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Blesson Chellakkan Selvanesan

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Obstetrics & Gynecology
DivisionObstet & Gyne: Rep Endo Infertility
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    I am a reproductive biologist specialized in reproductive endocrinology and metabolism. I have vast experience in the field of sex hormone signaling and its relevance in reproduction and metabolism. I am involved in translational research and teaching. I am passionate about applying my research expertise to improve health care. I also teach and mentor residents and fellows.

    My research team is working towards understanding the developmental origins of diseases and its role in reproduction and metabolism. Developmental programming is a recent concept whereby adverse environment during critical periods of early development predisposes the organism to increased risk of metabolic diseases in adult life. We are currently investigating the roles of hormones and nutrition during early development and its implication in the developmental origin of polycystic ovary syndrome (PCOS) and type 2 diabetes respectively.

    We use mouse PCOS models to investigate the effects of the disease on ovary, oocytes and embryos. We are currently studying the role of androgens in mitochondrial function and metabolism. We also recently developed a novel low protein programmed lean type 2 diabetic rat model to investigate the role of developmental programming of type 2 diabetes.

    Our team is also involved in improving quality and developing novel technologies to assist in fertility treatments. My lab’s mission is to improve reproductive success by (i) bringing new cutting edge assisted reproductive technologies and to apply it to our patients, (ii) to better understand the mechanisms of reproductive diseases and (iii) to foster an environment of knowledge driven patient care and education in the center.

