IVAN GORLOV

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address
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    Collapse Research 
    Collapse research activities and funding
    R56LM012371     (GORLOV, IVAN P)Aug 1, 2017 - Jul 31, 2019
    NIH/NLM
    Predicting SNP priors for Cancer GWASs
    Role: Principal Investigator

    R03CA133885     (GORLOV, IVAN P)Sep 26, 2008 - Aug 31, 2011
    NIH/NCI
    Tobacco Smoke Sensitive Genes and Genetic Susceptibility to Small-Cell Lung Cance
    Role: Principal Investigator

    R03CA128025     (GORLOV, IVAN P)Sep 24, 2007 - Aug 31, 2010
    NIH/NCI
    The Odd-Even Effect of Polymorphic CA repeats in the 5' Regulatory Region of the
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li Y, Xiao X, Li J, Han Y, Cheng C, Fernandes GF, Slewitzke SE, Rosenberg SM, Zhu M, Byun J, Boss? Y, McKay JD, Albanes D, Lam S, Tardon A, Chen C, Bojesen SE, Landi MT, Johansson M, Risch A, Bickeb?ller H, Wichmann HE, Christiani DC, Rennert G, Arnold SM, Goodman GE, Field JK, Davies MPA, Shete S, Marchand LL, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Sun R, Zienolddiny S, Grankvist K, Johansson M, Caporaso NE, Cox A, Hong YC, Lazarus P, Schabath MB, Aldrich MC, Schwartz AG, Gorlov I, Purrington KS, Yang P, Liu Y, Bailey-Wilson JE, Pinney SM, Mandal D, Willey JC, Gaba C, Brennan P, Xia J, Shen H, Amos CI. Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies. Cancer Epidemiol Biomarkers Prev. 2024 03 01; 33(3):389-399. PMID: 38180474; PMCID: PMC10905670.
      Citations:    Fields:    Translation:Humans
    2. Zhao X, Yang M, Fan J, Wang M, Wang Y, Qin N, Zhu M, Jiang Y, Gorlova OY, Gorlov IP, Albanes D, Lam S, Tard?n A, Chen C, Goodman GE, Bojesen SE, Landi MT, Johansson M, Risch A, Wichmann HE, Bickeb?ller H, Christiani DC, Rennert G, Arnold SM, Brennan P, Field JK, Shete S, Le Marchand L, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Zienolddiny S, Grankvist K, Johansson M, Caporaso NE, Woll PJ, Lazarus P, Schabath MB, Aldrich MC, Patel AV, Davies MPA, Ma H, Jin G, Hu Z, Amos CI, Shen H, Dai J. Identification of genetically predicted DNA methylation markers associated with non-small cell lung cancer risk among 34,964 cases and 448,579 controls. Cancer. 2024 03 15; 130(6):913-926. PMID: 38055287.
      Citations: 1     Fields:    Translation:HumansCells
    3. Shi J, Shiraishi K, Choi J, Matsuo K, Chen TY, Dai J, Hung RJ, Chen K, Shu XO, Kim YT, Landi MT, Lin D, Zheng W, Yin Z, Zhou B, Song B, Wang J, Seow WJ, Song L, Chang IS, Hu W, Chien LH, Cai Q, Hong YC, Kim HN, Wu YL, Wong MP, Richardson BD, Funderburk KM, Li S, Zhang T, Breeze C, Wang Z, Blechter B, Bassig BA, Kim JH, Albanes D, Wong JYY, Shin MH, Chung LP, Yang Y, An SJ, Zheng H, Yatabe Y, Zhang XC, Kim YC, Caporaso NE, Chang J, Ho JCM, Kubo M, Daigo Y, Song M, Momozawa Y, Kamatani Y, Kobayashi M, Okubo K, Honda T, Hosgood DH, Kunitoh H, Patel H, Watanabe SI, Miyagi Y, Nakayama H, Matsumoto S, Horinouchi H, Tsuboi M, Hamamoto R, Goto K, Ohe Y, Takahashi A, Goto A, Minamiya Y, Hara M, Nishida Y, Takeuchi K, Wakai K, Matsuda K, Murakami Y, Shimizu K, Suzuki H, Saito M, Ohtaki Y, Tanaka K, Wu T, Wei F, Dai H, Machiela MJ, Su J, Kim YH, Oh IJ, Lee VHF, Chang GC, Tsai YH, Chen KY, Huang MS, Su WC, Chen YM, Seow A, Park JY, Kweon SS, Chen KC, Gao