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InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Reineke LC, Tsai WC, Jain A, Kaelber JT, Jung SY, Lloyd RE. Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1. Mol Cell Biol. 2017 Feb 15; 37(4). PMID: 27920254.
      View in: PubMed
    2. Tsai WC, Gayatri S, Reineke LC, Sbardella G, Bedford MT, Lloyd RE. Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly. J Biol Chem. 2016 Oct 21; 291(43):22671-22685. PMID: 27601476.
      View in: PubMed
    3. Lloyd RE, Estes MK. Editorial overview: Viruses and cell metabolism. Curr Opin Virol. 2016 Aug; 19:vii-viii. PMID: 27619793.
      View in: PubMed
    4. Lloyd RE. Enterovirus Control of Translation and RNA Granule Stress Responses. Viruses. 2016; 8(4). PMID: 27043612; PMCID: PMC4848588.
    5. Dougherty JD, Tsai WC, Lloyd RE. Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules. Viruses. 2015; 7(12):6127-40. PMID: 26610553.
      View in: PubMed
    6. Lloyd RE. Nuclear proteins hijacked by mammalian cytoplasmic plus strand RNA viruses. Virology. 2015 May; 479-480:457-74. PMID: 25818028.
      View in: PubMed
    7. Reineke LC, Kedersha N, Langereis MA, van Kuppeveld FJ, Lloyd RE. Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1. MBio. 2015; 6(2):e02486. PMID: 25784705; PMCID: PMC4453520.
    8. Reineke LC, Lloyd RE. The stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses. J Virol. 2015 Mar; 89(5):2575-89. PMID: 25520508; PMCID: PMC4325707.
    9. Tsai WC, Lloyd RE. Cytoplasmic RNA Granules and Viral Infection. Annu Rev Virol. 2014 Nov; 1(1):147-70. PMID: 26958719; PMCID: PMC4867093.
    10. Feng Q, Langereis MA, Lork M, Nguyen M, Hato SV, Lanke K, Emdad L, Bhoopathi P, Fisher PB, Lloyd RE, van Kuppeveld FJ. Enterovirus 2Apro targets MDA5 and MAVS in infected cells. J Virol. 2014 Mar; 88(6):3369-78. PMID: 24390337; PMCID: PMC3957915.
    11. Dougherty JD, Reineke LC, Lloyd RE. mRNA decapping enzyme 1a (Dcp1a)-induced translational arrest through protein kinase R (PKR) activation requires the N-terminal enabled vasodilator-stimulated protein homology 1 (EVH1) domain. J Biol Chem. 2014 Feb 14; 289(7):3936-49. PMID: 24382890; PMCID: PMC3924262.
    12. Lloyd RE. Regulation of stress granules and P-bodies during RNA virus infection. Wiley Interdiscip Rev RNA. 2013 May-Jun; 4(3):317-31. PMID: 23554219; PMCID: PMC3652661.
    13. Reineke LC, Lloyd RE. Diversion of stress granules and P-bodies during viral infection. Virology. 2013 Feb 20; 436(2):255-67. PMID: 23290869; PMCID: PMC3611887.
    14. Reineke LC, Dougherty JD, Pierre P, Lloyd RE. Large G3BP-induced granules trigger eIF2? phosphorylation. Mol Biol Cell. 2012 Sep; 23(18):3499-510. PMID: 22833567; PMCID: PMC3442399.
    15. Lloyd RE. How do viruses interact with stress-associated RNA granules? PLoS Pathog. 2012; 8(6):e1002741. PMID: 22761570; PMCID: PMC3386173.
    16. White JP, Lloyd RE. Regulation of stress granules in virus systems. Trends Microbiol. 2012 Apr; 20(4):175-83. PMID: 22405519; PMCID: PMC3322245.
    17. Reineke LC, Lloyd RE. Animal virus schemes for translation dominance. Curr Opin Virol. 2011 Nov; 1(5):363-72. PMID: 22319551; PMCID: PMC3272495.
    18. White JP, Lloyd RE. Poliovirus unlinks TIA1 aggregation and mRNA stress granule formation. J Virol. 2011 Dec; 85(23):12442-54. PMID: 21957303; PMCID: PMC3209409.
    19. White JP, Reineke LC, Lloyd RE. Poliovirus switches to an eIF2-independent mode of translation during infection. J Virol. 2011 Sep; 85(17):8884-93. PMID: 21697471; PMCID: PMC3165854.
    20. Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3383-8. PMID: 21289279; PMCID: PMC3044415.
    21. Dougherty JD, White JP, Lloyd RE. Poliovirus-mediated disruption of cytoplasmic processing bodies. J Virol. 2011 Jan; 85(1):64-75. PMID: 20962086; PMCID: PMC3014174.
