TitleAssistant Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 7037
Houston, TX 77204-5037
Houston TX 77204-5047
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    R21GM147836     (STATSYUK, ALEXANDER V)Sep 1, 2022 - Aug 31, 2024
    Chemical platform to produce covalent biologics
    Role: Principal Investigator

    R01GM115632     (STATSYUK, ALEXANDER V)Jul 1, 2015 - Jun 30, 2021
    Pharmacological Inhibitors of Nedd4 ubiquitin ligase as anticancer therapeutics
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chowdhury SR, Chuong P, Mgbemena VE, Statsyuk A. Development of a PROTAC Targeting Chk1. bioRxiv. 2024 Jan 01. PMID: 38260247; PMCID: PMC10802242.
    2. Chuong P, Statsyuk A. Selective Smurf1 E3 ligase inhibitors that prevent transthiolation. bioRxiv. 2023 Oct 14. PMID: 37873387; PMCID: PMC10592800.
    3. Statsyuk AV. Inhibiting protein synthesis to treat malaria. Science. 2022 06 03; 376(6597):1049-1050. PMID: 35653471.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. ACS Chem Biol. 2020 04 17; 15(4):1036-1049. PMID: 32149490; PMCID: PMC7271629.
      Citations: 8     Fields:    Translation:HumansCells
    5. Parker BW, Goncz EJ, Krist DT, Statsyuk AV, Nesvizhskii AI, Weiss EL. Mapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21001-21011. PMID: 31578253; PMCID: PMC6800362.
      Citations: 6     Fields:    Translation:HumansCells
    6. Kathman SG, Statsyuk AV. Methodology for Identification of Cysteine-Reactive Covalent Inhibitors. Methods Mol Biol. 2019; 1967:245-262. PMID: 31069775.
      Citations:    Fields:    Translation:HumansCells
    7. Chowdhury SR, Kennedy S, Mishra R, Chuong P, Nguyen AU, Kathman SG, Statsyuk AV, Zhu K. Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments. Bioorg Med Chem Lett. 2019 01 01; 29(1):36-39. PMID: 30455147; PMCID: PMC6319256.
      Citations: 5     Fields:    Translation:HumansCells
    8. Altmann E, Kathman SG, Statsyuk AV, Ramirez YA, Adler TB, Klemm T, Tiesmeyer C, Sauer F, Sotriffer C, Kisker C. Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis. ChemMedChem. 2018 10 08; 13(19):2014-2023. PMID: 30028574; PMCID: PMC6177307.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Foote PK, Statsyuk AV. Monitoring PARKIN RBR Ubiquitin Ligase Activation States with UbFluor. Curr Protoc Chem Biol. 2018 09; 10(3):e45. PMID: 30063295; PMCID: PMC6125222.
      Citations:    Fields:    Translation:HumansCells
    10. Statsyuk AV. Let K-Ras activate its own inhibitor. Nat Struct Mol Biol. 2018 06; 25(6):435-437. PMID: 29760530.
      Citations: 1     Fields:    Translation:HumansCells
    11. Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Ovaa H, Reits EA, Kirstein J. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep. 2018 01 23; 8(1):1405. PMID: 29362455; PMCID: PMC5780509.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Foote PK, Krist DT, Statsyuk AV. High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor. Curr Protoc Chem Biol. 2017 Sep 14; 9(3):174-195. PMID: 28910856; PMCID: PMC5650195.
      Citations: 5     Fields:    Translation:Humans
    13. Park S, Foote PK, Krist DT, Rice SE, Statsyuk AV. UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN. J Biol Chem. 2017 10 06; 292(40):16539-16553. PMID: 28710279; PMCID: PMC5633118.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    14. An H, Statsyuk AV, Misra M, Kuhn M, L?bel M, Sotriffer C, Schindelin H. Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure. 2017 07 05; 25(7):1120-1129.e3. PMID: 28578874.
      Citations: 18     Fields:    Translation:HumansCells
    15. Krist DT, Foote PK, Statsyuk AV. UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis. Curr Protoc Chem Biol. 2017 03 02; 9(1):11-37. PMID: 28253433; PMCID: PMC5335898.
      Citations: 4     Fields:    Translation:Humans
    16. Krist DT, Park S, Boneh GH, Rice SE, Statsyuk AV. UbFluor: A Mechanism-Based Probe for HECT E3 Ligases. Chem Sci. 2016 Aug 01; 7(8):5587-5595. PMID: 27482366; PMCID: PMC4965700.
      Citations: 11     
    17. Kathman SG, Statsyuk AV. Covalent Tethering of Fragments For Covalent Probe Discovery. Medchemcomm. 2016 Apr 01; 7(4):576-585. PMID: 27398190; PMCID: PMC4933313.
      Citations: 15     
    18. An H, Statsyuk AV. Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis. Chem Commun (Camb). 2016 Feb 11; 52(12):2477-80. PMID: 26575161.
      Citations: 9     Fields:    Translation:Cells
    19. Kathman SG, Span I, Smith AT, Xu Z, Zhan J, Rosenzweig AC, Statsyuk AV. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 07; 137(39):12442-5. PMID: 26371805; PMCID: PMC4669213.
      Citations: 33     Fields:    Translation:Humans
    20. McShan D, Kathman S, Lowe B, Xu Z, Zhan J, Statsyuk A, Ogungbe IV. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain. Bioorg Med Chem Lett. 2015 Oct 15; 25(20):4509-12. PMID: 26342866; PMCID: PMC4592840.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. Krist DT, Statsyuk AV. Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers. Biochemistry. 2015 Jul 28; 54(29):4411-4. PMID: 26161728; PMCID: PMC4527872.
      Citations: 3     Fields:    Translation:HumansCells
    22. An H, Statsyuk AV. An inhibitor of ubiquitin conjugation and aggresome formation. Chem Sci. 2015 Sep 01; 6(9):5235-5245. PMID: 28717502; PMCID: PMC5500945.
      Citations: 17     
    23. Park S, Krist DT, Statsyuk AV. Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes. Chem Sci. 2015 Mar 01; 6(3):1770-1779. PMID: 28706640; PMCID: PMC5485889.
      Citations: 12     
    24. Kathman SG, Xu Z, Statsyuk AV. A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases. J Med Chem. 2014 Jun 12; 57(11):4969-74. PMID: 24870364; PMCID: PMC4113264.
      Citations: 47     Fields:    Translation:HumansCells
    25. An H, Krist DT, Statsyuk AV. Crosstalk between kinases and Nedd4 family ubiquitin ligases. Mol Biosyst. 2014 Jul; 10(7):1643-57. PMID: 24457516.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    26. An H, Statsyuk AV. Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways. J Am Chem Soc. 2013 Nov 13; 135(45):16948-62. PMID: 24138456.
      Citations: 21     Fields:    Translation:HumansCells
    27. Hong CM, Statsyuk AV. The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles. Org Biomol Chem. 2013 May 14; 11(18):2932-5. PMID: 23536160.
      Citations: 1     Fields:    Translation:Cells
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