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ROBERT BRYAN

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Anesthesiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
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    R01NS102594     (BRYAN, ROBERT M)Aug 1, 2018 - Jul 31, 2022
    NIH
    Gut Dysbiosis and Cerebral Small Vessel Disease
    Role: Principal Investigator
    R01NS103592     (BRYAN, ROBERT M;MCCULLOUGH, LOUISE D.)Apr 1, 2018 - Mar 31, 2023
    NIH
    Detrimental Effects of Age Related Dysbiosis
    Role: Co-Principal Investigator
    RF1AG058463     (MCCULLOUGH, LOUISE D.)Sep 15, 2017 - Mar 31, 2022
    NIH
    Dynamic Non-Neuronal Interactions between the Gut Microbiota and the Brain in Aging and in Cerebral Amyloid Angiopathy
    Role: Co-Principal Investigator
    R56NS102594     (BRYAN, ROBERT M)Aug 1, 2017 - Jul 31, 2018
    NIH
    Gut Dysbiosis and Cerebral Small Vessel Disease
    Role: Principal Investigator
    R21NS094806     (BRYAN, ROBERT M)Sep 1, 2015 - Aug 31, 2018
    NIH
    Cerebral small vessel disease, obstructive sleep apnea, and the gastrointestinal system
    Role: Principal Investigator
    R21NS078773     (BRYAN, ROBERT M)Jul 1, 2012 - Dec 31, 2014
    NIH
    Control of Cerebral Blood Flow by KCa2 and KCa3
    Role: Principal Investigator
    R01NS080531     (BRYAN, ROBERT M)May 1, 2012 - Feb 28, 2018
    NIH
    Effects of obstructive sleep apnea on cerebral circulation
    Role: Principal Investigator
    R21HL102778     (BRYAN, ROBERT M)Jul 1, 2010 - Jun 30, 2012
    NIH
    Cerebrovascular Consequences of Sleep Apnea
    Role: Principal Investigator
    R21HL098921     (BRYAN, ROBERT M)Feb 1, 2010 - Jan 31, 2012
    NIH
    Function of Two-Pore Domain K Channels in Vascular Smooth Muscle
    Role: Principal Investigator
    R01NS046666     (BRYAN, ROBERT M)Dec 1, 2004 - Nov 30, 2010
    NIH
    EDHF in the Cerebral Circulation
    Role: Principal Investigator
    R01NS037250     (BRYAN, ROBERT M)Dec 15, 1997 - Nov 30, 2001
    NIH
    FLOW INDUCED DILATIONS IN CEREBRAL VESSELS
    Role: Principal Investigator
    R01HL041960     (BRYAN, ROBERT M)Jul 1, 1990 - Jun 30, 1994
    NIH
    BLOOD FLOW AND ENERGY METABOLISM IN THE NEUROHYPOPHYSIS
    Role: Principal Investigator
    R01NS024109     (DUCKROW, ROBERT B)Jul 1, 1986 - Mar 31, 1994
    NIH
    CEREBRAL BLOOD FLOW DURING HYPERGLYCEMIA
    Role: Co-Principal Investigator
    R23NS019341     (BRYAN, ROBERT M)Jul 1, 1984 - Jun 30, 1987
    NIH
    CEREBRAL GLUCOSE UTILIZATION DURING STRESS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ayyaswamy S, Shi H, Zhang B, Bryan RM, Durgan DJ. Obstructive Sleep Apnea-Induced Hypertension Is Associated With Increased Gut and Neuroinflammation. J Am Heart Assoc. 2023 06 06; 12(11):e029218. PMID: 37260032; PMCID: PMC10381979.
      Citations:    Fields:    Translation:Animals
    2. Shi H, Nelson JW, Phillips S, Petrosino JF, Bryan RM, Durgan DJ. Alterations of the gut microbial community structure and function with aging in the spontaneously hypertensive stroke prone rat. Sci Rep. 2022 05 20; 12(1):8534. PMID: 35595870; PMCID: PMC9122926.
