RAYNE ROUCE

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Biography 
    Collapse awards and honors
    2015First Annual Immunooncology Young Investigator Forum Grant Award, Baylor College of Medicine
    2015 - 2018Lymphoma Research Foundation Career Development Award, Baylor College of Medicine
    2014American Society for Blood and Marrow Transplantation Clinical Research Training Course Scholar, Baylor College of Medicine
    2017 - 2018Leukemia Texas Supportive Research Grant, Baylor College of Medicine
    2016 - 2020American Society of Hematology Career Development Award, Baylor College of Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Steffin DHM, Muhsen IN, Hill LC, Ramos CA, Ahmed N, Hegde M, Wang T, Wu M, Gottschalk S, Whittle SB, Lulla PD, Mamonkin M, Omer B, Rouce RH, Heczey A, Metelitsa LS, Grilley BJ, Robertson C, Torrano V, Lapteva N, Gee AP, Rooney CM, Brenner MK, Heslop HE. Long-term follow-up for the development of subsequent malignancies in patients treated with genetically modified IECs. Blood. 2022 07 07; 140(1):16-24. PMID: 35325065.
      Citations:    Fields:    Translation:HumansCells
    2. Schultz LM, Baggott C, Prabhu S, Pacenta HL, Phillips CL, Rossoff J, Stefanski HE, Talano JA, Moskop A, Margossian SP, Verneris MR, Myers GD, Karras NA, Brown PA, Qayed M, Hermiston M, Satwani P, Krupski C, Keating AK, Wilcox R, Rabik CA, Fabrizio VA, Rouce RH, Chinnabhandar V, Kunicki M, Barsan VV, Goksenin AY, Li Y, Mavroukakis S, Egeler E, Curran KJ, Mackall CL, Laetsch TW. Disease Burden Affects Outcomes in Pediatric and Young Adult B-Cell Lymphoblastic Leukemia After Commercial Tisagenlecleucel: A Pediatric Real-World Chimeric Antigen Receptor Consortium Report. J Clin Oncol. 2022 03 20; 40(9):945-955. PMID: 34882493.
      Citations: 2     Fields:    Translation:Humans
    3. Forbes LR, Eckstein OS, Gulati N, Peckham-Gregory EC, Ozuah NW, Lubega J, El-Mallawany NK, Agrusa JE, Poli MC, Vogel TP, Chaimowitz NS, Rider NL, Mace EM, Orange JS, Caldwell JW, Aldave-Becerra JC, Jolles S, Saettini F, Chong HJ, Stray-Pedersen A, Heslop HE, Kamdar KY, Rouce RH, Muzny DM, Jhangiani SN, Gibbs RA, Coban-Akdemir ZH, Lupski JR, McClain KL, Allen CE, Chinn IK. Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders. J Allergy Clin Immunol. 2022 02; 149(2):758-766. PMID: 34329649.
      Citations: 1     Fields:    Translation:HumansCells
    4. Vasileiou S, Lulla PD, Tzannou I, Watanabe A, Kuvalekar M, Callejas WL, Bilgi M, Wang T, Wu MJ, Kamble R, Ramos CA, Rouce RH, Zeng Z, Gee AP, Grilley BJ, Vera JF, Bollard CM, Brenner MK, Heslop HE, Rooney CM, Leen AM, Carrum G. T-Cell Therapy for Lymphoma Using Nonengineered Multiantigen-Targeted T Cells Is Safe and Produces Durable Clinical Effects. J Clin Oncol. 2021 05 01; 39(13):1415-1425. PMID: 33507803.
      Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
    5. Hsieh EM, Rouce RH. Chimeric antigen receptor T cells for mature B-cell lymphoma and Burkitt lymphoma. Hematology Am Soc Hematol Educ Program. 2020 12 04; 2020(1):487-493. PMID: 33275669.
      Citations: 2     Fields:    Translation:Humans
    6. Agrusa JE, Scull BP, Abhyankar HA, Lin H, Ozuah NW, Chakraborty R, Eckstein OS, Gulati N, Fattah EA, El-Mallawany NK, Rouce RH, Dreyer ZE, Brackett J, Margolin JF, Lubega J, Horton TM, Bollard CM, Gramatges MM, Kamdar KY, McClain KL, Man TK, Allen CE. Defining the Inflammatory Plasma Proteome in Pediatric Hodgkin Lymphoma. Cancers (Basel). 2020 Dec 02; 12(12). PMID: 33276546.
