TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, 77030
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    Other Positions
    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine

    Collapse Research 
    Collapse research activities and funding
    R01HD097321     (RICHARDS, JOANNE STEWART)Sep 1, 2019 - May 31, 2025
    Novel Aspect of Androgen Action in Ovarian Cell Function and Dysfunction
    Role: Principal Investigator

    R01CA181808     (RICHARDS, JOANNE S)Sep 8, 2014 - Aug 31, 2020
    Steroid Hormones Regulate Ovarian Cancer Progression and Metastasis
    Role: Principal Investigator

    R01HD076980     (RICHARDS, JOANNE S)May 15, 2014 - Apr 30, 2019
    Mechanisms Controlling Divergent Fates of Ovarian Follicles and Fertility
    Role: Principal Investigator

    R01HD016229     (RICHARDS, JOANNE S.)Mar 1, 1982 - Jun 30, 2014
    LH Action in Ovarian Cell Differentiation
    Role: Principal Investigator

    R56HD016229     (RICHARDS, JOANNE S.)Mar 1, 1982 - Jun 30, 2009
    LH Action in Ovarian Cell Differentiation
    Role: Principal Investigator

    R37HD016229     (RICHARDS, JOANNE S.)Mar 1, 1982 - Feb 28, 2009
    LH Action in Ovarian Cell Differentiation
    Role: Principal Investigator

    R01HD016272     (RICHARDS, JOANNE S.)Sep 1, 1981 - Apr 30, 2009
    Ovarian Follicular Developmental and Hormone Action
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Candelaria NR, Richards JS. Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome??. Biol Reprod. 2024 Apr 11; 110(4):782-797. PMID: 38224314; PMCID: PMC11017119.
      Citations:    Fields:    
    2. Kawai T, Richards JS, Shimada M. Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development. Commun Biol. 2021 11 25; 4(1):1334. PMID: 34824385; PMCID: PMC8617273.
      Citations: 1     Translation:AnimalsCells
    3. Richards JS, Candelaria NR, Lanz RB. Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy?. Biol Reprod. 2021 08 03; 105(2):305-316. PMID: 34037700; PMCID: PMC8335353.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Kun EHS, Tsang YTM, Lin S, Pan S, Medapalli T, Malpica A, Richards JS, Gershenson DM, Wong KK. Differences in gynecologic tumor development in Amhr2-Cre mice with KRASG12D or KRASG12V mutations. Sci Rep. 2020 11 26; 10(1):20678. PMID: 33244099; PMCID: PMC7693266.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Richards JS. WOMEN IN REPRODUCTIVE SCIENCE: Discovering science and the ovary: a career of joy. Reproduction. 2019 12; 158(6):F69-F80. PMID: 30780130; PMCID: PMC6675678.
      Citations:    Fields:    Translation:HumansAnimals
    6. Padmanabhan A, Kaushik M, Niranjan R, Richards JS, Ebright B, Venkatasubbu GD. Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status. Appl Surf Sci. 2019 Sep; 487:807-818. PMID: 32042215; PMCID: PMC7009796.
      Citations: 8     
    7. Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Phillips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Richards JS, Coll TF. S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight. 2019 07 02; 5. PMID: 31265437; PMCID: PMC6675546.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    8. Candelaria NR, Padmanabhan A, Stossi F, Ljungberg MC, Shelly KE, Pew BK, Solis M, Rossano AM, McAllister JM, Wu S, Richards JS. VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess. Endocrinology. 2019 06 01; 160(6):1377-1393. PMID: 30951142; PMCID: PMC6507908.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Umehara T, Kawai T, Goto M, Richards JS, Shimada M. Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm. Hum Reprod. 2018 06 01; 33(6):1117-1129. PMID: 29635630; PMCID: PMC5972610.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    10. Kawai T, Richards JS, Shimada M. The Cell Type-Specific Expression of Lhcgr in Mouse Ovarian Cells: Evidence for a DNA-Demethylation-Dependent Mechanism. Endocrinology. 2018 05 01; 159(5):2062-2074. PMID: 29579175; PMCID: PMC5905396.
      Citations: 8     Fields:    Translation:AnimalsCells
    11. Padmanabhan A, Candelaria N, Wong KK, Nikolai BC, Lonard DM, O'Malley BW, Richards JS. USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells. Nat Commun. 2018 03 28; 9(1):1270. PMID: 29593334; PMCID: PMC5871815.