      Citations: 1     Fields:    Translation:Animals
    3. Nelson JW, Phillips SC, Ganesh BP, Petrosino JF, Durgan DJ, Bryan RM. The gut microbiome contributes to blood-brain barrier disruption in spontaneously hypertensive stroke prone rats. FASEB J. 2021 02; 35(2):e21201. PMID: 33496989; PMCID: PMC8238036.
      Citations: 5     Fields:    Translation:Animals
    4. Durgan DJ, Lee J, McCullough LD, Bryan RM. Examining the Role of the Microbiota-Gut-Brain Axis in Stroke. Stroke. 2019 08; 50(8):2270-2277. PMID: 31272315; PMCID: PMC6646086.
      Citations: 27     Fields:    Translation:Humans
    5. Kitagawa MG, Reynolds JO, Wehrens XHT, Bryan RM, Pandit LM. Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension. Front Med (Lausanne). 2017; 4:177. PMID: 29109948; PMCID: PMC5660113.
      Citations: 11     
    6. Durgan DJ, Crossland RF, Bryan RM. The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea. J Cereb Blood Flow Metab. 2017 Aug; 37(8):2806-2819. PMID: 27798273; PMCID: PMC5536790.
      Citations: 9     Fields:    Translation:Animals
    7. Durgan DJ, Ganesh BP, Cope JL, Ajami NJ, Phillips SC, Petrosino JF, Hollister EB, Bryan RM. Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension. Hypertension. 2016 Feb; 67(2):469-74. PMID: 26711739; PMCID: PMC4713369.
      Citations: 123     Fields:    Translation:Animals
    8. Lloyd EE, Durgan DJ, Martini SR, Bryan RM. Pathological effects of obstructive apneas during the sleep cycle in an animal model of cerebral small vessel disease. Hypertension. 2015 Oct; 66(4):913-7. PMID: 26259594; PMCID: PMC4567494.
      Citations: 4     Fields:    Translation:Animals
    9. Durgan DJ, Crossland RF, Lloyd EE, Phillips SC, Bryan RM. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab. 2015 Mar; 35(3):402-11. PMID: 25425077; PMCID: PMC4348382.
      Citations: 11     Fields:    Translation:AnimalsCells
    10. Schwingshackl A, Teng B, Makena P, Ghosh M, Sinclair SE, Luellen C, Balasz L, Rovnaghi C, Bryan RM, Lloyd EE, Fitzpatrick E, Saravia JS, Cormier SA, Waters CM. Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury. Crit Care Med. 2014 Nov; 42(11):e692-701. PMID: 25126877; PMCID: PMC4199872.
      Citations:    
    11. Crossland RF, Durgan DJ, Lloyd EE, Phillips SC, Reddy AK, Marrelli SP, Bryan RM. A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15; 305(4):R334-42. PMID: 23761641; PMCID: PMC3833398.
      Citations: 18     Fields:    Translation:Animals
    12. Lloyd EE, Pandit LM, Crossland RF, Marrelli SP, Bryan RM. Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice. Am J Physiol Regul Integr Comp Physiol. 2013 Jul 01; 305(1):R60-7. PMID: 23637138; PMCID: PMC3727024.
      Citations: 6     Fields:    Translation:Animals
    13. Durgan DJ, Bryan RM. Cerebrovascular consequences of obstructive sleep apnea. J Am Heart Assoc. 2012 Aug; 1(4):e000091. PMID: 23130152; PMCID: PMC3487354.
      Citations: 57     Fields:    
    14. Bryan RM. It matters how you slice it. J Physiol. 2012 Jun 01; 590(11):2547. PMID: 22787165; PMCID: PMC3424710.
      Citations:    Fields:    Translation:Animals
    15. Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM. Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension. 2011 Oct; 58(4):672-8. PMID: 21876070; PMCID: PMC3205080.