      Citations: 1     
    7. Pasquini MC, Hu ZH, Curran K, Laetsch T, Locke F, Rouce R, Pulsipher MA, Phillips CL, Keating A, Frigault MJ, Salzberg D, Jaglowski S, Sasine JP, Rosenthal J, Ghosh M, Landsburg D, Margossian S, Martin PL, Kamdar MK, Hematti P, Nikiforow S, Turtle C, Perales MA, Steinert P, Horowitz MM, Moskop A, Pacaud L, Yi L, Chawla R, Bleickardt E, Grupp S. Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma. Blood Adv. 2020 11 10; 4(21):5414-5424. PMID: 33147337.
      Citations: 55     Fields:    Translation:Humans
    8. Hsieh EM, Scherer LD, Rouce RH. Replacing CAR-T cell resistance with persistence by changing a single residue. J Clin Invest. 2020 06 01; 130(6):2806-2808. PMID: 32364534.
      Citations: 4     Fields:    Translation:HumansCells
    9. Rouce RH. The earlier the better: timely mitigation of CRS. Blood. 2019 12 12; 134(24):2119-2120. PMID: 31830277.
      Citations: 5     Fields:    Translation:HumansCells
    10. Lapteva N, Gilbert M, Diaconu I, Rollins LA, Al-Sabbagh M, Naik S, Krance RA, Tripic T, Hiregange M, Raghavan D, Dakhova O, Rouce RH, Liu H, Omer B, Savoldo B, Dotti G, Cruz CR, Sharpe K, Gates M, Orozco A, Durett A, Pacheco E, Gee AP, Ramos CA, Heslop HE, Brenner MK, Rooney CM. T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor-Expressing T Cells. Clin Cancer Res. 2019 12 15; 25(24):7340-7350. PMID: 31558475.
      Citations: 13     Fields:    Translation:HumansCells
    11. Gruner SE, Sayeed H, Suarez-Ferguson L, Perez C, Rouce R, Fisher KE, Rau RE. Ponatinib use in two pediatric patients with relapsed Ph?+?ALL with ABL1 kinase domain mutations. Pediatr Hematol Oncol. 2019 11; 36(8):514-519. PMID: 31510844.
      Citations: 1     Fields:    Translation:Humans
    12. Quach DH, Becerra-Dominguez L, Rouce RH, Rooney CM. A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells. J Transl Med. 2019 07 24; 17(1):240. PMID: 31340822.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    13. Steffin DHM, Hsieh EM, Rouce RH. Gene Therapy: Current Applications and Future Possibilities. Adv Pediatr. 2019 08; 66:37-54. PMID: 31230699.
      Citations: 4     Fields:    Translation:Humans
    14. Sharma S, Rouce RH. Are we there yet? The never-ending quest for an Epstein-Barr virus vaccine. J Clin Invest. 2019 04 15; 129(5):1836-1838. PMID: 30985295.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    15. Gomes-Silva D, Atilla E, Atilla PA, Mo F, Tashiro H, Srinivasan M, Lulla P, Rouce RH, Cabral JMS, Ramos CA, Brenner MK, Mamonkin M. CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia. Mol Ther. 2019 01 02; 27(1):272-280. PMID: 30391141.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    16. McLaughlin LP, Rouce R, Gottschalk S, Torrano V, Carrum G, Wu MF, Hoq F, Grilley B, Marcogliese AM, Hanley PJ, Gee AP, Brenner MK, Rooney CM, Heslop HE, Bollard CM. EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation. Blood. 2018 11 29; 132(22):2351-2361. PMID: 30262660.
      Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
    17. Ramos CA, Rouce R, Robertson CS, Reyna A, Narala N, Vyas G, Mehta B, Zhang H, Dakhova O, Carrum G, Kamble RT, Gee AP, Mei Z, Wu MF, Liu H, Grilley B, Rooney CM, Heslop HE, Brenner MK, Savoldo B, Dotti G. In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas. Mol Ther. 2018 12 05; 26(12):2727-2737. PMID: 30309819.
      Citations: 77     Fields:    Translation:HumansCells
    18. Doherty E, Rouce RH. Primed to Kill: CTV-1 Stimulated Haploidentical Natural Killer Cells for Consolidation of AML. Biol Blood Marrow Transplant. 2018 08; 24(8):1533-1535. PMID: 29933070.
      Citations: 1     Fields:    Translation:HumansCells
    19. Tashiro H, Sauer T, Shum T, Parikh K, Mamonkin M, Omer B, Rouce RH, Lulla P, Rooney CM, Gottschalk S, Brenner MK. Treatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1. Mol Ther. 2017 09 06; 25(9):2202-2213. PMID: 28676343.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    20. Rezvani K, Rouce R, Liu E, Shpall E. Engineering Natural Killer Cells for Cancer Immunotherapy. Mol Ther. 2017 08 02; 25(8):1769-1781. PMID: 28668320.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    21. Rouce RH, Heslop HE. Equal opportunity CAR T cells. Blood. 2017 06 22; 129(25):3275-3277. PMID: 28642356.
