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KAZUHIRO OKA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology


    Collapse Research 
    Collapse research activities and funding
    R01HL073144     (OKA, KAZUHIRO)Jul 1, 2003 - Jun 30, 2008
    NIH
    Novel Gene Therapy using Helper-Dependent Adenovirus
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ohashi K, Matsue Y, Maeda D, Fujimoto Y, Kagiyama N, Sunayama T, Dotare T, Jujo K, Saito K, Kamiya K, Saito H, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Wada H, Hiki M, Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S, Aizawa N, Wakaume K, Oka K, Momomura SI, Minamino T. Impact of Multidomain Frailty on the Mode of Death in Older Patients With Heart Failure: A Cohort Study. Circ Cardiovasc Qual Outcomes. 2024 Mar 26; e010416. PMID: 38529634.
      Citations:    Fields:    
    2. Kulkarni AA, Seal AG, Sonnet C, Oka K. Streamlined Adeno-Associated Virus Production Using Suspension HEK293T Cells. Bio Protoc. 2024 Feb 05; 14(3):e4931. PMID: 38379831; PMCID: PMC10875358.
      Citations:    
    3. Henrickson A, Ding X, Seal AG, Qu Z, Tomlinson L, Forsey J, Gradinaru V, Oka K, Demeler B. Characterization and quantification of adeno-associated virus capsid-loading states by multi-wavelength analytical ultracentrifugation with UltraScan. Nanomedicine (Lond). 2023 Sep; 18(22):1519-1534. PMID: 37877696; PMCID: PMC10652292.
      Citations:    Fields:    Translation:Cells
    4. Maeda D, Matsue Y, Kagiyama N, Jujo K, Saito K, Kamiya K, Saito H, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Wada H, Hiki M, Dotare T, Sunayama T, Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S, Aizawa N, Wakaume K, Oka K, Momomura SI, Minamino T. Sex differences in the prevalence and prognostic impact of physical frailty and sarcopenia among older patients with heart failure. Nutr Metab Cardiovasc Dis. 2022 Feb; 32(2):365-372. PMID: 34893406.
      Citations:    Fields:    Translation:Humans
    5. Deng S, Oka K. Adeno-Associated Virus as Gene Delivery Vehicle into the Retina. Methods Mol Biol. 2020; 2092:77-90. PMID: 31786783.
      Citations: 1     Fields:    Translation:HumansCells
    6. Ogawa N, Terashima T, Oka K, Chan L, Kojima H. Gene therapy for neuropathic pain using dorsal root ganglion-targeted helper-dependent adenoviral vectors with GAD67 expression. Pain Rep. 2018 Nov; 3(6):e695. PMID: 30706038; PMCID: PMC6344132.
      Citations: 4     
    7. Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Bensinger SJ, Chan L, Tontonoz P, Diaz M, Castrillo A. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326. PMID: 28002731; PMCID: PMC5181791.
      Citations: 43     Fields:    Translation:AnimalsCells
    8. Chen Q, Takahashi Y, Oka K, Ma JX. Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling. Mol Cell Biol. 2016 10 15; 36(20):2645-54. PMID: 27528615; PMCID: PMC5038150.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    9. Son SH, Goo YH, Choi M, Saha PK, Oka K, Chan LC, Paul A. Enhanced atheroprotection and lesion remodelling by targeting the foam cell and increasing plasma cholesterol acceptors. Cardiovasc Res. 2016 Feb 01; 109(2):294-304. PMID: 26487692; PMCID: PMC4724936.
      Citations: 13     Fields:    Translation:AnimalsCells
    10. Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V. Erratum. PD-L1-Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice. Diabetes 2015;64:529-540. Diabetes. 2015 Jul; 64(7):2685. PMID: 26106199; PMCID: PMC4877680.
      Citations:    Fields:    
    11. Willecke F, Yuan C, Oka K, Chan L, Hu Y, Barnhart S, Bornfeldt KE, Goldberg IJ, Fisher EA. Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice. PLoS One. 2015; 10(6):e0128996. PMID: 26046657; PMCID: PMC4457481.
