ANDRAS HECZEY

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse awards and honors
    2015Fellows' Excellence in Education Award, Texas Children's Cancer and Hematology Centers
    2012TXCH Tumor Board Award, Baylor College of Medicine
    2009Pediatric Associates and Affiliates Award, Children's Hospital of Los Angeles
    2000Good Student and Good Athlete of the Republic of Hungary , Ministry of Education of Hungary
    2020Young Investigator Award, Baylor College of Medicine

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    Dr. Andras Heczey is a physician-scientist and full-time faculty in the Department of Pediatrics of Baylor College of Medicine, Section of Pediatric Hematology and Oncology. He is a member of the multidisciplinary solid tumor team and the Center for Cell and Gene Therapy (CAGT).

    His research focuses on developing novel treatments for children with solid tumors by redirecting the immune system to attack cancer cells.

    Dr. Heczey has studied and published the first adoptive immunotherapy approach utilizing Natural Killer T cells genetically modified to attack neuroblastoma, he is working on moving this approach from bench-to-bedside in a form of a Phase 1/2a clinical trial.

    As the Director of the Liver Tumor Center, Dr. Heczey has developed a strategy to target hepatoblastoma and hepatocellular carcinoma with genetically engineered T lymphocytes and he is currently optimizing this strategy for a smooth transition into the clinic.