YT, Qian B, Wu C, Lu D, Liu J, Schwartz AG, Houlston R, Spitz MR, Gorlov IP, Wu X, Yang P, Lam S, Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeb?ller H, Ji BT, Wichmann HE, Christiani DC, Rennert G, Arnold S, Brennan P, McKay J, Field JK, Shete SS, Le Marchand L, Liu G, Andrew A, Kiemeney LA, Zienolddiny-Narui S, Grankvist K, Johansson M, Cox A, Taylor F, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Jeon HS, Jiang SS, Sung JS, Chen CH, Hsiao CF, Jung YJ, Guo H, Hu Z, Burdett L, Yeager M, Hutchinson A, Hicks B, Liu J, Zhu B, Berndt SI, Wu W, Wang J, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Wang WC, Xu J, Guan P, Tan W, Yu CJ, Yang G, Sihoe ADL, Chen Y, Choi YY, Kim JS, Yoon HI, Park IK, Xu P, He Q, Wang CL, Hung HH, Vermeulen RCH, Cheng I, Wu J, Lim WY, Tsai FY, Chan JKC, Li J, Chen H, Lin HC, Jin L, Liu J, Sawada N, Yamaji T, Wyatt K, Li SA, Ma H, Zhu M, Wang Z, Cheng S, Li X, Ren Y, Chao A, Iwasaki M, Zhu J, Jiang G, Fei K, Wu G, Chen CY, Chen CJ, Yang PC, Yu J, Stevens VL, Fraumeni JF, Chatterjee N, Gorlova OY, Hsiung CA, Amos CI, Shen H, Chanock SJ, Rothman N, Kohno T, Lan Q. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. Nat Commun. 2023 05 26; 14(1):3043. PMID: 37236969; PMCID: PMC10220065.
      Citations: 2     Fields:    Translation:Humans
    4. Tardon A, Bojesen SE, Rennert G, Field JK, Kiemeney LA, Zienolddiny S, Grankvist K, Johansson M, Hong YC, Cheng C, Hong W, Li Y, Xiao X, McKay J, Han Y, Byun J, Peng B, Albanes D, Lam S, Chen C, Landi MT, Johansson M, Risch A, Bickeb?ller H, Wichmann HE, Christiani DC, Arnold S, Goodman G, Davies MPA, Shete SS, Le Marchand L, Liu G, Hung RJ, Andrew AS, Zhu M, Shen H, Cox A, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Brennan P, Li Y, Gorlova O, Gorlov I, Amos CI, INTEGRAL-ILCCO Lung Cancer Consortium. Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis. J Thorac Oncol. 2023 08; 18(8):1003-1016. PMID: 37150255; PMCID: PMC10435278.
      Citations:    Fields:    Translation:Humans
    5. Cheng C, Nguyen TT, Tang M, Wang X, Jiang C, Liu Y, Gorlov I, Gorlova O, Iafrate J, Lanuti M, Christiani DC, Amos CI. Immune Infiltration in Tumor and Adjacent Non-Neoplastic Regions Codetermines Patient Clinical Outcomes in Early-Stage Lung Cancer. J Thorac Oncol. 2023 09; 18(9):1184-1198. PMID: 37146750; PMCID: PMC10528252.
      Citations:    Fields:    Translation:Humans
    6. Kostrzewa CE, Luo L, Arora A, Seshan VE, Ernstoff MS, Edmiston SN, Conway K, Gorlov I, Busam K, Orlow I, Hernando-Monge E, Thomas NE, Berwick M, Begg CB, Shen R, for InterMEL. Pathway Alterations in Stage II/III Primary Melanoma. JCO Precis Oncol. 2023 03; 7:e2200439. PMID: 36926987; PMCID: PMC10309586.
      Citations:    
    7. Gorlov IP, Amos CI. Why does the X chromosome lag behind autosomes in GWAS findings? PLoS Genet. 2023 02; 19(2):e1010472. PMID: 36848382; PMCID: PMC9997976.
      Citations: 1     Fields:    Translation:HumansCells
    8. Gorlov IP, Conway K, Edmiston SN, Hao H, Amos CI, Tsavachidis S, Gorlova OY, Begg C, Hernando E, Cheng C, Shen R, Orlow I, Luo L, Ernstoff MS, Kuan PF, Ollila DW, Tsai YS, Berwick M, Thomas NE, Parrish EA. Methylation of nonessential genes in cutaneous melanoma - Rule Out hypothesis. Melanoma Res. 2023 06 01; 33(3):163-172. PMID: 36805567; PMCID: PMC10148896.
