ERIC CHANG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentBreast Center
    DivisionBreast Cancer Center


    Collapse Research 
    Collapse research activities and funding
    R01CA090464     (CHANG, ERIC C)Apr 1, 2001 - Jan 31, 2013
    NIH
    REGULATION OF GENETIC STABILITY BY THE INT6 FAMILY
    Role: Principal Investigator

    R01CA107187     (CHANG, ERIC C)Apr 19, 2005 - Mar 31, 2009
    NIH
    Selective control of multiple Ras signaling activities
    Role: Principal Investigator

    R21CA226567     (CHANG, ERIC C)Jun 4, 2018 - May 31, 2021
    NIH
    A novel N-Ras pathway driving DCIS to basal-like breast cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Magesh S, John D, Li WT, Li Y, Mattingly-App A, Jain S, Chang EY, Ongkeko WM. Disparities in COVID-19 Outcomes by Race, Ethnicity, and Socioeconomic Status: A Systematic-Review and Meta-analysis. JAMA Netw Open. 2021 11 01; 4(11):e2134147. PMID: 34762110.
      Citations: 16     Fields:    Translation:Humans
    2. Bakeer N, Dover S, Babyn P, Feldman BM, von Drygalski A, Doria AS, Ignas DM, Abad A, Bailey C, Beggs I, Chang EY, Dunn A, Funk S, Gibikote S, Goddard N, Hilliard P, Keshava SN, Kruse-Jarres R, Li Y, Lobet S, Manco-Johnson M, Martinoli C, O'Donnell JS, Papakonstantinou O, Pergantou H, Poonnoose P, Querol F, Srivastava A, Steiner B, Strike K, Timmer M, Tyrrell PN, Vidarsson L, Blanchette VS. Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting. Res Pract Thromb Haemost. 2021 Jul; 5(5):e12531. PMID: 34268464.
      Citations:    
    3. Lee AC, Castaneda G, Li WT, Chen C, Shende N, Chakladar J, Taub PR, Chang EY, Ongkeko WM. COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation. Viruses. 2021 05 28; 13(6). PMID: 34071557.
      Citations: 2     Fields:    Translation:Humans
    4. Lee AC, Chakladar J, Li WT, Chen C, Chang EY, Wang-Rodriguez J, Ongkeko WM. Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune Dysregulation. Int J Mol Sci. 2020 Jul 31; 21(15). PMID: 32752138.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    5. Jerban S, Lu X, Jang H, Ma Y, Namiranian B, Le N, Li Y, Chang EY, Du J. Significant correlations between human cortical bone mineral density and quantitative susceptibility mapping (QSM) obtained with 3D Cones ultrashort echo time magnetic resonance imaging (UTE-MRI). Magn Reson Imaging. 2019 10; 62:104-110. PMID: 31247253.
      Citations: 10     Fields:    Translation:Humans
    6. Weksberg DC, Yang JN, Tam AL, Li J, Wang XA, Zhao Z, McRae SE, Settle SH, Rhines LD, Chang EL, Brown PD, Ghia AJ. Prospective validation of treatment accuracy using implanted fiducial markers for spinal stereotactic body radiation therapy. J Radiosurg SBRT. 2016; 4(1):7-14. PMID: 29296421.
      Citations: 1     
    7. Veeraraghavan J, Tan Y, Cao XX, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS. Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers. Nat Commun. 2014 Aug 07; 5:4577. PMID: 25099679.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    8. Chen. X, Zhu, Y., Zhu, Li, F., Zheng, Z., Chang, E., Ma, J. and Wong, Stephen W. Accurate Segmentation of Touching Cells in Multi-channel Microscopy Images with Geodesic Distance Based Clustering. Neurocomputing. 2014; In press..
    9. Chen. X, Zhu, Y., Zhu, Li, F., Zheng, Z., Chang, E., Ma, J. and Wong, Stephen W. International Symposium on Neural Networks (ISNN13). A Novel Geodesic Distance Based Clustering Approach to Delineating Boundaries of Touching Cells. 2013; 7952:315-322.
    10. Wang XS, Rhines LD, Shiu AS, Yang JN, Selek U, Gning I, Liu P, Allen PK, Azeem SS, Brown PD, Sharp HJ, Weksberg DC, Cleeland CS, Chang EL. Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol. 2012 Apr; 13(4):395-402. PMID: 22285199.
      Citations: 95     Fields:    Translation:HumansCTClinical Trials
    11. Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene. 2012 Oct 25; 31(43):4630-8. PMID: 22231449.
      Citations: 15     Fields:    Translation:HumansCells
    12. Garg AK, Wang XS, Shiu AS, Allen P, Yang J, McAleer MF, Azeem S, Rhines LD, Chang EL. Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center experience. Cancer. 2011 Aug 01; 117(15):3509-16. PMID: 21319143.
