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Antone Robert Opekun

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Gastroenterology & Hepatol
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentSchool of Health Professions
    DivisionSchool of Health Professions


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Estes MK, Ettayebi K, Tenge VR, Murakami K, Karandikar U, Lin SC, Ayyar BV, Cortes-Penfield NW, Haga K, Neill FH, Opekun AR, Broughman JR, Zeng XL, Blutt SE, Crawford SE, Ramani S, Graham DY, Atmar RL. Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges. Viruses. 2019 Jul 11; 11(7). PMID: 31336765.
      View in: PubMed
    2. Graham DY, Ketwaroo GA, Money ME, Opekun AR. Enzyme therapy for functional bowel disease-like post-prandial distress. J Dig Dis. 2018 Nov; 19(11):650-656. PMID: 30101562.
      View in: PubMed
    3. Chumpitazi BP, Robayo-Torres CC, Tsai CM, Opekun AR, Baker SS, Nichols BL, Gilger MA. Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia. J Pediatr Gastroenterol Nutr. 2018 Jun; 66 Suppl 3:S52-S55. PMID: 29762379.
      View in: PubMed
    4. Robayo-Torres CC, Diaz-Sotomayor M, Hamaker BR, Baker SS, Chumpitazi BP, Opekun AR, Nichols BL. 13C-Labeled-Starch Breath Test in Congenital Sucrase-isomaltase Deficiency. J Pediatr Gastroenterol Nutr. 2018 Jun; 66 Suppl 3:S61-S64. PMID: 29762381.
      View in: PubMed
    5. Opekun AR, Gonzales SA, Al-Saadi MA, Graham DY. Brief report: Lactobacillus bulgaricus GLB44 (Proviotic™ ) plus esomeprazole for Helicobacter pylori eradication: A pilot study. Helicobacter. 2018 Apr; 23(2):e12476. PMID: 29504209.
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    6. Mindikoglu AL, Opekun AR, Mitch WE, Magder LS, Christenson RH, Dowling TC, Weir MR, Seliger SL, Howell CD, Raufman JP, Rana A, Goss JA, Khaderi SA, Vierling JM. Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis. Dig Dis Sci. 2018 03; 63(3):665-675. PMID: 29392554.
      View in: PubMed
    7. Cisse F, Erickson DP, Hayes AMR, Opekun AR, Nichols BL, Hamaker BR. Traditional Malian Solid Foods Made from Sorghum and Millet Have Markedly Slower Gastric Emptying than Rice, Potato, or Pasta. Nutrients. 2018 Jan 26; 10(2). PMID: 29373493.
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    8. Mindikoglu AL, Opekun AR, Putluri N, Devaraj S, Sheikh-Hamad D, Vierling JM, Goss JA, Rana A, Sood GK, Jalal PK, Inker LA, Mohney RP, Tighiouart H, Christenson RH, Dowling TC, Weir MR, Seliger SL, Hutson WR, Howell CD, Raufman JP, Magder LS, Coarfa C. Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis. Transl Res. 2018 05; 195:25-47. PMID: 29291380.
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    9. Mindikoglu AL, Opekun AR, Gagan SK, Devaraj S. Impact of Time-Restricted Feeding and Dawn-to-Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease. Gastroenterol Res Pract. 2017; 2017:3932491. PMID: 29348746.
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    10. Nichols BL, Avery SE, Quezada-Calvillo R, Kilani SB, Lin AH, Burrin DG, Hodges BE, Chacko SK, Opekun AR, Hindawy ME, Hamaker BR, Oda SI. Improved Starch Digestion of Sucrase-deficient Shrews Treated With Oral Glucoamylase Enzyme Supplements. J Pediatr Gastroenterol Nutr. 2017 08; 65(2):e35-e42. PMID: 28267073.
      View in: PubMed
    11. Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science. 2016 09 23; 353(6306):1387-1393. PMID: 27562956.
      View in: PubMed
    12. Opekun AR, Balesh AM, Shelby HT. Use of the Biphasic (13)C-Sucrose/Glucose Breath Test to Assess Sucrose Maldigestion in Adults with Functional Bowel Disorders. Biomed Res Int. 2016; 2016:7952891. PMID: 27579322.
