Loading...
Header Logo
Keywords
Last Name
Institution

ROBERT M BRYAN JR

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Anesthesiology
DivisionAnesthesiology
vCardDownload vCard
    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Cardiovascular Science

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics


    Collapse ORNG Applications 
    Collapse Aliases
    Collapse Verify Publications

    Collapse Research 
    Collapse research activities and funding
    R23NS019341     (BRYAN, ROBERT M)Jul 1, 1984 - Jun 30, 1987
    NIH/NINDS
    CEREBRAL GLUCOSE UTILIZATION DURING STRESS
    Role: Principal Investigator

    R01NS024109     (DUCKROW, ROBERT B)Jul 1, 1986 - Mar 31, 1994
    NIH/NINDS
    CEREBRAL BLOOD FLOW DURING HYPERGLYCEMIA
    Role: Co-Principal Investigator

    R01HL041960     (BRYAN, ROBERT M)Jul 1, 1990 - Jun 30, 1994
    NIH/NHLBI
    BLOOD FLOW AND ENERGY METABOLISM IN THE NEUROHYPOPHYSIS
    Role: Principal Investigator

    R01NS037250     (BRYAN, ROBERT M)Dec 15, 1997 - Nov 30, 2001
    NIH/NINDS
    FLOW INDUCED DILATIONS IN CEREBRAL VESSELS
    Role: Principal Investigator

    R01NS046666     (BRYAN, ROBERT M)Dec 1, 2004 - Nov 30, 2010
    NIH/NINDS
    EDHF in the Cerebral Circulation
    Role: Principal Investigator

    R21HL098921     (BRYAN, ROBERT M)Feb 1, 2010 - Jan 31, 2012
    NIH/NHLBI
    Function of Two-Pore Domain K Channels in Vascular Smooth Muscle
    Role: Principal Investigator

    R21HL102778     (BRYAN, ROBERT M)Jul 1, 2010 - Jun 30, 2012
    NIH/NHLBI
    Cerebrovascular Consequences of Sleep Apnea
    Role: Principal Investigator

    R01NS080531     (BRYAN, ROBERT M)May 1, 2012 - Feb 28, 2017
    NIH/NINDS
    Effects of obstructive sleep apnea on cerebral circulation
    Role: Principal Investigator

    R21NS078773     (BRYAN, ROBERT M)Jul 1, 2012 - Jun 30, 2014
    NIH/NINDS
    Control of Cerebral Blood Flow by KCa2 and KCa3
    Role: Principal Investigator

    R21NS094806     (BRYAN, ROBERT M)Sep 1, 2015 - Aug 31, 2017
    NIH/NINDS
    Cerebral small vessel disease, obstructive sleep apnea, and the gastrointestinal system
    Role: Principal Investigator

    R56NS102594     (BRYAN, ROBERT M)Aug 1, 2017 - Jul 31, 2018
    NIH/NINDS
    Gut Dysbiosis and Cerebral Small Vessel Disease
    Role: Principal Investigator

    RF1AG058463     (MCCULLOUGH, LOUISE D)Sep 15, 2017 - Jun 30, 2022
    NIH/NIA
    Dynamic Non-Neuronal Interactions between the Gut Microbiota and the Brain in Aging and in Cerebral Amyloid Angiopathy
    Role: Co-Principal Investigator

    R01NS103592     (MCCULLOUGH, LOUISE D.)Apr 1, 2018 - Mar 31, 2023
    NIH/NINDS
    Detrimental Effects of Age Related Dysbiosis
    Role: Co-Principal Investigator

