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Richard E. Lloyd

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
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    F32AI007085     (LLOYD, RICHARD E)Jul 1, 1985
    NIH/NIAID
    POLIOVIRUS ACTIVATION OF HOST P220-SPECIFIC PROTEINASE
    Role: Principal Investigator

    R01AI027914     (LLOYD, RICHARD E)Aug 1, 1989 - Nov 30, 2000
    NIH/NIAID
    CONTROL OF TRANSLATION BY POLIOVIRUS PROTEINASE
    Role: Principal Investigator

    R01GM059803     (LLOYD, RICHARD E)Aug 1, 1999 - Aug 31, 2009
    NIH/NIGMS
    Mechanisms of Translation Control During Apoptosis
    Role: Principal Investigator

    R56AI050237     (LLOYD, RICHARD E)Jul 1, 2001 - Dec 14, 2007
    NIH/NIAID
    Translation Regulation by Enterovirus Proteinase
    Role: Principal Investigator

    R01AI050237     (LLOYD, RICHARD E)Jul 1, 2001 - Jun 30, 2023
    NIH/NIAID
    Translation Regulation by Enterovirus Proteinase
    Role: Principal Investigator

    R21AI132985     (RAMANI, SASIREKHA)Aug 9, 2018 - Jul 31, 2020
    NIH/NIAID
    Oral vaccine interactions in human intestinal enteroids
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vehik K, Lynch KF, Wong MC, Tian X, Ross MC, Gibbs RA, Ajami NJ, Petrosino JF, Rewers M, Toppari J, Ziegler AG, She JX, Lernmark A, Akolkar B, Hagopian WA, Schatz DA, Krischer JP, Hyöty H, Lloyd RE. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019 Dec; 25(12):1865-1872. PMID: 31792456.
      View in: PubMed
    2. Lindfors K, Lin J, Lee HS, Hyöty H, Nykter M, Kurppa K, Liu E, Koletzko S, Rewers M, Hagopian W, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Petrosino JF, Lloyd RE, Agardh D. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2019 Nov 19. PMID: 31744911.
      View in: PubMed
    3. Liu H, Hu PW, Budhiraja S, Misra A, Couturier J, Lloyd RE, Lewis DE, Kimata JT, Rice AP. PACS1 is an HIV-1 cofactor that functions in Rev-mediated nuclear export of viral RNA. Virology. 2019 Oct 19; 540:88-96. PMID: 31759187.
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    4. Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A. Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]. Diabetologia. 2019 06; 62(6):1100-1103. PMID: 31016358.
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    5. Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A. Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia. 2019 05; 62(5):744-753. PMID: 30675626.
      View in: PubMed
    6. Stewart CJ, Ajami NJ, O'Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She JX, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018 10; 562(7728):583-588. PMID: 30356187.
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    7. Ajami NJ, Wong MC, Ross MC, Lloyd RE, Petrosino JF. Maximal viral information recovery from sequence data using VirMAP. Nat Commun. 2018 08 10; 9(1):3205. PMID: 30097567.
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    8. Nguyen TM, Kabotyanski EB, Dou Y, Reineke LC, Zhang P, Zhang XH, Malovannaya A, Jung SY, Mo Q, Roarty KP, Chen Y, Zhang B, Neilson JR, Lloyd RE, Perou CM, Ellis MJ, Rosen JM. FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation. Cancer Res. 2018 08 01; 78(15):4229-4240. PMID: 29844125.
      View in: PubMed
    9. Tsai WC, Reineke LC, Jain A, Jung SY, Lloyd RE. Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule-nucleating protein G3BP1. J Biol Chem. 2017 11 17; 292(46):18886-18896. PMID: 28972166.
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    10. Reineke LC, Tsai WC, Jain A, Kaelber JT, Jung SY, Lloyd RE. Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1. Mol Cell Biol. 2017 02 15; 37(4). PMID: 27920254.
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    11. Emmott E, Sorgeloos F, Caddy SL, Vashist S, Sosnovtsev S, Lloyd R, Heesom K, Locker N, Goodfellow I. Norovirus-Mediated Modification of the Translational Landscape via Virus and Host-Induced Cleavage of Translation Initiation Factors. Mol Cell Proteomics. 2017 04; 16(4 suppl 1):S215-S229. PMID: 28087593.
      View in: PubMed
    12. Margolskee A, Darwich AS, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Laplanche L, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B. IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results. Eur J Pharm Sci. 2017 Jan 01; 96:610-625. PMID: 27816631.