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    13. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2016 01 01; 90(1):43-56. PMID: 26446608.
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    14. Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinjé J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PM. Serological Correlates of Protection against a GII.4 Norovirus. Clin Vaccine Immunol. 2015 Aug; 22(8):923-9. PMID: 26041041.
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    15. Schaefer JS, Attumi T, Opekun AR, Abraham B, Hou J, Shelby H, Graham DY, Streckfus C, Klein JR. MicroRNA signatures differentiate Crohn's disease from ulcerative colitis. BMC Immunol. 2015 Feb 10; 16:5. PMID: 25886994.
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    16. Ramani S, Neill FH, Opekun AR, Gilger MA, Graham DY, Estes MK, Atmar RL. Mucosal and Cellular Immune Responses to Norwalk Virus. J Infect Dis. 2015 Aug 01; 212(3):397-405. PMID: 25635121.
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    17. Czakó R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MK. Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity. Clin Vaccine Immunol. 2015 Feb; 22(2):221-8. PMID: 25540269.
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    18. Atmar RL, Opekun AR, Estes MK, Graham DY. Reply to Kirby et al. J Infect Dis. 2015 Jan 01; 211(1):167. PMID: 25015947.
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    19. Harris RA, Nagy-Szakal D, Mir SA, Frank E, Szigeti R, Kaplan JL, Bronsky J, Opekun A, Ferry GD, Winter H, Kellermayer R. DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis. Epigenetics. 2014 Aug; 9(8):1131-7. PMID: 24937444.
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    20. Shaiken TE, Opekun AR. Dissecting the cell to nucleus, perinucleus and cytosol. Sci Rep. 2014 May 12; 4:4923. PMID: 24815916.
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    21. Hergenroeder GW, Ward NH, Yu X, Opekun A, Moore AN, Kozinetz CA, Powner DJ. Randomized trial to evaluate nutritional status and absorption of enteral feeding after brain death. Prog Transplant. 2013 Dec; 23(4):374-82. PMID: 24311403.
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    22. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Ramani S, Hill H, Ferreira J, Graham DY. Determination of the 50% human infectious dose for Norwalk virus. J Infect Dis. 2014 Apr 01; 209(7):1016-22. PMID: 24253285.
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    23. Robayo-Torres CC, Baker SS, Chumpitazi BP, Lecea CE, Nichols BL, Opekun AR. Poor starch digestion in children with CSID and recurrent abdominal pain. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S32-4. PMID: 23103649.
      View in: PubMed
    24. Gilger M, Hamaker B, Nichols BL, Auricchio S, Treem WR, Naim HY, Heine M, Zimmer KP, Jones K, Eskandari R, Pinto BM, Rose DR, Lee BH, Quezada-Calvillo R, Adams B, Roach CM, Ma CX, Baker SS, Slawson MH, Robayo-Torres CC, Chumpitazi BP, Lecea CE, Opekun AR, Uhrich S, Wu Z, Huang JY, Scott CR, Chumpitazi BP, McMeans AR, Scholz D, Shulman RJ, Ao Z, Sterchi EE, Lin AH. Research progress reported at the 50th Anniversary of the Discovery of Congenital Sucrase-Isomaltase Deficiency Workshop. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S1. PMID: 23103641.
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    25. Chumpitazi BP, Robayo-Torres CC, Opekun AR, Nichols BL, Naim HY. Congenital sucrase-isomaltase deficiency: summary of an evaluation in one family. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S36. PMID: 23103651.
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    26. Ajami NJ, Barry MA, Carrillo B, Muhaxhiri Z, Neill FH, Prasad BV, Opekun AR, Gilger MA, Graham DY, Atmar RL, Estes MK. Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus. Clin Vaccine Immunol. 2012 Dec; 19(12):1980-3. PMID: 23035177.
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    27. Harris RA, Nagy-Szakal D, Pedersen N, Opekun A, Bronsky J, Munkholm P, Jespersgaard C, Andersen P, Melegh B, Ferry G, Jess T, Kellermayer R. Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases. Inflamm Bowel Dis. 2012 Dec; 18(12):2334-41. PMID: 22467598.
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    28. Czakó R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MK. Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus. Clin Vaccine Immunol. 2012 Feb; 19(2):284-7. PMID: 22190401.
