TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    Collapse Biography 
    Collapse education and training
    Peking University, Beijing, ChinaB.Sc
    Academia Sinica, Institute of Biophysics, Beijing, ChinaM.Sc
    University of Calgary, Alberta , Canada, Calgary, CanadaPh.D

    Collapse Overview 
    Collapse overview
    Loning Fu received a Bachelor’s degree in cell biology in Peking University and a Master degree in developmental biology in Academia Sinica in Beijing, China. She then completed Ph.D studies at the University of Calgary, Canada and two postdoctoral fellowships in the University of Toronto in Canada and Baylor College of Medicine in the United States, respectively. Her Ph.D and first post-doctoral studies discovered the role of translational control of gene expression in early development, tumor suppression, and DNA damage response. Her second post-doctoral studies discovered the role of the mammalian circadian gene Period 2 in DNA damage response, cell cycle control, and tumor suppression. Her research as an independent researcher is focused on the role of chronic circadian disruption in obesity, metabolic syndrome, and non-alcoholic fatty-liver disease (NAFLD)-related hepatocellular carcinoma (HCC) and the role of circadian homeostasis in the future precision oncology.
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    Collapse Research 
    Collapse research activities and funding
    R01CA238988     (FU, LONING NONE)Sep 1, 2019 - Aug 31, 2024
    Sympathetic circadian dysfunction in obesity-related hepatocarcinogenesis
    Role: Principal Investigator

    R01CA230848     (FU, LONING NONE ;MOORE, DAVID D)Sep 18, 2018 - Aug 31, 2023
    (PQ6)Nuclear receptor mechanisms in circadian disruption induced hepatocarcinogenesis
    Role: Principal Investigator

    R01CA137019     (FU, LONING NONE)Sep 1, 2010 - Jul 31, 2017
    The Study of the Circadian Rhythm in p53 Signaling
    Role: Principal Investigator

