Cancer-Associated Fibroblasts

"Cancer-Associated Fibroblasts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Subpopulation of heterogeneous fibroblasts within the TUMOR MICROENVIRONMENT that support NEOPLASTIC CELL TRANSFORMATION and NEOPLASTIC PROCESSES.

Descriptor ID	D000072645
MeSH Number(s)	A11.329.228.105
Concept/Terms	Cancer-Associated Fibroblasts Cancer-Associated Fibroblasts Cancer-Associated Fibroblast Fibroblast, Cancer-Associated Fibroblasts, Cancer-Associated Cancer Associated Fibroblasts Cancer Associated Fibroblast Fibroblast, Cancer Associated Fibroblasts, Cancer Associated Tumor-Associated Fibroblasts Fibroblast, Tumor-Associated Fibroblasts, Tumor-Associated Tumor Associated Fibroblasts Tumor-Associated Fibroblast

Below are MeSH descriptors whose meaning is more general than "Cancer-Associated Fibroblasts".

Anatomy [A]
Cells [A11]
Connective Tissue Cells [A11.329]
Fibroblasts [A11.329.228]
Cancer-Associated Fibroblasts [A11.329.228.105]

Below are MeSH descriptors whose meaning is related to "Cancer-Associated Fibroblasts".

Below are MeSH descriptors whose meaning is more specific than "Cancer-Associated Fibroblasts".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cancer-Associated Fibroblasts" by people in this website by year, and whether "Cancer-Associated Fibroblasts" was a major or minor topic of these publications.

Bar chart showing 41 publications over 7 distinct years, with a maximum of 9 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2016	1	2	3
2017	4	2	6
2018	5	2	7
2019	4	2	6
2020	5	2	7
2021	7	2	9
2022	3	0	3

Below are the most recent publications written about "Cancer-Associated Fibroblasts" by people in Profiles.

McAndrews KM, Chen Y, Darpolor JK, Zheng X, Yang S, Carstens JL, Li B, Wang H, Miyake T, Correa de Sampaio P, Kirtley ML, Natale M, Wu CC, Sugimoto H, LeBleu VS, Kalluri R. Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discov. 2022 06 02; 12(6):1580-1597.

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Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo HH, Elemento O, Martin ML, Cordes T, Thompson TC, Metallo CM, Moscat J, Diaz-Meco MT. The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62. Cell Rep. 2022 May 10; 39(6):110792.

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Garcia Garcia CJ, Huang Y, Fuentes NR, Turner MC, Monberg ME, Lin D, Nguyen ND, Fujimoto TN, Zhao J, Lee JJ, Bernard V, Yu M, Delahoussaye AM, Jimenez Sacarello I, Caggiano EG, Phan JL, Deorukhkar A, Molkentine JM, Saur D, Maitra A, Taniguchi CM. Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment. Gastroenterology. 2022 Jun; 162(7):2018-2031.

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Tran LL, Dang T, Thomas R, Rowley DR. ELF3 mediates IL-1a induced differentiation of mesenchymal stem cells to inflammatory iCAFs. Stem Cells. 2021 12; 39(12):1766-1777.

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Chen Y, McAndrews KM, Kalluri R. Clinical and therapeutic relevance of cancer-associated fibroblasts. Nat Rev Clin Oncol. 2021 12; 18(12):792-804.

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Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P. Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth. Cancer Res. 2021 10 15; 81(20):5336-5352.

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McAndrews KM, Vázquez-Arreguín K, Kwak C, Sugimoto H, Zheng X, Li B, Kirtley ML, LeBleu VS, Kalluri R. aSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression. Oncogene. 2021 07; 40(26):4440-4452.

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Bhattacharjee S, Hamberger F, Ravichandra A, Miller M, Nair A, Affo S, Filliol A, Chin L, Savage TM, Yin D, Wirsik NM, Mehal A, Arpaia N, Seki E, Mack M, Zhu D, Sims PA, Kalluri R, Stanger BZ, Olive KP, Schmidt T, Wells RG, Mederacke I, Schwabe RF. Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. J Clin Invest. 2021 06 01; 131(11).

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Bagaev A, Kotlov N, Nomie K, Svekolkin V, Gafurov A, Isaeva O, Osokin N, Kozlov I, Frenkel F, Gancharova O, Almog N, Tsiper M, Ataullakhanov R, Fowler N. Conserved pan-cancer microenvironment subtypes predict response to immunotherapy. Cancer Cell. 2021 06 14; 39(6):845-865.e7.

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Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 06 14; 39(6):866-882.e11.

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