      Citations: 32     Fields:    Translation:HumansCells
    12. Richards JS, Ascoli M. Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation. Trends Endocrinol Metab. 2018 05; 29(5):313-325. PMID: 29602523.
      Citations: 34     Fields:    Translation:HumansAnimals
    13. Akison LK, Robertson SA, Gonzalez MB, Richards JS, Smith CW, Russell DL, Robker RL. Regulation of the ovarian inflammatory response at ovulation by nuclear progesterone receptor. Am J Reprod Immunol. 2018 06; 79(6):e12835. PMID: 29484756.
      Citations: 7     Fields:    Translation:AnimalsCells
    14. Richards JS. The Ovarian Cycle. Vitam Horm. 2018; 107:1-25. PMID: 29544627.
      Citations: 7     Fields:    Translation:HumansAnimals
    15. Richards JS. From Follicular Development and Ovulation to Ovarian Cancers: An Unexpected Journey. Vitam Horm. 2018; 107:453-472. PMID: 29544640.
      Citations: 6     Fields:    Translation:HumansAnimals
    16. Richards JS, Ren YA, Candelaria N, Adams JE, Rajkovic A. Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update. Endocr Rev. 2018 02 01; 39(1):1-20. PMID: 29028960; PMCID: PMC5807095.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    17. Umehara T, Richards JS, Shimada M. The stromal fibrosis in aging ovary. Aging (Albany NY). 2018 Jan 19; 10(1):9-10. PMID: 29356685; PMCID: PMC5811253.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, Rosen JM. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017 11 20; 43(4):436-448.e6. PMID: 29103953; PMCID: PMC5698144.
      Citations: 17     Fields:    Translation:AnimalsCells
    19. Umehara T, Kawai T, Kawashima I, Tanaka K, Okuda S, Kitasaka H, Richards JS, Shimada M. The acceleration of reproductive aging in Nrg1flox/flox ;Cyp19-Cre female mice. Aging Cell. 2017 12; 16(6):1288-1299. PMID: 28857490; PMCID: PMC5676068.
      Citations: 14     Fields:    Translation:Animals
    20. Umehara T, Kawashima I, Kawai T, Hoshino Y, Morohashi KI, Shima Y, Zeng W, Richards JS, Shimada M. Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice. Endocrinology. 2016 Dec; 157(12):4899-4913. PMID: 27732090; PMCID: PMC5133346.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Adams J, Liu Z, Ren YA, Wun WS, Zhou W, Kenigsberg S, Librach C, Valdes C, Gibbons W, Richards J. Enhanced Inflammatory Transcriptome in the Granulosa Cells of Women With Polycystic Ovarian Syndrome. J Clin Endocrinol Metab. 2016 09; 101(9):3459-68. PMID: 27228368; PMCID: PMC5010574.
      Citations: 34     Fields:    Translation:HumansCells
    22. Kawai T, Yanaka N, Richards JS, Shimada M. De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility. Endocrinology. 2016 05; 157(5):2160-72. PMID: 27022678; PMCID: PMC4870881.
      Citations: 21     Fields:    Translation:AnimalsCells
    23. Ren YA, Mullany LK, Liu Z, Herron AJ, Wong KK, Richards JS. Mutant p53 Promotes Epithelial Ovarian Cancer by Regulating Tumor Differentiation, Metastasis, and Responsiveness to Steroid Hormones. Cancer Res. 2016 04 15; 76(8):2206-18. PMID: 26964623; PMCID: PMC4873372.
      Citations: 26     Fields:    Translation:Animals
    24. Ren YA, Liu Z, Mullany LK, Fan CM, Richards JS. Growth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice. Biol Reprod. 2016 Feb; 94(2):44. PMID: 26740594; PMCID: PMC4787628.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Mereness AL, Murphy ZC, Forrestel AC, Butler S, Ko C, Richards JS, Sellix MT. Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice. Endocrinology. 2016 Feb; 157(2):913-27. PMID: 26671182; PMCID: PMC5393362.
      Citations: 30     Fields:    Translation:AnimalsCells
    26. Mullany LK, Wong KK, Marciano DC, Katsonis P, King-Crane ER, Ren YA, Lichtarge O, Richards JS. Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. Neoplasia. 2015 Oct; 17(10):789-803. PMID: 26585234; PMCID: PMC4656807.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    27. Crane EK, Kwan SY, Izaguirre DI, Tsang YT, Mullany LK, Zu Z, Richards JS, Gershenson DM, Wong KK. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015; 10(8):e0135101. PMID: 26248031; PMCID: PMC4527847.