      Citations: 46     Fields:    Translation:Humans
    13. Walker GV, Ahmed S, Allen P, Gidley PW, Woo SY, DeMonte F, Chang EL, Mahajan A. Radiation-induced middle ear and mastoid opacification in skull base tumors treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2011 Dec 01; 81(5):e819-23. PMID: 21277110.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    14. Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 2011 Feb 10; 30(6):724-36. PMID: 20890303.
      Citations: 14     Fields:    Translation:HumansCells
    15. Nguyen QN, Shiu AS, Rhines LD, Wang H, Allen PK, Wang XS, Chang EL. Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 15; 76(4):1185-92. PMID: 19632064.
      Citations: 51     Fields:    Translation:Humans
    16. Torres MA, Chang EL, Mahajan A, Lege DG, Riley BA, Zhang X, Lii M, Kornguth DG, Pelloski CE, Woo SY. Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both? Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1033-9. PMID: 19356861.
      Citations: 11     Fields:    Translation:Humans
    17. Nguyen QN, Chang EL. Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base. Curr Oncol Rep. 2008 Jul; 10(4):338-43. PMID: 18778560.
      Citations: 11     Fields:    Translation:Humans
    18. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007 Aug; 7(2):151-60. PMID: 17688054.
      Citations: 128     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    19. Wang C, Shiu A, Lii M, Woo S, Chang EL. Automatic target localization and verification for on-line image-guided stereotactic body radiotherapy of the spine. Technol Cancer Res Treat. 2007 Jun; 6(3):187-96. PMID: 17535027.
      Citations: 2     Fields:    Translation:Humans
    20. Chang EL, Akyurek S, Avalos T, Rebueno N, Spicer C, Garcia J, Famiglietti R, Allen PK, Chao KS, Mahajan A, Woo SY, Maor MH. Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma. Int J Radiat Oncol Biol Phys. 2007 May 01; 68(1):144-50. PMID: 17306935.
      Citations: 80     Fields:    Translation:Humans
    21. Hermanto U, Frija EK, Lii MJ, Chang EL, Mahajan A, Woo SY. Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: does IMRT increase the integral dose to normal brain? Int J Radiat Oncol Biol Phys. 2007 Mar 15; 67(4):1135-44. PMID: 17208388.
      Citations: 37     Fields:    Translation:Humans
    22. Nguyen QN, Chang EL, Allen PK, Maor MH, Ater JL, Mahajan A, Wolff JE, Weinberg JS, Woo SY. Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure. Cancer. 2006 Nov 01; 107(9):2228-36. PMID: 17019739.
      Citations: 11     Fields:    Translation:Humans
    23. Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutcheon I, Mahajan A, Maor MH, Woo SY. Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol. 2006 Nov; 80(2):177-83. PMID: 16648988.
      Citations: 46     Fields:    Translation:Humans
    24. Lee CT, Bilton SD, Famiglietti RM, Riley BA, Mahajan A, Chang EL, Maor MH, Woo SY, Cox JD, Smith AR. Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys. 2005 Oct 01; 63(2):362-72. PMID: 16168831.
      Citations: 61     Fields:    Translation:HumansPHPublic Health
    25. Mahajan A, McCutcheon IE, Suki D, Chang EL, Hassenbusch SJ, Weinberg JS, Shiu A, Maor MH, Woo SY. Case-control study of stereotactic radiosurgery for recurrent glioblastoma multiforme. J Neurosurg. 2005 Aug; 103(2):210-7. PMID: 16175848.
      Citations: 27     Fields:    Translation:Humans
    26. Hutchinson LM, Chang EL, Becker CM, Ushiyama N, Behonick D, Shih MC, DeWolf WC, Gaston SM, Zetter BR. Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer. Clin Biochem. 2005 Jun; 38(6):558-71. PMID: 15885237.
      Citations: 6     Fields:    Translation:HumansCells
    27. Pelloski CE, Mahajan A, Maor M, Chang EL, Woo S, Gilbert M, Colman H, Yang H, Ledoux A, Blair H, Passe S, Jenkins RB, Aldape KD. YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma. Clin Cancer Res. 2005 May 01; 11(9):3326-34. PMID: 15867231.
      Citations: 76     Fields:    Translation:HumansCells
    28. Chang EL, Shiu AS, Lii MF, Rhines LD, Mendel E, Mahajan A, Weinberg JS, Mathews LA, Brown BW, Maor MH, Cox JD. Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2004 Aug 01; 59(5):1288-94. PMID: 15275711.
      Citations: 30     Fields:    Translation:HumansCTClinical Trials
    29. Kudchadker RJ, Chang EL, Bryan F, Maor MH, Famiglietti R. An evaluation of radiation exposure from portal films taken during definitive course of pediatric radiotherapy. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1229-35. PMID: 15234060.
      Citations: 6     Fields:    Translation:Humans
    30. Selek U, Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen P, Weinberg J, Sawaya R, Maor MH. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1097-106. PMID: 15234044.
