InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology

    Collapse Research 
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    R01CA239645     (MILLS, JASON C)Jun 10, 2020 - May 31, 2025
    Mechanisms Governing Expansion of Embryonic Progenitor Cells (EPCs) inMetaplasia
    Role: Principal Investigator

    R01CA246208     (MILLS, JASON C)May 1, 2020 - Apr 30, 2025
    Mechanisms and biomarkers in aberrant paligenosis-induced stomach tumorigenesis
    Role: Principal Investigator

    R01DK105129     (MILLS, JASON C)Sep 30, 2015 - Aug 31, 2024
    Role: Principal Investigator

    R01DK094989     (MILLS, JASON C)Sep 11, 2012 - Apr 30, 2023
    Role: Principal Investigator

    R01DK079798     (MILLS, JASON C)Mar 1, 2008 - Feb 28, 2014
    Role: Principal Investigator

    K08DK066062     (MILLS, JASON C)Feb 1, 2004 - Dec 31, 2008
    Molecular regulation of gastric epithelial renewal
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nguyen T, Mills JC, Cho CJ. The coordinated management of ribosome and translation during injury and regeneration. Front Cell Dev Biol. 2023; 11:1186638. PMID: 37427381; PMCID: PMC10325863.
    2. Willet SG, Thanintorn N, McNeill H, Huh SH, Ornitz DM, Huh WJ, Hoft SG, DiPaolo RJ, Mills JC. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cell Mol Gastroenterol Hepatol. 2023; 16(3):325-339. PMID: 37270061; PMCID: PMC10444955.
      Citations:    Fields:    Translation:AnimalsCells
    3. Mills JC, Casanova JE, Hecht G. Presentation of the AGA Distinguished Achievement Award in Basic Science to James R. Goldenring, MD, PhD, AGAF. Gastroenterology. 2023 Jul; 165(1):297-300. PMID: 37227336.
      Citations:    Fields:    Translation:Humans
    4. Zeng Y, Li QK, Roy S, Mills JC, Jin RU. Shared features of metaplasia and the development of adenocarcinoma in the stomach and esophagus. Front Cell Dev Biol. 2023; 11:1151790. PMID: 36994101; PMCID: PMC10040611.
    5. Huang XZ, Pang MJ, Li JY, Chen HY, Sun JX, Song YX, Ni HJ, Ye SY, Bai S, Li TH, Wang XY, Lu JY, Yang JJ, Sun X, Mills JC, Miao ZF, Wang ZN. Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis. Nat Commun. 2023 02 14; 14(1):822. PMID: 36788228; PMCID: PMC9929081.
      Citations: 1     Fields:    Translation:Humans
    6. Konda V, Souza RF, Dunbar KB, Mills JC, Kim DS, Odze RD, Spechler SJ. An Endoscopic and Histologic Study on Healing of Radiofrequency Ablation Wounds in Patients With Barrett's Esophagus. Am J Gastroenterol. 2022 10 01; 117(10):1583-1592. PMID: 35970814.
    7. Adkins-Threats M, Mills JC. Cell plasticity in regeneration in the stomach and beyond. Curr Opin Genet Dev. 2022 08; 75:101948. PMID: 35809361; PMCID: PMC10378711.
      Citations:    Fields:    
    8. Cho CJ, Mills JC. Stroma New Tune: Emerging Role of PKA in Maintaining Gastric Homeostasis. Cell Mol Gastroenterol Hepatol. 2022; 14(3):722-723. PMID: 35793768; PMCID: PMC9421578.
      Citations:    Fields:    
    9. Vargas N, Cho CJ, Mills JC, S?enz JB. Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium. JCI Insight. 2022 02 08; 7(3). PMID: 35132959; PMCID: PMC8855806.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Brown JW, Das KK, Kalas V, Das KM, Mills JC. mAb Das-1 recognizes 3'-Sulfated Lewis A/C, which is aberrantly expressed during metaplastic and oncogenic transformation of several gastrointestinal Epithelia. PLoS One. 2021; 16(12):e0261082. PMID: 34910746; PMCID: PMC8673611.
      Citations:    Fields:    Translation:HumansCells
    11. Cho CJ, Park D, Mills JC. ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G49-G65. PMID: 34816763; PMCID: PMC8698547.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Jacome-Sosa M, Miao ZF, Peche VS, Morris EF, Narendran R, Pietka KM, Samovski D, Lo HG, Pietka T, Varro A, Love-Gregory L, Goldenring JR, Kuda O, Gamazon ER, Mills JC, Abumrad NA. CD36 maintains the gastric mucosa and associates with gastric disease. Commun Biol. 2021 11 02; 4(1):1247. PMID: 34728772; PMCID: PMC8563937.
