Header Logo

FANG-TSYR LIN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin WC, Lin FT. Super-enhanced MARCO variant drives triple-negative breast cancer progression. Proc Natl Acad Sci U S A. 2022 12 13; 119(50):e2217953119. PMID: 36469785; PMCID: PMC9897437.
      Citations:    Fields:    Translation:Humans
    2. Ho SR, Lee YC, Ittmann MM, Lin FT, Chan KS, Lin WC. RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis. Cancer Lett. 2021 11 01; 520:344-360. PMID: 34400221; PMCID: PMC9420248.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Liu K, Graves JD, Lin FT, Lin WC. Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer. J Biol Chem. 2021 Jan-Jun; 296:100382. PMID: 33556369; PMCID: PMC7949146.
      Citations: 2     Fields:    Translation:HumansCells
    4. Xiao Y, Lin FT, Lin WC. ACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). PMID: 33408251; PMCID: PMC7826354.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    5. Graves JD, Lee YJ, Liu K, Li G, Lin FT, Lin WC. E2F1 sumoylation as a protective cellular mechanism in oxidative stress response. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):14958-14969. PMID: 32541040; PMCID: PMC7334650.
      Citations: 4     Fields:    Translation:HumansCells
    6. Liu K, Graves JD, Lee YJ, Lin FT, Lin WC. Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt. Mol Cell Biol. 2020 03 30; 40(8). PMID: 31964753; PMCID: PMC7108819.
      Citations: 5     Fields:    Translation:HumansCells
    7. Liu K, Lin FT, Graves JD, Lee YJ, Lin WC. Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):E3766-E3775. PMID: 28439015; PMCID: PMC5441733.
      Citations: 19     Fields:    Translation:HumansCells
    8. Lin FT, Lin VY, Lin VT, Lin WC. TRIP6 antagonizes the recruitment of A20 and CYLD to TRAF6 to promote the LPA2 receptor-mediated TRAF6 activation. Cell Discov. 2016; 2. PMID: 27134758; PMCID: PMC4850058.
      Citations: 7     
    9. Chowdhury P, Lin GE, Liu K, Song Y, Lin FT, Lin WC. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014 Nov 17; 5:5476. PMID: 25400145; PMCID: PMC4254804.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    10. Xiao Y, Lin VY, Ke S, Lin GE, Lin FT, Lin WC. 14-3-3t promotes breast cancer invasion and metastasis by inhibiting RhoGDIa. Mol Cell Biol. 2014 Jul; 34(14):2635-49. PMID: 24820414; PMCID: PMC4097670.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    11. Lin VT, Lin VY, Lai YJ, Chen CS, Liu K, Lin WC, Lin FT. TRIP6 regulates p27 KIP1 to promote tumorigenesis. Mol Cell Biol. 2013 Apr; 33(7):1394-409. PMID: 23339869; PMCID: PMC3624266.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Fells JI, Gupte R, Lee SC, Liu J, Lim KG, Ray RM, Lin FT, Parrill AL, Miller DD, Tigyi G, Kiss GN, Nusser N, S?megi B. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol Pharmacol. 2012 Dec; 82(6):1162-73. PMID: 22968304; PMCID: PMC3502618.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    13. Brindley DN, Lin FT, Tigyi GJ. Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim Biophys Acta. 2013 Jan; 1831(1):74-85. PMID: 22954454; PMCID: PMC3584168.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    14. Budhavarapu VN, White ED, Mahanic CS, Chen L, Lin FT, Lin WC. Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012 May 15; 11(10):2030-8. PMID: 22580462; PMCID: PMC3359126.
      Citations: 28     Fields:    Translation:HumansCells
    15. Lin VT, Lin FT. TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. Cell Signal. 2011 Nov; 23(11):1691-7. PMID: 21689746; PMCID: PMC3156290.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    16. Zheng Y, Qin H, Frank SJ, Deng L, Litchfield DW, Tefferi A, Pardanani A, Lin FT, Li J, Sha B, Benveniste EN. A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway. Blood. 2011 Jul 07; 118(1):156-66. PMID: 21527517; PMCID: PMC3139382.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    17. Lai YJ, Lin VT, Zheng Y, Benveniste EN, Lin FT. The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration. Mol Cell Biol. 2010 Dec; 30(23):5582-96. PMID: 20876301; PMCID: PMC2976429.
      Citations: 20     Fields:    Translation:HumansCells
    18. E S, Lai YJ, Tsukahara R, Chen CS, Fujiwara Y, Yue J, Yu JH, Guo H, Kihara A, Lin FT, Tigyi G. Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J Biol Chem. 2009 May 22; 284(21):14558-71. PMID: 19293149; PMCID: PMC2682904.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    19. Yang SZ, Lin FT, Lin WC. MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep. 2008 Sep; 9(9):907-15. PMID: 18660752; PMCID: PMC2529348.
      Citations: 42     Fields:    Translation:HumansCells
    20. Lin FT, Lai YJ. Regulation of the LPA2 receptor signaling through the carboxyl-terminal tail-mediated protein-protein interactions. Biochim Biophys Acta. 2008 Sep; 1781(9):558-62. PMID: 18501721; PMCID: PMC2574565.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    21. Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. J Biol Chem. 2007 Dec 28; 282(52):37759-69. PMID: 17965021; PMCID: PMC3496872.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    22. Lai YJ, Lin WC, Lin FT. PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration. J Biol Chem. 2007 Aug 17; 282(33):24381-7. PMID: 17591779; PMCID: PMC3923842.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    23. Liu K, Paik JC, Wang B, Lin FT, Lin WC. Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J. 2006 Oct 18; 25(20):4795-807. PMID: 17006541; PMCID: PMC1618094.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    24. Lai YJ, Chen CS, Lin WC, Lin FT. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol Cell Biol. 2005 Jul; 25(14):5859-68. PMID: 15988003; PMCID: PMC1168818.
