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IRINA AGOULNIK

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R21CA270712     (AGOULNIK, IRINA)Mar 3, 2023 - Feb 28, 2025
    NIH
    Targeting breast cancer microenvironment with small molecule agonist of relaxin receptor
    Role: Principal Investigator
    R41DK131681     (DISTEFANO, PETER S)Sep 17, 2021 - Aug 31, 2022
    NIH
    Engineering a long-acting relaxin agonist to treat liver fibrosis
    Role: Co-Principal Investigator
    R15CA179287     (AGOULNIK, IRINA)Apr 4, 2014 - Mar 31, 2018
    NIH
    Regulation of metastases by tumor suppressor INPP4B
    Role: Principal Investigator
    R21CA129265     (AGOULNIK, IRINA)Apr 1, 2008 - Sep 30, 2011
    NIH
    Role of NCoR in Antiandrogen Resistance in Prostate Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Esteban-Lopez M, Wilson KJ, Myhr C, Kaftanovskaya EM, Henderson MJ, Southall NT, Xu X, Wang A, Hu X, Barnaeva E, Ye W, George ER, Sherrill JT, Ferrer M, Morello R, Agoulnik IU, Marugan JJ, Agoulnik AI. Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2. Commun Biol. 2022 Nov 04; 5(1):1183. PMID: 36333465; PMCID: PMC9636434.
      Citations:    Translation:HumansAnimals
    2. Ceyhan Y, Zhang M, Sandoval CG, Agoulnik AI, Agoulnik IU. Expression patterns and the roles of phosphatidylinositol phosphatases in testis?. Biol Reprod. 2022 10 11; 107(4):902-915. PMID: 35766372; PMCID: PMC9562111.
      Citations:    Fields:    
    3. Zhang M, Ceyhan Y, Kaftanovskaya EM, Vasquez JL, Knop FK, Nathanson L, Agoulnik AI, Ittmann MM, Agoulnik IU, Vacher J. INPP4B protects from metabolic?syndrome and associated disorders. Commun Biol. 2021 03 26; 4(1):416. PMID: 33772116; PMCID: PMC7998001.
      Citations: 2     Translation:AnimalsCells
    4. Ceyhan Y, Zhang M, Guo J, Sandoval CG, Kaftanovskaya EM, Agoulnik AI, Agoulnik IU, Vacher J. Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice. PLoS One. 2020; 15(5):e0233163. PMID: 32413098; PMCID: PMC7228085.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Zhang M, Lai Y, Vasquez JL, James DI, Smith KM, Waddell ID, Ogilvie DJ, Liu Y, Agoulnik IU. Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. Sci Rep. 2020 03 02; 10(1):3836. PMID: 32123273; PMCID: PMC7052214.
      Citations: 2     Fields:    Translation:HumansCells
    6. Kaftanovskaya EM, Ng HH, Soula M, Rivas B, Myhr C, Ho BA, Cervantes BA, Shupe TD, Devarasetty M, Hu X, Xu X, Patnaik S, Wilson KJ, Barnaeva E, Ferrer M, Southall NT, Marugan JJ, Bishop CE, Agoulnik IU, Agoulnik AI. Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis. FASEB J. 2019 11; 33(11):12435-12446. PMID: 31419161; PMCID: PMC6988856.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. Zhang M, Suarez E, Vasquez JL, Nathanson L, Peterson LE, Rajapakshe K, Basil P, Weigel NL, Coarfa C, Agoulnik IU. Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity. Oncogene. 2019 02; 38(7):1121-1135. PMID: 30228349; PMCID: PMC6377303.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    8. Wilson KJ, Xiao J, Chen CZ, Huang Z, Agoulnik IU, Ferrer M, Southall N, Hu X, Zheng W, Xu X, Wang A, Myhr C, Barnaeva E, George ER, Agoulnik AI, Marugan JJ. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem. 2018 Aug 05; 156:79-92. PMID: 30006176; PMCID: PMC6102074.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Zhang M, Krause WC, Agoulnik IU. Techniques for Evaluation of AR Transcriptional Output and Recruitment to DNA. Methods Mol Biol. 2018; 1786:219-236. PMID: 29786796.
      Citations: 2     Fields:    Translation:HumansCells
    10. Kaftanovskaya EM, Soula M, Myhr C, Ho BA, Moore SN, Yoo C, Cervantes B, How J, Marugan J, Agoulnik IU, Agoulnik AI. Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290. J Endocr Soc. 2017 Jun; 1(6):712-725. PMID: 28825052; PMCID: PMC5562169.