      Citations: 1     Translation:AnimalsCells
    13. Goldenring JR, Mills JC. Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond. Gastroenterology. 2022 02; 162(2):415-430. PMID: 34728185; PMCID: PMC8792220.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Brown JW, Cho CJ, Mills JC. Paligenosis: Cellular Remodeling During Tissue Repair. Annu Rev Physiol. 2022 02 10; 84:461-483. PMID: 34705482; PMCID: PMC8831470.
      Citations: 2     Fields:    Translation:HumansCells
    15. Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE. Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury. Gastroenterology. 2022 02; 162(2):604-620.e20. PMID: 34695382; PMCID: PMC8792222.
      Citations: 4     Fields:    Translation:HumansCells
    16. Pang MJ, Burclaff JR, Jin R, Adkins-Threats M, Osaki LH, Han Y, Mills JC, Miao ZF, Wang ZN. Gastric Organoids: Progress and Remaining Challenges. Cell Mol Gastroenterol Hepatol. 2022; 13(1):19-33. PMID: 34547535; PMCID: PMC8600088.
      Citations:    Fields:    Translation:HumansAnimals
    17. Radyk MD, Spatz LB, Brown JW, Burclaff J, Cho CJ, Kefalov Y, Shih CC, Fitzpatrick JA, Mills JC, Pe?a BL. ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program. EMBO Rep. 2021 09 06; 22(9):e51806. PMID: 34309175; PMCID: PMC8419698.
      Citations: 4     Fields:    Translation:Animals
    18. Spatz LB, Jin RU, Mills JC. Cellular plasticity at the nexus of development and disease. Development. 2021 02 05; 148(3). PMID: 33547203.
      Citations: 1     Fields:    Translation:HumansAnimals
    19. Das KK, Brown JW, Fernandez Del-Castillo C, Huynh T, Mills JC, Matsuda Y, Das KM, Mino-Kenudson M. mAb Das-1 identifies pancreatic ductal adenocarcinoma and high-grade pancreatic intraepithelial neoplasia with high accuracy. Hum Pathol. 2021 05; 111:36-44. PMID: 33524436; PMCID: PMC8817765.
      Citations: 2     Fields:    Translation:Humans
    20. Jin RU, Brown JW, Li QK, Bayguinov PO, Wang JS, Mills JC. Tropism of Severe Acute Respiratory Syndrome Coronavirus 2 for Barrett's Esophagus May Increase Susceptibility to Developing Coronavirus Disease 2019. Gastroenterology. 2021 05; 160(6):2165-2168.e4. PMID: 33484686; PMCID: PMC7816599.
      Citations: 2     Fields:    Translation:HumansCells
    21. Blanc V, Riordan JD, Soleymanjahi S, Nadeau JH, Nalbantoglu I, Xie Y, Molitor EA, Madison BB, Brunt EM, Mills JC, Rubin DC, Ng IO, Ha Y, Roberts LR, Davidson NO. Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer. J Clin Invest. 2021 01 04; 131(1). PMID: 33445170; PMCID: PMC7773377.
      Citations: 5     Fields:    Translation:Animals
    22. Miao ZF, Cho CJ, Wang ZN, Mills JC. Autophagy repurposes cells during paligenosis. Autophagy. 2021 02; 17(2):588-589. PMID: 33280496; PMCID: PMC8007135.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    23. De Salvo C, Pastorelli L, Petersen CP, Buela KA, Omenetti S, Locovei SA, Ray S, Friedman HR, Duijser J, Xin W, Osme A, Cominelli F, Mahabeleshwar GH, Mills JC, Goldenring JR, Pizarro TT, Butt? LF. Interleukin 33 Triggers Early Eosinophil-Dependent Events Leading to Metaplasia in a Chronic Model of Gastritis-Prone Mice. Gastroenterology. 2021 01; 160(1):302-316.e7. PMID: 33010253; PMCID: PMC7755675.
      Citations: 9     Fields:    Translation:AnimalsCells
    24. Miao ZF, Sun JX, Adkins-Threats M, Pang MJ, Zhao JH, Wang X, Tang KW, Wang ZN, Mills JC. DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia. Gastroenterology. 2021 01; 160(1):260-271.e10. PMID: 32956680; PMCID: PMC7857017.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    25. Bockerstett KA, Lewis SA, Noto CN, Ford EL, Jackson NM, Ahn TH, Mills JC, DiPaolo RJ, Saenz JB. Single-Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus. Gastroenterology. 2020 12; 159(6):2116-2129.e4. PMID: 32835664; PMCID: PMC7725914.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    26. Miao ZF, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun JX, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang ZN, Mills JC. A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle. Dev Cell. 2020 10 26; 55(2):178-194.e7. PMID: 32768422; PMCID: PMC7606764.
