Vitamin D3 24-Hydroxylase
"Vitamin D3 24-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytochrome P-450 enzyme that has specificity for CHOLECALCIFEROL (Vitamin D3). It hydroxylates the molecule at carbon position 24.
| Descriptor ID |
D065668
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| MeSH Number(s) |
D08.244.453.496.500 D08.811.682.690.708.170.469.500 D12.776.422.220.453.496.500
|
| Concept/Terms |
Vitamin D3 24-Hydroxylase- Vitamin D3 24-Hydroxylase
- 24-Hydroxylase, Vitamin D3
- Vitamin D3 24 Hydroxylase
- 1 alpha,25-Dihydroxycholecalciferol-24-Hydroxylase
- 1 alpha,25 Dihydroxycholecalciferol 24 Hydroxylase
- alpha,25-Dihydroxycholecalciferol-24-Hydroxylase, 1
- 1 alpha,25-Dihydroxyvitamin D(3)-24-Hydroxylase
- Cytochrome P-450 CYP24A1
- CYP24A1, Cytochrome P-450
- Cytochrome P 450 CYP24A1
- P-450 CYP24A1, Cytochrome
- 25-Hydroxycholecalciferol-24-Hydroxylase
- 25 Hydroxycholecalciferol 24 Hydroxylase
- CYP24A1
- Calcitriol 24-Hydroxylase
- Calcitriol 24 Hydroxylase
- Vitamin D 24-Hydroxylase
- Vitamin D 24 Hydroxylase
- 1,25-Dihydroxyvitamin D3 24-Hydroxylase
- 1,25 Dihydroxyvitamin D3 24 Hydroxylase
- D3 24-Hydroxylase, 1,25-Dihydroxyvitamin
|
Below are MeSH descriptors whose meaning is more general than "Vitamin D3 24-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Vitamin D3 24-Hydroxylase".
This graph shows the total number of publications written about "Vitamin D3 24-Hydroxylase" by people in this website by year, and whether "Vitamin D3 24-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 2 | 3 |
| 2017 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Vitamin D3 24-Hydroxylase" by people in Profiles.
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Analysis of 1,25-dihydroxyvitamin D genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin D in human intestinal physiology. Front Endocrinol (Lausanne). 2025; 16:1538463.
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Genomic analysis of 1,25-dihydroxyvitamin D3 action in mouse intestine reveals compartment and segment-specific gene regulatory effects. J Biol Chem. 2022 08; 298(8):102213.
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Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG. Oncotarget. 2017 Jul 04; 8(27):44447-44464.
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Genetic mutation of p53 and suppression of the miR-17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling. Cancer Res. 2015 Feb 15; 75(4):666-75.
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Genetic variants in CYP2R1, CYP24A1, and VDR modify the efficacy of vitamin D3 supplementation for increasing serum 25-hydroxyvitamin D levels in a randomized controlled trial. J Clin Endocrinol Metab. 2014 Oct; 99(10):E2133-7.
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The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling. Endocrinology. 2014 Sep; 155(9):3262-73.
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Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies. FASEB J. 2014 Jan; 28(1):364-72.
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Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet. 2012 Jul 15; 44(8):895-9.
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Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study. Breast Cancer Res. 2012 Apr 04; 14(2):R58.
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A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients. Cancer Res. 2011 Jan 15; 71(2):413-23.