      Citations:    Fields:    Translation:HumansCells
    9. Li Y, Xiao X, Li J, Byun J, Cheng C, McKay J, Albanes D, Lam S, Tardon A, Chen C, Bojesen SE, Landi MT, Johansson M, Risch A, Wichmann HE, Christiani DC, Rennert G, Arnold S, Goodman G, Field JK, Davies MPA, Shete SS, Le Marchand L, Melander O, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Shen H, Sun R, Zienolddiny S, Caporaso N, Teare DM, Hong YC, Lazarus P, Schabath MB, Aldrich MC, Schwartz AG, Gorlov I, Purrington K, Yang P, Liu Y, Han Y, Bailey-Wilson JE, Pinney SM, Mandal D, Willey JC, Gaba C, Brennan P, Amos CI, INTEGRAL-ILCCO lung cancer consortium, Boss? Y, Bickeb?ller H, Brunnstr?m H, Grankvist K, Johansson M. Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk. Hum Mol Genet. 2022 08 23; 31(16):2831-2843. PMID: 35138370; PMCID: PMC9402242.
      Citations:    Fields:    
    10. Luo L, Shen R, Arora A, Orlow I, Busam KJ, Lezcano C, Lee TK, Hernando E, Gorlov I, Amos C, Ernstoff MS, Seshan VE, Cust AE, Wilmott J, Scolyer RA, Mann G, Nagore E, Funchain P, Ko J, Ngo P, Edmiston SN, Conway K, Googe PB, Ollila D, Lee JE, Fang S, Rees JR, Thompson CL, Gerstenblith M, Bosenberg M, Gould Rothberg B, Osman I, Saenger Y, Reynolds AZ, Schwartz M, Boyce T, Holmen S, Brunsgaard E, Bogner P, Kuan PF, Wiggins C, Thomas NE, Begg CB, Berwick M, InterMEL. Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study. Pigment Cell Melanoma Res. 2022 11; 35(6):605-612. PMID: 35876628; PMCID: PMC9640183.
      Citations:    Fields:    
    11. Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Boss? Y, Song Z, Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov I, Gorlova O, Zhu D, Rosenberg SM, Pinney S, Bailey-Wilson JE, Mandal D, de Andrade M, Gaba C, Willey JC, You M, Anderson M, Wiencke JK, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojeson S, Brenner H, Landi MT, Chanock SJ, Johansson M, Muley T, Risch A, Wichmann HE, Bickeb?ller H, Christiani DC, Rennert G, Arnold S, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Andrew AS, Kiemeney LA, Shen H, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Cox A, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Patel A, Lan Q, Rothman N, Taylor F, Kachuri L, Witte JS, Sakoda LC, Spitz M, Brennan P, Lin X, McKay J, Hung RJ, Amos CI. Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. Nat Genet. 2022 08; 54(8):1167-1177. PMID: 35915169; PMCID: PMC9373844.
      Citations:    
    12. Gorlova OY, Kimmel M, Tsavachidis S, Amos CI, Gorlov IP. Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes. Oncotarget. 2022; 13:756-767. PMID: 35634240; PMCID: PMC9132259.
      Citations:    Fields:    
    13. Gorlova OY, Xiao X, Tsavachidis S, Amos CI, Gorlov IP. SNP characteristics and validation success in genome wide association studies. Hum Genet. 2022 Feb; 141(2):229-238. PMID: 34981173; PMCID: PMC8855685.
      Citations:    Fields:    Translation:HumansCells
    14. Jia X, Sun C, Tang O, Gorlov I, Nambi V, Virani SS, Villareal DT, Taffet GE, Yu B, Bressler J, Boerwinkle E, Windham BG, de Lemos JA, Matsushita K, Selvin E, Michos ED, Hoogeveen RC, Ballantyne CM. Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women. J Clin Endocrinol Metab. 2020 12 01; 105(12). PMID: 32785663; PMCID: PMC7526732.
      Citations: 5     Fields:    Translation:Humans
    15. Gorlov IP, Xia X, Tsavachidis S, Gorlova OY, Amos CI. Tumor somatic mutations also existing as germline polymorphisms may help to identify functional SNPs from genome-wide association studies. Carcinogenesis. 2020 10 15; 41(10):1353-1362. PMID: 32681635; PMCID: PMC7566444.
      Citations:    Fields:    Translation:Humans
    16. Gorlov IP, Amos CI, Tsavachidis S, Begg C, Hernando E, Cheng C, Shen R, Orlow I, Luo L, Ernstoff MS, Parker J, Thomas NE, Gorlova OY, Berwick M. Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma. Hum Mutat. 2020 10; 41(10):1751-1760. PMID: 32643855; PMCID: PMC7794094.
