 Fang-Tsyr Lin
| Title | Associate Professor |
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| Institution | Baylor College of Medicine |
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| Department | Department of Medicine |
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| Division | Medicine-Hematology & Oncology |
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 ORNG Applications Research R01CA100848 (LIN, FANG-TSYR)May 1, 2003 - Apr 30, 2008 NIH/NCI
Lysophosphatidic Acid Signaling in Ovarian Cancer
Role: Principal Investigator |
| R21NS066332 (LIN, FANG-TSYR)May 15, 2009 - Apr 30, 2012 NIH/NINDS
Role of TRIP6 in Malignant Glioma Progression
Role: Principal Investigator |
| R01CA203824 (LIN, WEEI-CHIN)Dec 15, 2016 - Nov 30, 2021 NIH/NCI
Novel therapeutics for targeting checkpoint dysfunction in cancer
Role: Principal Investigator |
Bibliographic
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Lin VT, Lin VY, Lai YJ, Chen CS, Liu K, Lin WC, Lin FT. TRIP6 regulates p27 KIP1 to promote tumorigenesis. Mol Cell Biol. 2013 Apr; 33(7):1394-409. PMID: 23339869.
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Kiss GN, Fells JI, Gupte R, Lee SC, Liu J, Nusser N, Lim KG, Ray RM, Lin FT, Parrill AL, Sümegi B, Miller DD, Tigyi G. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol Pharmacol. 2012 Dec; 82(6):1162-73. PMID: 22968304.
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Brindley DN, Lin FT, Tigyi GJ. Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim Biophys Acta. 2013 Jan; 1831(1):74-85. PMID: 22954454.
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Budhavarapu VN, White ED, Mahanic CS, Chen L, Lin FT, Lin WC. Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012 May 15; 11(10):2030-8. PMID: 22580462.
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Lin VT, Lin FT. TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. Cell Signal. 2011 Nov; 23(11):1691-7. PMID: 21689746.
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Lai YJ, Lin VT, Zheng Y, Benveniste EN, Lin FT. The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration. Mol Cell Biol. 2010 Dec; 30(23):5582-96. PMID: 20876301.
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E S, Lai YJ, Tsukahara R, Chen CS, Fujiwara Y, Yue J, Yu JH, Guo H, Kihara A, Tigyi G, Lin FT. Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J Biol Chem. 2009 May 22; 284(21):14558-71. PMID: 19293149.
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Lin FT, Lai YJ. Regulation of the LPA2 receptor signaling through the carboxyl-terminal tail-mediated protein-protein interactions. Biochim Biophys Acta. 2008 Sep; 1781(9):558-62. PMID: 18501721.
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Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. J Biol Chem. 2007 Dec 28; 282(52):37759-69. PMID: 17965021.
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Lai YJ, Lin WC, Lin FT. PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration. J Biol Chem. 2007 Aug 17; 282(33):24381-7. PMID: 17591779.
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Lai YJ, Chen CS, Lin WC, Lin FT. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol Cell Biol. 2005 Jul; 25(14):5859-68. PMID: 15988003.
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Xu J, Lai YJ, Lin WC, Lin FT. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12; 279(11):10459-68. PMID: 14688263.
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Lin FT, Chen W, Shenoy S, Cong M, Exum ST, Lefkowitz RJ. Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. Biochemistry. 2002 Aug 27; 41(34):10692-9. PMID: 12186555.
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Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15; 15(14):1833-44. PMID: 11459832.
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Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1601-6. PMID: 11171997.
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Cong M, Perry SJ, Lin FT, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, Lefkowitz RJ. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem. 2001 May 04; 276(18):15192-9. PMID: 11278469.
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Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature. 2000 Dec 07; 408(6813):720-3. PMID: 11130073.
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McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000 Nov 24; 290(5496):1574-7. PMID: 11090355.
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Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science. 1999 Dec 24; 286(5449):2495-8. PMID: 10617462.
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Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. J Biol Chem. 1999 Jun 04; 274(23):15971-4. PMID: 10347142.
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McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. J Biol Chem. 1999 Apr 16; 274(16):10677-80. PMID: 10196135.
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Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29; 283(5402):655-61. PMID: 9924018.
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Lin FT, Daaka Y, Lefkowitz RJ. beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem. 1998 Nov 27; 273(48):31640-3. PMID: 9822622.
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Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ. Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J Biol Chem. 1997 Dec 05; 272(49):31051-7. PMID: 9388255.
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Ménard L, Ferguson SS, Zhang J, Lin FT, Lefkowitz RJ, Caron MG, Barak LS. Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Mol Pharmacol. 1997 May; 51(5):800-8. PMID: 9145918.
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Lane MD, Lin FT, MacDougald OA, Vasseur-Cognet M. Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha). Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S91-6. PMID: 8680485.
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Lin FT, Lane MD. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8757-61. PMID: 8090719.
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MacDougald OA, Cornelius P, Lin FT, Chen SS, Lane MD. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue. J Biol Chem. 1994 Jul 22; 269(29):19041-7. PMID: 8034662.
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Lin FT, MacDougald OA, Diehl AM, Lane MD. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9606-10. PMID: 8415748.
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Lin FT, Lane MD. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes Dev. 1992 Apr; 6(4):533-44. PMID: 1373117.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 1992 | 1 | | 1993 | 1 | | 1994 | 2 | | 1996 | 1 | | 1997 | 2 | | 1998 | 1 | | 1999 | 4 | | 2000 | 2 | | 2001 | 3 | | 2002 | 1 | | 2003 | 1 | | 2005 | 1 | | 2007 | 2 | | 2008 | 1 | | 2009 | 1 | | 2010 | 1 | | 2011 | 1 | | 2012 | 3 | | 2013 | 1 |
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