      Citations: 6     
    11. Agoulnik AI, Agoulnik IU, Hu X, Marugan J. Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. Br J Pharmacol. 2017 05; 174(10):977-989. PMID: 27771940; PMCID: PMC5406302.
      Citations: 8     Fields:    Translation:HumansAnimals
    12. Lopez SM, Agoulnik AI, Zhang M, Peterson LE, Suarez E, Gandarillas GA, Frolov A, Li R, Rajapakshe K, Coarfa C, Ittmann MM, Weigel NL, Agoulnik IU. Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression. Clin Cancer Res. 2016 08 01; 22(15):3937-49. PMID: 26968201; PMCID: PMC4970919.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    13. Hu X, Myhr C, Huang Z, Xiao J, Barnaeva E, Ho BA, Agoulnik IU, Ferrer M, Marugan JJ, Southall N, Agoulnik AI. Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists. Biochemistry. 2016 Mar 29; 55(12):1772-83. PMID: 26866459; PMCID: PMC5137375.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Agoulnik IU, Agoulnik AI. Long-Lasting Consequences of Testosterone Exposure. Endocrinology. 2015 Oct; 156(10):3488-9. PMID: 26380936; PMCID: PMC5398639.
      Citations:    Fields:    Translation:Animals
    15. Hodgson MC, Deryugina EI, Suarez E, Lopez SM, Lin D, Xue H, Gorlov IP, Wang Y, Agoulnik IU. INPP4B suppresses prostate cancer cell invasion. Cell Commun Signal. 2014 Sep 25; 12:61. PMID: 25248616; PMCID: PMC4181726.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    16. Hodgson MC, Vanostran G, Alghamdi S, Poppiti RJ, Agoulnik AI, Agoulnik IU. Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice. PLoS One. 2013; 8(4):e60455. PMID: 23593223; PMCID: PMC3620158.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Xiao J, Huang Z, Chen CZ, Agoulnik IU, Southall N, Hu X, Jones RE, Ferrer M, Zheng W, Agoulnik AI, Marugan JJ. Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. Nat Commun. 2013; 4:1953. PMID: 23764525; PMCID: PMC4915074.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    18. Nakka M, Agoulnik IU, Weigel NL. Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells. Int J Biochem Cell Biol. 2013 Apr; 45(4):763-72. PMID: 23270728; PMCID: PMC3593820.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    19. Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI. Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay. J Biomol Screen. 2013 Jul; 18(6):670-7. PMID: 23212924; PMCID: PMC4804196.
      Citations: 13     Fields:    Translation:HumansCells
    20. Hodgson MC, Bowden WA, Agoulnik IU. Androgen receptor footprint on the way to prostate cancer progression. World J Urol. 2012 Jun; 30(3):279-85. PMID: 21927983; PMCID: PMC3360873.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    21. Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM. INPP4B: the new kid on the PI3K block. Oncotarget. 2011 Apr; 2(4):321-8. PMID: 21487159; PMCID: PMC3248162.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    22. Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, Ayala G, Ittmann MM, Weigel NL, Agoulnik IU. Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer. Cancer Res. 2011 Jan 15; 71(2):572-82. PMID: 21224358; PMCID: PMC3077543.
      Citations: 67     Fields:    Translation:HumansCells
    23. Feng S, Agoulnik IU, Truong A, Li Z, Creighton CJ, Kaftanovskaya EM, Pereira R, Han HD, Lopez-Berestein G, Klonisch T, Ittmann MM, Sood AK, Agoulnik AI. Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis. Endocr Relat Cancer. 2010 Dec; 17(4):1021-33. PMID: 20861284.
