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JAMIE ANASTAS

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurosurgery
Address7200 CAMBRIDGE
Email
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Biography 
    Collapse education and training
    Boston Children's Hospital , Boston, MA2020Postdoctoral Fellow in Cancer Biology
    University of Washington, Seattle, WAPh.D.2013Molecular and Cell Biolology
    Cornell University, Ithaca, NYB.S.2006Molecular Biology

    Collapse Overview 
    Collapse overview
    My lab’s current focus is on pediatric high grade glioma (pHGG) driven by H3K27M and H3G34R histone mutations, which result in profound epigenetic dysregulation to drive tumorigenesis. This research addresses a critical unmet medical need as there are no effective therapies for these tumors. My ongoing studies center around the hypothesis that aberrant chromatin regulation in glioma gives rise to clinically-relevant cancer phenotypes including, tumor initiating cancer stem cells (CSCs) and drug resistant subpopulations. The overall goals of my lab are to determine how chromatin dysregulation drives CSC maintenance and the development of therapeutic resistance on a mechanistic level, and to leverage this knowledge towards the development of new therapies.
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    Collapse Research 
    Collapse research activities and funding
    R01NS129860     (ANASTAS, JAMIE N.)Feb 15, 2023 - Jan 31, 2028
    NIH
    MECHANISMS OF POL II ELONGATION IN DIFFUSE MIDLINE GLIOMA
    Role: Principal Investigator
    F32CA189741     (ANASTAS, JAMIE N.)Sep 15, 2014 - Sep 14, 2017
    NIH
    The role of ATRX and H3.3 mutations in pediatric glioblastoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Uryu H, Tovy A, Callen E, Murdaugh RL, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas J, Takahashi K, Vassiliou G, Goodell MA. SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells. Elife. 2024 Jun 18; 12. PMID: 38896450; PMCID: PMC11186636.
      Citations: 1     Fields:    Translation:HumansCells
    2. Lin FY, Stuckert A, Tat C, White M, Ruggieri L, Zhang H, Mehta B, Lapteva N, Mei Z, Major A, Thakkar S, Shum T, Parikh K, Wu MF, Lindsay HB, Scherer L, Shekar M, Baxter P, Wang T, Grilley B, Moeller K, Hicks J, Roy A, Anastas J, Malbari F, Aldave G, Chintagumpala M, Blaney S, Parsons DW, Brenner MK, Heslop HE, Rooney CM, Omer B. Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors. J Clin Oncol. 2024 Aug 10; 42(23):2769-2779. PMID: 38771986; PMCID: PMC11305939.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    3. Patel TD, Urya H, Guzman AG, Martell AG, Tovy A, Callen E, Murdaugh R, Richard R, Nussenzweig A, Zhang L, Hsu JI, Braekeleer ED, Chen CW, Wohlan K, Waldvogel SM, Jansen S, Vissers L, de Vries BBA, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MA. SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells. bioRxiv. 2024 Jan 17. PMID: 37693622; PMCID: PMC10491179.
      Citations:    
    4. Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti S. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024 01 08; 42(1):1-5. PMID: 38039965; PMCID: PMC11067690.
      Citations: 1     Fields:    Translation:Humans
    5. Murdaugh RL, Anastas JN. Applying single cell multi-omic analyses to understand treatment resistance in pediatric high grade glioma. Front Pharmacol. 2023; 14:1002296. PMID: 37205910; PMCID: PMC10191214.