    R01NS102594     (BRYAN, ROBERT M)Aug 1, 2018 - Jul 31, 2022
    NIH/NINDS
    Gut Dysbiosis and Cerebral Small Vessel Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Durgan DJ, Lee J, McCullough LD, Bryan RM. Examining the Role of the Microbiota-Gut-Brain Axis in Stroke. Stroke. 2019 Aug; 50(8):2270-2277. PMID: 31272315.
      View in: PubMed
    2. Abbasgholizadeh R, Zhang H, Craft JW, Bryan RM, Bark SJ, Briggs JM, Fox RO, Agarkov A, Zimmer WE, Gilbertson SR, Schwartz RJ. Feature article: Discovery of vascular Rho kinase (ROCK) inhibitory peptides. Exp Biol Med (Maywood). 2019 Aug; 244(11):940-951. PMID: 31132884.
      View in: PubMed
    3. Kitagawa MG, Reynolds JO, Durgan D, Rodney G, Karmouty-Quintana H, Bryan R, Pandit LM. Twik-2-/- mouse demonstrates pulmonary vascular heterogeneity in intracellular pathways for vasocontractility. Physiol Rep. 2019 Jan; 7(1):e13950. PMID: 30632293.
      View in: PubMed
    4. Ganesh BP, Nelson JW, Eskew JR, Ganesan A, Ajami NJ, Petrosino JF, Bryan RM, Durgan DJ. Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea. Hypertension. 2018 11; 72(5):1141-1150. PMID: 30354816.
      View in: PubMed
    5. Spychala MS, Venna VR, Jandzinski M, Doran SJ, Durgan DJ, Ganesh BP, Ajami NJ, Putluri N, Graf J, Bryan RM, McCullough LD. Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome. Ann Neurol. 2018 07; 84(1):23-36. PMID: 29733457.
      View in: PubMed
    6. Madry C, Kyrargyri V, Arancibia-Cárcamo IL, Jolivet R, Kohsaka S, Bryan RM, Attwell D. Microglial Ramification, Surveillance, and Interleukin-1ß Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 2018 01 17; 97(2):299-312.e6. PMID: 29290552.
      View in: PubMed
    7. Kitagawa MG, Reynolds JO, Wehrens XHT, Bryan RM, Pandit LM. Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension. Front Med (Lausanne). 2017; 4:177. PMID: 29109948.
      View in: PubMed
    8. Adnan S, Nelson JW, Ajami NJ, Venna VR, Petrosino JF, Bryan RM, Durgan DJ. Alterations in the gut microbiota can elicit hypertension in rats. Physiol Genomics. 2017 02 01; 49(2):96-104. PMID: 28011881.
      View in: PubMed
    9. Du Y, Kiyoshi CM, Wang Q, Wang W, Ma B, Alford CC, Zhong S, Wan Q, Chen H, Lloyd EE, Bryan RM, Zhou M. Genetic Deletion of TREK-1 or TWIK-1/TREK-1 Potassium Channels does not Alter the Basic Electrophysiological Properties of Mature Hippocampal Astrocytes In Situ. Front Cell Neurosci. 2016; 10:13. PMID: 26869883.
      View in: PubMed
    10. Durgan DJ, Crossland RF, Bryan RM. The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea. J Cereb Blood Flow Metab. 2017 Aug; 37(8):2806-2819. PMID: 27798273.
      View in: PubMed
    11. Durgan DJ, Ganesh BP, Cope JL, Ajami NJ, Phillips SC, Petrosino JF, Hollister EB, Bryan RM. Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension. Hypertension. 2016 Feb; 67(2):469-74. PMID: 26711739.
      View in: PubMed
    12. Lloyd EE, Durgan DJ, Martini SR, Bryan RM. Pathological effects of obstructive apneas during the sleep cycle in an animal model of cerebral small vessel disease. Hypertension. 2015 Oct; 66(4):913-7. PMID: 26259594.
      View in: PubMed
    13. Durgan DJ, Crossland RF, Lloyd EE, Phillips SC, Bryan RM. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab. 2015 Mar; 35(3):402-11. PMID: 25425077.
      View in: PubMed
    14. Schwingshackl A, Teng B, Makena P, Ghosh M, Sinclair SE, Luellen C, Balasz L, Rovnaghi C, Bryan RM, Lloyd EE, Fitzpatrick E, Saravia JS, Cormier SA, Waters CM. Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury. Crit Care Med. 2014 Nov; 42(11):e692-701. PMID: 25126877.