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    29. Atmar RL, Bernstein DI, Harro CD, Al-Ibrahim MS, Chen WH, Ferreira J, Estes MK, Graham DY, Opekun AR, Richardson C, Mendelman PM. Norovirus vaccine against experimental human Norwalk Virus illness. N Engl J Med. 2011 Dec 08; 365(23):2178-87. PMID: 22150036.
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    30. Kavanagh O, Estes MK, Reeck A, Raju RM, Opekun AR, Gilger MA, Graham DY, Atmar RL. Serological responses to experimental Norwalk virus infection measured using a quantitative duplex time-resolved fluorescence immunoassay. Clin Vaccine Immunol. 2011 Jul; 18(7):1187-90. PMID: 21593238.
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    31. Reeck A, Kavanagh O, Estes MK, Opekun AR, Gilger MA, Graham DY, Atmar RL. Serological correlate of protection against norovirus-induced gastroenteritis. J Infect Dis. 2010 Oct 15; 202(8):1212-8. PMID: 20815703.
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    32. Graham DY, Javed SU, Keihanian S, Abudayyeh S, Opekun AR. Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: studies from the United States. J Gastroenterol. 2010 Aug; 45(8):816-20. PMID: 20195646.
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    33. Malaty HM, Fan X, Opekun AR, Thibodeaux C, Ferry GD. Rising incidence of inflammatory bowel disease among children: a 12-year study. J Pediatr Gastroenterol Nutr. 2010 Jan; 50(1):27-31. PMID: 19934770.
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    34. Wu DC, Hsu PI, Wu JY, Opekun AR, Kuo CH, Wu IC, Wang SS, Chen A, Hung WC, Graham DY. Sequential and concomitant therapy with four drugs is equally effective for eradication of H pylori infection. Clin Gastroenterol Hepatol. 2010 Jan; 8(1):36-41.e1. PMID: 19804842.
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    35. Elitsur Y, Tolia V, Gilger MA, Reeves-Garcia J, Schmidt-Sommerfeld E, Opekun AR, El-Zimaity H, Graham DY, Enmei K. Urea breath test in children: the United States prospective, multicenter study. Helicobacter. 2009 Apr; 14(2):134-40. PMID: 19298341.
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    36. Robayo-Torres CC, Opekun AR, Quezada-Calvillo R, Villa X, Smith EO, Navarrete M, Baker SS, Nichols BL. 13C-breath tests for sucrose digestion in congenital sucrase isomaltase-deficient and sacrosidase-supplemented patients. J Pediatr Gastroenterol Nutr. 2009 Apr; 48(4):412-8. PMID: 19330928.
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    37. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Graham DY. Norwalk virus shedding after experimental human infection. Emerg Infect Dis. 2008 Oct; 14(10):1553-7. PMID: 18826818.
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    38. Quezada-Calvillo R, Robayo-Torres CC, Opekun AR, Sen P, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Wattler S, Nehls MC, Sterchi EE, Nichols BL. Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis. J Nutr. 2007 Jul; 137(7):1725-33. PMID: 17585022.
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    39. Shiotani A, Opekun AR, Graham DY. Visualization of the small intestine using capsule endoscopy in healthy subjects. Dig Dis Sci. 2007 Apr; 52(4):1019-25. PMID: 17380402.
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    40. Brunetti-Pierri N, Opekun AR, Craigen WJ. Two familial cases of high blood galactose of unknown aetiology. J Inherit Metab Dis. 2006 Dec; 29(6):762. PMID: 16988899.
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    41. Opekun AR, Luu P, Gotschall AB, Abdalla N, Torres E, Rudd SB, Graham DY, Nurgalieva ZZ, Tsuchiya K. Point-of-care Helicobacter pylori urine antibody detection in a multi-ethnic adult population in the United States. Transl Res. 2006 Jul; 148(1):13-8. PMID: 16887493.
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    42. Nurgalieva ZZ, Nugalieva ZZ, Opekun AR, Graham DY. Problem of distinguishing false-positive tests from acute or transient Helicobacter pylori infections. Helicobacter. 2006 Apr; 11(2):69-74. PMID: 16579835.