      Citations: 20     Fields:    Translation:HumansCells
    28. Liu Z, Ren YA, Pangas SA, Adams J, Zhou W, Castrillon DH, Wilhelm D, Richards JS. FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol. 2015 Jul; 29(7):1006-24. PMID: 26061565; PMCID: PMC4484779.
      Citations: 35     Fields:    Translation:HumansAnimals
    29. Zhang YL, Xia Y, Yu C, Richards JS, Liu J, Fan HY. CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation. Mol Hum Reprod. 2014 Sep; 20(9):850-60. PMID: 24878634; PMCID: PMC4131766.
      Citations: 7     Fields:    Translation:AnimalsCells
    30. Kawashima I, Umehara T, Noma N, Kawai T, Shitanaka M, Richards JS, Shimada M. Targeted disruption of Nrg1 in granulosa cells alters the temporal progression of oocyte maturation. Mol Endocrinol. 2014 May; 28(5):706-21. PMID: 24650175; PMCID: PMC4004775.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    31. Dumesic DA, Richards JS. Ontogeny of the ovary in polycystic ovary syndrome. Fertil Steril. 2013 Jul; 100(1):23-38. PMID: 23472949; PMCID: PMC4562327.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    32. Liu Z, Castrillon DH, Zhou W, Richards JS. FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH. Mol Endocrinol. 2013 Feb; 27(2):238-52. PMID: 23322722; PMCID: PMC3683807.
      Citations: 39     Fields:    Translation:AnimalsCells
    33. Mullany LK, Liu Z, Wong KK, Deneke V, Ren YA, Herron A, Richards JS. Tumor repressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases. Mol Endocrinol. 2014 Jan; 28(1):127-37. PMID: 24264574; PMCID: PMC3874458.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    34. Boyer A, Franco HL, Gossen J, DeMayo FJ, Richards JS, Boerboom D, Lapointe E, Rico C, Paquet M. FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biol Reprod. 2012 Nov; 87(5):104. PMID: 22954793; PMCID: PMC3509776.
      Citations: 19     Fields:    Translation:AnimalsCells
    35. Kawashima I, Liu Z, Mullany LK, Mihara T, Richards JS, Shimada M. EGF-like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement. Endocrinology. 2012 Aug; 153(8):3949-59. PMID: 22673225; PMCID: PMC3404342.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    36. Richards JS, Liu Z, Kawai T, Tabata K, Watanabe H, Suresh D, Kuo FT, Pisarska MD, Shimada M. Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human. Fertil Steril. 2012 Aug; 98(2):471-9.e1. PMID: 22633650; PMCID: PMC3523112.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    37. Mullany LK, Richards JS. Minireview: animal models and mechanisms of ovarian cancer development. Endocrinology. 2012 Apr; 153(4):1585-92. PMID: 22396450; PMCID: PMC3320247.
      Citations: 30     Fields:    Translation:Animals
    38. Mullany LK, Liu Z, King ER, Wong KK, Richards JS. Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival. Endocrinology. 2012 Apr; 153(4):1638-48. PMID: 22396451; PMCID: PMC3320246.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    39. Kawai T, Mihara T, Kawashima I, Fujita Y, Ikeda C, Negishi H, Richards JS, Shimada M. Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary. Reprod Toxicol. 2012 Jun; 33(3):322-30. PMID: 22285649; PMCID: PMC3327754.
      Citations: 9     Fields:    Translation:Animals
    40. Fan HY, Liu Z, Mullany LK, Richards JS. Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly. Mol Cell Endocrinol. 2012 Jun 05; 356(1-2):74-9. PMID: 22197887; PMCID: PMC3327778.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    41. Richards JS, Fan HY, Liu Z, Tsoi M, Boyer A, Boerboom D, Lagu? MN. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene. 2012 Mar 22; 31(12):1504-20. PMID: 21860425; PMCID: PMC3223552.