    22. Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 2011 Feb 10; 30(6):724-36. PMID: 20890303; PMCID: PMC3017639.
    23. Bonderoff JM, Lloyd RE. Time-dependent increase in ribosome processivity. Nucleic Acids Res. 2010 Nov; 38(20):7054-67. PMID: 20571082; PMCID: PMC2978347.
    24. Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, Lloyd RE, Rosen JM. Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. Cancer Res. 2010 Jun 15; 70(12):4868-79. PMID: 20501844; PMCID: PMC3005245.
    25. Bonderoff JM, Larey JL, Lloyd RE. Cleavage of poly(A)-binding protein by poliovirus 3C proteinase inhibits viral internal ribosome entry site-mediated translation. J Virol. 2008 Oct; 82(19):9389-99. PMID: 18632855; PMCID: PMC2546981.
    26. de Breyne S, Bonderoff JM, Chumakov KM, Lloyd RE, Hellen CU. Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. Virology. 2008 Aug 15; 378(1):118-22. PMID: 18572216; PMCID: PMC2580754.
    27. Rivera CI, Lloyd RE. Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors. Virology. 2008 May 25; 375(1):59-72. PMID: 18321554; PMCID: PMC2409284.
    28. Sherrill KW, Lloyd RE. Translation of cIAP2 mRNA is mediated exclusively by a stress-modulated ribosome shunt. Mol Cell Biol. 2008 Mar; 28(6):2011-22. PMID: 18195037; PMCID: PMC2268400.
    29. Bonderoff JM, Lloyd RE. CVB translation: lessons from the polioviruses. Curr Top Microbiol Immunol. 2008; 323:123-47. PMID: 18357768.
      View in: PubMed
    30. White JP, Cardenas AM, Marissen WE, Lloyd RE. Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase. Cell Host Microbe. 2007 Nov 15; 2(5):295-305. PMID: 18005751.
      View in: PubMed
    31. Lloyd RE. Translational control by viral proteinases. Virus Res. 2006 Jul; 119(1):76-88. PMID: 16303201.
      View in: PubMed
    32. Byrd MP, Zamora M, Lloyd RE. Translation of eukaryotic translation initiation factor 4GI (eIF4GI) proceeds from multiple mRNAs containing a novel cap-dependent internal ribosome entry site (IRES) that is active during poliovirus infection. J Biol Chem. 2005 May 13; 280(19):18610-22. PMID: 15755734.
      View in: PubMed
    33. Kuyumcu-Martinez M, Belliot G, Sosnovtsev SV, Chang KO, Green KY, Lloyd RE. Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein. J Virol. 2004 Aug; 78(15):8172-82. PMID: 15254188; PMCID: PMC446144.
    34. Graham KL, Gustin KE, Rivera C, Kuyumcu-Martinez NM, Choe SS, Lloyd RE, Sarnow P, Utz PJ. Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection. J Virol. 2004 Jun; 78(12):6313-21. PMID: 15163725; PMCID: PMC416498.
    35. Sherrill KW, Byrd MP, Van Eden ME, Lloyd RE. BCL-2 translation is mediated via internal ribosome entry during cell stress. J Biol Chem. 2004 Jul 9; 279(28):29066-74. PMID: 15123638.
      View in: PubMed
    36. Van Eden ME, Byrd MP, Sherrill KW, Lloyd RE. Demonstrating internal ribosome entry sites in eukaryotic mRNAs using stringent RNA test procedures. RNA. 2004 Apr; 10(4):720-30. PMID: 15037781; PMCID: PMC1370562.
    37. Van Eden ME, Byrd MP, Sherrill KW, Lloyd RE. Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress. RNA. 2004 Mar; 10(3):469-81. PMID: 14970392; PMCID: PMC1370942.
    38. Kuyumcu-Martinez NM, Van Eden ME, Younan P, Lloyd RE. Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff. Mol Cell Biol. 2004 Feb; 24(4):1779-90. PMID: 14749392; PMCID: PMC344173.
    39. Marissen WE, Triyoso D, Younan P, Lloyd RE. Degradation of poly(A)-binding protein in apoptotic cells and linkage to translation regulation. Apoptosis. 2004 Jan; 9(1):67-75. PMID: 14739600.
      View in: PubMed
    40. Byrd MP, Zamora M, Lloyd RE. Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons. Mol Cell Biol. 2002 Jul; 22(13):4499-511. PMID: 12052860; PMCID: PMC133909.
    41. Kuyumcu-Martinez NM, Joachims M, Lloyd RE. Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease. J Virol. 2002 Mar; 76(5):2062-74. PMID: 11836384; PMCID: PMC135927.
    42. Zamora M, Marissen WE, Lloyd RE. Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells. J Virol. 2002 Jan; 76(1):165-77. PMID: 11739682; PMCID: PMC135685.
