TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    R01CA100848     (LIN, FANG-TSYR)May 1, 2003 - Apr 30, 2008
    Lysophosphatidic Acid Signaling in Ovarian Cancer
    Role: Principal Investigator

    R21NS066332     (LIN, FANG-TSYR)May 15, 2009 - Apr 30, 2012
    Role of TRIP6 in Malignant Glioma Progression
    Role: Principal Investigator

    R01CA203824     (LIN, WEEI-CHIN)Dec 15, 2016 - Nov 30, 2021
    Novel therapeutics for targeting checkpoint dysfunction in cancer
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin VT, Lin VY, Lai YJ, Chen CS, Liu K, Lin WC, Lin FT. TRIP6 regulates p27 KIP1 to promote tumorigenesis. Mol Cell Biol. 2013 Apr; 33(7):1394-409. PMID: 23339869.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    2. Kiss GN, Fells JI, Gupte R, Lee SC, Liu J, Nusser N, Lim KG, Ray RM, Lin FT, Parrill AL, Sümegi B, Miller DD, Tigyi G. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol Pharmacol. 2012 Dec; 82(6):1162-73. PMID: 22968304.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    3. Brindley DN, Lin FT, Tigyi GJ. Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim Biophys Acta. 2013 Jan; 1831(1):74-85. PMID: 22954454.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    4. Budhavarapu VN, White ED, Mahanic CS, Chen L, Lin FT, Lin WC. Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012 May 15; 11(10):2030-8. PMID: 22580462.
      Citations: 27     Translation:HumansCells
    5. Lin VT, Lin FT. TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. Cell Signal. 2011 Nov; 23(11):1691-7. PMID: 21689746.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    6. Lai YJ, Lin VT, Zheng Y, Benveniste EN, Lin FT. The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration. Mol Cell Biol. 2010 Dec; 30(23):5582-96. PMID: 20876301.
      Citations: 19     Fields:    Translation:HumansCells
    7. E S, Lai YJ, Tsukahara R, Chen CS, Fujiwara Y, Yue J, Yu JH, Guo H, Kihara A, Tigyi G, Lin FT. Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J Biol Chem. 2009 May 22; 284(21):14558-71. PMID: 19293149.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    8. Lin FT, Lai YJ. Regulation of the LPA2 receptor signaling through the carboxyl-terminal tail-mediated protein-protein interactions. Biochim Biophys Acta. 2008 Sep; 1781(9):558-62. PMID: 18501721.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    9. Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. J Biol Chem. 2007 Dec 28; 282(52):37759-69. PMID: 17965021.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    10. Lai YJ, Lin WC, Lin FT. PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration. J Biol Chem. 2007 Aug 17; 282(33):24381-7. PMID: 17591779.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    11. Lai YJ, Chen CS, Lin WC, Lin FT. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol Cell Biol. 2005 Jul; 25(14):5859-68. PMID: 15988003.
      Citations: 33     Fields:    Translation:AnimalsCells
    12. Xu J, Lai YJ, Lin WC, Lin FT. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12; 279(11):10459-68. PMID: 14688263.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    13. Lin FT, Chen W, Shenoy S, Cong M, Exum ST, Lefkowitz RJ. Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. Biochemistry. 2002 Aug 27; 41(34):10692-9. PMID: 12186555.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    14. Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15; 15(14):1833-44. PMID: 11459832.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    15. Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1601-6. PMID: 11171997.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    16. Cong M, Perry SJ, Lin FT, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, Lefkowitz RJ. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem. 2001 May 04; 276(18):15192-9. PMID: 11278469.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    17. Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature. 2000 Dec 07; 408(6813):720-3. PMID: 11130073.
      Citations: 251     Fields:    Translation:Animals
    18. McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000 Nov 24; 290(5496):1574-7. PMID: 11090355.
      Citations: 243     Fields:    Translation:HumansAnimalsCells
    19. Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science. 1999 Dec 24; 286(5449):2495-8. PMID: 10617462.
      Citations: 329     Fields:    Translation:AnimalsCells
    20. Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. J Biol Chem. 1999 Jun 04; 274(23):15971-4. PMID: 10347142.
      Citations: 45     Fields:    Translation:HumansCells
    21. McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. J Biol Chem. 1999 Apr 16; 274(16):10677-80. PMID: 10196135.
      Citations: 39     Fields:    Translation:AnimalsCells
    22. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29; 283(5402):655-61. PMID: 9924018.
      Citations: 427     Fields:    Translation:HumansAnimalsCells
    23. Lin FT, Daaka Y, Lefkowitz RJ. beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem. 1998 Nov 27; 273(48):31640-3. PMID: 9822622.
      Citations: 54     Fields:    Translation:HumansCells
    24. Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ. Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J Biol Chem. 1997 Dec 05; 272(49):31051-7. PMID: 9388255.
      Citations: 79     Fields:    Translation:HumansCells
    25. Ménard L, Ferguson SS, Zhang J, Lin FT, Lefkowitz RJ, Caron MG, Barak LS. Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Mol Pharmacol. 1997 May; 51(5):800-8. PMID: 9145918.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    26. Lane MD, Lin FT, MacDougald OA, Vasseur-Cognet M. Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha). Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S91-6. PMID: 8680485.
      Citations: 12     Fields:    Translation:AnimalsCells
    27. Lin FT, Lane MD. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8757-61. PMID: 8090719.
      Citations: 124     Fields:    Translation:AnimalsCells
    28. MacDougald OA, Cornelius P, Lin FT, Chen SS, Lane MD. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue. J Biol Chem. 1994 Jul 22; 269(29):19041-7. PMID: 8034662.
      Citations: 28     Fields:    Translation:AnimalsCells
    29. Lin FT, MacDougald OA, Diehl AM, Lane MD. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9606-10. PMID: 8415748.
      Citations: 109     Fields:    Translation:AnimalsCells
    30. Lin FT, Lane MD. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes Dev. 1992 Apr; 6(4):533-44. PMID: 1373117.
      Citations: 85     Fields:    Translation:AnimalsCells
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