      View in: PubMed
    15. Pandit LM, Lloyd EE, Reynolds JO, Lawrence WS, Reynolds C, Wehrens XH, Bryan RM. TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process. Hypertension. 2014 Dec; 64(6):1260-5. PMID: 25245387.
      View in: PubMed
    16. Nielsen G, Wandall-Frostholm C, Sadda V, Oliván-Viguera A, Lloyd EE, Bryan RM, Simonsen U, Köhler R. Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. Basic Clin Pharmacol Toxicol. 2013 Oct; 113(4):250-8. PMID: 23724868.
      View in: PubMed
    17. Durgan DJ, Bryan RM. The same but different. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1485. PMID: 23778165.
      View in: PubMed
    18. Crossland RF, Durgan DJ, Lloyd EE, Phillips SC, Reddy AK, Marrelli SP, Bryan RM. A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15; 305(4):R334-42. PMID: 23761641.
      View in: PubMed
    19. Lloyd EE, Pandit LM, Crossland RF, Marrelli SP, Bryan RM. Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice. Am J Physiol Regul Integr Comp Physiol. 2013 Jul 01; 305(1):R60-7. PMID: 23637138.
      View in: PubMed
    20. Ford KJ, Arroyo DA, Kay JN, Lloyd EE, Bryan RM, Sanes JR, Feller MB. A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells. J Neurophysiol. 2013 May; 109(9):2250-9. PMID: 23390312.
      View in: PubMed
    21. Durgan DJ, Bryan RM. Cerebrovascular consequences of obstructive sleep apnea. J Am Heart Assoc. 2012 Aug; 1(4):e000091. PMID: 23130152.
      View in: PubMed
    22. Bryan RM. It matters how you slice it. J Physiol. 2012 Jun 01; 590(11):2547. PMID: 22787165.
      View in: PubMed
    23. Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM. Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension. 2011 Oct; 58(4):672-8. PMID: 21876070.
      View in: PubMed
    24. Bryan RM, Marrelli SP. Endothelium-dependent hyperpolarization: out of the dish and into the brain. J Cereb Blood Flow Metab. 2011 May; 31(5):1173-4. PMID: 21179071.
      View in: PubMed
    25. Namiranian K, Brink CD, Goodman JC, Robertson CS, Bryan RM. Traumatic brain injury in mice lacking the K channel, TREK-1. J Cereb Blood Flow Metab. 2011 Mar; 31(3):e1-6. PMID: 21157470.
      View in: PubMed
    26. Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Am J Physiol Regul Integr Comp Physiol. 2010 Aug; 299(2):R461-9. PMID: 20357027.
      View in: PubMed
    27. Parelkar NK, Silswal N, Jansen K, Vaughn J, Bryan RM, Andresen J. 2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery. J Pharmacol Exp Ther. 2010 Mar; 332(3):803-10. PMID: 19955488.
      View in: PubMed
    28. Lloyd EE, Marrelli SP, Namiranian K, Bryan RM. Characterization of TWIK-2, a two-pore domain K+ channel, cloned from the rat middle cerebral artery. Exp Biol Med (Maywood). 2009 Dec; 234(12):1493-502. PMID: 19934370.
      View in: PubMed
    29. Lloyd EE, Marrelli SP, Bryan RM. cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle. Am J Physiol Heart Circ Physiol. 2009 Jun; 296(6):H1774-80. PMID: 19363137.
      View in: PubMed
    30. Shafi NI, Andresen J, Marrelli SP, Bryan RM. Erythropoietin potentiates EDHF-mediated dilations in rat middle cerebral arteries. J Neurotrauma. 2008 Mar; 25(3):257-65. PMID: 18352839.
      View in: PubMed
    31. Bryan RM, Joseph BK, Lloyd E, Rusch NJ. Starring TREK-1: the next generation of vascular K+ channels. Circ Res. 2007 Jul 20; 101(2):119-21. PMID: 17641234.
      View in: PubMed
