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Paul J. Pfaffinger

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
DivisionNeuroscience
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    Other Positions
    TitleInterim Chair
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    P30HD024064     (ZOGHBI, HUDA Y)Aug 1, 1988 - Jun 30, 2014
    NIH/NICHD
    Baylor Intellectual and Developmental Disabilities Research Center
    Role: Co-Principal Investigator

    R01NS031583     (PFAFFINGER, PAUL)May 1, 1993 - Nov 30, 2004
    NIH/NINDS
    FUNCTIONAL DOMAINS OF K+ CHANNEL SUBUNIT PROTEINS
    Role: Principal Investigator

    R01GM090029     (PFAFFINGER, PAUL)Jan 1, 2010 - Dec 31, 2014
    NIH/NIGMS
    A Current Regulation by Dipeptidyl Peptidase-Like Proteins
    Role: Principal Investigator

    U01NS111692     (PFAFFINGER, PAUL)May 15, 2019 - Apr 30, 2022
    NIH/NINDS
    Multilevel Analysis of Neuronal Computations Underlying the Robust Encoding of Sensory Information in the Mammalian Olfactory System
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jerng HH, Pfaffinger PJ. Modulatory mechanisms and multiple functions of somatodendritic A-type K (+) channel auxiliary subunits. Front Cell Neurosci. 2014; 8:82. PMID: 24723849.
      View in: PubMed
    2. Jerng HH, Pfaffinger PJ. S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation. PLoS One. 2014; 9(3):e93315. PMID: 24675763.
      View in: PubMed
    3. Pfaffinger PJ. A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation. PLoS One. 2013; 8(11):e79891. PMID: 24236164.
      View in: PubMed
    4. Kunjilwar K, Qian Y, Pfaffinger PJ. Functional stoichiometry underlying KChIP regulation of Kv4.2 functional expression. J Neurochem. 2013 Aug; 126(4):462-72. PMID: 23692269.
      View in: PubMed
    5. Prince A, Pfaffinger PJ. Conserved N-terminal negative charges support optimally efficient N-type inactivation of Kv1 channels. PLoS One. 2013; 8(4):e62695. PMID: 23638135.
      View in: PubMed
    6. Nadin BM, Pfaffinger PJ. A new TASK for Dipeptidyl Peptidase-like Protein 6. PLoS One. 2013; 8(4):e60831. PMID: 23593319.
      View in: PubMed
    7. Tam Tam KB, George E, Cockrell K, Arany M, Speed J, Martin JN, Lamarca B, Granger JP. Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance. Am J Obstet Gynecol. 2011 Apr; 204(4):330.e1-4. PMID: 22675523.
      View in: PubMed
    8. Nadin BM, Pfaffinger PJ. Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells. J Neurosci. 2010 Jun 23; 30(25):8551-65. PMID: 20573902.
      View in: PubMed
    9. Jerng HH, Dougherty K, Covarrubias M, Pfaffinger PJ. A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism. Channels (Austin). 2009 Nov; 3(6):448-61. PMID: 19901547.
      View in: PubMed
    10. Prince-Carter A, Pfaffinger PJ. Multiple intermediate states precede pore block during N-type inactivation of a voltage-gated potassium channel. J Gen Physiol. 2009 Jul; 134(1):15-34. PMID: 19528261.
      View in: PubMed
    11. Jerng HH, Pfaffinger PJ. Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating. J Biol Chem. 2008 Dec 19; 283(51):36046-59. PMID: 18957440.
      View in: PubMed
    12. Jerng HH, Lauver AD, Pfaffinger PJ. DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels. Mol Cell Neurosci. 2007 Aug; 35(4):604-24. PMID: 17475505.
      View in: PubMed
    13. Wang G, Strang C, Pfaffinger PJ, Covarrubias M. Zn2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel. J Biol Chem. 2007 May 04; 282(18):13637-47. PMID: 17331952.