      Citations: 15     Fields:    Translation:Animals
    27. Jin RU, Mills JC. Tumor organoids to study gastroesophageal cancer: a primer. J Mol Cell Biol. 2020 08 01; 12(8):593-606. PMID: 32652008; PMCID: PMC7683018.
      Citations: 2     Fields:    Translation:HumansAnimals
    28. Bockerstett KA, Petersen CP, Noto CN, Kuehm LM, Wong CF, Ford EL, Teague RM, Mills JC, Goldenring JR, DiPaolo RJ. Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis. Cell Mol Gastroenterol Hepatol. 2020; 10(3):561-579. PMID: 32376420; PMCID: PMC7399182.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    29. Mills JC, S?enz JB. Helicobacter pylori: preying on SIVA for survival in the stomach. J Clin Invest. 2020 05 01; 130(5):2183-2185. PMID: 32250343; PMCID: PMC7190974.
      Citations:    Fields:    Translation:HumansCells
    30. Miao ZF, Adkins-Threats M, Burclaff JR, Osaki LH, Sun JX, Kefalov Y, He Z, Wang ZN, Mills JC. A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation. Cell Stem Cell. 2020 06 04; 26(6):910-925.e6. PMID: 32243780; PMCID: PMC7275895.
      Citations: 12     Fields:    Translation:AnimalsCells
    31. Jackson DN, Panopoulos M, Neumann WL, Turner K, Cantarel BL, Thompson-Snipes L, Dassopoulos T, Feagins LA, Souza RF, Mills JC, Blumberg RS, Venuprasad K, Thompson WE, Theiss AL. Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis. Gut. 2020 11; 69(11):1928-1938. PMID: 32111635; PMCID: PMC7483170.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    32. Spatz LB, Mills JC. DeMISTifying Paneth Cell Maturation. Cell Mol Gastroenterol Hepatol. 2019; 8(4):643-644. PMID: 31593647; PMCID: PMC6889777.
      Citations: 1     Fields:    Translation:Cells
    33. Burclaff J, Willet SG, Mills JC, S?enz JB. Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia. Gastroenterology. 2020 02; 158(3):598-609.e5. PMID: 31589873; PMCID: PMC7010566.
      Citations: 26     Fields:    Translation:AnimalsCells
    34. Mills JC, Stanger BZ, Sander M. Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves? EMBO J. 2019 10 01; 38(19):e103148. PMID: 31475380; PMCID: PMC6769377.
      Citations: 15     Fields:    Translation:HumansAnimals
    35. Jin RU, Mills JC. The cyclical hit model: how paligenosis might establish the mutational landscape in Barrett's esophagus and esophageal adenocarcinoma. Curr Opin Gastroenterol. 2019 07; 35(4):363-370. PMID: 31021922.
      Citations: 8     Fields:    Translation:HumansCells
    36. Meyer AR, Engevik AC, Willet SG, Williams JA, Zou Y, Massion PP, Mills JC, Choi E, Goldenring JR. Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury. Cell Mol Gastroenterol Hepatol. 2019; 8(3):379-405. PMID: 31071489; PMCID: PMC6713894.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    37. Cho CJ, Mills JC. Calcified, top secretion only: epithelial repair in gastric organoids requires calcium mobilization. J Physiol. 2019 05; 597(10):2617-2618. PMID: 30968957; PMCID: PMC6826224.
      Citations: 1     Fields:    
    38. Osaki LH, Bockerstett KA, Wong CF, Ford EL, Madison BB, DiPaolo RJ, Mills JC. Interferon-? directly induces gastric epithelial cell death and is required for progression to metaplasia. J Pathol. 2019 04; 247(4):513-523. PMID: 30511397; PMCID: PMC6402979.
      Citations: 19     Fields:    Translation:AnimalsCells
    39. Blanc V, Xie Y, Kennedy S, Riordan JD, Rubin DC, Madison BB, Mills JC, Nadeau JH, Davidson NO. Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver. RNA. 2019 01; 25(1):70-81. PMID: 30309881; PMCID: PMC6298562.