      Citations: 20     Fields:    Translation:Animals
    16. Bryan RM, Marrelli SP. Endothelium-dependent hyperpolarization: out of the dish and into the brain. J Cereb Blood Flow Metab. 2011 May; 31(5):1173-4. PMID: 21179071; PMCID: PMC3099633.
      Citations:    
    17. Namiranian K, Brink CD, Goodman JC, Robertson CS, Bryan RM. Traumatic brain injury in mice lacking the K channel, TREK-1. J Cereb Blood Flow Metab. 2011 Mar; 31(3):e1-6. PMID: 21157470; PMCID: PMC3063636.
      Citations: 7     Fields:    Translation:AnimalsCells
    18. Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Am J Physiol Regul Integr Comp Physiol. 2010 Aug; 299(2):R461-9. PMID: 20357027; PMCID: PMC2928619.
      Citations: 18     Fields:    Translation:AnimalsCells
    19. Lloyd EE, Marrelli SP, Namiranian K, Bryan RM. Characterization of TWIK-2, a two-pore domain K+ channel, cloned from the rat middle cerebral artery. Exp Biol Med (Maywood). 2009 Dec; 234(12):1493-502. PMID: 19934370; PMCID: PMC2847578.
      Citations:    
    20. Lloyd EE, Marrelli SP, Bryan RM. cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle. Am J Physiol Heart Circ Physiol. 2009 Jun; 296(6):H1774-80. PMID: 19363137; PMCID: PMC2716098.
      Citations:    
    21. Marrelli SP, O'neil RG, Brown RC, Bryan RM. PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1390-7. PMID: 17071727.
      Citations:    
    22. Bryan RM, You J, Phillips SC, Andresen JJ, Lloyd EE, Rogers PA, Dryer SE, Marrelli SP. Evidence for two-pore domain potassium channels in rat cerebral arteries. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H770-80. PMID: 16565299.
      Citations: 27     Fields:    Translation:Animals
    23. Andresen JJ, Shafi NI, Durante W, Bryan RM. Effects of carbon monoxide and heme oxygenase inhibitors in cerebral vessels of rats and mice. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H223-30. PMID: 16489113.
      Citations:    
    24. Andresen J, Shafi NI, Bryan RM. Endothelial influences on cerebrovascular tone. J Appl Physiol (1985). 2006 Jan; 100(1):318-27. PMID: 16357085.
      Citations:    
    25. Jiang X, Yang F, Tan H, Liao D, Bryan RM, Randhawa JK, Rumbaut RE, Durante W, Schafer AI, Yang X, Wang H. Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2515-21. PMID: 16210565; PMCID: PMC4400833.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    26. Bryan RM, You J, Golding EM, Marrelli SP. Endothelium-derived hyperpolarizing factor: a cousin to nitric oxide and prostacyclin. Anesthesiology. 2005 Jun; 102(6):1261-77. PMID: 15915041.
      Citations:    
    27. You J, Golding EM, Bryan RM. Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1077-83. PMID: 15863454.
      Citations:    
    28. Golding EM, Robertson CS, Fitch JC, Goodman JC, Bryan RM. Segmental vascular resistance after mild controlled cortical impact injury in the rat. J Cereb Blood Flow Metab. 2003 Feb; 23(2):210-8. PMID: 12571452.
      Citations: 6     Fields:    Translation:Animals
    29. Schildmeyer LA, Bryan RM. Effect of NO on EDHF response in rat middle cerebral arteries. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H734-8. PMID: 11788424.
      Citations: 4     Fields:    Translation:Animals
    30. Bryan RM, Marrelli SP, Steenberg ML, Schildmeyer LA, Johnson TD. Effects of luminal shear stress on cerebral arteries and arterioles. Am J Physiol Heart Circ Physiol. 2001 May; 280(5):H2011-22. PMID: 11299201.