      Citations: 2     Fields:    Translation:HumansCells
    22. Gomes-Silva D, Srinivasan M, Sharma S, Lee CM, Wagner DL, Davis TH, Rouce RH, Bao G, Brenner MK, Mamonkin M. CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies. Blood. 2017 07 20; 130(3):285-296. PMID: 28539325.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    23. Rouce RH, Sharma S, Huynh M, Heslop HE. Recent advances in T-cell immunotherapy for haematological malignancies. Br J Haematol. 2017 03; 176(5):688-704. PMID: 27897332.
      Citations: 12     Fields:    Translation:HumansCells
    24. Rouce RH, Heslop HE. Forecasting Cytokine Storms with New Predictive Biomarkers. Cancer Discov. 2016 06; 6(6):579-80. PMID: 27261481.
      Citations: 6     Fields:    Translation:HumansCells
    25. Aguayo-Hiraldo P, Arasaratnam R, Rouce RH. Recent advances in the risk factors, diagnosis and management of Epstein-Barr virus post-transplant lymphoproliferative disease. Bol Med Hosp Infant Mex. 2016 Jan - Feb; 73(1):31-40. PMID: 29421230.
      Citations:    Fields:    
    26. Rouce RH, Shaim H, Sekine T, Weber G, Ballard B, Ku S, Barese C, Murali V, Wu MF, Liu H, Shpall EJ, Bollard CM, Rabin KR, Rezvani K. The TGF-ß/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia. Leukemia. 2016 Apr; 30(4):800-11. PMID: 26621337.
      Citations: 61     Fields:    Translation:HumansCells
    27. Rezvani K, Rouce RH. The Application of Natural Killer Cell Immunotherapy for the Treatment of Cancer. Front Immunol. 2015; 6:578. PMID: 26635792.
      Citations: 116     Fields:    
    28. P. Aguayo-Hiraldo, R. Arasaratnam, and R. Rouce. The Medical Journal of the Children’s Hospital of Mexico. Recent advances in the risk factors, diagnosis and management of Epstein-Barr virus post-transplant lymphoproliferative disease. 2015.
    29. Rouce RH. More than Memory: Potential of Adaptive Natural Killer Cells. Biol Blood Marrow Transplant. 2015 Sep; 21(9):1534-6. PMID: 26211986.
      Citations: 1     Fields:    Translation:HumansCells
    30. Mamonkin M, Rouce RH, Tashiro H, Brenner MK. A T-cell-directed chimeric antigen receptor for the selective treatment of T-cell malignancies. Blood. 2015 Aug 20; 126(8):983-92. PMID: 26056165.
      Citations: 108     Fields:    Translation:HumansAnimals
    31. Rouce RH, Louis CU, Heslop HE. Epstein-Barr virus lymphoproliferative disease after hematopoietic stem cell transplant. Curr Opin Hematol. 2014 Nov; 21(6):476-81. PMID: 25159713.
      Citations: 14     Fields:    Translation:HumansCells
    32. Khoder A, Sarvaria A, Alsuliman A, Chew C, Sekine T, Cooper N, Mielke S, de Lavallade H, Muftuoglu M, Fernandez Curbelo I, Liu E, Muraro PA, Alousi A, Stringaris K, Parmar S, Shah N, Shaim H, Yvon E, Molldrem J, Rouce R, Champlin R, McNiece I, Mauri C, Shpall EJ, Rezvani K. Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD. Blood. 2014 Sep 25; 124(13):2034-45. PMID: 25051962.
      Citations: 93     Fields:    Translation:HumansCells
    33. Weber G, Caruana I, Rouce RH, Barrett AJ, Gerdemann U, Leen AM, Rabin KR, Bollard CM. Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia--implications for immunotherapy. Clin Cancer Res. 2013 Sep 15; 19(18):5079-91. PMID: 23838315.
      Citations: 35     Fields:    Translation:HumansCells
    34. Moreira A, Rouce R, Richardson CJ, Jain S. A premature neonate with leukocytosis. Clin Pediatr (Phila). 2012 Jul; 51(7):692-3. PMID: 21525086.
      Citations:    Fields:    Translation:Humans
    35. R. Rouce and F. Huang. Synopsis of Pediatric Emergency Care. PeePee Publishing, 2010. Oncological Emergencies. 2010.
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