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Philip J. Hastings

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
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    R01GM064022     (HASTINGS, PHILIP J)Aug 1, 2001 - Apr 30, 2012
    NIH/NIGMS
    Mechanisms of Adaptive Amplification
    Role: Principal Investigator

    R01GM106373     (HASTINGS, PHILIP J)Sep 5, 2014 - Feb 28, 2023
    NIH/NIGMS
    MUTATIONAL SIGNATURE(S) OF HUMAN GENOMIC REARRANGEMENT MECHANISMS
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hastings PJ, Rosenberg SM. A radical way to die. Nat Microbiol. 2017 12; 2(12):1582-1583. PMID: 29176695.
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    2. Carvalho CM, Pehlivan D, Ramocki MB, Fang P, Alleva B, Franco LM, Belmont JW, Hastings PJ, Lupski JR. Replicative mechanisms for CNV formation are error prone. Nat Genet. 2013 Nov; 45(11):1319-26. PMID: 24056715.
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    3. Wimberly H, Shee C, Thornton PC, Sivaramakrishnan P, Rosenberg SM, Hastings PJ. R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli. Nat Commun. 2013; 4:2115. PMID: 23828459.
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    4. Al Mamun AA, Lombardo MJ, Shee C, Lisewski AM, Gonzalez C, Lin D, Nehring RB, Saint-Ruf C, Gibson JL, Frisch RL, Lichtarge O, Hastings PJ, Rosenberg SM. Identity and function of a large gene network underlying mutagenic repair of DNA breaks. Science. 2012 Dec 07; 338(6112):1344-8. PMID: 23224554.
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    5. Moore JM, Wimberly H, Thornton PC, Rosenberg SM, Hastings PJ. Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli. Ann N Y Acad Sci. 2012 Sep; 1267:103-9. PMID: 22954223.
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    6. Rosenberg SM, Shee C, Frisch RL, Hastings PJ. Stress-induced mutation via DNA breaks in Escherichia coli: a molecular mechanism with implications for evolution and medicine. Bioessays. 2012 Oct; 34(10):885-92. PMID: 22911060.
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    7. Ira G, Hastings PJ. DNA breakage drives nuclear search. Nat Cell Biol. 2012 May 02; 14(5):448-50. PMID: 22552144.
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    8. Liu P, Carvalho CM, Hastings PJ, Lupski JR. Mechanisms for recurrent and complex human genomic rearrangements. Curr Opin Genet Dev. 2012 Jun; 22(3):211-20. PMID: 22440479.
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    9. Hastings PJ, Rosenberg SM. Genomic rearrangement in three dimensions. Nat Biotechnol. 2011 Dec 08; 29(12):1096-8. PMID: 22158363.
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    10. Liu P, Lacaria M, Zhang F, Withers M, Hastings PJ, Lupski JR. Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over. Am J Hum Genet. 2011 Oct 07; 89(4):580-8. PMID: 21981782.
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    11. Carvalho CM, Ramocki MB, Pehlivan D, Franco LM, Gonzaga-Jauregui C, Fang P, McCall A, Pivnick EK, Hines-Dowell S, Seaver LH, Friehling L, Lee S, Smith R, Del Gaudio D, Withers M, Liu P, Cheung SW, Belmont JW, Zoghbi HY, Hastings PJ, Lupski JR. Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genome. Nat Genet. 2011 Oct 02; 43(11):1074-81. PMID: 21964572.
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    12. Liu P, Erez A, Nagamani SC, Dhar SU, Kolodziejska KE, Dharmadhikari AV, Cooper ML, Wiszniewska J, Zhang F, Withers MA, Bacino CA, Campos-Acevedo LD, Delgado MR, Freedenberg D, Garnica A, Grebe TA, Hernández-Almaguer D, Immken L, Lalani SR, McLean SD, Northrup H, Scaglia F, Strathearn L, Trapane P, Kang SH, Patel A, Cheung SW, Hastings PJ, Stankiewicz P, Lupski JR, Bi W. Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell. 2011 Sep 16; 146(6):889-903. PMID: 21925314.
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    13. Lin D, Gibson IB, Moore JM, Thornton PC, Leal SM, Hastings PJ. Global chromosomal structural instability in a subpopulation of starving Escherichia coli cells. PLoS Genet. 2011 Aug; 7(8):e1002223. PMID: 21901104.