      Citations:    Fields:    Translation:Humans
    17. Bernhardt EB, Chamberlin MD, Gorlov IP, de Abreu FB, Bloch KJ, Peterson JD, Tsongalis GJ, Shirai K, Dragnev KH, Miller TW, Tafe LJ. Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board. Pract Lab Med. 2020 Aug; 21:e00174. PMID: 32613070; PMCID: PMC7322356.
      Citations:    
    18. Ji X, Mukherjee S, Landi MT, Zhu D, Gorlov I, Xiao X, Han Y, Gorlova O, Hung RJ, Brhane Y, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bush WS, Tardon A, Rennert G, Chen C, Byun J, Dragnev KH, Field JK, Kiemeney LF, Lazarus P, Zienolddiny S, Lam S, Schabath MB, Andrew AS, Bertazzi PA, Pesatori AC, Diao N, Su L, Song L, Zhang R, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, Heijden EHFMV, Kim JH, Davies MPA, Marcus MW, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Goodman GE, Cox A, Taylor F, Woll P, Muley T, Risch A, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Butler LM, Offit K, Srinivasan P, Hellmann MD, Solit DB, Robson ME, Rudin CM, Stadler ZK, Berger MF, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Shete S, Brenner H, Chanock S, Brennan P, McKay JD, Amos CI, Bosse Y, Joubert P, Bickeb?ller H, Aldrich MC, Brunnstr?m H, Wichmann E, Rosenberger A, Grankvist K, Johansson M, Bandlamudi C, Taylor BS, Artigas MS. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun. 2020 05 11; 11(1):2220. PMID: 32393777; PMCID: PMC7214407.
      Citations: 7     Fields:    Translation:Humans
    19. Wang Y, Gorlova OY, Gorlov IP, Zhu M, Dai J, Albanes D, Lam S, Tardon A, Chen C, Goodman GE, Bojesen SE, Landi MT, Johansson M, Risch A, Wichmann HE, Bickeboller H, Christiani DC, Rennert G, Arnold SM, Brennan P, Field JK, Shete S, Melander O, Brunnstrom H, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Zienolddiny S, Caporaso NE, Woll PJ, Lazarus P, Schabath MB, Aldrich MC, Stevens VL, Ma H, Jin G, Hu Z, Amos CI, Shen H, Le Marchand L, Grankvist K, Johansson M. Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls. Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1423-1429. PMID: 32277007; PMCID: PMC8120681.
      Citations: 2     Fields:    Translation:Humans
    20. Gorlov I, Xiao X, Mayes M, Gorlova O, Amos C. SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies. BMC Genet. 2019 11 12; 20(1):85. PMID: 31718536; PMCID: PMC6852916.
      Citations: 2     Fields:    Translation:Humans
    21. Hung RJ, Spitz MR, Houlston RS, Schwartz AG, Field JK, Ying J, Li Y, Han Y, Ji X, Chen W, Wu X, Gorlov IP, Na J, de Andrade M, Liu G, Brhane Y, Diao N, Wenzlaff A, Davies MPA, Liloglou T, Timofeeva M, Muley T, Rennert H, Saliba W, Bowman E, Morgenstern H, Zienolddiny S, Skaug V, Ugolini D, Bonassi S, van der Heijden EHFM, Tardon A, Bojesen SE, Landi MT, Johansson M, Arnold S, Le Marchand L, Melander O, Andrew A, Caporaso N, Teare MD, Schabath MB, Aldrich MC, Kiemeney LA, Wichmann HE, Lazarus P, Mayordomo J, Neri M, Haugen A, Zhang ZF, Brenner H, Harris CC, Orlow I, Rennert G, Risch A, Brennan P, Christiani DC, Amos CI, Yang P, Gorlova OY, Ryan BM, Barros-Dios JM, P?rez-R?os M, Bickeb?ller H, Grankvist K, Ruano-Ravi?a A. Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region. J Thorac Oncol. 2019 08; 14(8):1360-1369. PMID: 31009812; PMCID: PMC6833942.
      Citations: 10     Fields:    Translation:HumansCells
    22. Li Y, Xiao X, Gorlova O, Gorlov I, Han Y, Byun J, Leighl N, Johansen JS, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Muley T, Risch A, Han J, Siminovitch K, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Houlston R, Shepherd FA, Marcus MW, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Liu G, Bojesen SE, Wu X, Le Marchand L, Albanes D, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Bertazzi PA, Pesatori AC, Christiani DC, Caporaso N, Johansson M, McKay JD, Brennan P, Hung RJ, Amos CI, Boss? Y, Wichmann HE, Manz J, Rosenberger A, Artigas MS, Grankvist K, Johansson M, Brunnstr?m H, Bickeb?ller H. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development. Oncotarget. 2019 Mar 05; 10(19):1760-1774. PMID: 30956756; PMCID: PMC6442994.