    Other than research and teaching, I also work as an andrologist and junior embryologist at the Family Fertility Center, Texas Children’s Hospital.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. William R Surin, Surbhi Mundra, Chellakkan S Blesson, Ramachandra S Gudde. Involvement of Gas6 protein in mouse model of lipopolysaccharide-induced lung inflammation. Biomedical and Biotechnology Research Journal. 2018; 2(2):146-151.
    2. Chappell N.R, and Blesson C.S . Endocrinology and Diabetes Open Access. Polycystic Ovary Syndrome: A Multifaceted Enigma. Endocrinology and Diabetes Open Access. 2018; 1(1).
    3. Blesson CS, Schutt A, Mathew PR, Tanchico D, Balakrishnan M, Yallampalli U, Yallampalli C. Folate treatment partially reverses gestational low-protein diet-induced glucose intolerance and the magnitude of reversal is age and sex dependent. Nutrition. 2018 05; 49:81-89. PMID: 29500969.
      View in: PubMed
    4. Blesson CS, Chinnathambi V, Kumar S, Yallampalli C. Gestational Protein Restriction Impairs Glucose Disposal in the Gastrocnemius Muscles of Female Rats. Endocrinology. 2017 04 01; 158(4):756-767. PMID: 28324067.
      View in: PubMed
    5. Blesson CS, Schutt AK, Balakrishnan MP, Pautler RG, Pedersen SE, Sarkar P, Gonzales D, Zhu G, Marini JC, Chacko SK, Yallampalli U, Yallampalli C. Novel lean type 2 diabetic rat model using gestational low-protein programming. Am J Obstet Gynecol. 2016 Apr; 214(4):540.e1-540.e7. PMID: 26874300.
      View in: PubMed
    6. More AS, Mishra JS, Gopalakrishnan K, Blesson CS, Hankins GD, Sathishkumar K. Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring. Biol Reprod. 2016 Jan; 94(1):5. PMID: 26586841.
      View in: PubMed
    7. Blesson CS, Yallampalli C. Pregnancy is a new window of susceptibility for bisphenol a exposure. Endocrinology. 2015 May; 156(5):1611-2. PMID: 25886069.
      View in: PubMed
    8. Blesson CS, Chinnathambi V, Hankins GD, Yallampalli C, Sathishkumar K. Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cd-mediated mechanism. Hypertension. 2015 Mar; 65(3):683-690. PMID: 25489059.
      View in: PubMed
    9. Chauhan M, Balakrishnan M, Blesson CS, Yallampalli C. Adrenomedullin2 (ADM2)/intermedin (IMD) in rat ovary: changes in estrous cycle and pregnancy and its role in ovulation and steroidogenesis. Biol Reprod. 2015 Feb; 92(2):39. PMID: 25395681.
      View in: PubMed
    10. Chinnathambi V, Blesson CS, Vincent KL, Saade GR, Hankins GD, Yallampalli C, Sathishkumar K. Elevated testosterone levels during rat pregnancy cause hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in uterine arteries. Hypertension. 2014 Aug; 64(2):405-14. PMID: 24842922.
      View in: PubMed
    11. Chellakkan Selvanesan Blesson and Lena Sahlin . Receptors and Clinical Investigation. Prostaglandin E and F receptors in the uterus. 2014; 1(2).
    12. Blesson CS, Sathishkumar K, Chinnathambi V, Yallampalli C. Gestational protein restriction impairs insulin-regulated glucose transport mechanisms in gastrocnemius muscles of adult male offspring. Endocrinology. 2014 Aug; 155(8):3036-46. PMID: 24797633.
      View in: PubMed
    13. Roos N, Blesson CS, Stephansson O, Masironi B, Vladic Stjernholm Y, Ekman-Ordeberg G, Sahlin L. The expression of prostaglandin receptors EP3 and EP4 in human cervix in post-term pregnancy differs between failed and successful labor induction. Acta Obstet Gynecol Scand. 2014 Feb; 93(2):159-67. PMID: 24180609.
      View in: PubMed
    14. Chellakkan S. Blesson, Nathalie Roos, Olof Stephansson, Britt Masironi, Susann Reinert, Ylva Vladic Stjernholm, Gunvor Ekman-Ordeberg, Lena Sahlin . Expression and localization of prostaglandin receptors and stromal factors in human cervix—Variations in pregnant and non-pregnant states. Open Journal of Molecular and Integrative Physiology. 2013; 3(4).
    15. Saxena R, Fatima I, Chandra V, Blesson CS, Kharkwal G, Hussain MK, Hajela K, Roy BG, Dwivedi A. Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors a- and ß-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft. Steroids. 2013 Nov; 78(11):1071-86. PMID: 23891847.
      View in: PubMed
    16. Blesson CS, Sahlin L. Expression pattern and signalling pathways in neutrophil like HL-60 cells after treatment with estrogen receptor selective ligands. Mol Cell Endocrinol. 2012 Sep 25; 361(1-2):179-90. PMID: 22554835.
      View in: PubMed
    17. Blesson C.S, Masironi B and Sahlin L. . Effects of selective estrogen receptor agonists on estrogen receptor expression in the uterus of ovariectomized rats. Open Journal of Molecular and Integrative Physiology. 2012; 2:35-43.
    18. Blesson CS, Büttner E, Masironi B, Sahlin L. Prostaglandin receptors EP and FP are regulated by estradiol and progesterone in the uterus of ovariectomized rats. Reprod Biol Endocrinol. 2012 Jan 18; 10:3. PMID: 22257560.
      View in: PubMed
    19. Chellakkan Selvanesan Blesson. Estrogen Receptors in Leukocytes - Possible Impact on Inflammatory Processes in the Female Reproductive System. Update on Mechanisms of Hormone Action. 2011.
    20. Vladic-Stjernholm Y, Vladic T, Blesson CS, Ekman-Ordeberg G, Sahlin L. Prostaglandin treatment is associated with a withdrawal of progesterone and androgen at the receptor level in the uterine cervix. Reprod Biol Endocrinol. 2009 Oct 23; 7:116. PMID: 19852793.
      View in: PubMed
    21. Srinivasan KR, Blesson CS, Fatima I, Kitchlu S, Jain SK, Mehrotra PK, Dwivedi A. Expression of alphaVbeta3 integrin in rat endometrial epithelial cells and its functional role during implantation. Gen Comp Endocrinol. 2009 Jan 15; 160(2):124-33. PMID: 19027743.
      View in: PubMed
    22. Awasthi S, Blesson CS, Dwivedi A. Expression of oestrogen receptors alpha and beta during the period of uterine receptivity in rat: effect of ormeloxifene, a selective oestrogen receptor modulator. Acta Physiol (Oxf). 2007 Jan; 189(1):47-56. PMID: 17280556.
      View in: PubMed
    23. Blesson CS, Awasthi S, Kharkwal G, Daverey A, Dwivedi A. Modulation of estrogen receptor transactivation and estrogen-induced gene expression by ormeloxifene-a triphenylethylene derivative. Steroids. 2006 Nov; 71(11-12):993-1000. PMID: 16965798.
      View in: PubMed
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