      Citations: 24     Fields:    Translation:HumansAnimals
    42. Fujita Y, Mihara T, Okazaki T, Shitanaka M, Kushino R, Ikeda C, Negishi H, Liu Z, Richards JS, Shimada M. Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis. Hum Reprod. 2011 Oct; 26(10):2799-806. PMID: 21775336; PMCID: PMC3174031.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    43. Zheng X, Lapointe E, Mittaz L, Boyer A, Pritchard MA, DeMayo FJ, Mort JS, Drolet R, Richards JS, Boerboom D, Lafond JF. Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011 Jul; 240(7):1806-14. PMID: 21584905; PMCID: PMC3116038.
      Citations: 12     Fields:    Translation:Animals
    44. Fan HY, Liu Z, Johnson PF, Richards JS. CCAAT/enhancer-binding proteins (C/EBP)-a and -? are essential for ovulation, luteinization, and the expression of key target genes. Mol Endocrinol. 2011 Feb; 25(2):253-68. PMID: 21177758; PMCID: PMC3386543.
      Citations: 52     Fields:    Translation:AnimalsCells
    45. Noma N, Kawashima I, Fan HY, Fujita Y, Kawai T, Tomoda Y, Mihara T, Richards JS, Shimada M. LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation. Mol Endocrinol. 2011 Jan; 25(1):104-16. PMID: 21047912; PMCID: PMC3089030.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    46. Detmar J, Boyer A, Richards JS, Adamson SL, Boerboom D, Lagu? MN, Paquet M. Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E936-46. PMID: 20858757; PMCID: PMC3006249.
      Citations: 14     Fields:    Translation:AnimalsCells
    47. Fan HY, O'Connor A, Shitanaka M, Shimada M, Liu Z, Richards JS. Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization. Mol Endocrinol. 2010 Aug; 24(8):1529-42. PMID: 20610534; PMCID: PMC2940463.
      Citations: 60     Fields:    Translation:AnimalsCells
    48. Liu Z, Fan HY, Wang Y, Richards JS. Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility. Mol Endocrinol. 2010 Sep; 24(9):1794-804. PMID: 20610537; PMCID: PMC2940481.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    49. Lapointe E, Zheng X, Cowan RG, Li H, Quirk SM, DeMayo FJ, Richards JS, Boerboom D, Boyer A. WNT4 is required for normal ovarian follicle development and female fertility. FASEB J. 2010 Aug; 24(8):3010-25. PMID: 20371632; PMCID: PMC2909279.
      Citations: 63     Fields:    Translation:AnimalsCells
    50. Richards JS, Pangas SA. The ovary: basic biology and clinical implications. J Clin Invest. 2010 Apr; 120(4):963-72. PMID: 20364094; PMCID: PMC2846061.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    51. Nautiyal J, Steel JH, Rosell MM, Nikolopoulou E, Lee K, Demayo FJ, White R, Richards JS, Parker MG. The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary. Endocrinology. 2010 Jun; 151(6):2923-32. PMID: 20308529; PMCID: PMC2875814.
      Citations: 16     Fields:    Translation:AnimalsCells
    52. Richards JS, Pangas SA. New insights into ovarian function. Handb Exp Pharmacol. 2010; (198):3-27. PMID: 20839083; PMCID: PMC4551424.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    53. Fan HY, Richards JS. Minireview: physiological and pathological actions of RAS in the ovary. Mol Endocrinol. 2010 Feb; 24(2):286-98. PMID: 19880654; PMCID: PMC2817603.
      Citations: 20     Fields:    Translation:HumansAnimals
    54. Sriraman V, Sinha M, Richards JS. Progesterone receptor-induced gene expression in primary mouse granulosa cell cultures. Biol Reprod. 2010 Feb; 82(2):402-12. PMID: 19726735; PMCID: PMC2809228.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    55. Fan HY, Liu Z, Paquet M, Wang J, Lydon JP, DeMayo FJ, Richards JS. Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells. Cancer Res. 2009 Aug 15; 69(16):6463-72. PMID: 19679546; PMCID: PMC2741085.
      Citations: 50     Fields:    Translation:AnimalsCells
    56. Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS. MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science. 2009 May 15; 324(5929):938-41. PMID: 19443782; PMCID: PMC2847890.
      Citations: 212     Fields:    Translation:AnimalsCells
    57. Liu Z, de Matos DG, Fan HY, Shimada M, Palmer S, Richards JS. Interleukin-6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process. Endocrinology. 2009 Jul; 150(7):3360-8. PMID: 19299453; PMCID: PMC2703543.