      Citations: 10     Fields:    
    23. Gorlov IP, Gorlova OY, Amos CI. Untouchable genes in the human genome: Identifying ideal targets for cancer treatment. Cancer Genet. 2019 02; 231-232:67-79. PMID: 30803560; PMCID: PMC6727980.
      Citations: 1     Fields:    Translation:Humans
    24. Gorlov IP, Pikielny CW, Frost HR, Her SC, Cole MD, Strohbehn SD, Wallace-Bradley D, Kimmel M, Gorlova OY, Amos CI. Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples. BMC Bioinformatics. 2018 Nov 19; 19(1):430. PMID: 30453881; PMCID: PMC6245819.
      Citations: 3     Fields:    Translation:Humans
    25. Gorlov I, Orlow I, Ringelberg C, Hernando E, Ernstoff MS, Cheng C, Her S, Parker JS, Thompson CL, Gerstenblith MR, Berwick M, Amos C. Identification of gene expression levels in primary melanoma associated with clinically meaningful characteristics. Melanoma Res. 2018 10; 28(5):380-389. PMID: 29975213; PMCID: PMC6448582.
      Citations: 8     Fields:    Translation:Humans
    26. Zhao Y, Schaafsma E, Gorlov IP, Hernando E, Thomas NE, Shen R, Turk MJ, Berwick M, Amos CI, Cheng C. A Leukocyte Infiltration Score Defined by a Gene Signature Predicts Melanoma Patient Prognosis. Mol Cancer Res. 2019 01; 17(1):109-119. PMID: 30171176; PMCID: PMC6318018.
      Citations: 19     Fields:    Translation:HumansCells
    27. Ji X, Landi MT, Gui J, Xiao X, Qian D, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Muley T, Risch A, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Tobin MD, Wain LV, Gu F, Byun J, Kamal A, Zhu D, Tyndale RF, Wei WQ, Chanock S, Brennan P, Amos CI, Boss? Y, Joubert P, Lamontagne M, Bickeb?ller H, Brunnstr?m H, Br?ske I, Manz J, Rosenberger A, Grankvist K, Johansson M, Holcatova I, Janout V, Artigas MS. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nat Commun. 2018 08 13; 9(1):3221. PMID: 30104567; PMCID: PMC6089967.
      Citations: 21     Fields:    Translation:HumansCells
    28. Ji X, Niu X, Qian J, Martucci V, Pendergrass SA, Gorlov IP, Amos CI, Denny JC, Massion PP, Aldrich MC. A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 06; 58(6):777-779. PMID: 29856256; PMCID: PMC6002656.
      Citations: 3     Fields:    Translation:Humans
    29. Gorlova OY, Li Y, Gorlov I, Ying J, Chen WV, Assassi S, Reveille JD, Arnett FC, Zhou X, Bossini-Castillo L, Gregersen PK, Lee AT, Steen VD, Fessler BJ, Khanna D, Schiopu E, Silver RM, Molitor JA, Furst DE, Kafaja S, Simms RW, Lafyatis RA, Carreira P, Castellvi I, Ortego N, Amos CI, Mayes MD, Lopez-Isac E, Acosta-Herrera M, Simeon CP, Beltran E, Martin J. Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations. PLoS One. 2018; 13(1):e0189498. PMID: 29293537; PMCID: PMC5749683.
      Citations: 10     Fields:    Translation:Humans
    30. Byun J, Han Y, Gorlov IP, Busam JA, Seldin MF, Amos CI. Ancestry inference using principal component analysis and spatial analysis: a distance-based analysis to account for population substructure. BMC Genomics. 2017 Oct 16; 18(1):789. PMID: 29037167; PMCID: PMC5644186.
      Citations: 11     Fields:    Translation:Humans
    31. Gorlova OY, Demidenko EI, Amos CI, Gorlov IP. Downstream targets of GWAS-detected genes for breast, lung, and prostate and colon cancer converge to G1/S transition pathway. Hum Mol Genet. 2017 04 15; 26(8):1465-1471. PMID: 28334950; PMCID: PMC6317572.
      Citations: 1     Fields:    Translation:Humans
    32. Dagrosa LM, Ingimarsson JP, Gorlov IP, Higgins JH, Hyams ES. Is age an independent risk factor for medical complications following minimally invasive radical prostatectomy? An evaluation of contemporary American College of Surgeons National Surgical Quality Improvement (ACS-NSQIP) data. J Robot Surg. 2016 Dec; 10(4):343-346. PMID: 27263110.
