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Paul Dalling Ling

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
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    F32CA009165     (LING, PAUL DALLING)Mar 25, 1992
    NIH/NCI
    MECHANISM OF ACTION OF THE EBV EBNA-2 PROTEIN
    Role: Principal Investigator

    R29CA069437     (LING, PAUL DALLING)Mar 15, 1996 - Feb 28, 2001
    NIH/NCI
    MECHANISMS FOR EBV EBNA-2 IMMORTALIZING FUNCTION
    Role: Principal Investigator

    R01CA124309     (LING, PAUL DALLING)Jul 26, 2006 - May 31, 2012
    NIH/NCI
    Role of PML nuclear body proteins for establishment of EBV latent infection
    Role: Principal Investigator

    R56AI080681     (LING, PAUL DALLING)Sep 25, 2009 - Apr 14, 2010
    NIH/NIAID
    Evasion of intrinsic antiviral host cell responses by herpesviruses
    Role: Principal Investigator

    R01AI080681     (LING, PAUL DALLING)Apr 15, 2010 - Mar 31, 2015
    NIH/NIAID
    Evasion of intrinsic antiviral host cell responses by herpesviruses
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pich D, Mrozek-Gorska P, Bouvet M, Sugimoto A, Akidil E, Grundhoff A, Hamperl S, Ling PD, Hammerschmidt W. First Days in the Life of Naive Human B Lymphocytes Infected with Epstein-Barr Virus. MBio. 2019 Sep 17; 10(5). PMID: 31530670.
      View in: PubMed
    2. Fuery A, Leen AM, Peng R, Wong MC, Liu H, Ling PD. Asian Elephant T Cell Responses to Elephant Endotheliotropic Herpesvirus. J Virol. 2018 03 15; 92(6). PMID: 29263271.
      View in: PubMed
    3. Bronson E, McClure M, Sohl J, Wiedner E, Cox S, Latimer EM, Pearson VR, Hayward GS, Fuery A, Ling PD. EPIDEMIOLOGIC EVALUATION OF ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 3B INFECTION IN AN AFRICAN ELEPHANT (LOXODONTA AFRICANA). J Zoo Wildl Med. 2017 Jun; 48(2):335-343. PMID: 28749266.
      View in: PubMed
    4. Pursell T, Tan J, Peng R, Ling PD. Erratum to 'Generation and validation of new quantitative real time PCR assays to detect Elephant Endotheliotropic herpesviruses 1A, 1B, and 4' [J. Virol. Methods 237 (2016) 138-142]. J Virol Methods. 2017 02; 240:85-86. PMID: 28012506.
      View in: PubMed
    5. Pursell T, Tan J, Peng R, Ling PD. Generation and validation of new quantitative real time PCR assays to detect elephant endotheliotropic herpesviruses 1A, 1B, and 4. J Virol Methods. 2016 11; 237:138-142. PMID: 27542531.
      View in: PubMed
    6. Ling PD, Long SY, Fuery A, Peng RS, Heaggans SY, Qin X, Worley KC, Dugan S, Hayward GS. Complete Genome Sequence of Elephant Endotheliotropic Herpesvirus 4, the First Example of a GC-Rich Branch Proboscivirus. mSphere. 2016 May-Jun; 1(3). PMID: 27340695.
      View in: PubMed
    7. Ling PD, Long SY, Zong JC, Heaggans SY, Qin X, Hayward GS. Comparison of the Gene Coding Contents and Other Unusual Features of the GC-Rich and AT-Rich Branch Probosciviruses. mSphere. 2016 May-Jun; 1(3). PMID: 27340696.
      View in: PubMed
    8. Fuery A, Browning GR, Tan J, Long S, Hayward GS, Cox SK, Flanagan JP, Tocidlowski ME, Howard LL, Ling PD. CLINICAL INFECTION OF CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 4. J Zoo Wildl Med. 2016 Mar; 47(1):311-8. PMID: 27010293.
      View in: PubMed
    9. Fuery A, Tan J, Peng R, Flanagan JP, Tocidlowski ME, Howard LL, Ling PD. CLINICAL INFECTION OF TWO CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 1B. J Zoo Wildl Med. 2016 Mar; 47(1):319-24. PMID: 27010294.
      View in: PubMed
    10. van den Doel PB, Prieto VR, van Rossum-Fikkert SE, Schaftenaar W, Latimer E, Howard L, Chapman S, Masters N, Osterhaus AD, Ling PD, Dastjerdi A, Martina B. Erratum to: A novel antigen capture ELISA for the specific detection of IgG antibodies to elephant endotheliotropic herpes virus. BMC Public Health. 2015 Sep 03; 15:851. PMID: 26336090.