      Citations: 17     Fields:    Translation:AnimalsCells
    40. Vargas N, Mills JC, S?enz JB. Tropism for Spasmolytic Polypeptide-Expressing Metaplasia Allows Helicobacter pylori to Expand Its Intragastric Niche. Gastroenterology. 2019 01; 156(1):160-174.e7. PMID: 30287170; PMCID: PMC6309511.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    41. Burclaff J, Mills JC. Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine. Dis Model Mech. 2018 08 31; 11(9). PMID: 30171151; PMCID: PMC6177008.
      Citations: 18     Fields:    Translation:HumansAnimals
    42. Jin RU, Mills JC. Are Gastric and Esophageal Metaplasia Relatives? The Case for Barrett's Stemming from SPEM. Dig Dis Sci. 2018 08; 63(8):2028-2041. PMID: 29948563.
      Citations: 7     Fields:    Translation:HumansCells
    43. Burclaff J, Mills JC. Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas. Dis Model Mech. 2018 07 23; 11(7). PMID: 30037967; PMCID: PMC6078397.
      Citations: 13     Fields:    Translation:HumansAnimals
    44. Mills JC, Samuelson LC. Past Questions and Current Understanding About Gastric Cancer. Gastroenterology. 2018 10; 155(4):939-944. PMID: 29964037; PMCID: PMC6174109.
      Citations: 8     Fields:    Translation:HumansAnimals
    45. Brown JW, Badahdah A, Iticovici M, Vickers TJ, Alvarado DM, Helmerhorst EJ, Oppenheim FG, Mills JC, Ciorba MA, Fleckenstein JM, Bullitt E. A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli. J Infect Dis. 2018 04 11; 217(9):1435-1441. PMID: 29528423; PMCID: PMC5894089.
      Citations: 5     Fields:    Translation:HumansCells
    46. Willet SG, Lewis MA, Miao ZF, Liu D, Radyk MD, Cunningham RL, Burclaff J, Sibbel G, Lo HG, Blanc V, Davidson NO, Wang ZN, Mills JC. Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. EMBO J. 2018 04 03; 37(7). PMID: 29467218; PMCID: PMC5881627.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    47. Mills JC, S?enz JB. Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer. Nat Rev Gastroenterol Hepatol. 2018 05; 15(5):257-273. PMID: 29463907; PMCID: PMC6016373.
      Citations: 42     Fields:    Translation:HumansAnimals
    48. Bockerstett KA, Osaki LH, Petersen CP, Cai CW, Wong CF, Nguyen TM, Ford EL, Hoft DF, Mills JC, Goldenring JR, DiPaolo RJ. Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis. Cell Mol Gastroenterol Hepatol. 2018; 5(4):678-690.e1. PMID: 29930985; PMCID: PMC6009015.
      Citations: 20     Fields:    
    49. Radyk MD, Burclaff J, Willet SG, Mills JC. Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells. Gastroenterology. 2018 03; 154(4):839-843.e2. PMID: 29248442; PMCID: PMC5847468.
      Citations: 40     Fields:    Translation:AnimalsCells
    50. Lewis MA, Sharabash N, Miao ZF, Lyons LN, Piccirillo J, Kallogjeri D, Schootman M, Mutch M, Yan Y, Levin MS, Castells A, Cuatrecasas M, Mills JC, Wang ZN, Rubin DC. Increased IFRD1 Expression in Human Colon Cancers Predicts Reduced Patient Survival. Dig Dis Sci. 2017 12; 62(12):3460-3467. PMID: 29094309; PMCID: PMC6167971.
      Citations: 2     Fields:    Translation:Humans
    51. Brown JW, Mills JC. Implantable synthetic organoid matrices for intestinal regeneration. Nat Cell Biol. 2017 Oct 31; 19(11):1307-1308. PMID: 29087385.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    52. Burclaff J, Mills JC. Cell biology: Healthy skin rejects cancer. Nature. 2017 08 17; 548(7667):289-290. PMID: 28783724.
      Citations: 2     Fields:    Translation:Humans
    53. Radyk MD, Mills JC. A chief source of cancer and repair in stomachs. EMBO J. 2017 08 15; 36(16):2318-2320. PMID: 28666994; PMCID: PMC5556266.
      Citations: 4     Fields:    Translation:Humans
    54. Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA. A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jul; 153(1):e6-e13. PMID: 28583825; PMCID: PMC5828164.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    55. Mills JC, Goldenring JR. Metaplasia in the Stomach Arises From Gastric Chief Cells. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):85-88. PMID: 28560292; PMCID: PMC5440355.
      Citations: 26     Fields:    
    56. Lim J, Burclaff J, He G, Mills JC, Long F. Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice. Bone Res. 2017; 5:16049. PMID: 28163952; PMCID: PMC5282469.