    Dr. Heczey is a member of the Bone Marrow Transplant (BMT) / Stem Cell Transplant Program, the Liver Tumor Program, and the Neuroblastoma Program.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heczey A, Courtney AN, Montalbano A, Robinson S, Liu K, Li M, Ghatwai N, Dakhova O, Liu B, Raveh-Sadka T, Chauvin-Fleurence CN, Xu X, Ngai H, Di Pierro EJ, Savoldo B, Dotti G, Metelitsa LS. Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis. Nat Med. 2020 Oct 12. PMID: 33046868.
      Citations:    Fields:    
    2. Goss MB, Munoz FM, Ruan W, Galván NTN, O'Mahony CA, Rana A, Cotton RT, Moreno NF, Heczey AA, Leung DH, Goss JA. Liver Transplant in a Recently COVID-19 Positive Child with Hepatoblastoma. Pediatr Transplant. 2020 Sep 26; e13880. PMID: 32979013.
      Citations:    Fields:    
    3. Whittle SB, Smith V, Silverstein A, Parmeter M, Minard CG, Bernhardt MB, Zage PE, Venkatramani R, Nuchtern JG, Heczey A, Russell HV, Shohet JM, Foster JH. Is high-risk neuroblastoma induction chemotherapy possible without G-CSF? A pilot study of safety and treatment delays in the absence of primary prophylactic hematopoietic growth factors. Pediatr Blood Cancer. 2020 Jul 30; e28417. PMID: 32729196.
      Citations:    Fields:    
    4. Tay SY, Foster J, Heczey A, Sitton M. Pediatric Oncology Patients With Vincristine-Induced Recurrent Laryngeal Nerve Palsy: Two Case Reports and a Brief Review of Literature. Ear Nose Throat J. 2020 May 19; 145561320924868. PMID: 32425060.
      Citations:    Fields:    
    5. Batra SA, Rathi P, Guo L, Courtney AN, Fleurence J, Balzeau J, Shaik RS, Nguyen TP, Wu MF, Bulsara S, Mamonkin M, Metelitsa LS, Heczey A. Glypican-3-Specific CAR T Cells Coexpressing IL15 and IL21 Have Superior Expansion and Antitumor Activity against Hepatocellular Carcinoma. Cancer Immunol Res. 2020 03; 8(3):309-320. PMID: 31953246.
      Citations: 6     Fields:    
    6. Luckie TM, Potter SL, Bacino CA, Shah R, Heczey A, Venkatramani R. Agenesis of the corpus callosum and hepatoblastoma. . 2020 01; 182(1):224-228. PMID: 31729153.
      Citations:    
    7. Xu X, Huang W, Heczey A, Liu D, Guo L, Wood M, Jin J, Courtney AN, Liu B, Di Pierro EJ, Hicks J, Barragan GA, Ngai H, Chen Y, Savoldo B, Dotti G, Metelitsa LS. NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against Neuroblastoma. Clin Cancer Res. 2019 12 01; 25(23):7126-7138. PMID: 31484667.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    8. Heczey A. Alliance of the Titans: An Effective Combination of a TKI with CAR T Cells. Mol Ther. 2019 08 07; 27(8):1348-1349. PMID: 31337604.
      Citations:    Fields:    Translation:AnimalsCells
    9. Cowell E, Patel K, Heczey A, Finegold M, Venkatramani R, Wu H, López-Terrada D, Miloh T. Predisposing Conditions to Pediatric Hepatocellular Carcinoma and Association With Outcomes: Single-center Experience. J Pediatr Gastroenterol Nutr. 2019 05; 68(5):695-699. PMID: 30676520.
      Citations:    Fields:    Translation:Humans
    10. Haines K, Sarabia SF, Alvarez KR, Tomlinson G, Vasudevan SA, Heczey AA, Roy A, Finegold MJ, Parsons DW, Plon SE, López-Terrada D. Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation. Pediatr Blood Cancer. 2019 07; 66(7):e27745. PMID: 30977242.
      Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
    11. Rios X, Heczey AA. 50 Years Ago in The Journal of Pediatrics: Survival of Children with Neuroblastoma Treated with Combination Chemotherapy. J Pediatr. 2018 12; 203:233. PMID: 30470379.
      Citations:    Fields:    Translation:Humans
    12. Bavle A, Grimes A, Zhao S, Zinn D, Jackson A, Patel B, Porea T, Dutta A, Russell H, Heczey A. Cost-effectiveness and Improved Parent and Provider Satisfaction With Outpatient Management of Pediatric Oncology Patients, With Low-risk Fever and Neutropenia. J Pediatr Hematol Oncol. 2018 10; 40(7):e415-e420. PMID: 29334532.
      Citations:    Fields:    Translation:Humans
    13. Ng K, Rana A, Masand P, Patel K, Heczey A, Goss J, Himes R. Fatal Central Nervous System Post-Transplant Lymphoproliferative Disease in a Patient Who Underwent Liver Transplantation for Hepatoblastoma. J Pediatr Gastroenterol Nutr. 2018 01; 66(1):e21-e23. PMID: 28837514.
      Citations:    Fields:    Translation:Humans
    14. Newsome JR, Venkatramani R, Heczey A, Danysh HE, Fishman DS, Miloh T. Cholangiocarcinoma Among Children and Adolescents: A Review of the Literature and Surveillance, Epidemiology, and End Results Program Database Analysis. J Pediatr Gastroenterol Nutr. 2018 01; 66(1):e12-e18. PMID: 28937543.