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    11. van den Doel PB, Prieto VR, van Rossum-Fikkert SE, Schaftenaar W, Latimer E, Howard L, Chapman S, Masters N, Osterhaus AD, Ling PD, Dastjerdi A, Martina B. A novel antigen capture ELISA for the specific detection of IgG antibodies to elephant endotheliotropic herpes virus. BMC Vet Res. 2015 Aug 14; 11:203. PMID: 26268467.
      View in: PubMed
    12. Friberg A, Thumann S, Hennig J, Zou P, Nössner E, Ling PD, Sattler M, Kempkes B. The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation. PLoS Pathog. 2015 May; 11(5):e1004910. PMID: 26024477.
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    13. Humphreys AF, Tan J, Peng R, Benton SM, Qin X, Worley KC, Mikulski RL, Chow DC, Palzkill TG, Ling PD. Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA. PLoS One. 2015; 10(2):e0116318. PMID: 25658336.
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    14. Kempkes B, Ling PD. EBNA2 and Its Coactivator EBNA-LP. Curr Top Microbiol Immunol. 2015; 391:35-59. PMID: 26428371.
      View in: PubMed
    15. Stanton JJ, Nofs SA, Zachariah A, Kalaivannan N, Ling PD. Detection of elephant endotheliotropic herpesvirus infection among healthy Asian elephants (Elephas maximus) in South India. J Wildl Dis. 2014 Apr; 50(2):279-87. PMID: 24484479.
      View in: PubMed
    16. Sewatanon J, Ling PD. Murine gammaherpesvirus 68 encodes a second PML-modifying protein. J Virol. 2014 Mar; 88(6):3591-7. PMID: 24371073.
      View in: PubMed
    17. Stanton JJ, Cray C, Rodriguez M, Arheart KL, Ling PD, Herron A. Acute phase protein expression during elephant endotheliotropic herpesvirus-1 viremia in Asian elephants (Elephas maximus). J Zoo Wildl Med. 2013 Sep; 44(3):605-12. PMID: 24063088.
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    18. Sewatanon J, Liu H, Ling PD. Promyelocytic leukemia protein modulates establishment and maintenance of latent gammaherpesvirus infection in peritoneal cells. J Virol. 2013 Nov; 87(22):12151-7. PMID: 23986598.
      View in: PubMed
    19. Ling PD, Reid JG, Qin X, Muzny DM, Gibbs R, Petrosino J, Peng R, Zong JC, Heaggans SY, Hayward GS. Complete Genome Sequence of Elephant Endotheliotropic Herpesvirus 1A. Genome Announc. 2013 Apr 11; 1(2):e0010613. PMID: 23580705.
      View in: PubMed
    20. Sewatanon J, Ling PD. Murine gammaherpesvirus 68 ORF75c contains ubiquitin E3 ligase activity and requires PML SUMOylation but not other known cellular PML regulators, CK2 and E6AP, to mediate PML degradation. Virology. 2013 Jun 05; 440(2):140-9. PMID: 23541081.
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    21. Nofs SA, Atmar RL, Keitel WA, Hanlon C, Stanton JJ, Tan J, Flanagan JP, Howard L, Ling PD. Prenatal passive transfer of maternal immunity in Asian elephants (Elephas maximus). Vet Immunol Immunopathol. 2013 Jun 15; 153(3-4):308-11. PMID: 23582266.
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    22. Atkins L, Zong JC, Tan J, Mejia A, Heaggans SY, Nofs SA, Stanton JJ, Flanagan JP, Howard L, Latimer E, Stevens MR, Hoffman DS, Hayward GS, Ling PD. Elephant endotheliotropic herpesvirus 5, a newly recognized elephant herpesvirus associated with clinical and subclinical infections in captive Asian elephants (Elephas maximus). J Zoo Wildl Med. 2013 Mar; 44(1):136-43. PMID: 23505714.
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    23. Stanton JJ, Zong JC, Eng C, Howard L, Flanagan J, Stevens M, Schmitt D, Wiedner E, Graham D, Junge RE, Weber MA, Fischer M, Mejia A, Tan J, Latimer E, Herron A, Hayward GS, Ling PD. Kinetics of viral loads and genotypic analysis of elephant endotheliotropic herpesvirus-1 infection in captive Asian elephants (Elephas maximus). J Zoo Wildl Med. 2013 Mar; 44(1):42-54. PMID: 23505702.
      View in: PubMed
    24. Stanton JJ, Nofs SA, Peng R, Hayward GS, Ling PD. Development and validation of quantitative real-time polymerase chain reaction assays to detect elephant endotheliotropic herpesviruses-2, 3, 4, 5, and 6. J Virol Methods. 2012 Dec; 186(1-2):73-7. PMID: 22842286.