      Citations: 25     
    57. Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Joens MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev. 2017 01 15; 31(2):154-171. PMID: 28174210; PMCID: PMC5322730.
      Citations: 38     Fields:    Translation:AnimalsCells
    58. Mills JC, S?enz JB. Biological techniques: Stomach growth in a dish. Nature. 2017 01 12; 541(7636):160-161. PMID: 28052062.
      Citations: 1     Fields:    Translation:Humans
    59. Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC. Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach. Gastroenterology. 2017 03; 152(4):762-766.e7. PMID: 27932312; PMCID: PMC5391042.
      Citations: 40     Fields:    Translation:AnimalsCells
    60. Goldenring JR, Mills JC. Isthmus Time Is Here: Runx1 Identifies Mucosal Stem Cells in the?Gastric Corpus. Gastroenterology. 2017 01; 152(1):16-19. PMID: 27889575.
      Citations: 4     Fields:    Translation:HumansCells
    61. Weis VG, Petersen CP, Weis JA, Meyer AR, Choi E, Mills JC, Goldenring JR. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2017 01 01; 312(1):G67-G76. PMID: 27881402; PMCID: PMC5283902.
      Citations: 20     Fields:    Translation:AnimalsCells
    62. Osaki LH, Mills JC. A Perfect Match: Explant and Organoid Systems Help Study Cytokines in Sickness and Health. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):4-5. PMID: 28174752; PMCID: PMC5247415.
      Citations: 1     Fields:    
    63. Petersen CP, Mills JC, Goldenring JR. Murine Models of Gastric Corpus Preneoplasia. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):11-26. PMID: 28174755; PMCID: PMC5247421.
      Citations: 38     Fields:    
    64. Willet SG, Mills JC. Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5):546-559. PMID: 27642625; PMCID: PMC5025260.
      Citations: 41     Fields:    
    65. Moore BD, Khurana SS, Huh WJ, Mills JC. Hepatocyte nuclear factor 4a is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. Am J Physiol Gastrointest Liver Physiol. 2016 08 01; 311(2):G267-75. PMID: 27340127; PMCID: PMC5007292.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    66. Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Urano F, Mills JC, Wollheim CB. Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4a (HNF4?) Is Vital to Beta-cell Function. J Biol Chem. 2016 Mar 18; 291(12):6146-57. PMID: 26792861; PMCID: PMC4813565.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    67. Saenz JB, Burclaff J, Mills JC. Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss. Methods Mol Biol. 2016; 1422:329-39. PMID: 27246044; PMCID: PMC5221414.
      Citations: 29     Fields:    Translation:AnimalsCells
    68. Moore BD, Jin RU, Osaki L, Romero-Gallo J, Noto J, Peek RM, Mills JC. Identification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15; 309(12):G955-64. PMID: 26514774; PMCID: PMC4683299.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    69. Mills JC, Sansom OJ. Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signal. 2015 Jul 14; 8(385):re8. PMID: 26175494; PMCID: PMC4858190.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    70. Ye L, Morse LR, Zhang L, Sasaki H, Mills JC, Odgren PR, Sibbel G, Stanley JR, Wong G, Battaglino RA, Zamarioli A. Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet. 2015 Mar; 11(3):e1005057. PMID: 25811986; PMCID: PMC4374855.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    71. Weis VG, Petersen CP, Mills JC, Tuma PL, Whitehead RH, Goldenring JR. Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G777-92. PMID: 25190476; PMCID: PMC4200317.
      Citations: 19     Fields:    Translation:AnimalsCells
    72. Jin RU, Mills JC. RAB26 coordinates lysosome traffic and mitochondrial localization. J Cell Sci. 2014 Mar 01; 127(Pt 5):1018-32. PMID: 24413166; PMCID: PMC3937772.
      Citations: 20     Fields:    Translation:HumansCells
    73. Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Chronic tamoxifen use is associated with a decreased risk of intestinal metaplasia in human gastric epithelium. Dig Dis Sci. 2014 Jun; 59(6):1244-54. PMID: 24368421; PMCID: PMC4035390.
      Citations: 3     Fields:    Translation:Humans
    74. Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H, Stange DE. Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell. 2013 Oct 10; 155(2):357-68. PMID: 24120136; PMCID: PMC4094146.
      Citations: 228     Fields:    Translation:AnimalsCells
    75. Geahlen JH, Lapid C, Thorell K, Nikolskiy I, Huh WJ, Oates EL, Lennerz JK, Tian X, Weis VG, Khurana SS, Lundin SB, Templeton AR, Mills JC. Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3. Physiol Genomics. 2013 Aug 01; 45(15):667-83. PMID: 23715263; PMCID: PMC3742967.
