InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    R21CA175404     (MARRIOTT, SUSAN J)Apr 1, 2013 - Mar 31, 2016
    Development of a Novel Mouse Model to Evaluate HTLV Tax Transformation
    Role: Principal Investigator

    R21AI078307     (MARRIOTT, SUSAN J)Sep 25, 2008 - Aug 31, 2011
    Transforming Potential of Emerging Human Retroviruses
    Role: Principal Investigator

    R01CA077371     (MARRIOTT, SUSAN J)Apr 1, 1999 - Feb 28, 2010
    Mechanisms of Cellular Transformation by HTLV-1 TAX
    Role: Principal Investigator

    R01CA062921     (MARRIOTT, SUSAN J)Apr 15, 1994 - Mar 31, 1999
    Role: Principal Investigator

    R01CA055684     (MARRIOTT, SUSAN J)Feb 6, 1992 - Mar 31, 2008
    Transcriptional Regulation of HTLV Gene Expression
    Role: Principal Investigator

    T32GM008231     (NELSON, DAVID LOREN)Jul 1, 1990 - Jun 30, 2020
    Training Program in Cell and Molecular Biology
    Role: Co-Principal Investigator

    T32CA009197     (MARRIOTT, SUSAN J)Sep 15, 1979 - Jul 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dayaram T, Lemoine FJ, Donehower LA, Marriott SJ. Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage. PLoS One. 2013; 8(2):e55989. PMID: 23405243; PMCID: PMC3566092.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    2. . T-Cell Leukemia - Characteristics, Treatment and Prevention, ed. Tomita. Pleitropic functions of HTLV-1 Tax contribute to cellular transformation. 2013.
    3. Irvin-Wilson CV, Newberg JY, Kong K, Javier RT, Marriott SJ. High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cells. Viruses. 2011 12; 3(12):2396-411. PMID: 22355445; PMCID: PMC3280515.
      Citations:    Fields:    Translation:HumansCells
    4. Marriott SJ, Switzer WM, Barbeau B, Larocque ?, Halin M, Landry S. Human T-cell lymphotropic virus type 3 (HTLV-3)- and HTLV-4-derived antisense transcripts encode proteins with similar Tax-inhibiting functions but distinct subcellular localization. J Virol. 2011 Dec; 85(23):12673-85. PMID: 21917984; PMCID: PMC3209360.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    5. Crawford LB, Feuer G, Marriott SJ, Guimaraes-Correa AB, Figueiredo CR, Gimenes KP, Pinto LA, Grassi MFR, Travassos LR, Caires ACF, Rodrigues EG. C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. Viruses. 2011 Jul; 3(7):1041-1058. PMID: 21994769; PMCID: PMC3185797.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    6. Ducu RI, Dayaram T, Marriott SJ. The HTLV-1 Tax oncoprotein represses Ku80 gene expression. Virology. 2011 Jul 20; 416(1-2):1-8. PMID: 21571351; PMCID: PMC3112475.
      Citations: 12     Fields:    Translation:HumansCells
    7. Pise-Masison CA, Marriott SJ. Memories of John N. Brady: scientist, mentor and friend. Retrovirology. 2009 May 19; 6:48. PMID: 19454030; PMCID: PMC2693500.
      Citations: 1     Fields:    Translation:Humans
    8. Switzer WM, Salemi M, Qari SH, Jia H, Gray RR, Katzourakis A, Marriott SJ, Pryor KN, Wolfe ND, Burke DS, Folks TM, Heneine W. Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4. Retrovirology. 2009 Feb 02; 6:9. PMID: 19187529; PMCID: PMC2647524.
      Citations: 34     Fields:    Translation:HumansCells
    9. Torti FM, Altieri D, Broach J, Fan H, Lotze M, Manfredi J, Matrisian L, Yu D, Giaccia A, Cancer Biology Training Consortium. Ph.D. Training in cancer biology. Cancer Res. 2008 Nov 15; 68(22):9122-4. PMID: 19010881.