      Citations: 1     
    6. Panditharatna E, Marques JG, Wang T, Trissal MC, Liu I, Jiang L, Beck A, Groves A, Dharia NV, Li D, Hoffman SE, Kugener G, Shaw ML, Mire HM, Hack OA, Dempster JM, Lareau C, Dai L, Sigua LH, Quezada MA, Stanton AJ, Wyatt M, Kalani Z, Goodale A, Vazquez F, Piccioni F, Doench JG, Root DE, Anastas JN, Jones KL, Conway AS, Stopka S, Regan MS, Liang Y, Seo HS, Song K, Bashyal P, Jerome WP, Mathewson ND, Dhe-Paganon S, Suv? ML, Carcaboso AM, Lavarino C, Mora J, Nguyen QD, Ligon KL, Shi Y, Agnihotri S, Agar NYR, Stegmaier K, Stiles CD, Monje M, Golub TR, Qi J, Filbin MG. BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Cancer Discov. 2022 12 02; 12(12):2880-2905. PMID: 36305736; PMCID: PMC9716260.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    7. Jiao F, Li Z, He C, Xu W, Yang G, Liu T, Shen H, Cai J, Anastas JN, Mao Y, Yu Y, Lan F, Shi YG, Jones C, Xu Y, Baker SJ, Shi Y, Guo R. RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma. Sci Adv. 2020 07; 6(29):eaba2113. PMID: 32832624; PMCID: PMC7439511.
      Citations: 5     Fields:    Translation:Humans
    8. Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y. Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10. PMID: 31631026.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    9. Anastas JN, Shi Y. Histone Serotonylation: Can the Brain Have "Happy" Chromatin? Mol Cell. 2019 05 02; 74(3):418-420. PMID: 31051139; PMCID: PMC6662934.
      Citations: 5     Fields:    Translation:Cells
    10. Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S. Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation. Am J Respir Crit Care Med. 2018 01 01; 197(1):104-116. PMID: 28853608; PMCID: PMC5765387.
      Citations: 205     Fields:    Translation:HumansAnimalsCells
    11. Jambhekar A, Anastas JN, Shi Y. Histone Lysine Demethylase Inhibitors. Cold Spring Harb Perspect Med. 2017 Jan 03; 7(1). PMID: 28049654; PMCID: PMC5204329.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    12. Anastas JN. Functional crosstalk between WNT signaling and tyrosine kinase signaling in cancer: Seminars in Oncology, Vol 42, No 6, December 2015, pp 820-831. Semin Oncol. 2016 Aug; 43(4):526. PMID: 27663484.
      Citations: 1     Fields:    
    13. Anastas JN, Kulikauskas RM, Tamir T, Rizos H, Long GV, von Euw EM, Yang PT, Chen HW, Haydu L, Toroni RA, Lucero OM, Chien AJ, Moon RT. WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. J Clin Invest. 2014 Jul; 124(7):2877-90. PMID: 24865425; PMCID: PMC4071371.
      Citations: 72     Fields:    Translation:HumansCells
    14. Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 2013 Jan; 13(1):11-26. PMID: 23258168.
      Citations: 928     Fields:    Translation:HumansAnimalsCells
    15. Yang PT, Anastas JN, Toroni RA, Shinohara MM, Goodson JM, Bosserhoff AK, Chien AJ, Moon RT. WLS inhibits melanoma cell proliferation through the ?-catenin signalling pathway and induces spontaneous metastasis. EMBO Mol Med. 2012 Dec; 4(12):1294-307. PMID: 23129487; PMCID: PMC3531604.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    16. Anastas JN, Biechele TL, Robitaille M, Muster J, Allison KH, Angers S, Moon RT. A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene. 2012 Aug 09; 31(32):3696-708. PMID: 22179838; PMCID: PMC3419983.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    17. Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/?-catenin signaling. J Cell Biol. 2011 Sep 05; 194(5):737-50. PMID: 21875946; PMCID: PMC3171123.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    18. Major MB, Roberts BS, Berndt JD, Marine S, Anastas J, Chung N, Ferrer M, Yi X, Stoick-Cooper CL, von Haller PD, Kategaya L, Chien A, Angers S, MacCoss M, Cleary MA, Arthur WT, Moon RT. New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal. 2008 Nov 11; 1(45):ra12. PMID: 19001663.
      Citations: 85     Fields:    Translation:HumansCells
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