      Citations: 9     Fields:    Translation:HumansAnimals
    76. Khurana SS, Riehl TE, Moore BD, Fassan M, Rugge M, Romero-Gallo J, Noto J, Peek RM, Stenson WF, Mills JC. The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem. 2013 May 31; 288(22):16085-97. PMID: 23589310; PMCID: PMC3668764.
      Citations: 59     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    77. Capoccia BJ, Jin RU, Kong YY, Peek RM, Fassan M, Rugge M, Mills JC. The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation. J Clin Invest. 2013 Apr; 123(4):1475-91. PMID: 23478405; PMCID: PMC3613919.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    78. Nguyen TL, Khurana SS, Bellone CJ, Capoccia BJ, Sagartz JE, Kesman RA, Mills JC, DiPaolo RJ. Autoimmune gastritis mediated by CD4+ T cells promotes the development of gastric cancer. Cancer Res. 2013 Apr 01; 73(7):2117-26. PMID: 23378345; PMCID: PMC3652548.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    79. Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM. Helicobacter pylori promotes the expression of Kr?ppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One. 2013; 8(1):e54344. PMID: 23372710; PMCID: PMC3553174.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    80. Yeung CC, Mills JC, Hassan A, Kreisel FH, Nguyen TT, Frater JL. MIST1-a novel marker of plasmacytic differentiation. Appl Immunohistochem Mol Morphol. 2012 Dec; 20(6):561-5. PMID: 22495370; PMCID: PMC4858179.
      Citations: 1     Fields:    Translation:HumansCells
    81. Stemler KM, Crock LW, Lai HH, Mills JC, Gereau RW, Mysorekar IU. Protamine sulfate induced bladder injury protects from distention induced bladder pain. J Urol. 2013 Jan; 189(1):343-51. PMID: 23174261; PMCID: PMC3662487.
      Citations: 16     Fields:    Translation:Animals
    82. Oduro KA, Liu F, Tan Q, Kim CK, Lubman O, Fremont D, Mills JC, Choi K. Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells. Blood. 2012 Sep 13; 120(11):2203-13. PMID: 22855602; PMCID: PMC3447779.
      Citations: 26     Fields:    Translation:AnimalsCells
    83. Raghoebir L, Bakker ER, Mills JC, Swagemakers S, Kempen MB, Munck AB, Driegen S, Meijer D, Grosveld F, Tibboel D, Smits R, Rottier RJ. SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype. J Mol Cell Biol. 2012 Dec; 4(6):377-85. PMID: 22679103; PMCID: PMC3523556.
      Citations: 29     Fields:    Translation:AnimalsCells
    84. Mills JC, Taghert PH. Scaling factors: transcription factors regulating subcellular domains. Bioessays. 2012 Jan; 34(1):10-6. PMID: 22028036; PMCID: PMC3692000.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    85. Huh WJ, Khurana SS, Geahlen JH, Kohli K, Waller RA, Mills JC. Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach. Gastroenterology. 2012 Jan; 142(1):21-24.e7. PMID: 22001866; PMCID: PMC3708546.
      Citations: 110     Fields:    Translation:AnimalsCells
    86. Goldenring JR, Nam KT, Mills JC. The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist. Exp Cell Res. 2011 Nov 15; 317(19):2759-64. PMID: 21907708; PMCID: PMC3210373.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    87. Mills JC, Shivdasani RA. Gastric epithelial stem cells. Gastroenterology. 2011 Feb; 140(2):412-24. PMID: 21144849; PMCID: PMC3708552.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    88. Capoccia BJ, Lennerz JK, Bredemeyer AJ, Klco JM, Frater JL, Mills JC. Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells. Physiol Genomics. 2011 Feb 11; 43(3):174-86. PMID: 21098683; PMCID: PMC3055710.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    89. Lim JW, Hummert P, Mills JC, Kroll KL. Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo. Development. 2011 Jan; 138(1):33-44. PMID: 21098561; PMCID: PMC2998164.
      Citations: 29     Fields:    Translation:Animals
    90. Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC. XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology. 2010 Dec; 139(6):2038-49. PMID: 20816838; PMCID: PMC2997137.
      Citations: 61     Fields:    Translation:AnimalsCells
    91. Nam KT, Lee HJ, Sousa JF, Weis VG, O'Neal RL, Finke PE, Romero-Gallo J, Shi G, Mills JC, Peek RM, Konieczny SF, Goldenring JR. Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology. 2010 Dec; 139(6):2028-2037.e9. PMID: 20854822; PMCID: PMC2997152.