      Citations: 21     Fields:    Translation:AnimalsCells
    12. Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V. PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice. Diabetes. 2015 Feb; 64(2):529-40. PMID: 25332429; PMCID: PMC4303975.
      Citations: 11     Fields:    Translation:AnimalsCells
    13. Hopkins J, Hwang G, Jacob J, Sapp N, Bedigian R, Oka K, Overbeek P, Murray S, Jordan PW. Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes. PLoS Genet. 2014 Jul; 10(7):e1004413. PMID: 24992337; PMCID: PMC4081007.
      Citations: 60     Fields:    Translation:AnimalsCells
    14. Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H. Gene therapy for neuropathic pain by silencing of TNF-a expression with lentiviral vectors targeting the dorsal root ganglion in mice. PLoS One. 2014; 9(3):e92073. PMID: 24642694; PMCID: PMC3958473.
      Citations: 27     Fields:    Translation:AnimalsCells
    15. Caburet S, Arboleda VA, Llano E, Overbeek PA, Barbero JL, Oka K, Harrison W, Vaiman D, Ben-Neriah Z, Garc?a-Tu??n I, Fellous M, Pend?s AM, Veitia RA, Vilain E. Mutant cohesin in premature ovarian failure. N Engl J Med. 2014 Mar 06; 370(10):943-949. PMID: 24597867; PMCID: PMC4068824.
      Citations: 101     Fields:    Translation:HumansAnimals
    16. Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H. Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. Nat Commun. 2013; 4:1526. PMID: 23443554; PMCID: PMC3640364.
      Citations: 8     Fields:    Translation:AnimalsCells
    17. Li R, Oka K, Yechoor V. Neo-islet formation in liver of diabetic mice by helper-dependent adenoviral vector-mediated gene transfer. J Vis Exp. 2012 Oct 10; (68). PMID: 23093064; PMCID: PMC3490299.
      Citations:    Fields:    Translation:AnimalsCells
    18. Ali YO, Zhu J, Wu CS, Oka K, Zhai RG, Lu HC, Ljungberg MC. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet. 2012 Jan 15; 21(2):251-67. PMID: 22027994; PMCID: PMC3276285.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    19. Li R, Chao H, Ko KW, Cormier S, Dieker C, Nour EA, Wang S, Chan L, Oka K. Gene Therapy Targeting LDL Cholesterol but not HDL Cholesterol Induces Regression of Advanced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia. J Genet Syndr Gene Ther. 2011 Sep 28; 2:106. PMID: 23106034; PMCID: PMC3480198.
      Citations: 13     
    20. Li R, Paul A, Ko KW, Sheldon M, Rich BE, Terashima T, Dieker C, Cormier S, Li L, Nour EA, Chan L, Oka K. Interleukin-7 induces recruitment of monocytes/macrophages to endothelium. Eur Heart J. 2012 Dec; 33(24):3114-23. PMID: 21804111; PMCID: PMC3598429.
      Citations: 22     Fields:    Translation:AnimalsCells
    21. Hu Y, Ren X, Wang H, Ma Y, Wang L, Shen Y, Oka K, Zhang Z, Zhang Y. Liver-specific expression of an exogenous gene controlled by human apolipoprotein A-I promoter. Int J Pharm. 2010 Oct 15; 398(1-2):161-4. PMID: 20656001.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    22. Moulik M, Vatta M, Witt SH, Arola AM, Murphy RT, McKenna WJ, Boriek AM, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA. ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 2009 Jul 21; 54(4):325-33. PMID: 19608030; PMCID: PMC2915893.
      Citations: 60     Fields:    Translation:HumansCells
    23. Terashima T, Oka K, Kritz AB, Kojima H, Baker AH, Chan L. DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. J Clin Invest. 2009 Jul; 119(7):2100-112. PMID: 19603551; PMCID: PMC2701884.
      Citations: 20     Fields:    Translation:AnimalsCells
    24. Sakai K, Tiebel O, Ljungberg MC, Sullivan M, Lee HJ, Terashima T, Li R, Kobayashi K, Lu HC, Chan L, Oka K. A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins. Brain Res. 2009 Jun 18; 1276:11-21. PMID: 19393635; PMCID: PMC2733343.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    25. Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Chan L, Oka K, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):843-9. PMID: 19286630; PMCID: PMC2761013.