    32. Marrelli SP, O'neil RG, Brown RC, Bryan RM. PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1390-7. PMID: 17071727.
      View in: PubMed
    33. Rogers PA, Chilian WM, Bratz IN, Bryan RM, Dick GM. H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1404-11. PMID: 17071731.
      View in: PubMed
    34. Prisby RD, Wilkerson MK, Sokoya EM, Bryan RM, Wilson E, Delp MD. Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms. J Appl Physiol (1985). 2006 Jul; 101(1):348-53. PMID: 16627679.
      View in: PubMed
    35. Bryan RM, You J, Phillips SC, Andresen JJ, Lloyd EE, Rogers PA, Dryer SE, Marrelli SP. Evidence for two-pore domain potassium channels in rat cerebral arteries. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H770-80. PMID: 16565299.
      View in: PubMed
    36. Andresen JJ, Shafi NI, Durante W, Bryan RM. Effects of carbon monoxide and heme oxygenase inhibitors in cerebral vessels of rats and mice. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H223-30. PMID: 16489113.
      View in: PubMed
    37. Andresen J, Shafi NI, Bryan RM. Endothelial influences on cerebrovascular tone. J Appl Physiol (1985). 2006 Jan; 100(1):318-27. PMID: 16357085.
      View in: PubMed
    38. Jiang X, Yang F, Tan H, Liao D, Bryan RM, Randhawa JK, Rumbaut RE, Durante W, Schafer AI, Yang X, Wang H. Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2515-21. PMID: 16210565.
      View in: PubMed
    39. Bryan RM, You J, Golding EM, Marrelli SP. Endothelium-derived hyperpolarizing factor: a cousin to nitric oxide and prostacyclin. Anesthesiology. 2005 Jun; 102(6):1261-77. PMID: 15915041.
      View in: PubMed
    40. You J, Golding EM, Bryan RM. Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1077-83. PMID: 15863454.
      View in: PubMed
    41. Yang J, Clark JW, Bryan RM, Robertson CS. Mathematical modeling of the nitric oxide/cGMP pathway in the vascular smooth muscle cell. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H886-97. PMID: 15833804.
      View in: PubMed
    42. Wilkerson MK, Lesniewski LA, Golding EM, Bryan RM, Amin A, Wilson E, Delp MD. Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1652-61. PMID: 15576439.
      View in: PubMed
    43. Yang J, Clark JW, Bryan RM, Robertson C. The myogenic response in isolated rat cerebrovascular arteries: smooth muscle cell model. Med Eng Phys. 2003 Oct; 25(8):691-709. PMID: 12900184.
      View in: PubMed
    44. Yang J, Clark JW, Bryan RM, Robertson CS. The myogenic response in isolated rat cerebrovascular arteries: vessel model. Med Eng Phys. 2003 Oct; 25(8):711-7. PMID: 12900185.
      View in: PubMed
    45. Golding EM, Robertson CS, Fitch JC, Goodman JC, Bryan RM. Segmental vascular resistance after mild controlled cortical impact injury in the rat. J Cereb Blood Flow Metab. 2003 Feb; 23(2):210-8. PMID: 12571452.
      View in: PubMed
    46. You J, Marrelli SP, Bryan RM. Role of cytoplasmic phospholipase A2 in endothelium-derived hyperpolarizing factor dilations of rat middle cerebral arteries. J Cereb Blood Flow Metab. 2002 10; 22(10):1239-47. PMID: 12368663.
      View in: PubMed
    47. Golding EM, Marrelli SP, You J, Bryan RM. Endothelium-derived hyperpolarizing factor in the brain: a new regulator of cerebral blood flow? Stroke. 2002 Mar; 33(3):661-3. PMID: 11872883.
      View in: PubMed
    48. Schildmeyer LA, Bryan RM. Effect of NO on EDHF response in rat middle cerebral arteries. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H734-8. PMID: 11788424.
      View in: PubMed
    BRYAN's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description