      Citations: 144     Fields:    Translation:AnimalsCells
    92. Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol. 2010 Sep; 177(3):1514-33. PMID: 20709804; PMCID: PMC2928982.
      Citations: 71     Fields:    Translation:HumansCells
    93. Goldenring JR, Nam KT, Wang TC, Mills JC, Wright NA. Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology. 2010 Jun; 138(7):2207-10, 2210.e1. PMID: 20450866; PMCID: PMC3769643.
      Citations: 88     Fields:    Translation:HumansAnimals
    94. Huh WJ, Mysorekar IU, Mills JC. Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of "floxed" alleles. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G368-80. PMID: 20413717; PMCID: PMC3774481.
      Citations: 39     Fields:    Translation:AnimalsCells
    95. Khurana S, Mills JC. The gastric mucosa development and differentiation. Prog Mol Biol Transl Sci. 2010; 96:93-115. PMID: 21075341.
      Citations: 7     Fields:    Translation:HumansAnimals
    96. Tian X, Jin RU, Bredemeyer AJ, Oates EJ, Blazewska KM, McKenna CE, Mills JC. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. Mol Cell Biol. 2010 Mar; 30(5):1269-84. PMID: 20038531; PMCID: PMC2820885.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    97. Kao JY, Zhang M, Miller MJ, Mills JC, Wang B, Liu M, Eaton KA, Zou W, Berndt BE, Cole TS, Takeuchi T, Owyang SY, Luther J. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology. 2010 Mar; 138(3):1046-54. PMID: 19931266; PMCID: PMC2831148.
      Citations: 135     Fields:    Translation:AnimalsCells
    98. Lennerz JK, Perry A, Mills JC, Huettner PC, Pfeifer JD. Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion. Am J Surg Pathol. 2009 Jun; 33(6):835-43. PMID: 19092631.
      Citations: 20     Fields:    Translation:HumansCells
    99. Mysorekar IU, Isaacson-Schmid M, Walker JN, Mills JC, Hultgren SJ. Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host Microbe. 2009 May 08; 5(5):463-75. PMID: 19454350; PMCID: PMC2696285.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    100. Kim M, Habiba A, Doherty JM, Mills JC, Mercer RW, Huettner JE. Regulation of mouse embryonic stem cell neural differentiation by retinoic acid. Dev Biol. 2009 Apr 15; 328(2):456-71. PMID: 19217899; PMCID: PMC2666105.
      Citations: 36     Fields:    Translation:AnimalsCells
    101. Capoccia BJ, Huh WJ, Mills JC. How form follows functional genomics: gene expression profiling gastric epithelial cells with a particular discourse on the parietal cell. Physiol Genomics. 2009 Apr 10; 37(2):67-78. PMID: 19208773; PMCID: PMC2685495.
      Citations: 14     Fields:    Translation:HumansCells
    102. Liu JY, Seno H, Miletic AV, Mills JC, Swat W, Stappenbeck TS. Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes. J Cell Sci. 2009 Feb 01; 122(Pt 3):324-34. PMID: 19139088; PMCID: PMC2724729.
      Citations: 15     Fields:    Translation:AnimalsCells
    103. Calderon B, Suri A, Pan XO, Mills JC, Unanue ER. IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes. J Immunol. 2008 Nov 15; 181(10):6964-74. PMID: 18981116; PMCID: PMC2653256.
      Citations: 18     Fields:    Translation:AnimalsCells
    104. Cella M, Fuchs A, Vermi W, Facchetti F, Otero K, Lennerz JK, Doherty JM, Mills JC, Colonna M. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature. 2009 Feb 05; 457(7230):722-5. PMID: 18978771; PMCID: PMC3772687.
      Citations: 599     Fields:    Translation:HumansAnimalsCells
    105. Bredemeyer AJ, Geahlen JH, Weis VG, Huh WJ, Zinselmeyer BH, Srivatsan S, Miller MJ, Shaw AS, Mills JC. The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol. 2009 Jan 01; 325(1):211-24. PMID: 19013146; PMCID: PMC2634829.