      Citations: 28     Fields:    Translation:Animals
    31. Golding EM, Steenberg ML, Johnson TD, Bryan RM. Nitric oxide in the potassium-induced response of the rat middle cerebral artery: a possible permissive role. Brain Res. 2001 Jan 19; 889(1-2):98-104. PMID: 11166692.
      Citations: 5     Fields:    Translation:Animals
    32. You J, Edvinsson L, Bryan RM. Neuropeptide Y-mediated constriction and dilation in rat middle cerebral arteries. J Cereb Blood Flow Metab. 2001 Jan; 21(1):77-84. PMID: 11149671.
      Citations: 14     Fields:    Translation:Animals
    33. Golding EM, Steenberg ML, Johnson TD, Bryan RM. The effects of potassium on the rat middle cerebral artery. Brain Res. 2000 Oct 13; 880(1-2):159-66. PMID: 11033000.
      Citations: 4     Fields:    Translation:Animals
    34. Golding EM, Robertson CS, Bryan RM. L-arginine partially restores the diminished CO2 reactivity after mild controlled cortical impact injury in the adult rat. J Cereb Blood Flow Metab. 2000 May; 20(5):820-8. PMID: 10826532.
      Citations: 2     Fields:    Translation:Animals
    35. Giri BK, Krishnappa IK, Bryan RM, Robertson C, Watson J. Regional cerebral blood flow after cortical impact injury complicated by a secondary insult in rats. Stroke. 2000 Apr; 31(4):961-7. PMID: 10754006.
      Citations: 15     Fields:    Translation:Animals
    36. Hirschfield W, Moody MR, O'Brien WE, Gregg AR, Bryan RM, Reid MB. Nitric oxide release and contractile properties of skeletal muscles from mice deficient in type III NOS. Am J Physiol Regul Integr Comp Physiol. 2000 Jan; 278(1):R95-R100. PMID: 10644626.
      Citations: 21     Fields:    Translation:Animals
    37. Golding EM, Steenberg ML, Contant CF, Krishnappa I, Robertson CS, Bryan RM. Cerebrovascular reactivity to CO(2) and hypotension after mild cortical impact injury. Am J Physiol. 1999 10; 277(4):H1457-66. PMID: 10516183.
      Citations: 20     Fields:    Translation:Animals
    38. You J, Johnson TD, Marrelli SP, Bryan RM. Functional heterogeneity of endothelial P2 purinoceptors in the cerebrovascular tree of the rat. Am J Physiol. 1999 09; 277(3):H893-900. PMID: 10484408.
      Citations: 31     Fields:    Translation:AnimalsCells
    39. You J, Johnson TD, Marrelli SP, Mombouli JV, Bryan RM. P2u receptor-mediated release of endothelium-derived relaxing factor/nitric oxide and endothelium-derived hyperpolarizing factor from cerebrovascular endothelium in rats. Stroke. 1999 May; 30(5):1125-33. PMID: 10229754.
      Citations: 22     Fields:    Translation:Animals
    40. Golding EM, Robertson CS, Bryan RM. The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin Exp Hypertens. 1999 May; 21(4):299-332. PMID: 10369378.
      Citations: 36     Fields:    Translation:HumansAnimals
    41. Marrelli SP, Khorovets A, Johnson TD, Childres WF, Bryan RM. P2 purinoceptor-mediated dilations in the rat middle cerebral artery after ischemia-reperfusion. Am J Physiol. 1999 01; 276(1):H33-41. PMID: 9887014.
      Citations: 28     Fields:    Translation:Animals
    42. Golding EM, Contant CF, Robertson CS, Bryan RM. Temporal effect of severe controlled cortical impact injury in the rat on the myogenic response of the middle cerebral artery. J Neurotrauma. 1998 Nov; 15(11):973-84. PMID: 9840770.