      Citations: 2     Fields:    Translation:Humans
    15. Whittle SB, Punia JN, López-Terrada D, Gaikwad A, Hampton OA, Heczey A. Therapy-related Acute Leukemia With Mixed Phenotype and Novel t(1: 6)(q25;p23) After Treatment for High-risk Neuroblastoma. J Pediatr Hematol Oncol. 2017 11; 39(8):e486-e488. PMID: 28902076.
      Citations:    Fields:    Translation:HumansCells
    16. Hamilton EC, Balogh J, Nguyen DT, Graviss EA, Heczey AA, Austin MT. Liver transplantation for primary hepatic malignancies of childhood: The UNOS experience. J Pediatr Surg. 2017 Oct 12. PMID: 29108844.
      Citations: 1     Fields:    
    17. Szoor A, Vaidya A, Velasquez MP, Mei Z, Galvan DL, Torres D, Gee A, Heczey A, Gottschalk S. T Cell-Activating Mesenchymal Stem Cells as a Biotherapeutic for HCC. Mol Ther Oncolytics. 2017 Sep 15; 6:69-79. PMID: 28856237.
      Citations:    
    18. Heczey A, Louis CU, Savoldo B, Dakhova O, Durett A, Grilley B, Liu H, Wu MF, Mei Z, Gee A, Mehta B, Zhang H, Mahmood N, Tashiro H, Heslop HE, Dotti G, Rooney CM, Brenner MK. CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma. Mol Ther. 2017 09 06; 25(9):2214-2224. PMID: 28602436.
      Citations: 56     Fields:    Translation:HumansCells
    19. Shi Y, Commander SJ, Masand PM, Heczey A, Goss JA, Vasudevan SA. Vascular invasion is a prognostic indicator in hepatoblastoma. J Pediatr Surg. 2017 Jun; 52(6):956-961. PMID: 28347528.
      Citations: 4     Fields:    Translation:Humans
    20. Fleurence J, Fougeray S, Bahri M, Cochonneau D, Clémenceau B, Paris F, Heczey A, Birklé S. Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy. J Immunol Res. 2017; 2017:5604891. PMID: 28154831.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    21. Sumazin P, Chen Y, Treviño LR, Sarabia SF, Hampton OA, Patel K, Mistretta TA, Zorman B, Thompson P, Heczey A, Comerford S, Wheeler DA, Chintagumpala M, Meyers R, Rakheja D, Finegold MJ, Tomlinson G, Parsons DW, López-Terrada D. Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups. Hepatology. 2017 01; 65(1):104-121. PMID: 27775819.
      Citations: 26     Fields:    Translation:Humans
    22. Li W, Guo L, Rathi P, Marinova E, Gao X, Wu MF, Liu H, Dotti G, Gottschalk S, Metelitsa LS, Heczey A. Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity. Hum Gene Ther. 2017 05; 28(5):437-448. PMID: 27530312.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    23. Tian G, Courtney AN, Jena B, Heczey A, Liu D, Marinova E, Guo L, Xu X, Torikai H, Mo Q, Dotti G, Cooper LJ, Metelitsa LS. CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo. J Clin Invest. 2016 06 01; 126(6):2341-55. PMID: 27183388.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    24. Techavichit P, Masand PM, Himes RW, Abbas R, Goss JA, Vasudevan SA, Finegold MJ, Heczey A. Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature. J Pediatr Hematol Oncol. 2016 05; 38(4):261-8. PMID: 26925712.
      Citations: 12     Fields:    Translation:Humans
    25. Heczey A, Louis C. IMAGES IN CLINICAL MEDICINE. Osteopetrosis and Erlenmeyer-Flask Deformity. N Engl J Med. 2015 Sep 03; 373(10):e12. PMID: 26332566.
      Citations: 1     Fields:    Translation:Humans
    26. Austin MT, Nguyen H, Eberth JM, Chang Y, Heczey A, Hughes DP, Lally KP, Elting LS. Health disparities are important determinants of outcome for children with solid tumor malignancies. J Pediatr Surg. 2015 Jan; 50(1):161-6. PMID: 25598116.
      Citations: 5     Fields:    Translation:Humans
    27. Heczey A, Liu D, Tian G, Courtney AN, Wei J, Marinova E, Gao X, Guo L, Yvon E, Hicks J, Liu H, Dotti G, Metelitsa LS. Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy. Blood. 2014 Oct 30; 124(18):2824-33. PMID: 25049283.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    28. Heczey A, Louis CU. Advances in chimeric antigen receptor immunotherapy for neuroblastoma. Discov Med. 2013 Dec; 16(90):287-94. PMID: 24333408.
      Citations: 15     Fields:    Translation:Humans
    29. Liu D, Song L, Wei J, Courtney AN, Gao X, Marinova E, Guo L, Heczey A, Asgharzadeh S, Kim E, Dotti G, Metelitsa LS. IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity. J Clin Invest. 2012 Jun; 122(6):2221-33. PMID: 22565311.
      Citations: 45     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
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