      Citations: 43     Fields:    Translation:AnimalsCells
    58. Liu Z, Rudd MD, Hernandez-Gonzalez I, Gonzalez-Robayna I, Fan HY, Zeleznik AJ, Richards JS. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol. 2009 May; 23(5):649-61. PMID: 19196834; PMCID: PMC2675958.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    59. Fan HY, Kaartinen MJ, Chu S, Jamin SP, Behringer RR, Fuller PJ, Mitchell A, Huneault LM, Richards JS, Boerboom D, Lagu? MN, Paquet M, Dor? M. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis. 2008 Nov; 29(11):2062-72. PMID: 18687666; PMCID: PMC2577137.
      Citations: 48     Fields:    Translation:AnimalsCells
    60. Fan HY, Liu Z, Cahill N, Richards JS. Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Mol Endocrinol. 2008 Sep; 22(9):2128-40. PMID: 18606860; PMCID: PMC2631369.
      Citations: 78     Fields:    Translation:AnimalsCells
    61. Fan HY, Shimada M, Liu Z, Cahill N, Noma N, Wu Y, Gossen J, Richards JS. Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation. Development. 2008 Jun; 135(12):2127-37. PMID: 18506027; PMCID: PMC3541831.
      Citations: 80     Fields:    Translation:AnimalsCells
    62. Liu Z, Shimada M, Richards JS. The involvement of the Toll-like receptor family in ovulation. J Assist Reprod Genet. 2008 Jun; 25(6):223-8. PMID: 18509754; PMCID: PMC2582080.
      Citations: 19     Fields:    Translation:HumansAnimals
    63. Espey LL, Garcia RA, Kondo H, Ishizuka B, Yoshioka S, Fujii S, Hampton S, Richards JS. Expression of paralogs of cytochrome P 450 21a1 pseudogene (Cyp21a1-ps) and endogenous retrovirus SC1 (SC1) in the rat ovary during the ovulatory process. J Endocrinol. 2008 Jul; 198(1):231-41. PMID: 18456703.
      Citations:    Fields:    Translation:AnimalsCells
    64. Shimada M, Yanai Y, Okazaki T, Noma N, Kawashima I, Mori T, Richards JS. Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization. Development. 2008 Jun; 135(11):2001-11. PMID: 18434414.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    65. Richards JS, Liu Z, Shimada M. Immune-like mechanisms in ovulation. Trends Endocrinol Metab. 2008 Aug; 19(6):191-6. PMID: 18407514.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    66. Sriraman V, Eichenlaub-Ritter U, Rittger A, Mulders SM, Richards JS, Bartsch JW. Regulated expression of ADAM8 (a disintegrin and metalloprotease domain 8) in the mouse ovary: evidence for a regulatory role of luteinizing hormone, progesterone receptor, and epidermal growth factor-like growth factors. Biol Reprod. 2008 Jun; 78(6):1038-48. PMID: 18287572.
      Citations: 18     Fields:    Translation:AnimalsCells
    67. Yamashita Y, Kawashima I, Yanai Y, Nishibori M, Richards JS, Shimada M. Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor. Endocrinology. 2007 Dec; 148(12):6164-75. PMID: 17901238.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    68. Richards JS. Genetics of ovulation. Semin Reprod Med. 2007 Jul; 25(4):235-42. PMID: 17594604.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    69. Shimada M, Yanai Y, Okazaki T, Yamashita Y, Sriraman V, Wilson MC, Richards JS. Synaptosomal-associated protein 25 gene expression is hormonally regulated during ovulation and is involved in cytokine/chemokine exocytosis from granulosa cells. Mol Endocrinol. 2007 Oct; 21(10):2487-502. PMID: 17595323.
      Citations: 34     Fields:    Translation:AnimalsCells
    70. Rudd MD, Gonzalez-Robayna I, Hernandez-Gonzalez I, Weigel NL, Bingman WE, Richards JS. Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity. J Mol Endocrinol. 2007 Jun; 38(6):673-90. PMID: 17556536.
      Citations: 11     Fields:    Translation:AnimalsCells
    71. Wayne CM, Fan HY, Cheng X, Richards JS. Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation. Mol Endocrinol. 2007 Aug; 21(8):1940-57. PMID: 17536007.
      Citations: 75     Fields:    Translation:AnimalsCells
    72. Shimada M, Hernandez-Gonzalez I, Gonzalez-Robanya I, Richards JS. Induced expression of pattern recognition receptors in cumulus oocyte complexes: novel evidence for innate immune-like functions during ovulation. Mol Endocrinol. 2006 Dec; 20(12):3228-39. PMID: 16931571.