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    13. Darwich AS, Margolskee A, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B. IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes. Eur J Pharm Sci. 2017 Jan 01; 96:626-642. PMID: 27693299.
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    14. Tsai WC, Gayatri S, Reineke LC, Sbardella G, Bedford MT, Lloyd RE. Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly. J Biol Chem. 2016 Oct 21; 291(43):22671-22685. PMID: 27601476.
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    15. Lloyd RE, Estes MK. Editorial overview: Viruses and cell metabolism. Curr Opin Virol. 2016 08; 19:vii-viii. PMID: 27619793.
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    16. Lloyd RE. Enterovirus Control of Translation and RNA Granule Stress Responses. Viruses. 2016 Mar 30; 8(4):93. PMID: 27043612.
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    17. Dougherty JD, Tsai WC, Lloyd RE. Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules. Viruses. 2015 Nov 25; 7(12):6127-40. PMID: 26610553.
      View in: PubMed
    18. Lloyd RE. Nuclear proteins hijacked by mammalian cytoplasmic plus strand RNA viruses. Virology. 2015 May; 479-480:457-74. PMID: 25818028.
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    19. Reineke LC, Kedersha N, Langereis MA, van Kuppeveld FJ, Lloyd RE. Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1. MBio. 2015 Mar 17; 6(2):e02486. PMID: 25784705.
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    20. Reineke LC, Lloyd RE. The stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses. J Virol. 2015 Mar; 89(5):2575-89. PMID: 25520508.
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    21. Tsai WC, Lloyd RE. Cytoplasmic RNA Granules and Viral Infection. Annu Rev Virol. 2014 Nov; 1(1):147-70. PMID: 26958719.
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    22. Feng Q, Langereis MA, Lork M, Nguyen M, Hato SV, Lanke K, Emdad L, Bhoopathi P, Fisher PB, Lloyd RE, van Kuppeveld FJ. Enterovirus 2Apro targets MDA5 and MAVS in infected cells. J Virol. 2014 Mar; 88(6):3369-78. PMID: 24390337.
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    23. Dougherty JD, Reineke LC, Lloyd RE. mRNA decapping enzyme 1a (Dcp1a)-induced translational arrest through protein kinase R (PKR) activation requires the N-terminal enabled vasodilator-stimulated protein homology 1 (EVH1) domain. J Biol Chem. 2014 Feb 14; 289(7):3936-49. PMID: 24382890.
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    24. Lloyd RE. Regulation of stress granules and P-bodies during RNA virus infection. Wiley Interdiscip Rev RNA. 2013 May-Jun; 4(3):317-31. PMID: 23554219.
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    25. Reineke LC, Lloyd RE. Diversion of stress granules and P-bodies during viral infection. Virology. 2013 Feb 20; 436(2):255-67. PMID: 23290869.
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    26. Reineke LC, Dougherty JD, Pierre P, Lloyd RE. Large G3BP-induced granules trigger eIF2a phosphorylation. Mol Biol Cell. 2012 Sep; 23(18):3499-510. PMID: 22833567.
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    27. Lloyd RE. How do viruses interact with stress-associated RNA granules? PLoS Pathog. 2012; 8(6):e1002741. PMID: 22761570.
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    28. White JP, Lloyd RE. Regulation of stress granules in virus systems. Trends Microbiol. 2012 Apr; 20(4):175-83. PMID: 22405519.
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    29. Reineke LC, Lloyd RE. Animal virus schemes for translation dominance. Curr Opin Virol. 2011 Nov; 1(5):363-72. PMID: 22319551.
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    30. White JP, Lloyd RE. Poliovirus unlinks TIA1 aggregation and mRNA stress granule formation. J Virol. 2011 Dec; 85(23):12442-54. PMID: 21957303.
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    31. White JP, Reineke LC, Lloyd RE. Poliovirus switches to an eIF2-independent mode of translation during infection. J Virol. 2011 Sep; 85(17):8884-93. PMID: 21697471.
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    32. Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3383-8. PMID: 21289279.
