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ROBIN PARIHAR

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Oncology
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    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Biography 
    Collapse awards and honors
    2002Aventis Oncology Scholar-in-Training Award, American Association for Cancer Research (AACR)
    2003Dissertation Research Award, Susan G Komen Breast Cancer Foundation
    2004Takeda Pharmaceuticals Scholar-in-Training Award, American Association for Cancer Research (AACR)
    2011Trainee Research Award, American Society of Hematology (ASH)
    20151st-place Research Poster Award, Texas Children's Cancer Center Research Symposium, Baylor College of Medicine
    2015Faculty Teaching Award, Center for Cell and Gene Therapy, Texas Children's Hospital and Baylor College of Medicine
    2018Young Investigator Award, American Society for Pediatric Hematology/Oncology (ASPHO)
    2018Distinguished Young Investigator Research Award, SITC Immuno-Oncology Young Investigators’ Forum

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Devkota L, Starosolski Z, Rivas CH, Stupin I, Annapragada A, Ghaghada KB, Parihar R. Detection of response to tumor microenvironment-targeted cellular immunotherapy using nano-radiomics. Sci Adv. 2020 Jul; 6(28):eaba6156. PMID: 32832602.
      View in: PubMed
    2. Dysthe M, Parihar R. Myeloid-Derived Suppressor Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2020; 1224:117-140. PMID: 32036608.
      View in: PubMed
    3. Parihar R, Rivas C, Huynh M, Omer B, Lapteva N, Metelitsa LS, Gottschalk SM, Rooney CM. NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors. Cancer Immunol Res. 2019 03; 7(3):363-375. PMID: 30651290.
      View in: PubMed
    4. Omer B, Castillo PA, Tashiro H, Shum T, Huynh MTA, Cardenas M, Tanaka M, Lewis A, Sauer T, Parihar R, Lapteva N, Schmueck-Henneresse M, Mukherjee M, Gottschalk S, Rooney CM. Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells. Front Med (Lausanne). 2018; 5:343. PMID: 30619856.
      View in: PubMed
    5. Jayaraman P, Parikh F, Newton JM, Hanoteau A, Rivas C, Krupar R, Rajapakshe K, Pathak R, Kanthaswamy K, MacLaren C, Huang S, Coarfa C, Spanos C, Edwards DP, Parihar R, Sikora AG. TGF-ß1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy. Oncoimmunology. 2018; 7(10):e1490853. PMID: 30288358.
      View in: PubMed
    6. Shum T, Omer B, Tashiro H, Kruse RL, Wagner DL, Parikh K, Yi Z, Sauer T, Liu D, Parihar R, Castillo P, Liu H, Brenner MK, Metelitsa LS, Gottschalk S, Rooney CM. Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells. Cancer Discov. 2017 11; 7(11):1238-1247. PMID: 28830878.
      View in: PubMed
    7. Campbell AR, Duggan MC, Suarez-Kelly LP, Bhave N, Opheim KS, McMichael EL, Trikha P, Parihar R, Luedke E, Lewis A, Yung B, Lee R, Raulet D, Tridandapani S, Groh V, Yu L, Yildiz V, Byrd JC, Caligiuri MA, Carson WE. MICA-Expressing Monocytes Enhance Natural Killer Cell Fc Receptor-Mediated Antitumor Functions. Cancer Immunol Res. 2017 09; 5(9):778-789. PMID: 28724544.
      View in: PubMed
    8. Parihar R. Sensing Bad: Are Co-stimulatory CAR-Expressing ?d T Cells Safer? Mol Ther. 2017 05 03; 25(5):1064-1066. PMID: 28433402.
      View in: PubMed
    9. Lapteva N, Parihar R, Rollins LA, Gee AP, Rooney CM. Large-Scale Culture and Genetic Modification of Human Natural Killer Cells for Cellular Therapy. Methods Mol Biol. 2016; 1441:195-202. PMID: 27177667.
      View in: PubMed
    10. Campbell AR, Regan K, Bhave N, Pattanayak A, Parihar R, Stiff AR, Trikha P, Scoville SD, Liyanarachchi S, Kondadasula SV, Lele O, Davuluri R, Payne PR, Carson WE. Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12. BMC Med Genomics. 2015 Oct 15; 8:66. PMID: 26470881.
      View in: PubMed
    11. Jaime-Ramirez AC, Mundy-Bosse BL, Kondadasula S, Jones NB, Roda JM, Mani A, Parihar R, Karpa V, Papenfuss TL, LaPerle KM, Biller E, Lehman A, Chaudhury AR, Jarjoura D, Burry RW, Carson WE. IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-? production. J Immunol. 2011 Mar 15; 186(6):3401-9. PMID: 21321106.