    R03CA107821     (FU, LONING NONE)Sep 22, 2004 - Aug 31, 2007
    Study of the clock-controlled DNA-damage response
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Padilla J, Osman NM, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Fu L, Bissig-Choisat B, Bissig KD, Moore DD. Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model. J Hepatol. 2024 Feb; 80(2):282-292. PMID: 37890720; PMCID: PMC10929560.
      Citations: 1     Fields:    Translation:HumansAnimals
    2. Alexandrou AT, Duan Y, Xu S, Tepper C, Fan M, Tang J, Berg J, Basheer W, Valicenti T, Wilson PF, Coleman MA, Vaughan AT, Fu L, Grdina DJ, Murley J, Wang A, Woloschak G, Li JJ. PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3?/?-catenin/Per2 loop. iScience. 2022 Dec 22; 25(12):105546. PMID: 36465103; PMCID: PMC9708791.
    3. Fekry B, Ribas-Latre A, Baumgartner C, Deans JR, Kwok C, Patel P, Fu L, Berdeaux R, Sun K, Kolonin MG, Wang SH, Yoo SH, Sladek FM, Eckel-Mahan K. Incompatibility of the circadian protein BMAL1 and HNF4a in hepatocellular carcinoma. Nat Commun. 2018 10 19; 9(1):4349. PMID: 30341289; PMCID: PMC6195513.
      Citations: 36     Fields:    Translation:Cells
    4. Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L. Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. Cancer Cell. 2016 Dec 12; 30(6):909-924. PMID: 27889186; PMCID: PMC5695235.
      Citations: 141     Fields:    Translation:HumansAnimals
    5. Wu N, Kim KH, Zhou Y, Lee JM, Kettner NM, Mamrosh JL, Choi S, Fu L, Moore DD. Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice. Mol Endocrinol. 2016 Sep; 30(9):988-95. PMID: 27427832; PMCID: PMC5004116.
      Citations: 6     Fields:    Translation:AnimalsCells
    6. Fleet T, Stashi E, Zhu B, Rajapakshe K, Marcelo KL, Kettner NM, Gorman BK, Coarfa C, Fu L, O'Malley BW, York B. Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. J Biol Rhythms. 2016 10; 31(5):443-60. PMID: 27432117; PMCID: PMC5248931.
      Citations: 8     Fields:    Translation:HumansAnimals
    7. Lee C, Moore DD, Kettner NM, Mayo SA, Hua J, Fu L. Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metab. 2015 Sep 01; 22(3):448-59. PMID: 26166747; PMCID: PMC4558341.
      Citations: 81     Fields:    Translation:AnimalsCells
    8. Kettner NM, Katchy CA, Fu L. Circadian gene variants in cancer. Ann Med. 2014 Jun; 46(4):208-20. PMID: 24901356; PMCID: PMC4153443.
      Citations: 43     Fields:    Translation:HumansAnimals
    9. Stashi E, Lanz RB, Mao J, Michailidis G, Zhu B, Kettner NM, Putluri N, Reineke EL, Reineke LC, Dasgupta S, Dean A, Stevenson CR, Sivasubramanian N, Sreekumar A, Demayo F, York B, Fu L, O'Malley BW. SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014 Feb 27; 6(4):633-45. PMID: 24529706; PMCID: PMC4096300.
      Citations: 41     Fields:    Translation:AnimalsCells
    10. Fu L, Kettner NM. The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci. 2013; 119:221-82. PMID: 23899600; PMCID: PMC4103166.
      Citations: 93     Fields:    Translation:Humans
    11. Lee J, Kim MS, Li R, Liu VY, Fu L, Moore DD, Ma K, Yechoor VK. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in ?-cells. Islets. 2011 Nov-Dec; 3(6):381-8. PMID: 22045262; PMCID: PMC3329519.
      Citations: 52     Fields:    Translation:AnimalsCells
    12. Lee S, Donehower LA, Herron AJ, Moore DD, Fu L. Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One. 2010 Jun 07; 5(6):e10995. PMID: 20539819; PMCID: PMC2881876.
      Citations: 118     Fields:    Translation:AnimalsCells
    13. Ma K, Xiao R, Tseng HT, Shan L, Fu L, Moore DD. Circadian dysregulation disrupts bile acid homeostasis. PLoS One. 2009 Aug 31; 4(8):e6843. PMID: 19718444; PMCID: PMC2730029.
      Citations: 46     Fields:    Translation:Animals
    14. Fu L, Patel MS, Karsenty G. The circadian modulation of leptin-controlled bone formation. Prog Brain Res. 2006; 153:177-88. PMID: 16876575.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    15. Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell. 2005 Sep 09; 122(5):803-15. PMID: 16143109.
      Citations: 195     Fields:    Translation:HumansAnimalsCells
    16. Fu L, Lee CC. The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer. 2003 May; 3(5):350-61. PMID: 12724733.
      Citations: 272     Fields:    Translation:HumansAnimals
    17. Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002 Oct 04; 111(1):41-50. PMID: 12372299.
      Citations: 516     Fields:    Translation:AnimalsCells
    18. Fu L, Ma W, Benchimol S. A translation repressor element resides in the 3' untranslated region of human p53 mRNA. Oncogene. 1999 Nov 11; 18(47):6419-24. PMID: 10597243.
      Citations: 14     Fields:    Translation:HumansCells
    19. Sutcliffe T, Fu L, Abraham J, Vaziri H, Benchimol S. A functional wild-type p53 gene is expressed in human acute myeloid leukemia cell lines. Blood. 1998 Oct 15; 92(8):2977-9. PMID: 9763589.
      Citations: 5     Fields:    Translation:HumansCells
    20. Fu L, Benchimol S. Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation. EMBO J. 1997 Jul 01; 16(13):4117-25. PMID: 9233820; PMCID: PMC1170034.
      Citations: 35     Fields:    Translation:HumansCells
    21. Fu L, Minden MD, Benchimol S. Translational regulation of human p53 gene expression. EMBO J. 1996 Aug 15; 15(16):4392-401. PMID: 8861966; PMCID: PMC452163.
      Citations: 42     Fields:    Translation:HumansCells
    22. Fu LN, Ye RQ, Browder LW, Johnston RN. Translational potentiation of messenger RNA with secondary structure in Xenopus. Science. 1991 Feb 15; 251(4995):807-10. PMID: 1990443.
      Citations: 17     Fields:    Translation:AnimalsCells
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