DAVID MARCIANO

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pokharel MD, Garcia-Flores A, Marciano D, Franco MC, Fineman JR, Aggarwal S, Wang T, Black SM. Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics. Redox Biol. 2024 Apr; 70:103049. PMID: 38295575; PMCID: PMC10844980.
      Citations:    Fields:    Translation:Humans
    2. Isobe S, Nair RV, Kang HY, Wang L, Moonen JR, Shinohara T, Cao A, Taylor S, Otsuki S, Marciano DP, Harper RL, Adil MS, Zhang C, Lago-Docampo M, K?rbelin J, Engreitz JM, Snyder MP, Rabinovitch M. Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension. Nat Commun. 2023 Nov 21; 14(1):7578. PMID: 37989727; PMCID: PMC10663616.
      Citations:    Fields:    Translation:HumansAnimals
    3. Pokharel MD, Marciano DP, Fu P, Franco MC, Unwalla H, Tieu K, Fineman JR, Wang T, Black SM. Metabolic reprogramming, oxidative stress, and pulmonary hypertension. Redox Biol. 2023 08; 64:102797. PMID: 37392518; PMCID: PMC10363484.
      Citations:    Fields:    Translation:HumansCells
    4. Marciano DC, Wang C, Hsu TK, Bourquard T, Atri B, Nehring RB, Abel NS, Bowling EA, Chen TJ, Lurie PD, Katsonis P, Rosenberg SM, Herman C, Lichtarge O. Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli. Nat Commun. 2022 06 09; 13(1):3189. PMID: 35680894; PMCID: PMC9184624.
      Citations: 1     Fields:    Translation:Cells
    5. Van Bortle K, Marciano DP, Liu Q, Chou T, Lipchik AM, Gollapudi S, Geller BS, Monte E, Kamakaka RT, Snyder MP. A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA. Nat Commun. 2022 05 30; 13(1):3007. PMID: 35637192; PMCID: PMC9151912.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Wang C, Konecki DM, Marciano DC, Govindarajan H, Williams AM, Wastuwidyaningtyas B, Bourquard T, Katsonis P, Lichtarge O. Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and greater coronavirus family. Bioinformatics. 2021 11 18; 37(22):4033-4040. PMID: 34043002; PMCID: PMC8243408.
      Citations: 3     Fields:    
    7. Wang C, Konecki DM, Marciano DC, Govindarajan H, Williams AM, Wastuwidyaningtyas B, Bourquard T, Katsonis P, Lichtarge O. Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and the greater coronavirus family. Res Sq. 2021 Feb 15. PMID: 33106800; PMCID: PMC7587783.
      Citations:    
    8. Hennigs JK, Cao A, Li CG, Shi M, Mienert J, Miyagawa K, Marciano DP, Chen PI, Roughley M, Elliott MV, Harper RL, Bill MA, Chappell J, Moonen JR, Diebold I, Wang L, Snyder MP, Rabinovitch M, K?rbelin J. PPAR?-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension. Circ Res. 2021 02 05; 128(3):401-418. PMID: 33322916; PMCID: PMC7908816.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    9. Li CG, Mahon C, Sweeney NM, Verschueren E, Kantamani V, Li D, Hennigs JK, Marciano DP, Diebold I, Abu-Halawa O, Elliott M, Sa S, Guo F, Wang L, Cao A, Guignabert C, Sollier J, Nickel NP, Kaschwich M, Cimprich KA, Rabinovitch M. PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Cell Rep. 2019 01 29; 26(5):1333-1343.e7. PMID: 30699358; PMCID: PMC6436616.
      Citations: 20     Fields:    Translation:HumansCells
    10. de Vera IMS, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, Hughes TS, Rance M, Griffin PR, Kojetin DJ. Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1. Structure. 2019 01 02; 27(1):66-77.e5. PMID: 30416039; PMCID: PMC6318021.
      Citations: 18     Fields:    Translation:HumansCells
    11. Swings T, Marciano DC, Atri B, Bosserman RE, Wang C, Leysen M, Bonte C, Schalck T, Furey I, Van den Bergh B, Verstraeten N, Christie PJ, Herman C, Lichtarge O, Michiels J. CRISPR-FRT targets shared sites in a knock-out collection for off-the-shelf genome editing. Nat Commun. 2018 Jun 08; 9(1):2231. PMID: 29884781; PMCID: PMC5993718.