      Citations: 62     Fields:    Translation:AnimalsCells
    26. Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell. 2009 Mar; 16(3):358-73. PMID: 19289082; PMCID: PMC2676438.
      Citations: 86     Fields:    Translation:AnimalsCells
    27. Samson SL, Gonzalez EV, Yechoor V, Bajaj M, Oka K, Chan L. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 11; 16(11):1805-12. PMID: 18781141; PMCID: PMC2582376.
      Citations: 18     Fields:    Translation:AnimalsCells
    28. Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW, Bornfeldt KE. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2082-7. PMID: 18252823; PMCID: PMC2538884.
      Citations: 53     Fields:    Translation:AnimalsCells
    29. MacDougall ED, Kramer F, Polinsky P, Barnhart S, Askari B, Johansson F, Varon R, Rosenfeld ME, Oka K, Chan L, Schwartz SM, Bornfeldt KE. Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice. Am J Pathol. 2006 Jun; 168(6):2064-73. PMID: 16723719; PMCID: PMC1606621.
      Citations: 20     Fields:    Translation:AnimalsCells
    30. Johnson JL, Baker AH, Oka K, Chan L, Newby AC, Jackson CL, George SJ. Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis. Circulation. 2006 May 23; 113(20):2435-44. PMID: 16702468.
      Citations: 49     Fields:    Translation:AnimalsCells
    31. Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY. Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res. 2006 Apr 28; 98(8):1032-9. PMID: 16556868; PMCID: PMC1450325.
      Citations: 91     Fields:    Translation:HumansCells
    32. Oka K, Chan L. Helper-dependent adenoviral vectors. Curr Protoc Hum Genet. 2005 Nov; Chapter 12:Unit 12.13. PMID: 18428374.
      Citations: 1     Fields:    Translation:HumansCells
    33. Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L, O'Malley BW. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13789-94. PMID: 16162668; PMCID: PMC1236585.
      Citations: 22     Fields:    Translation:AnimalsCells
    34. Oka K, Chan L. Inhibition and regression of atherosclerotic lesions. Acta Biochim Pol. 2005; 52(2):311-9. PMID: 15940346; PMCID: PMC1360606.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    35. Nuno-Gonzalez P, Chao H, Oka K. Targeting site-specific chromosome integration. Acta Biochim Pol. 2005; 52(2):285-91. PMID: 15940345; PMCID: PMC1360607.
      Citations:    Fields:    Translation:HumansAnimalsCells
    36. Oka K, Chan L. Helper-dependent adenoviral vectors. Curr Protoc Mol Biol. 2005 Feb; Chapter 16:Unit 16.24. PMID: 18265354.
      Citations:    Fields:    Translation:Cells
    37. Oka K, Chan L. Construction and characterization of helper-dependent adenoviral vectors for sustained in vivo gene therapy. Methods Mol Med. 2005; 108:329-50. PMID: 16028693.
      Citations: 2     Fields:    Translation:HumansCells
    38. Oka K, Chan L. Liver-directed gene therapy for dyslipidemia and diabetes. Curr Atheroscler Rep. 2004 May; 6(3):203-9. PMID: 15068745; PMCID: PMC1224746.
      Citations: 3     Fields:    Translation:Humans
    39. Pastore L, Belalcazar LM, Oka K, Cela R, Lee B, Chan L, Beaudet AL. Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice. Gene. 2004 Mar 03; 327(2):153-60. PMID: 14980712.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    40. Belalcazar LM, Merched A, Carr B, Oka K, Chen KH, Pastore L, Beaudet A, Chan L. Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia. Circulation. 2003 Jun 03; 107(21):2726-32. PMID: 12742997.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    41. Oka K, Chan L. Recent advances in liver-directed gene therapy for dyslipidemia. Curr Atheroscler Rep. 2002 May; 4(3):199-207. PMID: 11931717.
      Citations: 3     Fields:    Translation:Humans
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