      View in: PubMed
    14. Fonville NC, Vaksman Z, DeNapoli J, Hastings PJ, Rosenberg SM. Pathways of resistance to thymineless death in Escherichia coli and the function of UvrD. Genetics. 2011 Sep; 189(1):23-36. PMID: 21705756.
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    15. Hastings PJ. Mechanisms of ectopic gene conversion. Genes (Basel). 2010 Nov 29; 1(3):427-39. PMID: 24000309.
      View in: PubMed
    16. Frisch RL, Su Y, Thornton PC, Gibson JL, Rosenberg SM, Hastings PJ. Separate DNA Pol II- and Pol IV-dependent pathways of stress-induced mutation during double-strand-break repair in Escherichia coli are controlled by RpoS. J Bacteriol. 2010 Sep; 192(18):4694-700. PMID: 20639336.
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    17. Hastings PJ, Hersh MN, Thornton PC, Fonville NC, Slack A, Frisch RL, Ray MP, Harris RS, Leal SM, Rosenberg SM. Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells. PLoS One. 2010 May 27; 5(5):e10862. PMID: 20523737.
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    18. Gibson JL, Lombardo MJ, Thornton PC, Hu KH, Galhardo RS, Beadle B, Habib A, Magner DB, Frost LS, Herman C, Hastings PJ, Rosenberg SM. The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli. Mol Microbiol. 2010 Jul; 77(2):415-30. PMID: 20497332.
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    19. Fonville NC, Bates D, Hastings PJ, Hanawalt PC, Rosenberg SM. Role of RecA and the SOS response in thymineless death in Escherichia coli. PLoS Genet. 2010 Mar 05; 6(3):e1000865. PMID: 20221259.
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    20. Hastings PJ, Lupski JR, Rosenberg SM, Ira G. Mechanisms of change in gene copy number. Nat Rev Genet. 2009 Aug; 10(8):551-64. PMID: 19597530.
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    21. Galhardo RS, Do R, Yamada M, Friedberg EC, Hastings PJ, Nohmi T, Rosenberg SM. DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli. Genetics. 2009 May; 182(1):55-68. PMID: 19270270.
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    22. Hastings PJ, Ira G, Lupski JR. A microhomology-mediated break-induced replication model for the origin of human copy number variation. PLoS Genet. 2009 Jan; 5(1):e1000327. PMID: 19180184.
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    23. Wu X, Strome ED, Meng Q, Hastings PJ, Plon SE, Kimmel M. A robust estimator of mutation rates. Mutat Res. 2009 Feb 10; 661(1-2):101-9. PMID: 19100753.
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    24. Gonzalez C, Hadany L, Ponder RG, Price M, Hastings PJ, Rosenberg SM. Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli. PLoS Genet. 2008 Oct 03; 4(10):e1000208. PMID: 18833303.
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    25. Galhardo RS, Hastings PJ, Rosenberg SM. Mutation as a stress response and the regulation of evolvability. Crit Rev Biochem Mol Biol. 2007 Sep-Oct; 42(5):399-435. PMID: 17917874.
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    26. Hastings PJ. Adaptive amplification. Crit Rev Biochem Mol Biol. 2007 Jul-Aug; 42(4):271-83. PMID: 17687669.
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    27. Mukhopadhyay SS, Leung KS, Hicks MJ, Hastings PJ, Youssoufian H, Plon SE. Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. J Cell Biol. 2006 Oct 23; 175(2):225-35. PMID: 17060495.
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    28. Slack A, Thornton PC, Magner DB, Rosenberg SM, Hastings PJ. On the mechanism of gene amplification induced under stress in Escherichia coli. PLoS Genet. 2006 Apr; 2(4):e48. PMID: 16604155.
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    29. Lopez CR, Yang S, Deibler RW, Ray SA, Pennington JM, Digate RJ, Hastings PJ, Rosenberg SM, Zechiedrich EL. A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol Microbiol. 2005 Oct; 58(1):80-101. PMID: 16164551.
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    30. Hastings PJ, Slack A, Petrosino JF, Rosenberg SM. Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms. PLoS Biol. 2004 Dec; 2(12):e399. PMID: 15550983.
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    31. Hastings PJ, Rosenberg SM, Slack A. Antibiotic-induced lateral transfer of antibiotic resistance. Trends Microbiol. 2004 Sep; 12(9):401-4. PMID: 15337159.
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    32. Rosenberg SM, Hastings PJ. Genomes: worming into genetic instability. Nature. 2004 Aug 05; 430(7000):625-6. PMID: 15295584.