      Citations: 57     Fields:    Translation:AnimalsCells
    106. Doherty JM, Geske MJ, Stappenbeck TS, Mills JC. Diverse adult stem cells share specific higher-order patterns of gene expression. Stem Cells. 2008 Aug; 26(8):2124-30. PMID: 18511597; PMCID: PMC2610416.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    107. Deutsch EW, Ball CA, Berman JJ, Bova GS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen JH, Daian F, Dauga D, Davidson DR, Gimenez G, Goo YA, Grimmond S, Henrich T, Herrmann BG, Johnson MH, Korb M, Mills JC, Oudes AJ, Parkinson HE, Pascal LE, Pollet N, Quackenbush J, Ramialison M, Ringwald M, Salgado D, Sansone SA, Sherlock G, Stoeckert CJ, Swedlow J, Taylor RC, Walashek L, Warford A, Wilkinson DG, Zhou Y, Zon LI, Liu AY, True LD. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol. 2008 Mar; 26(3):305-12. PMID: 18327244; PMCID: PMC4367930.
      Citations: 55     Fields:    
    108. Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology. 2008 Feb; 134(2):511-22. PMID: 18242217; PMCID: PMC2857727.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    109. Ramsey VG, Doherty JM, Chen CC, Stappenbeck TS, Konieczny SF, Mills JC. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development. 2007 Jan; 134(1):211-22. PMID: 17164426.
      Citations: 104     Fields:    Translation:AnimalsCells
    110. Lugus JJ, Chung YS, Mills JC, Kim SI, Grass J, Kyba M, Doherty JM, Bresnick EH, Choi K. GATA2 functions at multiple steps in hemangioblast development and differentiation. Development. 2007 Jan; 134(2):393-405. PMID: 17166922.
      Citations: 76     Fields:    Translation:AnimalsCells
    111. Yin KJ, Cirrito JR, Yan P, Hu X, Xiao Q, Pan X, Bateman R, Song H, Hsu FF, Turk J, Xu J, Hsu CY, Mills JC, Holtzman DM, Lee JM. Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. J Neurosci. 2006 Oct 25; 26(43):10939-48. PMID: 17065436; PMCID: PMC6674654.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    112. Huh WJ, Pan XO, Mysorekar IU, Mills JC. Location, allocation, relocation: isolating adult tissue stem cells in three dimensions. Curr Opin Biotechnol. 2006 Oct; 17(5):511-7. PMID: 16889955.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    113. Doherty JM, Carmichael LK, Mills JC. GOurmet: a tool for quantitative comparison and visualization of gene expression profiles based on gene ontology (GO) distributions. BMC Bioinformatics. 2006 Mar 17; 7:151. PMID: 16545118; PMCID: PMC1459206.
      Citations: 14     Fields:    
    114. Giannakis M, Stappenbeck TS, Mills JC, Leip DG, Lovett M, Clifton SW, Ippolito JE, Glasscock JI, Arumugam M, Brent MR, Gordon JI. Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J Biol Chem. 2006 Apr 21; 281(16):11292-300. PMID: 16464855.
      Citations: 89     Fields:    Translation:AnimalsCells
    115. Deutsch EW, Ball CA, Bova GS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen J, Davidson D, Eichner LJ, Goo YA, Grimmond S, Henrich T, Johnson MH, Korb M, Mills JC, Oudes A, Parkinson HE, Pascal LE, Quackenbush J, Ramialison M, Ringwald M, Sansone SA, Sherlock G, Stoeckert CJ, Swedlow J, Taylor RC, Walashek L, Zhou Y, Liu AY, True LD. Development of the Minimum Information Specification for In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE). OMICS. 2006; 10(2):205-8. PMID: 16901227.
      Citations: 9     Fields:    
    116. Pull SL, Doherty JM, Mills JC, Gordon JI, Stappenbeck TS. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):99-104. PMID: 15615857; PMCID: PMC544052.
      Citations: 273     Fields:    Translation:AnimalsCells
    117. Syder AJ, Karam SM, Mills JC, Ippolito JE, Ansari HR, Farook V, Gordon JI. A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4471-6. PMID: 15070742; PMCID: PMC384771.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    118. Mills JC, Andersson N, Stappenbeck TS, Chen CC, Gordon JI. Molecular characterization of mouse gastric zymogenic cells. J Biol Chem. 2003 Nov 14; 278(46):46138-45. PMID: 12963718.
      Citations: 19     Fields:    Translation:AnimalsCells
    119. Syder AJ, Oh JD, Guruge JL, O'Donnell D, Karlsson M, Mills JC, Gordon JI, Bj?rkholm BM. The impact of parietal cells on Helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3467-72. PMID: 12629225; PMCID: PMC152316.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    120. Stappenbeck TS, Mills JC, Gordon JI. Molecular features of adult mouse small intestinal epithelial progenitors. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1004-9. PMID: 12552106; PMCID: PMC298716.
      Citations: 44     Fields:    Translation:AnimalsCells
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