      Citations: 4     Fields:    Translation:Humans
    10. Edwards DC, Marriott SJ. Human T-cell leukemia virus type 1 Tax relieves repression of proliferating cell nuclear antigen gene expression. J Virol. 2008 Dec; 82(23):11714-22. PMID: 18799587; PMCID: PMC2583679.
      Citations: 4     Fields:    Translation:HumansCells
    11. Dayaram T, Marriott SJ. Effect of transforming viruses on molecular mechanisms associated with cancer. J Cell Physiol. 2008 Aug; 216(2):309-14. PMID: 18366075; PMCID: PMC4160108.
      Citations: 5     Fields:    Translation:HumansCells
    12. Chandhasin C, Ducu RI, Berkovich E, Kastan MB, Marriott SJ. Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. J Virol. 2008 Jul; 82(14):6952-61. PMID: 18434398; PMCID: PMC2446947.
      Citations: 31     Fields:    Translation:HumansCells
    13. . New Research on DNA Damage. Effects of the HTLV-1 viral oncoprotein, Tax, on cellular responses to DNA damage. 2008.
    14. MARRIOTT SJ. Viral Oncology: Basic Science and Clinical Perspectives, eds. Kuan Teh Jeang and Kamel Khalili. Oncogenic potential of HTLV-1 Tax Protein. 2008.
    15. Gatza ML, Dayaram T, Marriott SJ. Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export. Retrovirology. 2007 Dec 14; 4:95. PMID: 18081936; PMCID: PMC2234431.
      Citations: 23     Fields:    Translation:HumansCells
    16. Matsuoka M, Watanabe T, Kannagi M, Bangham C, Grassmann R, Marriott SJ, Green P, Jeang KT. Meeting report on the 13th International Conference on Human Retrovirology: human T-cell leukemia virus research 30 years after adult T-cell leukemia. Cancer Res. 2007 Nov 15; 67(22):10638-41. PMID: 17993628.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    17. Winter HY, Dayaram T, Marriott SJ. Activation of the human T-cell leukemia virus type 1 long terminal repeat by the ternary complex factor Elk-1. J Virol. 2007 Dec; 81(23):13075-81. PMID: 17898074; PMCID: PMC2169132.
      Citations: 4     Fields:    Translation:HumansCells
    18. Johnson C, Marriott SJ, Levy LS. Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival. Oncogene. 2007 Oct 25; 26(49):7049-57. PMID: 17486067.
      Citations: 8     Fields:    Translation:HumansCells
    19. Winter HY, Marriott SJ. Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection. J Virol. 2007 Jun; 81(11):6089-98. PMID: 17376895; PMCID: PMC1900302.
      Citations: 8     Fields:    Translation:HumansCells
    20. . The Cancer Handbook, ed. Malcolm R. Alison. Human RNA Tumor Viruses. 2007; 123-132.
    21. Gatza ML, Marriott SJ. Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanism. J Virol. 2006 Jul; 80(13):6657-68. PMID: 16775353; PMCID: PMC1488944.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    22. Audet B, Hivin P, Wattel E, Marriott SJ, Mesnard JM, Barbeau B, Cavanagh MH, Landry S, Arpin-Andr? C, Par? ME, Th?te J. HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated. Retrovirology. 2006 Mar 02; 3:15. PMID: 16512901; PMCID: PMC1459196.
      Citations: 97     Fields:    Translation:Cells
    23. . Viral Oncogenesis. ed. M Tognon. Transformation by human T-cell leukemia virus type-I. 2006; 183-202.
    24. Marriott SJ, Semmes OJ. Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response. Oncogene. 2005 Sep 05; 24(39):5986-95. PMID: 16155605.
      Citations: 100     Fields:    Translation:HumansCells
    25. Gauthier S, Sun J, Legault E, Leclerc D, Tanaka Y, Marriott SJ, Tremblay MJ, Barbeau B, Par? ME, Landry S. A new sensitive and quantitative HTLV-I-mediated cell fusion assay in T cells. Virology. 2005 Aug 01; 338(2):309-22. PMID: 15963547.