      Citations: 1     Fields:    Translation:Humans
    33. Kim J, Davis JW, Klein EA, Magi-Galluzzi C, Lotan Y, Ward JF, Pisters LL, Basler JW, Pettaway CA, Stephenson A, Li Ning Tapia EM, Efstathiou E, Wang X, Do KA, Lee JJ, Gorlov IP, Vornik LA, Hoque AM, Prokhorova IN, Parnes HL, Lippman SM, Thompson IM, Brown PH, Logothetis CJ, Troncoso P. Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer. EBioMedicine. 2016 May; 7:85-93. PMID: 27322462; PMCID: PMC4909608.
      Citations: 2     Fields:    Translation:Humans
    34. Li Y, Byun J, Cai G, Xiao X, Han Y, Cornelis O, Dinulos JE, Dennis J, Easton D, Gorlov I, Seldin MF, Amos CI. FastPop: a rapid principal component derived method to infer intercontinental ancestry using genetic data. BMC Bioinformatics. 2016 Mar 09; 17:122. PMID: 26961892; PMCID: PMC4784403.
      Citations: 20     Fields:    Translation:Humans
    35. Halloran JW, Zhu D, Qian DC, Byun J, Gorlova OY, Amos CI, Gorlov IP. Prediction of the gene expression in normal lung tissue by the gene expression in blood. BMC Med Genomics. 2015 Nov 17; 8:77. PMID: 26576671; PMCID: PMC4650316.
      Citations: 5     Fields:    Translation:Humans
    36. Tafe LJ, Gorlov IP, de Abreu FB, Lefferts JA, Liu X, Pettus JR, Marotti JD, Bloch KJ, Memoli VA, Suriawinata AA, Dragnev KH, Fadul CE, Schwartz GN, Morgan CR, Holderness BM, Peterson JD, Tsongalis GJ, Miller TW, Chamberlin MD. Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center. Oncologist. 2015 Sep; 20(9):1011-8. PMID: 26205736; PMCID: PMC4571816.
      Citations:    
    37. Gorlov IP, Gorlova OY, Amos CI. Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases. PLoS Genet. 2015 Jul; 11(7):e1005371. PMID: 26201053; PMCID: PMC4511800.
      Citations: 9     Fields:    Translation:HumansPHPublic Health
    38. Gorlov IP, Moore JH, Peng B, Jin JL, Gorlova OY, Amos CI. SNP characteristics predict replication success in association studies. Hum Genet. 2014 Dec; 133(12):1477-86. PMID: 25273843; PMCID: PMC4384517.
      Citations: 12     Fields:    Translation:Humans
    39. Gorlov IP, Yang JY, Byun J, Logothetis C, Gorlova OY, Do KA, Amos C. How to get the most from microarray data: advice from reverse genomics. BMC Genomics. 2014 Mar 21; 15:223. PMID: 24656147; PMCID: PMC3997969.
      Citations: 8     Fields:    Translation:Humans
    40. Gorlova O, Fedorov A, Logothetis C, Amos C, Gorlov I. Genes with a large intronic burden show greater evolutionary conservation on the protein level. BMC Evol Biol. 2014 Mar 16; 14(1):50. PMID: 24629165; PMCID: PMC3995522.
      Citations: 19     Fields:    Translation:HumansCells
    41. Zhao H, Logothetis CJ, Gorlov IP, Zeng J, Dai J. Modified logistic regression models using gene coexpression and clinical features to predict prostate cancer progression. Comput Math Methods Med. 2013; 2013:917502. PMID: 24367394; PMCID: PMC3866878.
      Citations: 1     Fields:    Translation:Humans
    42. Walsh KM, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, Lu EY, Wenzlaff AS, Sison JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrensch MR, Schwartz AG, Wiencke JK, Amos CI. Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev. 2013 Feb; 22(2):251-60. PMID: 23221128; PMCID: PMC3565099.
      Citations: 12     Fields:    Translation:HumansCells
    43. Gorlov IP, Logothetis CJ, Fang S, Gorlova OY, Amos C. Building a statistical model for predicting cancer genes. PLoS One. 2012; 7(11):e49175. PMID: 23166609; PMCID: PMC3499550.
      Citations: 2     Fields:    Translation:Humans
    44. Chen J, Pande M, Huang YJ, Wei C, Amos CI, Talseth-Palmer BA, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott RJ, Frazier ML. Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. Carcinogenesis. 2013 Feb; 34(2):299-306. PMID: 23125224; PMCID: PMC3564440.