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    43. Graham DY, Nurgalieva ZZ, El-Zimaity HM, Opekun AR, Campos A, Guerrero L, Chavez A, Cardenas V. Noninvasive versus histologic detection of gastric atrophy in a Hispanic population in North America. Clin Gastroenterol Hepatol. 2006 Mar; 4(3):306-14. PMID: 16527693.
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    44. Opekun AR, Gotschall AB, Abdalla N, Agent C, Torres E, Sutton FM, Graham DY, Tsuchiya K. Improved infrared spectrophotometer for point-of-care patient 13C-urea breath testing in the primary care setting. Clin Biochem. 2005 Aug; 38(8):731-4. PMID: 15963485.
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    45. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507.
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    46. Shahidzadeh R, Opekun A, Shiotani A, Graham DY. Effect of the carbonic anhydrase inhibitor, acetazolamide, on Helicobacter pylori infection in vivo: a pilot study. Helicobacter. 2005 Apr; 10(2):136-8. PMID: 15810944.
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    47. Graham DY, Kudo M, Reddy R, Opekun AR. Practical rapid, minimally invasive, reliable nonendoscopic method to obtain Helicobacter pylori for culture. Helicobacter. 2005 Feb; 10(1):1-3. PMID: 15691309.
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    48. Graham DY, Opekun AR, Willingham FF, Qureshi WA. Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol. 2005 Jan; 3(1):55-9. PMID: 15645405.
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    49. Nanavati SA, Opekun AR, Hacken-Bitar JB, Cole RA, Anand BS, Graham DY. Migrating shell fragment as a cause of recurrent obscure gastrointestinal bleeding. J Clin Gastroenterol. 2004 Feb; 38(2):137-8. PMID: 14745292.
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    50. Graham DY, Opekun AR, Jogi M, Yamaoka Y, Lu H, Reddy R, El-Zimaity HM. False negative urea breath tests with H2-receptor antagonists: interactions between Helicobacter pylori density and pH. Helicobacter. 2004 Feb; 9(1):17-27. PMID: 15156900.
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    51. Graham DY, Opekun AR, Hammoud F, Yamaoka Y, Reddy R, Osato MS, El-Zimaity HM. Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors. Am J Gastroenterol. 2003 May; 98(5):1005-9. PMID: 12809820.
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    52. Willingham FF, Opekun AR, Graham DY. Endoscopic demonstration of transient small bowel intussusception in a patient with adult celiac disease. Gastrointest Endosc. 2003 Apr; 57(4):626-7. PMID: 12665791.
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    53. Opekun AR, Abdalla N, Sutton FM, Hammoud F, Kuo GM, Torres E, Steinbauer J, Graham DY. Urea breath testing and analysis in the primary care office. J Fam Pract. 2002 Dec; 51(12):1030-2. PMID: 12540328.
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    54. Morrisett JD, Abdel-Fattah G, Hoogeveen R, Mitchell E, Ballantyne CM, Pownall HJ, Opekun AR, Jaffe JS, Oppermann S, Kahan BD. Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients. J Lipid Res. 2002 Aug; 43(8):1170-80. PMID: 12177161.
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    55. Opekun AR, Sutton FM, Graham DY. Lack of dose-response with Pancrease MT for the treatment of exocrine pancreatic insufficiency in adults. Aliment Pharmacol Ther. 1997 Oct; 11(5):981-6. PMID: 9354210.
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    56. Opekun AR, Klein PD, Graham DY. [13C]Aminopyrine breath test detects altered liver metabolism caused by low-dose oral contraceptives. Dig Dis Sci. 1995 Nov; 40(11):2417-22. PMID: 7587824.
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    57. Baghaie AA, Mojtahedzadeh M, Levine RL, Fromm RE, Guntupalli KK, Opekun AR. Comparison of the effect of intermittent administration and continuous infusion of famotidine on gastric pH in critically ill patients: results of a prospective, randomized, crossover study. Crit Care Med. 1995 Apr; 23(4):687-91. PMID: 7712759.
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    58. Levine RL, Fromm RE, Mojtahedzadeh M, Baghaie AA, Opekun AR. Equivalence of litmus paper and intragastric pH probes for intragastric pH monitoring in the intensive care unit. Crit Care Med. 1994 Jun; 22(6):945-8. PMID: 7911416.
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