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    25. Ramakrishnan R, Donahue H, Garcia D, Tan J, Shimizu N, Rice AP, Ling PD. Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas. PLoS One. 2011; 6(11):e27271. PMID: 22102884.
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    26. Kim YE, Lee JH, Kim ET, Shin HJ, Gu SY, Seol HS, Ling PD, Lee CH, Ahn JH. Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression. J Virol. 2011 Nov; 85(22):11928-37. PMID: 21880768.
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    27. Stanton JJ, Zong JC, Latimer E, Tan J, Herron A, Hayward GS, Ling PD. Detection of pathogenic elephant endotheliotropic herpesvirus in routine trunk washes from healthy adult Asian elephants (Elephas maximus) by use of a real-time quantitative polymerase chain reaction assay. Am J Vet Res. 2010 Aug; 71(8):925-33. PMID: 20673092.
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    28. Ling PD, Tan J, Peng R. Nuclear-cytoplasmic shuttling is not required for the Epstein-Barr virus EBNA-LP transcriptional coactivation function. J Virol. 2009 Jul; 83(14):7109-16. PMID: 19403674.
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    29. Echendu CW, Ling PD. Regulation of Sp100A subnuclear localization and transcriptional function by EBNA-LP and interferon. J Interferon Cytokine Res. 2008 Nov; 28(11):667-78. PMID: 18844582.
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    30. Ling PD, Tan J, Sewatanon J, Peng R. Murine gammaherpesvirus 68 open reading frame 75c tegument protein induces the degradation of PML and is essential for production of infectious virus. J Virol. 2008 Aug; 82(16):8000-12. PMID: 18508901.
      View in: PubMed
    31. Ling PD, Peng RS, Nakajima A, Yu JH, Tan J, Moses SM, Yang WH, Zhao B, Kieff E, Bloch KD, Bloch DB. Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J. 2005 Oct 19; 24(20):3565-75. PMID: 16177824.
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    32. Ling PD, Huls HM. Isolation and immortalization of lymphocytes. Curr Protoc Mol Biol. 2005 May; Chapter 28:Unit 28.2. PMID: 18265367.
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    33. Peng R, Moses SC, Tan J, Kremmer E, Ling PD. The Epstein-Barr virus EBNA-LP protein preferentially coactivates EBNA2-mediated stimulation of latent membrane proteins expressed from the viral divergent promoter. J Virol. 2005 Apr; 79(7):4492-505. PMID: 15767449.
      View in: PubMed
    34. Lee JM, Lee KH, Farrell CJ, Ling PD, Kempkes B, Park JH, Hayward SD. EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli. J Virol. 2004 Nov; 78(22):12694-7. PMID: 15507659.
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    35. Walling DM, Ling PD, Gordadze AV, Montes-Walters M, Flaitz CM, Nichols CM. Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia. J Infect Dis. 2004 Jul 15; 190(2):396-9. PMID: 15216478.
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    36. Gordadze AV, Onunwor CW, Peng R, Poston D, Kremmer E, Ling PD. EBNA2 amino acids 3 to 30 are required for induction of LMP-1 and immortalization maintenance. J Virol. 2004 Apr; 78(8):3919-29. PMID: 15047808.
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    37. Ling PD, Vilchez RA, Keitel WA, Poston DG, Peng RS, White ZS, Visnegarwala F, Lewis DE, Butel JS. Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapy. Clin Infect Dis. 2003 Nov 01; 37(9):1244-9. PMID: 14557970.
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    38. Walling DM, Brown AL, Etienne W, Keitel WA, Ling PD. Multiple Epstein-Barr virus infections in healthy individuals. J Virol. 2003 Jun; 77(11):6546-50. PMID: 12743312.
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    39. Ling PD, Lednicky JA, Keitel WA, Poston DG, White ZS, Peng R, Liu Z, Mehta SK, Pierson DL, Rooney CM, Vilchez RA, Smith EO, Butel JS. The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study. J Infect Dis. 2003 May 15; 187(10):1571-80. PMID: 12721937.
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    40. O'Sullivan CE, Peng R, Cole KS, Montelaro RC, Sturgeon T, Jenson HB, Ling PD. Epstein-Barr virus and human immunodeficiency virus serological responses and viral burdens in HIV-infected patients treated with HAART. J Med Virol. 2002 Jul; 67(3):320-6. PMID: 12116021.
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    41. Gordadze AV, Poston D, Ling PD. The EBNA2 polyproline region is dispensable for Epstein-Barr virus-mediated immortalization maintenance. J Virol. 2002 Jul; 76(14):7349-55. PMID: 12072534.