      Citations: 4     Fields:    Translation:HumansCells
    26. Gatza ML, Chandhasin C, Ducu RI, Marriott SJ. Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation. Environ Mol Mutagen. 2005 Mar-Apr; 45(2-3):304-25. PMID: 15645440.
      Citations: 12     Fields:    Translation:HumansCells
    27. Zhang SX, Garcia-Gras E, Wycuff DR, Marriot SJ, Kadeer N, Yu W, Olson EN, Garry DJ, Parmacek MS, Schwartz RJ. Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem. 2005 May 13; 280(19):19115-26. PMID: 15699019.
      Citations: 43     Fields:    Translation:AnimalsCells
    28. . Progress in Retrovirus Research, S Thebault (ed). De-regulation of the cell cycle by human T cell leukemia virus type I (HTLV-I) Tax: mechanisms and effects. 2005; 39-63.
    29. Wycuff DR, Marriott SJ. The HTLV-I Tax oncoprotein: hyper-tasking at the molecular level. Front Biosci. 2005 Jan 01; 10:620-42. PMID: 15569604.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Audet B, Legault E, Ouellet M, Roy J, Dumais N, Mesnard JM, Rothstein DM, Marriott SJ, Tremblay MJ, Barbeau B, Langlois M, Par? ME. Activation of HTLV-I gene transcription by protein tyrosine phosphatase inhibitors. Virology. 2004 Nov 24; 329(2):395-411. PMID: 15518818.
      Citations: 7     Fields:    Translation:HumansCells
    31. Wycuff DR, Yanites HL, Marriott SJ. Identification of a functional serum response element in the HTLV-I LTR. Virology. 2004 Jul 01; 324(2):540-53. PMID: 15207639.
      Citations: 3     Fields:    Translation:Cells
    32. Mercier S, Bounou S, Marriot SJ, Barbeau B, Tremblay MJ, Dumais N, Par? ME. T-cell receptor/CD28 engagement when combined with prostaglandin E2 treatment leads to potent activation of human T-cell leukemia virus type 1. J Virol. 2003 Oct; 77(20):11170-9. PMID: 14512564; PMCID: PMC224985.
      Citations: 9     Fields:    Translation:HumansCells
    33. Gatza ML, Watt JC, Marriott SJ. Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades. Oncogene. 2003 Aug 11; 22(33):5141-9. PMID: 12910251.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    34. . Modular control of HTLV-I transcription: A story of cooperation and competition. Current Topics in Virology. 2003; (3):109-117.
    35. Marriott SJ, Lemoine FJ, Jeang KT. Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells. J Biomed Sci. 2002 Jul-Aug; 9(4):292-8. PMID: 12145525.
      Citations: 20     Fields:    Translation:HumansCells
    36. Kao SY, Lemoine FJ, Marriott SJ. p53-independent induction of apoptosis by the HTLV-I tax protein following UV irradiation. Virology. 2001 Dec 20; 291(2):292-8. PMID: 11878898.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    37. Lemoine FJ, Marriott SJ. Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein. J Biol Chem. 2001 Aug 24; 276(34):31851-7. PMID: 11435441.
      Citations: 30     Fields:    Translation:Cells
    38. Wycuff DR, Goff MD, Marriott SJ. Identification of an initiator-like element within the HTLV-I promoter. Virology. 2001 Feb 01; 280(1):72-9. PMID: 11162820.
      Citations: 2     Fields:    Translation:HumansCells
    39. Lemoine FJ, Wycuff DR, Marriott SJ. Transcriptional activity of HTLV-I Tax influences the expression of marker genes associated with cellular transformation. Dis Markers. 2001; 17(3):129-37. PMID: 11790876; PMCID: PMC3851965.