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    33. Rosenberg SM, Hastings PJ. Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change. J Bacteriol. 2004 Aug; 186(15):4838-43. PMID: 15262914.
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    34. Rosenberg SM, Hastings PJ. Rebuttal: adaptive mutation in Escherichia coli (Foster). J Bacteriol. 2004 Aug; 186(15):4853. PMID: 15262918.
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    35. Rosenberg SM, Hastings PJ. Rebuttal: growth under selection stimulates Lac(+) reversion (Roth and Andersson). J Bacteriol. 2004 Aug; 186(15):4862-3. PMID: 15262922.
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    36. Hersh MN, Ponder RG, Hastings PJ, Rosenberg SM. Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress. Res Microbiol. 2004 Jun; 155(5):352-9. PMID: 15207867.
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    37. Rosenberg SM, Hastings PJ. Microbiology and evolution. Modulating mutation rates in the wild. Science. 2003 May 30; 300(5624):1382-3. PMID: 12775830.
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    38. Hastings PJ, Rosenberg SM. In pursuit of a molecular mechanism for adaptive gene amplification. DNA Repair (Amst). 2002 Feb 28; 1(2):111-23. PMID: 12509258.
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    39. McKenzie GJ, Lee PL, Lombardo MJ, Hastings PJ, Rosenberg SM. SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification. Mol Cell. 2001 Mar; 7(3):571-9. PMID: 11463382.
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    40. Brink B, Bugslag R, González Del Castillo B, Hastings P, Kipor GV, Lee SW, Lo CB, Poles L, Robinson P, Ronquillo EL, Staña J, Sydor J, Thani H. Multidisciplinary team interaction: summary and Action Plan. Prehosp Disaster Med. 2001 Jan-Mar; 16(1):39-41. PMID: 11367939.
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    41. Hastings PJ, Bull HJ, Klump JR, Rosenberg SM. Adaptive amplification: an inducible chromosomal instability mechanism. Cell. 2000 Nov 22; 103(5):723-31. PMID: 11114329.
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    42. Bull HJ, McKenzie GJ, Hastings PJ, Rosenberg SM. Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination. Genetics. 2000 Apr; 154(4):1427-37. PMID: 10747042.
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    43. Harris RS, Feng G, Ross KJ, Sidhu R, Thulin C, Longerich S, Szigety SK, Hastings PJ, Winkler ME, Rosenberg SM. Mismatch repair is diminished during stationary-phase mutation. Mutat Res. 1999 Jul; 437(1):51-60. PMID: 10425389.
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    44. Reiter LT, Hastings PJ, Nelis E, De Jonghe P, Van Broeckhoven C, Lupski JR. Human meiotic recombination products revealed by sequencing a hotspot for homologous strand exchange in multiple HNPP deletion patients. Am J Hum Genet. 1998 May; 62(5):1023-33. PMID: 9545397.
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    45. von Borstel RC, Savage EA, Wang Q, Hennig UG, Ritzel RG, Lee GS, Hamilton MD, Chrenek MA, Tomaszewski RW, Higgins JA, Tenove CJ, Liviero L, Hastings PJ, Korch CT, Steinberg CM. Topical reversion at the HIS1 locus of Saccharomyces cerevisiae. A tale of three mutants. Genetics. 1998 Apr; 148(4):1647-54. PMID: 9560384.
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    46. Manivasakam P, Rosenberg SM, Hastings PJ. Poorly repaired mismatches in heteroduplex DNA are hyper-recombinagenic in Saccharomyces cerevisiae. Genetics. 1996 Feb; 142(2):407-16. PMID: 8852840.
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    47. Hastings PJ, McGill C, Shafer B, Strathern JN. Ends-in vs. ends-out recombination in yeast. Genetics. 1993 Dec; 135(4):973-80. PMID: 8307337.
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    48. Hastings PJ. Mechanism and control of recombination in fungi. Mutat Res. 1992 Dec 01; 284(1):97-110. PMID: 1279396.
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    49. Rosenberg SM, Hastings PJ. The split-end model for homologous recombination at double-strand breaks and at Chi. Biochimie. 1991 Apr; 73(4):385-97. PMID: 1911939.
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    50. Schiestl RH, Gietz RD, Hastings PJ, Wintersberger U. Interchromosomal and intrachromosomal recombination in rad 18 mutants of Saccharomyces cerevisiae. Mol Gen Genet. 1990 Jun; 222(1):25-32. PMID: 2233677.