      Citations: 6     Fields:    Translation:Humans
    45. Walsh KM, Amos CI, Wenzlaff AS, Gorlov IP, Sison JD, Wu X, Spitz MR, Hansen HM, Lu EY, Wei C, Zhang H, Chen W, Lloyd SM, Frazier ML, Bracci PM, Seldin MF, Wrensch MR, Schwartz AG, Wiencke JK. Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. Oncotarget. 2012 Nov; 3(11):1428-38. PMID: 23232035; PMCID: PMC3717803.
      Citations: 6     Fields:    Translation:Humans
    46. Spitz MR, Gorlov IP, Dong Q, Wu X, Chen W, Chang DW, Etzel CJ, Caporaso NE, Zhao Y, Christiani DC, Brennan P, Albanes D, Shi J, Thun M, Landi MT, Amos CI. Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers. Cancer Epidemiol Biomarkers Prev. 2012 Jul; 21(7):1213-21. PMID: 22573796; PMCID: PMC3487592.
      Citations: 19     Fields:    Translation:Humans
    47. Gorlov IP, Byun J, Logothetis CJ. In silico functional profiling of individual prostate cancer tumors: many genes, few functions. Cancer Genomics Proteomics. 2012 May-Jun; 9(3):109-14. PMID: 22593245; PMCID: PMC3922615.
      Citations: 2     Fields:    Translation:Humans
    48. Gorlov IP, Byun J, Zhao H, Logothetis CJ, Gorlova OY. Beyond comparing means: the usefulness of analyzing interindividual variation in gene expression for identifying genes associated with cancer development. J Bioinform Comput Biol. 2012 Apr; 10(2):1241013. PMID: 22809348; PMCID: PMC3893106.
      Citations: 5     Fields:    Translation:Humans
    49. Gorlova OY, Ying J, Amos CI, Spitz MR, Peng B, Gorlov IP. Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases. J Bioinform Comput Biol. 2012 Apr; 10(2):1241008. PMID: 22809343; PMCID: PMC3655427.
      Citations: 4     Fields:    Translation:Humans
    50. Chen X, Gorlov IP, Ying J, Merriman KW, Kimmel M, Lu C, Reyes-Gibby CC, Gorlova OY. Initial medical attention on patients with early-stage non-small cell lung cancer. PLoS One. 2012; 7(3):e32644. PMID: 22412901; PMCID: PMC3296738.
      Citations: 3     Fields:    Translation:Humans
    51. Kaftanovskaya EM, Huang Z, Barbara AM, De Gendt K, Verhoeven G, Gorlov IP, Agoulnik AI. Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis. Mol Endocrinol. 2012 Apr; 26(4):598-607. PMID: 22322597; PMCID: PMC3327355.
      Citations: 26     Fields:    Translation:AnimalsCells
    52. Spitz MR, Gorlov IP, Amos CI, Dong Q, Chen W, Etzel CJ, Gorlova OY, Chang DW, Pu X, Zhang D, Wang L, Cunningham JM, Yang P, Wu X. Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke. Cancer Discov. 2011 Oct; 1(5):420-9. PMID: 22586632; PMCID: PMC3919666.
      Citations: 19     Fields:    Translation:HumansPHPublic Health
    53. Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV, Amos CI. Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. Carcinogenesis. 2011 Oct; 32(10):1493-9. PMID: 21771723; PMCID: PMC3179422.
      Citations: 41     Fields:    Translation:HumansCells
    54. Chen X, Gorlov IP, Merriman KW, Weng SF, Foy M, Keener G, Amos CI, Spitz MR, Kimmel M, Gorlova OY. Association of smoking with tumor size at diagnosis in non-small cell lung cancer. Lung Cancer. 2011 Dec; 74(3):378-83. PMID: 21645942; PMCID: PMC3197014.
      Citations: 6     Fields:    Translation:Humans
    55. Kaftanovskaya EM, Feng S, Huang Z, Tan Y, Barbara AM, Kaur S, Truong A, Gorlov IP, Agoulnik AI. Suppression of insulin-like3 receptor reveals the role of ?-catenin and Notch signaling in gubernaculum development. Mol Endocrinol. 2011 Jan; 25(1):170-83. PMID: 21147849; PMCID: PMC3089031.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    56. Gorlov IP, Sircar K, Zhao H, Maity SN, Navone NM, Gorlova OY, Troncoso P, Pettaway CA, Byun JY, Logothetis CJ. Prioritizing genes associated with prostate cancer development. BMC Cancer. 2010 Nov 02; 10:599. PMID: 21044312; PMCID: PMC2988752.