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    33. Dougherty JD, White JP, Lloyd RE. Poliovirus-mediated disruption of cytoplasmic processing bodies. J Virol. 2011 Jan; 85(1):64-75. PMID: 20962086.
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    34. Bonderoff JM, Lloyd RE. Time-dependent increase in ribosome processivity. Nucleic Acids Res. 2010 Nov; 38(20):7054-67. PMID: 20571082.
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    35. Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, Lloyd RE, Rosen JM. Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. Cancer Res. 2010 Jun 15; 70(12):4868-79. PMID: 20501844.
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    36. Bonderoff JM, Larey JL, Lloyd RE. Cleavage of poly(A)-binding protein by poliovirus 3C proteinase inhibits viral internal ribosome entry site-mediated translation. J Virol. 2008 Oct; 82(19):9389-99. PMID: 18632855.
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    37. de Breyne S, Bonderoff JM, Chumakov KM, Lloyd RE, Hellen CU. Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. Virology. 2008 Aug 15; 378(1):118-22. PMID: 18572216.
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    38. Rivera CI, Lloyd RE. Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors. Virology. 2008 May 25; 375(1):59-72. PMID: 18321554.
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    39. Sherrill KW, Lloyd RE. Translation of cIAP2 mRNA is mediated exclusively by a stress-modulated ribosome shunt. Mol Cell Biol. 2008 Mar; 28(6):2011-22. PMID: 18195037.
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    40. White JP, Cardenas AM, Marissen WE, Lloyd RE. Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase. Cell Host Microbe. 2007 Nov 15; 2(5):295-305. PMID: 18005751.
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    41. Lloyd RE. Translational control by viral proteinases. Virus Res. 2006 Jul; 119(1):76-88. PMID: 16303201.
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    42. Byrd MP, Zamora M, Lloyd RE. Translation of eukaryotic translation initiation factor 4GI (eIF4GI) proceeds from multiple mRNAs containing a novel cap-dependent internal ribosome entry site (IRES) that is active during poliovirus infection. J Biol Chem. 2005 May 13; 280(19):18610-22. PMID: 15755734.
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    43. Kuyumcu-Martinez M, Belliot G, Sosnovtsev SV, Chang KO, Green KY, Lloyd RE. Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein. J Virol. 2004 Aug; 78(15):8172-82. PMID: 15254188.
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    44. Graham KL, Gustin KE, Rivera C, Kuyumcu-Martinez NM, Choe SS, Lloyd RE, Sarnow P, Utz PJ. Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection. J Virol. 2004 Jun; 78(12):6313-21. PMID: 15163725.
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    45. Sherrill KW, Byrd MP, Van Eden ME, Lloyd RE. BCL-2 translation is mediated via internal ribosome entry during cell stress. J Biol Chem. 2004 Jul 09; 279(28):29066-74. PMID: 15123638.
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    46. Van Eden ME, Byrd MP, Sherrill KW, Lloyd RE. Demonstrating internal ribosome entry sites in eukaryotic mRNAs using stringent RNA test procedures. RNA. 2004 Apr; 10(4):720-30. PMID: 15037781.
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    47. Van Eden ME, Byrd MP, Sherrill KW, Lloyd RE. Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress. RNA. 2004 Mar; 10(3):469-81. PMID: 14970392.
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    48. Kuyumcu-Martinez NM, Van Eden ME, Younan P, Lloyd RE. Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff. Mol Cell Biol. 2004 Feb; 24(4):1779-90. PMID: 14749392.
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    49. Byrd MP, Zamora M, Lloyd RE. Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons. Mol Cell Biol. 2002 Jul; 22(13):4499-511. PMID: 12052860.
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    50. Kuyumcu-Martinez NM, Joachims M, Lloyd RE. Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease. J Virol. 2002 Mar; 76(5):2062-74. PMID: 11836384.
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    51. Zamora M, Marissen WE, Lloyd RE. Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells. J Virol. 2002 Jan; 76(1):165-77. PMID: 11739682.
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