      Citations: 5     Fields:    Translation:HumansCells
    40. Kao SY, Lemoine FJ, Marriott SJ. Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway. J Biol Chem. 2000 Nov 17; 275(46):35926-31. PMID: 10931836.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    41. Lemoine FJ, Kao SY, Marriott SJ. Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression. AIDS Res Hum Retroviruses. 2000 Nov 01; 16(16):1623-7. PMID: 11080801.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    42. Connor LM, Marriott SJ. Sequences flanking the cAMP responsive core of the HTLV-I tax response elements influence CREB protease sensitivity. Virology. 2000 May 10; 270(2):328-36. PMID: 10792992.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    43. Kao SY, Lemoine FJ, Mariott SJ. HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents. Oncogene. 2000 Apr 27; 19(18):2240-8. PMID: 10822374.
      Citations: 18     Fields:    Translation:AnimalsCells
    44. . Effect of human T cell leukemia virus type I (HTLV-I) on genome stability: implications in the progression of adult T cell leukemia. Research Advances in Virology. 2000; (1):1-12.
    45. Kao SY, Marriott SJ. Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax protein. J Virol. 1999 May; 73(5):4299-304. PMID: 10196328; PMCID: PMC104211.
      Citations: 41     Fields:    Translation:HumansCells
    46. Aono H, Fujisawa K, Hasunuma T, Marriott SJ, Nishioka K. Extracellular human T cell leukemia virus type I tax protein stimulates the proliferation of human synovial cells. Arthritis Rheum. 1998 Nov; 41(11):1995-2003. PMID: 9811055.
      Citations: 9     Fields:    Translation:HumansCells
    47. Lydy SL, Conner ME, Marriott SJ. Relationship between anti-Tax antibody responses and cocultivatable virus in HTLV-I-infected rabbits. Virology. 1998 Oct 10; 250(1):60-6. PMID: 9770420.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    48. Marriott SJ, Payne K, Connor LM. Augmentation of human T cell leukaemia virus type I Tax transactivation by octamer binding sites. J Gen Virol. 1997 Sep; 78 ( Pt 9):2259-67. PMID: 9292013.
      Citations:    Fields:    Translation:HumansAnimalsCells
    49. Ressler S, Morris GF, Marriott SJ. Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter. J Virol. 1997 Feb; 71(2):1181-90. PMID: 8995640; PMCID: PMC191171.
      Citations: 28     Fields:    Translation:HumansCells
    50. Barnhart MK, Connor LM, Marriott SJ. Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcription. J Virol. 1997 Jan; 71(1):337-44. PMID: 8985355; PMCID: PMC191056.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    51. Marriott SJ, Lee TH, Slagle BL, Butel JS. Activation of the HTLV-I long terminal repeat by the hepatitis B virus X protein. Virology. 1996 Oct 01; 224(1):206-13. PMID: 8862415.
      Citations:    Fields:    Translation:HumansCells
    52. Ressler S, Connor LM, Marriott SJ. Cellular transformation by human T-cell leukemia virus type I. FEMS Microbiol Lett. 1996 Jul 01; 140(2-3):99-109. PMID: 8764470.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    53. Kwok RP, Laurance ME, Lundblad JR, Goldman PS, Shih H, Connor LM, Marriott SJ, Goodman RH. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature. 1996 Apr 18; 380(6575):642-6. PMID: 8602268.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    54. Connor LM, Oxman MN, Brady JN, Marriott SJ. Twenty-one base pair repeat elements influence the ability of a Gal4-Tax fusion protein to transactivate the HTLV-I long terminal repeat. Virology. 1993 Aug; 195(2):569-77. PMID: 8337832.
      Citations: 13     Fields:    Translation:HumansCells
    55. Marriott SJ, Trinh D, Brady JN. Activation of interleukin-2 receptor alpha expression by extracellular HTLV-I Tax1 protein: a potential role in HTLV-I pathogenesis. Oncogene. 1992 Sep; 7(9):1749-55. PMID: 1501887.