      Citations: 2     Fields:    Translation:Cells
    12. de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, Brust R, Munoz-Tello P, Gardner WJ, Marciano DP, Kong X, Griffin PR, Kojetin DJ. Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA. Structure. 2017 10 03; 25(10):1506-1518.e4. PMID: 28890360; PMCID: PMC5653230.
      Citations: 16     Fields:    Translation:HumansCells
    13. Marciano DC, Lua RC, Herman C, Lichtarge O. Cooperativity of Negative Autoregulation Confers Increased Mutational Robustness. Phys Rev Lett. 2016 Jun 24; 116(25):258104. PMID: 27391757; PMCID: PMC5152588.
      Citations: 2     Fields:    Translation:Cells
    14. Mullany LK, Wong KK, Marciano DC, Katsonis P, King-Crane ER, Ren YA, Lichtarge O, Richards JS. Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. Neoplasia. 2015 Oct; 17(10):789-803. PMID: 26585234; PMCID: PMC4656807.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    15. Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning JB, Nettles KW. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nat Commun. 2015 Aug 20; 6:8013. PMID: 26289479; PMCID: PMC4547401.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    16. Marciano DP, Kuruvilla DS, Boregowda SV, Asteian A, Hughes TS, Garcia-Ordonez R, Corzo CA, Khan TM, Novick SJ, Park H, Kojetin DJ, Phinney DG, Bruning JB, Kamenecka TM, Griffin PR. Pharmacological repression of PPAR? promotes osteogenesis. Nat Commun. 2015 Jun 12; 6:7443. PMID: 26068133; PMCID: PMC4471882.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    17. Marciano DC, Lua RC, Katsonis P, Amin SR, Herman C, Lichtarge O. Negative feedback in genetic circuits confers evolutionary resilience and capacitance. Cell Rep. 2014 Jun 26; 7(6):1789-95. PMID: 24910431; PMCID: PMC4103627.
      Citations: 11     Fields:    
    18. Lua RC, Marciano DC, Katsonis P, Adikesavan AK, Wilkins AD, Lichtarge O. Prediction and redesign of protein-protein interactions. Prog Biophys Mol Biol. 2014 Nov-Dec; 116(2-3):194-202. PMID: 24878423; PMCID: PMC4246023.
      Citations: 10     Fields:    Translation:Humans
    19. Hughes TS, Giri PK, de Vera IM, Marciano DP, Kuruvilla DS, Shin Y, Blayo AL, Kamenecka TM, Burris TP, Griffin PR, Kojetin DJ. An alternate binding site for PPAR? ligands. Nat Commun. 2014 Apr 07; 5:3571. PMID: 24705063; PMCID: PMC4070320.
      Citations: 66     Fields:    Translation:Cells
    20. Wilkins AD, Venner E, Marciano DC, Erdin S, Atri B, Lua RC, Lichtarge O. Accounting for epistatic interactions improves the functional analysis of protein structures. Bioinformatics. 2013 Nov 01; 29(21):2714-21. PMID: 24021383; PMCID: PMC3799481.
      Citations: 18     Fields:    Translation:Cells
    21. Pascal BD, Willis S, Lauer JL, Landgraf RR, West GM, Marciano D, Novick S, Goswami D, Chalmers MJ, Griffin PR. HDX workbench: software for the analysis of H/D exchange MS data. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1512-21. PMID: 22692830; PMCID: PMC3808162.
      Citations: 154     Fields:    Translation:Cells
    22. Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Shulman GI, Spiegelman BM, Griffin PR, Sch?rer SC, Vidovic D. Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation. Nature. 2011 Sep 04; 477(7365):477-81. PMID: 21892191; PMCID: PMC3179551.
      Citations: 238     Fields:    Translation:HumansAnimalsCells
    23. Adikesavan AK, Katsonis P, Marciano DC, Lua R, Herman C, Lichtarge O. Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites. PLoS Genet. 2011 Sep; 7(9):e1002244. PMID: 21912525; PMCID: PMC3164682.
      Citations: 40     Fields:    Translation:Cells
    24. Das D, Finn RD, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Deller MC, Duan L, Ellrott K, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Lam WW, Marciano D, Miller MD, Morse AT, Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Tien HJ, Trame CB, van den Bedem H, Weekes D, Wooten T, Xu Q, Yeh A, Zhou J, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, Elsliger MA. The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu. Protein Sci. 2010 Nov; 19(11):2131-40. PMID: 20836087; PMCID: PMC3005784.