    43. Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. New ways of initiating translation in eukaryotes. Mol Cell Biol. 2001 Dec; 21(23):8238-46. PMID: 11710333; PMCID: PMC99989.
    44. Marissen WE, Gradi A, Sonenberg N, Lloyd RE. Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis. Cell Death Differ. 2000 Dec; 7(12):1234-43. PMID: 11175261.
      View in: PubMed
    45. Bushell M, Poncet D, Marissen WE, Flotow H, Lloyd RE, Clemens MJ, Morley SJ. Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage. Cell Death Differ. 2000 Jul; 7(7):628-36. PMID: 10889507.
      View in: PubMed
    46. Marissen WE, Guo Y, Thomas AA, Matts RL, Lloyd RE. Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis. J Biol Chem. 2000 Mar 31; 275(13):9314-23. PMID: 10734073.
      View in: PubMed
    47. Joachims M, Van Breugel PC, Lloyd RE. Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J Virol. 1999 Jan; 73(1):718-27. PMID: 9847378; PMCID: PMC103879.
    48. Marissen WE, Lloyd RE. Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells. Mol Cell Biol. 1998 Dec; 18(12):7565-74. PMID: 9819442; PMCID: PMC109337.
    49. Bovee ML, Lamphear BJ, Rhoads RE, Lloyd RE. Direct cleavage of elF4G by poliovirus 2A protease is inefficient in vitro. Virology. 1998 Jun 5; 245(2):241-9. PMID: 9636363.
      View in: PubMed
    50. Bovee ML, Marissen WE, Zamora M, Lloyd RE. The predominant elF4G-specific cleavage activity in poliovirus-infected HeLa cells is distinct from 2A protease. Virology. 1998 Jun 5; 245(2):229-40. PMID: 9636362.
      View in: PubMed
    51. Benton PA, Barrett DJ, Matts RL, Lloyd RE. The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation. J Virol. 1996 Aug; 70(8):5525-32. PMID: 8764065; PMCID: PMC190511.
    52. Benton PA, Murphy JW, Lloyd RE. K562 cell strains differ in their response to poliovirus infection. Virology. 1995 Oct 20; 213(1):7-18. PMID: 7483280.
      View in: PubMed
    53. Steele MI, Marshall CM, Lloyd RE, Randolph VE. Reovirus 3 not detected by reverse transcriptase-mediated polymerase chain reaction analysis of preserved tissue from infants with cholestatic liver disease. Hepatology. 1995 Mar; 21(3):697-702. PMID: 7533124.
      View in: PubMed
    54. Yu SF, Benton P, Bovee M, Sessions J, Lloyd RE. Defective RNA replication by poliovirus mutants deficient in 2A protease cleavage activity. J Virol. 1995 Jan; 69(1):247-52. PMID: 7983716; PMCID: PMC188570.
    55. Lloyd RE, Bovee M. Persistent infection of human erythroblastoid cells by poliovirus. Virology. 1993 May; 194(1):200-9. PMID: 8386873.
      View in: PubMed
    56. Wyckoff EE, Lloyd RE, Ehrenfeld E. Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity. J Virol. 1992 May; 66(5):2943-51. PMID: 1313911; PMCID: PMC241053.
    57. Yu SF, Lloyd RE. Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease. Virology. 1992 Feb; 186(2):725-35. PMID: 1310193.
      View in: PubMed
    58. Yu SF, Lloyd RE. Identification of essential amino acid residues in the functional activity of poliovirus 2A protease. Virology. 1991 Jun; 182(2):615-25. PMID: 1850921.
      View in: PubMed
    59. Lloyd RE, Grubman MJ, Ehrenfeld E. Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing. J Virol. 1988 Nov; 62(11):4216-23. PMID: 2845133; PMCID: PMC253854.
    60. Devaney MA, Vakharia VN, Lloyd RE, Ehrenfeld E, Grubman MJ. Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex. J Virol. 1988 Nov; 62(11):4407-9. PMID: 2845152; PMCID: PMC253884.
    61. Lloyd RE, Jense HG, Ehrenfeld E. Restriction of translation of capped mRNA in vitro as a model for poliovirus-induced inhibition of host cell protein synthesis: relationship to p220 cleavage. J Virol. 1987 Aug; 61(8):2480-8. PMID: 3037110; PMCID: PMC255675.
    62. Lloyd RE, Toyoda H, Etchison D, Wimmer E, Ehrenfeld E. Cleavage of the cap binding protein complex polypeptide p220 is not effected by the second poliovirus protease 2A. Virology. 1986 Apr 15; 150(1):299-303. PMID: 3006342.
      View in: PubMed
    63. Lloyd RE, Etchison D, Ehrenfeld E. Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex. Proc Natl Acad Sci U S A. 1985 May; 82(9):2723-7. PMID: 2986132; PMCID: PMC397637.
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