      Citations: 14     Fields:    Translation:HumansCells
    56. Marriott SJ, Lindholm PF, Reid RL, Brady JN. Soluble HTLV-I Tax1 protein stimulates proliferation of human peripheral blood lymphocytes. New Biol. 1991 Jul; 3(7):678-86. PMID: 1751450.
      Citations: 29     Fields:    Translation:HumansCells
    57. Gitlin SD, Lindholm PF, Marriott SJ, Brady JN. Transdominant human T-cell lymphotropic virus type I TAX1 mutant that fails to localize to the nucleus. J Virol. 1991 May; 65(5):2612-21. PMID: 2016773; PMCID: PMC240619.
      Citations: 21     Fields:    Translation:AnimalsCells
    58. Lindholm PF, Marriott SJ, Gitlin SD, Brady JN. Differential precipitation and zinc chelate chromatography purification of biologically active HTLV-I Tax1 expressed in E. coli. J Biochem Biophys Methods. 1991 Apr; 22(3):233-41. PMID: 1865054.
      Citations: 6     Fields:    Translation:HumansCells
    59. Lindholm PF, Marriott SJ, Gitlin SD, Bohan CA, Brady JN. Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein. New Biol. 1990 Nov; 2(11):1034-43. PMID: 2101630.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    60. Marriott SJ, Lindholm PF, Brown KM, Gitlin SD, Duvall JF, Radonovich MF, Brady JN. A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat. Mol Cell Biol. 1990 Aug; 10(8):4192-201. PMID: 2370863; PMCID: PMC360951.
      Citations: 38     Fields:    Translation:HumansCells
    61. Marriott SJ, Brady JN. Enhancer function in viral and cellular gene regulation. Biochim Biophys Acta. 1989 Dec 17; 989(2):97-110. PMID: 2688749.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    62. Marriott SJ, Boros I, Duvall JF, Brady JN. Indirect binding of human T-cell leukemia virus type I tax1 to a responsive element in the viral long terminal repeat. Mol Cell Biol. 1989 Oct; 9(10):4152-60. PMID: 2555684; PMCID: PMC362493.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    63. MARRIOTT SJ, PL Lindholm, S Gitlin, KM Brown, MF Radonovich, JF Duvall, and JN Brady. . Early Human Retroviruses, UCLA Symposia on Molecular and Cellular Biology. JE Groopman, ISY Chen, M Essex and R Weiss (eds),. Molecular analysis of trans-activation in the HTLV-I LTR. 1989; (119):13-22.
    64. Marriott SJ, Roeder DJ, Consigli RA. Anti-idiotypic antibodies to a polyomavirus monoclonal antibody recognize cell surface components of mouse kidney cells and prevent polyomavirus infection. J Virol. 1987 Sep; 61(9):2747-53. PMID: 3039167; PMCID: PMC255782.
      Citations: 22     Fields:    Translation:AnimalsCells
    65. Marriott SJ, Griffith GR, Consigli RA. Octyl-beta-D-glucopyranoside extracts polyomavirus receptor moieties from the surfaces of mouse kidney cells. J Virol. 1987 Feb; 61(2):375-82. PMID: 3027367; PMCID: PMC253959.
      Citations: 12     Fields:    Translation:AnimalsCells
    66. . Virus Attachment and Entry into Cells, RL Crowell and K Lonberg-Holm (ed). Biochemical characterization of the polyoma-receptor interaction. 1986; 44-53.
    67. Marriott SJ, Consigli RA. Production and characterization of monoclonal antibodies to polyomavirus major capsid protein VP1. J Virol. 1985 Nov; 56(2):365-72. PMID: 2414462; PMCID: PMC252585.
      Citations: 10     Fields:    Translation:Cells
    68. MARRIOTT SJ. Handbook of Neurovirology, RR McKendall and WG Stroop (eds). Human T-lymphotropic virus-I (HTLV-I).
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