      Citations: 3     Fields:    Translation:HumansCells
    25. Das D, Finn RD, Carlton D, Miller MD, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Chen C, Chiu HJ, Chiu M, Clayton T, Deller MC, Duan L, Ellrott K, Ernst D, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Marciano D, McMullan D, Morse AT, Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Rife CL, Sefcovic N, Tien HJ, Trame CB, van den Bedem H, Weekes D, Wooten T, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, Elsliger MA. The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 01; 66(Pt 10):1265-73. PMID: 20944221; PMCID: PMC2954215.
      Citations: 5     Fields:    Translation:Cells
    26. Das D, Moiani D, Axelrod HL, Miller MD, McMullan D, Jin KK, Abdubek P, Astakhova T, Burra P, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, Ernst D, Feuerhelm J, Grant JC, Grzechnik A, Grzechnik SK, Han GW, Jaroszewski L, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Marciano D, Morse AT, Nigoghossian E, Okach L, Paulsen J, Reyes R, Rife CL, Sefcovic N, Tien HJ, Trame CB, van den Bedem H, Weekes D, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Tainer JA, Wilson IA, Elsliger MA. Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. J Mol Biol. 2010 Apr 02; 397(3):647-63. PMID: 20122942; PMCID: PMC2839085.
      Citations: 26     Fields:    Translation:Cells
    27. Xu Q, Bateman A, Finn RD, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Ernst D, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Marciano D, McMullan D, Miller MD, Morse AT, Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Rife CL, Sefcovic N, Tien HJ, Trame CB, van den Bedem H, Weekes D, Wooten T, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, Elsliger MA. Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain. J Mol Biol. 2010 Feb 12; 396(1):31-46. PMID: 19913036; PMCID: PMC2817789.
      Citations: 17     Fields:    Translation:Cells
    28. Marciano DC, Brown NG, Palzkill T. Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase. Protein Sci. 2009 Oct; 18(10):2080-9. PMID: 19672877; PMCID: PMC2786972.
      Citations: 21     Fields:    Translation:Cells
    29. Xu Q, Carlton D, Miller MD, Krishna SS, Abdubek P, Astakhova T, Burra P, Chiu HJ, Clayton T, Deller MC, Duan L, Elias Y, Feuerhelm J, Grant JC, Grzechnik A, Grzechnik SK, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Kumar A, Marciano D, McMullan D, Morse AT, Nigoghossian E, Okach L, Oommachen S, Paulsen J, Reyes R, Rife CL, Sefcovic N, Trame C, Trout CV, van den Bedem H, Weekes D, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, Elsliger MA. Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus. J Mol Biol. 2009 Jul 24; 390(4):686-98. PMID: 19450606; PMCID: PMC2726009.
      Citations: 10     Fields:    Translation:Cells
    30. Xu Q, McMullan D, Abdubek P, Astakhova T, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, Elsliger MA, Feuerhelm J, Hale J, Han GW, Jaroszewski L, Jin KK, Johnson HA, Klock HE, Knuth MW, Kozbial P, Sri Krishna S, Kumar A, Marciano D, Miller MD, Morse AT, Nigoghossian E, Nopakun A, Okach L, Oommachen S, Paulsen J, Puckett C, Reyes R, Rife CL, Sefcovic N, Trame C, van den Bedem H, Weekes D, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA. A structural basis for the regulatory inactivation of DnaA. J Mol Biol. 2009 Jan 16; 385(2):368-80. PMID: 19000695; PMCID: PMC2667141.
      Citations: 9     Fields:    Translation:Cells
    31. Marciano DC, Pennington JM, Wang X, Wang J, Chen Y, Thomas VL, Shoichet BK, Palzkill T. Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase. J Mol Biol. 2008 Dec 05; 384(1):151-64. PMID: 18822298; PMCID: PMC2644635.
      Citations: 31     Fields:    Translation:Cells
    32. Marciano DC, Karkouti OY, Palzkill T. A fitness cost associated with the antibiotic resistance enzyme SME-1 beta-lactamase. Genetics. 2007 Aug; 176(4):2381-92. PMID: 17565956; PMCID: PMC1950639.
      Citations: 26     Fields:    Translation:Cells
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