      Citations: 19     Fields:    Translation:Humans
    57. Hirschfield GM, Liu X, Han Y, Gorlov IP, Lu Y, Xu C, Lu Y, Chen W, Juran BD, Coltescu C, Mason AL, Milkiewicz P, Myers RP, Odin JA, Luketic VA, Speiciene D, Vincent C, Levy C, Gregersen PK, Zhang J, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat Genet. 2010 Aug; 42(8):655-7. PMID: 20639879; PMCID: PMC2929126.
      Citations: 97     Fields:    Translation:Humans
    58. Amos CI, Gorlov IP, Dong Q, Wu X, Zhang H, Lu EY, Scheet P, Greisinger AJ, Mills GB, Spitz MR. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. J Natl Cancer Inst. 2010 Aug 04; 102(15):1199-205. PMID: 20554942; PMCID: PMC2914761.
      Citations: 41     Fields:    Translation:HumansCells
    59. Byun J, Logothetis CJ, Gorlov IP. Housekeeping genes in prostate tumorigenesis. Int J Cancer. 2009 Dec 01; 125(11):2603-8. PMID: 19551858; PMCID: PMC4531049.
      Citations: 9     Fields:    Translation:Humans
    60. Gorlov IP, Gallick GE, Gorlova OY, Amos C, Logothetis CJ. GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example. PLoS One. 2009 Aug 04; 4(8):e6511. PMID: 19652704; PMCID: PMC2714961.
      Citations: 25     Fields:    Translation:Humans
    61. Gorlov IP, Byun J, Gorlova OY, Aparicio AM, Efstathiou E, Logothetis CJ. Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data. BMC Med Genomics. 2009 Aug 04; 2:48. PMID: 19653896; PMCID: PMC2731785.
      Citations: 26     Fields:    
    62. Gorlov IP, Gorlova OY, Amos CI. Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome. BMC Genomics. 2008 Jun 17; 9:292. PMID: 18559102; PMCID: PMC2442617.
      Citations: 6     Fields:    Translation:HumansCells
    63. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet. 2008 May; 40(5):616-22. PMID: 18385676; PMCID: PMC2713680.
      Citations: 671     Fields:    Translation:HumansCells
    64. Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet. 2008 Jan; 82(1):100-12. PMID: 18179889; PMCID: PMC2253956.
      Citations: 179     Fields:    Translation:Humans
    65. Yang H, Spitz MR, Stewart DJ, Lu C, Gorlov IP, Wu X. ATM sequence variants associate with susceptibility to non-small cell lung cancer. Int J Cancer. 2007 Nov 15; 121(10):2254-9. PMID: 17582598; PMCID: PMC3477817.
      Citations: 17     Fields:    Translation:HumansCells
    66. Gorlov IP, Meyer P, Liloglou T, Myles J, Boettger MB, Cassidy A, Girard L, Minna JD, Fischer R, Duffy S, Spitz MR, Haeussinger K, Kammerer S, Cantor C, Dierkesmann R, Field JK, Amos CI. Seizure 6-like (SEZ6L) gene and risk for lung cancer. Cancer Res. 2007 Sep 01; 67(17):8406-11. PMID: 17804757.
      Citations: 19     Fields:    Translation:HumansCells
    67. Gorlov IP, Kimmel M, Amos CI. Strength of the purifying selection against different categories of the point mutations in the coding regions of the human genome. Hum Mol Genet. 2006 Apr 01; 15(7):1143-50. PMID: 16500998.
      Citations: 10     Fields:    Translation:Humans
    68. Gorlov IP, Gorlova OY, Amos CI. Predicting the oncogenicity of missense mutations reported in the International Agency for Cancer Research (IARC) mutation database on p53. Hum Mutat. 2005 Nov; 26(5):446-54. PMID: 16173033.
      Citations: 3     Fields:    Translation:Humans
    69. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs). Mutat Res. 2004 Oct 04; 554(1-2):175-83. PMID: 15450416.
      Citations: 6     Fields:    Translation:Cells
    70. Lin J, Spitz MR, Wang Y, Schabath MB, Gorlov IP, Hernandez LM, Pillow PC, Grossman HB, Wu X. Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study. Carcinogenesis. 2004 Sep; 25(9):1639-47. PMID: 15117811.
      Citations: 21     Fields:    Translation:Humans
    71. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers. Am J Hum Genet. 2003 Nov; 73(5):1157-61. PMID: 14526391; PMCID: PMC1180494.
      Citations: 19     Fields:    Translation:HumansCells
    72. Gorlov IP, Kamat A, Bogatcheva NV, Jones E, Lamb DJ, Truong A, Bishop CE, McElreavey K, Agoulnik AI. Mutations of the GREAT gene cause cryptorchidism. Hum Mol Genet. 2002 Sep 15; 11(19):2309-18. PMID: 12217959.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
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