      Citations: 7     Fields:    Translation:Animals
    43. Golding EM, Steenberg ML, Cherian L, Marrelli SP, Robertson CS, Bryan RM. Endothelial-mediated dilations following severe controlled cortical impact injury in the rat middle cerebral artery. J Neurotrauma. 1998 Aug; 15(8):635-44. PMID: 9726262.
      Citations: 2     Fields:    Translation:Animals
    44. Marrelli SP, Johnson TD, Khorovets A, Childres WF, Bryan RM. Altered function of inward rectifier potassium channels in cerebrovascular smooth muscle after ischemia/reperfusion. Stroke. 1998 Jul; 29(7):1469-74. PMID: 9660405.
      Citations: 22     Fields:    Translation:Animals
    45. Swafford MW, Raty S, Childres WF, Bryan RM. Effect of decreased glucose concentration on cerebrovascular tone in vitro. J Cereb Blood Flow Metab. 1998 Apr; 18(4):391-5. PMID: 9538904.
      Citations: 1     Fields:    Translation:Animals
    46. Golding EM, Robertson CS, Bryan RM. Comparison of the myogenic response in rat cerebral arteries of different calibers. Brain Res. 1998 Mar 02; 785(2):293-8. PMID: 9518656.
      Citations: 16     Fields:    Translation:Animals
    47. Johnson TD, Marrelli SP, Steenberg ML, Childres WF, Bryan RM. Inward rectifier potassium channels in the rat middle cerebral artery. Am J Physiol. 1998 02; 274(2):R541-7. PMID: 9486315.
      Citations: 13     Fields:    Translation:Animals
    48. You J, Johnson TD, Childres WF, Bryan RM. Endothelial-mediated dilations of rat middle cerebral arteries by ATP and ADP. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1472-7. PMID: 9321839.
      Citations: 29     Fields:    Translation:Animals
    49. Ignacio CS, Curling PE, Childres WF, Bryan RM. Nitric oxide-synthesizing perivascular nerves in the rat middle cerebral artery. Am J Physiol. 1997 Aug; 273(2 Pt 2):R661-8. PMID: 9277552.
      Citations: 6     Fields:    Translation:Animals
    50. Bryan RM, Eichler MY, Swafford MW, Johnson TD, Suresh MS, Childres WF. Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery. Anesthesiology. 1996 Jul; 85(1):82-90. PMID: 8694386.
      Citations: 10     Fields:    Translation:Animals
    51. Johnson TD, Childres WF, Bryan RM. The in vitro action of polyamines on rat basilar and femoral artery contractile activity. Life Sci. 1996; 59(7):529-36. PMID: 8761341.
      Citations:    Fields:    Translation:Animals
    52. Bryan RM, Steenberg ML, Eichler MY, Johnson TD, Swafford MW, Suresh MS. Permissive role of NO in alpha 2-adrenoceptor-mediated dilations in rat cerebral arteries. Am J Physiol. 1995 Sep; 269(3 Pt 2):H1171-4. PMID: 7573514.
      Citations: 2     Fields:    Translation:Animals
    53. Bryan RM, Duckrow RB. Radial columns in autoradiographs generated from tracer methods for measuring cerebral cortical blood flow. Am J Physiol. 1995 Aug; 269(2 Pt 2):H583-9. PMID: 7653622.
      Citations:    Fields:    Translation:Animals
    54. Bryan RM, Cherian L, Robertson C. Regional cerebral blood flow after controlled cortical impact injury in rats. Anesth Analg. 1995 Apr; 80(4):687-95. PMID: 7893019.
      Citations: 27     Fields:    Translation:Animals
    55. Bryan RM, Eichler MY, Johnson TD, Woodward WT, Williams JL. Cerebral blood flow, plasma catecholamines, and electroencephalogram during hypoglycemia and recovery after glucose infusion. J Neurosurg Anesthesiol. 1994 Jan; 6(1):24-34. PMID: 8298261.
      Citations: 3     Fields:    Translation:Animals
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