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    42. Savoldo B, Cubbage ML, Durett AG, Goss J, Huls MH, Liu Z, Teresita L, Gee AP, Ling PD, Brenner MK, Heslop HE, Rooney CM. Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individuals. J Immunol. 2002 Jan 15; 168(2):909-18. PMID: 11777989.
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    43. Gordadze AV, Peng R, Tan J, Liu G, Sutton R, Kempkes B, Bornkamm GW, Ling PD. Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virus. J Virol. 2001 Jul; 75(13):5899-912. PMID: 11390591.
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    44. Peng R, Tan J, Ling PD. Conserved regions in the Epstein-Barr virus leader protein define distinct domains required for nuclear localization and transcriptional cooperation with EBNA2. J Virol. 2000 Nov; 74(21):9953-63. PMID: 11024123.
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    45. Fuentes-Pananá EM, Peng R, Brewer G, Tan J, Ling PD. Regulation of the Epstein-Barr virus C promoter by AUF1 and the cyclic AMP/protein kinase A signaling pathway. J Virol. 2000 Sep; 74(17):8166-75. PMID: 10933728.
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    46. Peng R, Gordadze AV, Fuentes Pananá EM, Wang F, Zong J, Hayward GS, Tan J, Ling PD. Sequence and functional analysis of EBNA-LP and EBNA2 proteins from nonhuman primate lymphocryptoviruses. J Virol. 2000 Jan; 74(1):379-89. PMID: 10590127.
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    47. Cho YG, Gordadze AV, Ling PD, Wang F. Evolution of two types of rhesus lymphocryptovirus similar to type 1 and type 2 Epstein-Barr virus. J Virol. 1999 Nov; 73(11):9206-12. PMID: 10516028.
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    48. Fuentes-Pananá EM, Swaminathan S, Ling PD. Transcriptional activation signals found in the Epstein-Barr virus (EBV) latency C promoter are conserved in the latency C promoter sequences from baboon and Rhesus monkey EBV-like lymphocryptoviruses (cercopithicine herpesviruses 12 and 15). J Virol. 1999 Jan; 73(1):826-33. PMID: 9847397.
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    49. Fuentes-Pananá EM, Ling PD. Characterization of the CBF2 binding site within the Epstein-Barr virus latency C promoter and its role in modulating EBNA2-mediated transactivation. J Virol. 1998 Jan; 72(1):693-700. PMID: 9420275.
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    50. Robertson KD, Hayward SD, Ling PD, Samid D, Ambinder RF. Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial. Mol Cell Biol. 1995 Nov; 15(11):6150-9. PMID: 7565767.
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    51. Ling PD, Hayward SD. Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJk. J Virol. 1995 Mar; 69(3):1944-50. PMID: 7853539.
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    52. Ling PD, Hsieh JJ, Ruf IK, Rawlins DR, Hayward SD. EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1. J Virol. 1994 Sep; 68(9):5375-83. PMID: 8057421.
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    53. Henkel T, Ling PD, Hayward SD, Peterson MG. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa. Science. 1994 Jul 01; 265(5168):92-5. PMID: 8016657.
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    54. Ling PD, Rawlins DR, Hayward SD. The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9237-41. PMID: 8415684.
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    55. Ling PD, Ryon JJ, Hayward SD. EBNA-2 of herpesvirus papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif. J Virol. 1993 Jun; 67(6):2990-3003. PMID: 8388484.
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    56. Ling P, Kinchington PR, Sadeghi-Zadeh M, Ruyechan WT, Hay J. Transcription from varicella-zoster virus gene 67 (glycoprotein IV). J Virol. 1992 Jun; 66(6):3690-8. PMID: 1316476.
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    57. Lowry PW, Solem S, Watson BN, Koropchak CM, Thackray HM, Kinchington PR, Ruyechan WT, Ling P, Hay J, Arvin AM. Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62. J Gen Virol. 1992 Apr; 73 ( Pt 4):811-9. PMID: 1321876.
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    58. Ling P, Kinchington PR, Ruyechan WT, Hay J. A detailed analysis of transcripts mapping to varicella zoster virus gene 14 (glycoprotein V). Virology. 1991 Oct; 184(2):625-35. PMID: 1653492.
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    59. Kinchington PR, Ling P, Pensiero M, Moss B, Ruyechan WT, Hay J. The glycoprotein products of varicella-zoster virus gene 14 and their defective accumulation in a vaccine strain (Oka). J Virol. 1990 Sep; 64(9):4540-8. PMID: 2166829.
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    60. Kinchington PR, Ling P, Pensiero M, Gershon A, Hay J, Ruyechan WT. A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus. Adv Exp Med Biol. 1990; 278:83-91. PMID: 1963048.
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    61. Ling PD, Warren MK, Vogel SN. Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages. J Immunol. 1985 Sep; 135(3):1857-63. PMID: 3926890.
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