      View in: PubMed
    12. Kondadasula SV, Roda JM, Parihar R, Yu J, Lehman A, Caligiuri MA, Tridandapani S, Burry RW, Carson WE. Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. Blood. 2008 Apr 15; 111(8):4173-83. PMID: 18174382.
      View in: PubMed
    13. Roda JM, Parihar R, Lehman A, Mani A, Tridandapani S, Carson WE. Interleukin-21 enhances NK cell activation in response to antibody-coated targets. J Immunol. 2006 Jul 01; 177(1):120-9. PMID: 16785506.
      View in: PubMed
    14. Roda JM, Parihar R, Magro C, Nuovo GJ, Tridandapani S, Carson WE. Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells. Cancer Res. 2006 Jan 01; 66(1):517-26. PMID: 16397268.
      View in: PubMed
    15. Eisenbeis CF, Lesinski GB, Anghelina M, Parihar R, Valentino D, Liu J, Nadella P, Sundaram P, Young DC, Sznol M, Walker MJ, Carson WE. Phase I study of the sequential combination of interleukin-12 and interferon alfa-2b in advanced cancer: evidence for modulation of interferon signaling pathways by interleukin-12. J Clin Oncol. 2005 Dec 01; 23(34):8835-44. PMID: 16314644.
      View in: PubMed
    16. Parihar R, Trotta R, Roda JM, Ferketich AK, Tridandapani S, Caligiuri MA, Carson WE. Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12. Cancer Res. 2005 Oct 01; 65(19):9099-107. PMID: 16204085.
      View in: PubMed
    17. Roda JM, Parihar R, Carson WE. CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells. J Immunol. 2005 Aug 01; 175(3):1619-27. PMID: 16034101.
      View in: PubMed
    18. Parihar R, Carson WE. Novel cytokines in the treatment of malignancies. Cancer Treat Res. 2005; 126:353-73. PMID: 16209074.
      View in: PubMed
    19. Trotta R, Parihar R, Yu J, Becknell B, Allard J, Wen J, Ding W, Mao H, Tridandapani S, Carson WE, Caligiuri MA. Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. Blood. 2005 Apr 15; 105(8):3011-8. PMID: 15604218.
      View in: PubMed
    20. Sussman JJ, Parihar R, Winstead K, Finkelman FD. Prolonged culture of vaccine-primed lymphocytes results in decreased antitumor killing and change in cytokine secretion. Cancer Res. 2004 Dec 15; 64(24):9124-30. PMID: 15604282.
      View in: PubMed
    21. Parihar R, Nadella P, Lewis A, Jensen R, De Hoff C, Dierksheide JE, VanBuskirk AM, Magro CM, Young DC, Shapiro CL, Carson WE. A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: analysis of sustained interferon gamma production in a subset of patients. Clin Cancer Res. 2004 Aug 01; 10(15):5027-37. PMID: 15297404.
      View in: PubMed
    22. Lesinski GB, Anghelina M, Zimmerer J, Bakalakos T, Badgwell B, Parihar R, Hu Y, Becknell B, Abood G, Chaudhury AR, Magro C, Durbin J, Carson WE. The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse. J Clin Invest. 2003 Jul; 112(2):170-80. PMID: 12865406.
      View in: PubMed
    23. Dakappagari NK, Pyles J, Parihar R, Carson WE, Young DC, Kaumaya PT. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. J Immunol. 2003 Apr 15; 170(8):4242-53. PMID: 12682258.
      View in: PubMed
    24. Fleming GF, Meropol NJ, Rosner GL, Hollis DR, Carson WE, Caligiuri M, Mortimer J, Tkaczuk K, Parihar R, Schilsky RL, Ratain MJ. A phase I trial of escalating doses of trastuzumab combined with daily subcutaneous interleukin 2: report of cancer and leukemia group B 9661. Clin Cancer Res. 2002 Dec; 8(12):3718-27. PMID: 12473581.
      View in: PubMed
    25. Parihar R, Dierksheide J, Hu Y, Carson WE. IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells. J Clin Invest. 2002 Oct; 110(7):983-92. PMID: 12370276.
      View in: PubMed
    26. Badgwell B, Parihar R, Magro C, Dierksheide J, Russo T, Carson WE. Natural killer cells contribute to the lethality of a murine model of Escherichia coli infection. Surgery. 2002 Aug; 132(2):205-12. PMID: 12219013.
      View in: PubMed
    27. Biber JL, Jabbour S, Parihar R, Dierksheide J, Hu Y, Baumann H, Bouchard P, Caligiuri MA, Carson W. Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma. Cell Immunol. 2002 Mar-Apr; 216(1-2):31-42. PMID: 12381348.
      View in: PubMed
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