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    51. Schiestl RH, Chan WS, Gietz RD, Mehta RD, Hastings PJ. Safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast. Mutat Res. 1989 Dec; 224(4):427-36. PMID: 2685589.
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    52. Schiestl RH, Gietz RD, Mehta RD, Hastings PJ. Carcinogens induce intrachromosomal recombination in yeast. Carcinogenesis. 1989 Aug; 10(8):1445-55. PMID: 2665967.
      View in: PubMed
    53. Hastings PJ. Recombination in the eukaryotic nucleus. Bioessays. 1988 Aug-Sep; 9(2-3):61-4. PMID: 3066359.
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    54. Schiestl RH, Igarashi S, Hastings PJ. Analysis of the mechanism for reversion of a disrupted gene. Genetics. 1988 Jun; 119(2):237-47. PMID: 2840335.
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    55. von Borstel RC, Hastings PJ. Situation-dependent repair of DNA damage in yeast. Basic Life Sci. 1985; 34:121-45. PMID: 3904714.
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    56. Hastings PJ. Measurement of restoration and conversion: its meaning for the mismatch repair hypothesis of conversion. Cold Spring Harb Symp Quant Biol. 1984; 49:49-53. PMID: 6397304.
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    57. Mowat MR, Jachymczyk WJ, Hastings PJ, von Borstel RC. Repair of gamma-ray induced DNA strand breaks in the radiation-sensitive mutant rad18-2 of Saccharomyces cerevisiae. Mol Gen Genet. 1983; 189(2):256-62. PMID: 6343790.
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    58. Jachymczyk WJ, von Borstel RC, Mowat MR, Hastings PJ. Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: the RAD3 system and the RAD51 system. Mol Gen Genet. 1981; 182(2):196-205. PMID: 7026973.
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    59. Quah SK, von Borstel RC, Hastings PJ. The origin of spontaneous mutation in Saccharomyces cerevisiae. Genetics. 1980 Dec; 96(4):819-39. PMID: 7021317.
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    60. von Borstel RC, Hastings PJ. DNA repair and mutagen interaction in Saccharomyces: theoretical considerations. Basic Life Sci. 1980; 15:159-67. PMID: 7011306.
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    61. Morrison DP, Hastings PJ. Characterization of the mutator mutation mut5-1. Mol Gen Genet. 1979 Aug; 175(1):57-65. PMID: 390308.
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    62. Tan CK, Hastings PJ. DNA synthesis during meiosis of eight-spored strains of Chlamydomonas reinhardi. Mol Gen Genet. 1977 Apr 29; 152(3):311-7. PMID: 876028.
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    63. Hastings PJ, Quah SK, von Borstel RC. Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA. Nature. 1976 Dec 23-30; 264(5588):719-22. PMID: 796728.
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    64. Dicarprio L, Hastings PJ. Gene conversion and intragenic recombination at the SUP6 locus and the surrounding region in Saccharomyces cerevisiae. Genetics. 1976 Dec; 84(4):697-721. PMID: 795715.
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    65. Dicaprio L, Hastings PJ. Post-meiotic segregation in strains of Saccharomyces cerevisiae unable to excise pyrimidine dimers. Mutat Res. 1976 Oct; 37(1):137-40. PMID: 787775.
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    66. Hastings PJ. Some aspects of recombination in eukaryotic organisms. Annu Rev Genet. 1975; 9:129-44. PMID: 1108763.
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    67. Morgan K, Hastings PJ, von Borstel RC. A potential hazard: explosive production of mutations by induction of mutators. Environ Health Perspect. 1973 Dec; 6:207-10. PMID: 4780782.
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    68. Chiu SM, Hastings PJ. Pre-Meiotic DNA Synthesis and Recombination in CHLAMYDOMONAS REINHARDI. Genetics. 1973 Jan; 73(1):29-43. PMID: 17248590.
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    69. Hastings PJ. A possible source of primary nucleotide chain breaks in recombinant structures in eukaryotes. Genet Res. 1972 Oct; 20(2):253-6. PMID: 4654236.
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    70. HASTINGS PJ, WHITENOUSE HL. A POLARON MODEL OF GENETIC RECOMBINATION BY THE FORMATION OF HYBRID DEOXYRIBONUCLEIC ACID. Nature. 1964 Mar 07; 201:1052-4. PMID: 14191598.
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