Cyclic GMP-Dependent Protein Kinase Type I
"Cyclic GMP-Dependent Protein Kinase Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic GMP-dependent protein kinase subtype that is expressed in SMOOTH MUSCLE tissues and plays a role in regulation of smooth muscle contraction. Two isoforms, PKGIalpha and PKGIbeta, of the type I protein kinase exist due to alternative splicing of its mRNA.
| Descriptor ID |
D062965
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| MeSH Number(s) |
D08.811.913.696.620.682.700.150.150.500 D12.644.360.200.150.500 D12.776.476.200.150.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cyclic GMP-Dependent Protein Kinase Type I".
Below are MeSH descriptors whose meaning is more specific than "Cyclic GMP-Dependent Protein Kinase Type I".
This graph shows the total number of publications written about "Cyclic GMP-Dependent Protein Kinase Type I" by people in this website by year, and whether "Cyclic GMP-Dependent Protein Kinase Type I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2015 | 2 | 0 | 2 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclic GMP-Dependent Protein Kinase Type I" by people in Profiles.
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An auto-inhibited state of protein kinase G and implications for selective activation. Elife. 2022 08 05; 11.
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A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. J Biol Chem. 2020 07 24; 295(30):10394-10405.
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Structural basis for selective inhibition of human PKG Ia by the balanol-like compound N46. J Biol Chem. 2018 07 13; 293(28):10985-10992.
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Crystal structure of cGMP-dependent protein kinase I? cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation. FEBS Lett. 2017 Jan; 591(1):221-230.
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Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure. 2016 05 03; 24(5):710-720.
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Structures of cGMP-Dependent Protein Kinase (PKG) Ia Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability. Biochemistry. 2015 Jul 28; 54(29):4419-22.
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Hyperglycemia down-regulates cGMP-dependent protein kinase I expression in first trimester cytotrophoblast cells. Mol Cell Biochem. 2015 Jul; 405(1-2):81-8.
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Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I. Structure. 2014 Jan 07; 22(1):116-24.
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Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. 2013 Aug 08; 93(2):398-404.
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Co-crystal structures of PKG I? (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413.