      Citations: 25     Fields:    Translation:AnimalsCells
    24. Li Z, Burzawa JK, Troung A, Feng S, Agoulnik IU, Tong X, Anderson ML, Kovanci E, Rajkovic A, Agoulnik AI. Relaxin signaling in uterine fibroids. Ann N Y Acad Sci. 2009 Apr; 1160:374-8. PMID: 19416222; PMCID: PMC2954601.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    25. Feng S, Agoulnik IU, Li Z, Han HD, Lopez-Berestein G, Sood A, Ittmann MM, Agoulnik AI. Relaxin/RXFP1 signaling in prostate cancer progression. Ann N Y Acad Sci. 2009 Apr; 1160:379-80. PMID: 19416223; PMCID: PMC2945500.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    26. Agoulnik IU, Weigel NL. Coactivator selective regulation of androgen receptor activity. Steroids. 2009 Aug; 74(8):669-74. PMID: 19463689; PMCID: PMC2687407.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    27. Agoulnik IU, Bingman WE, Nakka M, Li W, Wang Q, Liu XS, Brown M, Weigel NL. Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase. Mol Endocrinol. 2008 Nov; 22(11):2420-32. PMID: 18787043; PMCID: PMC2582542.
      Citations: 17     Fields:    Translation:HumansCells
    28. Agoulnik IU, Weigel NL. Androgen receptor coactivators and prostate cancer. Adv Exp Med Biol. 2008; 617:245-55. PMID: 18497048.
      Citations: 24     Fields:    Translation:Humans
    29. Feng S, Bogatcheva NV, Truong A, Korchin B, Bishop CE, Klonisch T, Agoulnik IU, Agoulnik AI. Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs. Biol Reprod. 2007 Oct; 77(4):671-80. PMID: 17615407.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    30. Feng S, Agoulnik IU, Bogatcheva NV, Kamat AA, Kwabi-Addo B, Li R, Ayala G, Ittmann MM, Agoulnik AI. Relaxin promotes prostate cancer progression. Clin Cancer Res. 2007 Mar 15; 13(6):1695-702. PMID: 17363522.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    31. Agoulnik IU, Vaid A, Nakka M, Alvarado M, Bingman WE, Erdem H, Frolov A, Smith CL, Ayala GE, Ittmann MM, Weigel NL. Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res. 2006 Nov 01; 66(21):10594-602. PMID: 17079484.
      Citations: 89     Fields:    Translation:HumansCells
    32. Agoulnik IU, Weigel NL. Androgen receptor action in hormone-dependent and recurrent prostate cancer. J Cell Biochem. 2006 Oct 01; 99(2):362-72. PMID: 16619264.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    33. Marcelli M, Stenoien DL, Szafran AT, Simeoni S, Agoulnik IU, Weigel NL, Moran T, Mikic I, Price JH, Mancini MA. Quantifying effects of ligands on androgen receptor nuclear translocation, intranuclear dynamics, and solubility. J Cell Biochem. 2006 Jul 01; 98(4):770-88. PMID: 16440331.
      Citations: 42     Fields:    Translation:HumansCells
    34. Kamat AA, Feng S, Agoulnik IU, Kheradmand F, Bogatcheva NV, Coffey D, Sood AK, Agoulnik AI. The role of relaxin in endometrial cancer. Cancer Biol Ther. 2006 Jan; 5(1):71-7. PMID: 16322684.
      Citations: 13     Fields:    Translation:Humans
    35. Dai H, Li R, Wheeler T, Diaz de Vivar A, Frolov A, Tahir S, Agoulnik I, Thompson T, Rowley D, Ayala G. Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer. Prostate. 2005 Nov 01; 65(3):276-86. PMID: 16015593.
      Citations: 38     Fields:    Translation:HumansCells
    36. Murthy S, Agoulnik IU, Weigel NL. Androgen receptor signaling and vitamin D receptor action in prostate cancer cells. Prostate. 2005 Sep 01; 64(4):362-72. PMID: 15754350.
      Citations: 23     Fields:    Translation:HumansCells
    37. Agoulnik IU, Vaid A, Bingman WE, Erdeme H, Frolov A, Smith CL, Ayala G, Ittmann MM, Weigel NL. Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression. Cancer Res. 2005 Sep 01; 65(17):7959-67. PMID: 16140968.
      Citations: 90     Fields:    Translation:HumansCells
    38. Agoulnik IU, Tong XW, Fischer DC, Atkinson NE, Edwards DP, Headon DR, Weigel NL, Kieback DG, K?rner K. A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk. J Clin Endocrinol Metab. 2004 Dec; 89(12):6340-7. PMID: 15579801.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    39. Agoulnik IU, Krause WC, Bingman WE, Rahman HT, Amrikachi M, Ayala GE, Weigel NL. Repressors of androgen and progesterone receptor action. J Biol Chem. 2003 Aug 15; 278(33):31136-48. PMID: 12771131.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
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