632; PMCID: PMC8656163.
      Citations: 1     
    21. Luck B, Horvath TD, Engevik KA, Ruan W, Haidacher SJ, Hoch KM, Oezguen N, Spinler JK, Haag AM, Versalovic J, Engevik MA. Neurotransmitter Profiles Are Altered in the Gut and Brain of Mice Mono-Associated with Bifidobacterium dentium. Biomolecules. 2021 07 23; 11(8). PMID: 34439760; PMCID: PMC8392031.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Engevik MA, Danhof HA, Hall A, Engevik KA, Horvath TD, Haidacher SJ, Hoch KM, Endres BT, Bajaj M, Garey KW, Britton RA, Spinler JK, Haag AM, Versalovic J. The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal. BMC Microbiol. 2021 05 24; 21(1):154. PMID: 34030655; PMCID: PMC8145834.
      Citations: 5     Fields:    Translation:HumansCells
    23. Horvath TD, Dagan S, Scaraffia PY. Unraveling mosquito metabolism with mass spectrometry-based metabolomics. Trends Parasitol. 2021 08; 37(8):747-761. PMID: 33896683; PMCID: PMC8282712.
      Citations:    
    24. Ihekweazu FD, Engevik MA, Ruan W, Shi Z, Fultz R, Engevik KA, Chang-Graham AL, Freeborn J, Park ES, Venable S, Horvath TD, Haidacher SJ, Haag AM, Goodwin A, Schady DA, Hyser JM, Spinler JK, Liu Y, Versalovic J. Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid-Driven Colonic Inflammation. Am J Pathol. 2021 04; 191(4):704-719. PMID: 33516788; PMCID: PMC8027925.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Engevik MA, Herrmann B, Ruan W, Engevik AC, Engevik KA, Ihekweazu F, Shi Z, Luck B, Chang-Graham AL, Esparza M, Venable S, Horvath TD, Haidacher SJ, Hoch KM, Haag AM, Schady DA, Hyser JM, Spinler JK, Versalovic J. Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation. Gut Microbes. 2021 Jan-Dec; 13(1):1-21. PMID: 33985416; PMCID: PMC8128206.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Engevik MA, Luck B, Visuthranukul C, Ihekweazu FD, Engevik AC, Shi Z, Danhof HA, Chang-Graham AL, Hall A, Endres BT, Haidacher SJ, Horvath TD, Haag AM, Devaraj S, Garey KW, Britton RA, Hyser JM, Shroyer NF, Versalovic J. Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis. Cell Mol Gastroenterol Hepatol. 2021; 11(1):221-248. PMID: 32795610; PMCID: PMC7683275.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    27. Horvath TD, Haidacher SJ, Oezguen N, Hoch KM, Auchtung JM, Haag AM. Ruggedness testing of liquid chromatography-tandem mass spectrometry system components using microbiome-relevant methods and matrices. J Microbiol Methods. 2020 10; 177:106020. PMID: 32795635.
      Citations: 1     Fields:    Translation:HumansCells
    28. Horvath TD, Haidacher SJ, Hoch KM, Auchtung JM, Haag AM. A high-throughput LC-MS/MS method for the measurement of the bile acid/salt content in microbiome-derived sample sets. MethodsX. 2020; 7:100951. PMID: 32637329; PMCID: PMC7327831.
      Citations:    
    29. Petchampai N, Isoe J, Horvath TD, Dagan S, Tan L, Lorenzi PL, Hawke DH, Scaraffia PY. Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes. Insect Biochem Mol Biol. 2020 06; 121:103366. PMID: 32276114; PMCID: PMC7249512.
      Citations:    
    30. Horvath TD, Ak S, Haidacher SJ, Hoch KM, Savidge TC, Haag AM. Sterilization performance comparison between an autosampler-ready microporous filter vial and a syringe-based filter. J Microbiol Methods. 2019 09; 164:105669. PMID: 31356842; PMCID: PMC6732000.
      Citations:    Fields:    Translation:CellsPHPublic Health
    31. Horvath TD, Chan WK, Pontikos MA, Martin LA, Du D, Tan L, Konopleva M, Weinstein JN, Lorenzi PL. Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer. Metabolites. 2019 Jan 09; 9(1). PMID: 30634463; PMCID: PMC6359345.
      Citations: 3     
    32. Khong H, Volmari A, Sharma M, Dai Z, Imo CS, Hailemichael Y, Singh M, Moore DT, Xiao Z, Huang XF, Horvath TD, Hawke DH, Overwijk WW. Peptide Vaccine Formulation Controls the Duration of Antigen Presentation and Magnitude of Tumor-Specific CD8+ T Cell Response. J Immunol. 2018 05 15; 200(10):3464-3474. PMID: 29643190; PMCID: PMC5940548.
      Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
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