      Citations: 36     Fields:    Translation:AnimalsCells
    25. Wang B, Liu K, Lin FT, Lin WC. A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 2004 Dec 24; 279(52):54140-52. PMID: 15494392; PMCID: PMC3904440.
      Citations: 51     Fields:    Translation:Cells
    26. Luo Y, Lin FT, Lin WC. ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol. 2004 Jul; 24(14):6430-44. PMID: 15226443; PMCID: PMC434232.
      Citations: 27     Fields:    Translation:HumansCells
    27. Liu K, Luo Y, Lin FT, Lin WC. TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev. 2004 Mar 15; 18(6):673-86. PMID: 15075294; PMCID: PMC387242.
      Citations: 77     Fields:    Translation:Cells
    28. Xu J, Lai YJ, Lin WC, Lin FT. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12; 279(11):10459-68. PMID: 14688263; PMCID: PMC3904432.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    29. Wu JH, Peppel K, Nelson CD, Lin FT, Kohout TA, Miller WE, Exum ST, Freedman NJ. The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. J Biol Chem. 2003 Nov 07; 278(45):44238-45. PMID: 12944399.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    30. Liu K, Lin FT, Ruppert JM, Lin WC. Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol. 2003 May; 23(9):3287-304. PMID: 12697828; PMCID: PMC153207.
      Citations: 74     Fields:    Translation:HumansCells
    31. Lin FT, Chen W, Shenoy S, Cong M, Exum ST, Lefkowitz RJ. Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. Biochemistry. 2002 Aug 27; 41(34):10692-9. PMID: 12186555.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    32. Nitzki A, Lin FT, Oppermann M, Huttenrauch F, H?ning S. Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif. J Biol Chem. 2002 Aug 23; 277(34):30769-77. PMID: 12065593.
      Citations: 30     Fields:    Translation:Cells
    33. Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15; 15(14):1833-44. PMID: 11459832; PMCID: PMC312742.
      Citations: 180     Fields:    Translation:HumansAnimalsCells
    34. Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1601-6. PMID: 11171997; PMCID: PMC29303.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    35. Cong M, Perry SJ, Lin FT, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, Lefkowitz RJ. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem. 2001 May 04; 276(18):15192-9. PMID: 11278469.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    36. Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature. 2000 Dec 07; 408(6813):720-3. PMID: 11130073.
      Citations: 344     Fields:    Translation:Animals
    37. McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000 Nov 24; 290(5496):1574-7. PMID: 11090355.
      Citations: 282     Fields:    Translation:HumansAnimalsCells
    38. Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science. 1999 Dec 24; 286(5449):2495-8. PMID: 10617462.
      Citations: 435     Fields:    Translation:AnimalsCells
    39. Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. J Biol Chem. 1999 Jun 04; 274(23):15971-4. PMID: 10347142.
      Citations: 49     Fields:    Translation:HumansCells
    40. McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. J Biol Chem. 1999 Apr 16; 274(16):10677-80. PMID: 10196135.
      Citations: 43     Fields:    Translation:AnimalsCells
    41. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29; 283(5402):655-61. PMID: 9924018.
      Citations: 493     Fields:    Translation:HumansAnimalsCells
    42. Lin FT, Daaka Y, Lefkowitz RJ. beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem. 1998 Nov 27; 273(48):31640-3. PMID: 9822622.
      Citations: 59     Fields:    Translation:HumansCells
    43. Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ. Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J Biol Chem. 1997 Dec 05; 272(49):31051-7. PMID: 9388255.
      Citations: 85     Fields:    Translation:HumansCells
    44. Ferguson SS, Zhang J, Lin FT, Lefkowitz RJ, Caron MG, Barak LS, M?nard L. Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Mol Pharmacol. 1997 May; 51(5):800-8. PMID: 9145918.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    45. Lane MD, Lin FT, MacDougald OA, Vasseur-Cognet M. Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha). Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S91-6. PMID: 8680485.
      Citations: 14     Fields:    Translation:AnimalsCells
    46. Lin FT, Lane MD. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8757-61. PMID: 8090719; PMCID: PMC44685.
      Citations: 135     Fields:    Translation:AnimalsCells
    47. MacDougald OA, Cornelius P, Lin FT, Chen SS, Lane MD. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue. J Biol Chem. 1994 Jul 22; 269(29):19041-7. PMID: 8034662.
      Citations: 28     Fields:    Translation:AnimalsCells
    48. Lin FT, MacDougald OA, Diehl AM, Lane MD. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9606-10. PMID: 8415748; PMCID: PMC47618.
      Citations: 113     Fields:    Translation:AnimalsCells
    49. Lin FT, Lane MD. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes Dev. 1992 Apr; 6(4):533-44. PMID: 1373117.
      Citations: 90     Fields:    Translation:AnimalsCells
    LIN's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (340)
    Explore
    _
    Co-Authors (5)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _