TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurosurgery
Address7200 CAMBRIDGE
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    Collapse Biography 
    Collapse education and training
    Boston Children's Hospital , Boston, MA2020Postdoctoral Fellow in Cancer Biology
    University of Washington, Seattle, WAPh.D.2013Molecular and Cell Biolology
    Cornell University, Ithaca, NYB.S.2006Molecular Biology

    Collapse Overview 
    Collapse overview
    My lab’s current focus is on pediatric high grade glioma (pHGG) driven by H3K27M and H3G34R histone mutations, which result in profound epigenetic dysregulation to drive tumorigenesis. This research addresses a critical unmet medical need as there are no effective therapies for these tumors. My ongoing studies center around the hypothesis that aberrant chromatin regulation in glioma gives rise to clinically-relevant cancer phenotypes including, tumor initiating cancer stem cells (CSCs) and drug resistant subpopulations. The overall goals of my lab are to determine how chromatin dysregulation drives CSC maintenance and the development of therapeutic resistance on a mechanistic level, and to leverage this knowledge towards the development of new therapies.
    Collapse media links

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jiao F, Li Z, He C, Xu W, Yang G, Liu T, Shen H, Cai J, Anastas JN, Mao Y, Yu Y, Lan F, Shi YG, Jones C, Xu Y, Baker SJ, Shi Y, Guo R. RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma. Sci Adv. 2020 07; 6(29):eaba2113. PMID: 32832624.
      Citations: 5     Fields:    Translation:Humans
    2. Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y. Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10. PMID: 31631026.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    3. Anastas JN, Shi Y. Histone Serotonylation: Can the Brain Have "Happy" Chromatin? Mol Cell. 2019 05 02; 74(3):418-420. PMID: 31051139.
      Citations: 5     Fields:    Translation:Cells
    4. Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S. Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation. Am J Respir Crit Care Med. 2018 01 01; 197(1):104-116. PMID: 28853608.
      Citations: 198     Fields:    Translation:HumansAnimalsCells
    5. Jambhekar A, Anastas JN, Shi Y. Histone Lysine Demethylase Inhibitors. Cold Spring Harb Perspect Med. 2017 Jan 03; 7(1). PMID: 28049654.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    6. Anastas JN. Functional crosstalk between WNT signaling and tyrosine kinase signaling in cancer: Seminars in Oncology, Vol 42, No 6, December 2015, pp 820-831. Semin Oncol. 2016 Aug; 43(4):526. PMID: 27663484.
      Citations: 1     Fields:    
    7. Anastas JN, Kulikauskas RM, Tamir T, Rizos H, Long GV, von Euw EM, Yang PT, Chen HW, Haydu L, Toroni RA, Lucero OM, Chien AJ, Moon RT. WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. J Clin Invest. 2014 Jul; 124(7):2877-90. PMID: 24865425.
      Citations: 72     Fields:    Translation:HumansCells
    8. Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 2013 Jan; 13(1):11-26. PMID: 23258168.
      Citations: 917     Fields:    Translation:HumansAnimalsCells
    9. Yang PT, Anastas JN, Toroni RA, Shinohara MM, Goodson JM, Bosserhoff AK, Chien AJ, Moon RT. WLS inhibits melanoma cell proliferation through the ß-catenin signalling pathway and induces spontaneous metastasis. EMBO Mol Med. 2012 Dec; 4(12):1294-307. PMID: 23129487.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    10. Anastas JN, Biechele TL, Robitaille M, Muster J, Allison KH, Angers S, Moon RT. A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene. 2012 Aug 09; 31(32):3696-708. PMID: 22179838.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    11. Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/ß-catenin signaling. J Cell Biol. 2011 Sep 05; 194(5):737-50. PMID: 21875946.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    12. Major MB, Roberts BS, Berndt JD, Marine S, Anastas J, Chung N, Ferrer M, Yi X, Stoick-Cooper CL, von Haller PD, Kategaya L, Chien A, Angers S, MacCoss M, Cleary MA, Arthur WT, Moon RT. New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal. 2008 Nov 11; 1(45):ra12. PMID: 19001663.
      Citations: 85     Fields:    Translation:HumansCells
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