      Citations: 37     Fields:    Translation:AnimalsCells
    73. Shimada M, Hernandez-Gonzalez I, Gonzalez-Robayna I, Richards JS. Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor. Mol Endocrinol. 2006 Jun; 20(6):1352-65. PMID: 16543407.
      Citations: 139     Fields:    Translation:AnimalsCells
    74. Boerboom D, White LD, Dalle S, Richards JS, Courty J. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Cancer Res. 2006 Feb 15; 66(4):1964-73. PMID: 16488995.
      Citations: 32     Fields:    Translation:AnimalsCells
    75. Hernandez-Gonzalez I, Gonzalez-Robayna I, Shimada M, Wayne CM, Ochsner SA, White L, Richards JS. Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: does this expand their role in the ovulation process? Mol Endocrinol. 2006 Jun; 20(6):1300-21. PMID: 16455817.
      Citations: 81     Fields:    Translation:AnimalsCells
    76. Falender AE, Shimada M, Lo YK, Richards JS. TAF4b, a TBP associated factor, is required for oocyte development and function. Dev Biol. 2005 Dec 15; 288(2):405-19. PMID: 16289522.
      Citations: 31     Fields:    Translation:AnimalsCells
    77. Boerboom D, Paquet M, Hsieh M, Liu J, Jamin SP, Behringer RR, Sirois J, Taketo MM, Richards JS. Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res. 2005 Oct 15; 65(20):9206-15. PMID: 16230381.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    78. Sriraman V, Rudd MD, Lohmann SM, Mulders SM, Richards JS. Cyclic guanosine 5'-monophosphate-dependent protein kinase II is induced by luteinizing hormone and progesterone receptor-dependent mechanisms in granulosa cells and cumulus oocyte complexes of ovulating follicles. Mol Endocrinol. 2006 Feb; 20(2):348-61. PMID: 16210344.
      Citations: 16     Fields:    Translation:AnimalsCells
    79. MacLean JA, Rao MK, Doyle KM, Richards JS, Wilkinson MF. Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP. Biol Reprod. 2005 Dec; 73(6):1126-34. PMID: 16093360.
      Citations: 14     Fields:    Translation:AnimalsCells
    80. Hsieh M, Boerboom D, Shimada M, Lo Y, Parlow AF, Luhmann UF, Berger W, Richards JS. Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function. Biol Reprod. 2005 Dec; 73(6):1135-46. PMID: 16093361.
      Citations: 57     Fields:    Translation:Animals
    81. Richards JS. Ovulation: new factors that prepare the oocyte for fertilization. Mol Cell Endocrinol. 2005 Apr 29; 234(1-2):75-9. PMID: 15836955.
      Citations: 78     Fields:    Translation:AnimalsCells
    82. Falender AE, Freiman RN, Geles KG, Lo KC, Hwang K, Lamb DJ, Morris PL, Tjian R, Richards JS. Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID. Genes Dev. 2005 Apr 01; 19(7):794-803. PMID: 15774719; PMCID: PMC1074317.
      Citations: 89     Fields:    Translation:AnimalsCells
    83. Richards JS, Hernandez-Gonzalez I, Gonzalez-Robayna I, Teuling E, Lo Y, Boerboom D, Falender AE, Doyle KH, LeBaron RG, Thompson V, Sandy JD. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005 May; 72(5):1241-55. PMID: 15659705.
      Citations: 43     Fields:    Translation:AnimalsCells
    84. Doyle KM, Russell DL, Sriraman V, Richards JS. Coordinate transcription of the ADAMTS-1 gene by luteinizing hormone and progesterone receptor. Mol Endocrinol. 2004 Oct; 18(10):2463-78. PMID: 15256533.
      Citations: 45     Fields:    Translation:AnimalsCells
    85. Shimada M, Nishibori M, Yamashita Y, Ito J, Mori T, Richards JS. Down-regulated expression of A disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexes. Endocrinology. 2004 Oct; 145(10):4603-14. PMID: 15231699.