      View in: PubMed
    14. Lauver A, Yuan LL, Jeromin A, Nadin BM, Rodríguez JJ, Davies HA, Stewart MG, Wu GY, Pfaffinger PJ. Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression. J Neurochem. 2006 Nov; 99(4):1207-23. PMID: 17026528.
      View in: PubMed
    15. Ren Y, Barnwell LF, Alexander JC, Lubin FD, Adelman JP, Pfaffinger PJ, Schrader LA, Anderson AE. Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase. J Biol Chem. 2006 Apr 28; 281(17):11769-79. PMID: 16513649.
      View in: PubMed
    16. Baker KA, Hilty C, Peti W, Prince A, Pfaffinger PJ, Wider G, Wüthrich K, Choe S. NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain. Biochemistry. 2006 Feb 14; 45(6):1663-72. PMID: 16460013.
      View in: PubMed
    17. Yuan LL, Chen X, Kunjilwar K, Pfaffinger P, Johnston D. Acceleration of K+ channel inactivation by MEK inhibitor U0126. Am J Physiol Cell Physiol. 2006 Jan; 290(1):C165-71. PMID: 16135544.
      View in: PubMed
    18. Jerng HH, Kunjilwar K, Pfaffinger PJ. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. J Physiol. 2005 Nov 01; 568(Pt 3):767-88. PMID: 16123112.
      View in: PubMed
    19. Wang G, Shahidullah M, Rocha CA, Strang C, Pfaffinger PJ, Covarrubias M. Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels. J Gen Physiol. 2005 Jul; 126(1):55-69. PMID: 15955876.
      View in: PubMed
    20. Jerng HH, Pfaffinger PJ, Covarrubias M. Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci. 2004 Dec; 27(4):343-69. PMID: 15555915.
      View in: PubMed
    21. Kunjilwar K, Strang C, DeRubeis D, Pfaffinger PJ. KChIP3 rescues the functional expression of Shal channel tetramerization mutants. J Biol Chem. 2004 Dec 24; 279(52):54542-51. PMID: 15485870.
      View in: PubMed
    22. Jerng HH, Qian Y, Pfaffinger PJ. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J. 2004 Oct; 87(4):2380-96. PMID: 15454437.
      View in: PubMed
    23. Zhou W, Qian Y, Kunjilwar K, Pfaffinger PJ, Choe S. Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. Neuron. 2004 Feb 19; 41(4):573-86. PMID: 14980206.
      View in: PubMed
    24. Jeromin A, Yuan LL, Frick A, Pfaffinger P, Johnston D. A modified Sindbis vector for prolonged gene expression in neurons. J Neurophysiol. 2003 Oct; 90(4):2741-5. PMID: 12853440.
      View in: PubMed
    25. Nanao MH, Zhou W, Pfaffinger PJ, Choe S. Determining the basis of channel-tetramerization specificity by x-ray crystallography and a sequence-comparison algorithm: Family Values (FamVal). Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8670-5. PMID: 12835418.
      View in: PubMed
    26. Strang C, Kunjilwar K, DeRubeis D, Peterson D, Pfaffinger PJ. The role of Zn2+ in Shal voltage-gated potassium channel formation. J Biol Chem. 2003 Aug 15; 278(33):31361-71. PMID: 12754210.
      View in: PubMed
    27. Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD. PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci. 2002 Dec 01; 22(23):10123-33. PMID: 12451113.
      View in: PubMed
    28. Jahng AW, Strang C, Kaiser D, Pollard T, Pfaffinger P, Choe S. Zinc mediates assembly of the T1 domain of the voltage-gated K channel 4.2. J Biol Chem. 2002 Dec 06; 277(49):47885-90. PMID: 12372826.
      View in: PubMed
    29. Choe S, Cushman S, Baker KA, Pfaffinger P. Excitability is mediated by the T1 domain of the voltage-gated potassium channel. Novartis Found Symp. 2002; 245:169-75; discussion 175-7, 261-4. PMID: 12027006.
      View in: PubMed
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