      Citations: 15     Fields:    Translation:AnimalsCells
    86. Hirvonen-Santti SJ, Sriraman V, Anttonen M, Savolainen S, Palvimo JJ, Heikinheimo M, Richards JS, J?nne OA. Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovary. Endocrinology. 2004 May; 145(5):2433-44. PMID: 14749358.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    87. Sriraman V, Richards JS. Cathepsin L gene expression and promoter activation in rodent granulosa cells. Endocrinology. 2004 Feb; 145(2):582-91. PMID: 14563703.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    88. Russell DL, Doyle KM, Ochsner SA, Sandy JD, Richards JS. Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. J Biol Chem. 2003 Oct 24; 278(43):42330-9. PMID: 12907688.
      Citations: 101     Fields:    Translation:AnimalsCells
    89. Falender AE, Lanz R, Malenfant D, Belanger L, Richards JS. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Endocrinology. 2003 Aug; 144(8):3598-610. PMID: 12865342.
      Citations: 60     Fields:    Translation:AnimalsCells
    90. Ochsner SA, Day AJ, Rugg MS, Breyer RM, Gomer RH, Richards JS. Disrupted function of tumor necrosis factor-alpha-stimulated gene 6 blocks cumulus cell-oocyte complex expansion. Endocrinology. 2003 Oct; 144(10):4376-84. PMID: 12959984.
      Citations: 54     Fields:    Translation:AnimalsCells
    91. Hsieh M, Mulders SM, Friis RR, Dharmarajan A, Richards JS. Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells. Endocrinology. 2003 Oct; 144(10):4597-606. PMID: 12960062.
      Citations: 33     Fields:    Translation:AnimalsCells
    92. Ochsner SA, Russell DL, Day AJ, Breyer RM, Richards JS. Decreased expression of tumor necrosis factor-alpha-stimulated gene 6 in cumulus cells of the cyclooxygenase-2 and EP2 null mice. Endocrinology. 2003 Mar; 144(3):1008-19. PMID: 12586778.
      Citations: 36     Fields:    Translation:Animals
    93. Russell DL, Ochsner SA, Hsieh M, Mulders S, Richards JS. Hormone-regulated expression and localization of versican in the rodent ovary. Endocrinology. 2003 Mar; 144(3):1020-31. PMID: 12586779.
      Citations: 36     Fields:    Translation:AnimalsCells
    94. Huang JH, Rajkovic A, Szafranski P, Ochsner S, Richards J, Goode S. Expression of Drosophila neoplastic tumor suppressor genes discslarge, scribble, and lethal giant larvae in the mammalian ovary. Gene Expr Patterns. 2003 Mar; 3(1):3-11. PMID: 12609595.
      Citations: 2     Fields:    Translation:HumansAnimals
    95. Russell DL, Doyle KM, Gonzales-Robayna I, Pipaon C, Richards JS. Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1, and early growth response factor-1. Mol Endocrinol. 2003 Apr; 17(4):520-33. PMID: 12554779.
      Citations: 32     Fields:    Translation:AnimalsCells
    96. Sriraman V, Sharma SC, Richards JS. Transactivation of the progesterone receptor gene in granulosa cells: evidence that Sp1/Sp3 binding sites in the proximal promoter play a key role in luteinizing hormone inducibility. Mol Endocrinol. 2003 Mar; 17(3):436-49. PMID: 12554796.
      Citations: 21     Fields:    Translation:AnimalsCells
    97. Espey LL, Richards JS. Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat. Biol Reprod. 2002 Dec; 67(6):1662-70. PMID: 12444039.
      Citations: 43     Fields:    Translation:AnimalsCells
    98. Hsieh M, Johnson MA, Greenberg NM, Richards JS. Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary. Endocrinology. 2002 Mar; 143(3):898-908. PMID: 11861511.
      Citations: 61     Fields:    Translation:AnimalsCells
    99. Richards JS, Sharma SC, Falender AE, Lo YH. Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins. Mol Endocrinol. 2002 Mar; 16(3):580-99. PMID: 11875118.
      Citations: 73     Fields:    Translation:AnimalsCells
    100. Richards JS, Russell DL, Ochsner S, Hsieh M, Doyle KH, Falender AE, Lo YK, Sharma SC. Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization. Recent Prog Horm Res. 2002; 57:195-220. PMID: 12017544.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    101. Richards JS, Russell DL, Ochsner S, Espey LL. Ovulation: new dimensions and new regulators of the inflammatory-like response. Annu Rev Physiol. 2002; 64:69-92. PMID: 11826264.
      Citations: 122     Fields:    Translation:HumansAnimals
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