      Citations: 64     Fields:    Translation:Humans
    31. Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH. Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. Cancer. 2004 Apr 01; 100(7):1491-7. PMID: 15042684.
      Citations: 42     Fields:    Translation:Humans
    32. Soyuer S, Chang EL, Selek U, Shi W, Maor MH, DeMonte F. Radiotherapy after surgery for benign cerebral meningioma. Radiother Oncol. 2004 Apr; 71(1):85-90. PMID: 15066300.
      Citations: 28     Fields:    Translation:Humans
    33. Shiu AS, Chang EL, Ye JS, Lii M, Rhines LD, Mendel E, Weinberg J, Singh S, Maor MH, Mohan R, Cox JD. Near simultaneous computed tomography image-guided stereotactic spinal radiotherapy: an emerging paradigm for achieving true stereotaxy. Int J Radiat Oncol Biol Phys. 2003 Nov 01; 57(3):605-13. PMID: 14529763.
      Citations: 21     Fields:    Translation:Humans
    34. Lee HK, Chang EL, Fuller GN, Aldape KD, Atkinson GJ, Levy LB, McCutcheon IE, Maor MH. The prognostic value of neurologic function in astrocytic spinal cord glioma. Neuro Oncol. 2003 07; 5(3):208-13. PMID: 12816727.
      Citations: 9     Fields:    Translation:Humans
    35. Chang EL, Yi W, Allen PK, Levin VA, Sawaya RE, Maor MH. Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys. 2003 Jun 01; 56(2):519-28. PMID: 12738329.
      Citations: 17     Fields:    Translation:Humans
    36. Chang EL, Wong PF, Forster KM, Petru MD, Kowalski AV, Maor MH. Verification techniques and dose distribution for computed tomographic planned supine craniospinal radiation therapy. Med Dosim. 2003; 28(2):127-31. PMID: 12804712.
      Citations: 3     Fields:    Translation:Humans
    37. Chang EL, Maor MH. Standard and novel radiotherapeutic approaches to neoplastic meningitis. Curr Oncol Rep. 2003 Jan; 5(1):24-8. PMID: 12493147.
      Citations: 14     Fields:    Translation:Humans
    38. Chang EL, Lo S. Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 2003; 8(5):398-410. PMID: 14530493.
      Citations: 53     Fields:    Translation:Humans
    39. Yen HC, Chang EC. Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14370-5. PMID: 11121040.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    40. Chen CR, Chen J, Chang EC. A conserved interaction between Moe1 and Mal3 is important for proper spindle formation in Schizosaccharomyces pombe. Mol Biol Cell. 2000 Dec; 11(12):4067-77. PMID: 11102508.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    41. Chen CR, Li YC, Chen J, Hou MC, Papadaki P, Chang EC. Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):517-22. PMID: 9892665.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    42. Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6180-4. PMID: 7597098.
      Citations: 63     Fields:    Translation:AnimalsCells
    43. Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell. 1994 Oct 07; 79(1):131-41. PMID: 7923372.
      Citations: 133     Fields:    Translation:AnimalsCells
    44. Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J, Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Mol Cell Biol. 1993 Jan; 13(1):487-95. PMID: 8417346.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    45. Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV. Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9831-5. PMID: 1384061.
      Citations: 45     Fields:    Translation:AnimalsCells
    46. Chang EC, Crawford BF, Hong Z, Bilinski T, Kosman DJ. Genetic and biochemical characterization of Cu,Zn superoxide dismutase mutants in Saccharomyces cerevisiae. J Biol Chem. 1991 Mar 05; 266(7):4417-24. PMID: 1999425.
      Citations: 21     Fields:    Translation:AnimalsCells
    47. Chang EC, Kosman DJ. O2-dependent methionine auxotrophy in Cu,Zn superoxide dismutase-deficient mutants of Saccharomyces cerevisiae. J Bacteriol. 1990 Apr; 172(4):1840-5. PMID: 2180907.
      Citations: 21     Fields:    Translation:AnimalsCells
    48. Chang EC, Kosman DJ, Willsky GR. Arsenic oxide-induced thermotolerance in Saccharomyces cerevisiae. J Bacteriol. 1989 Nov; 171(11):6349-52. PMID: 2681165.
      Citations: 6     Fields:    Translation:Animals
    49. Chang EC, Kosman DJ. Intracellular Mn (II)-associated superoxide scavenging activity protects Cu,Zn superoxide dismutase-deficient Saccharomyces cerevisiae against dioxygen stress. J Biol Chem. 1989 Jul 25; 264(21):12172-8. PMID: 2545701.
      Citations: 43     Fields:    Translation:Animals
    50. Gralla, E. B., Bermingham-McDonogh, O., Valentine, J. S. Chang, E. C., Frueger, T., Kosman, D. J. . Cloning and Biological Activity of the Cu, Zn SOD gene of S. cerevisiae. UCLA Symp. Mol. Cell. Biol. New Ser. 1988; 82:173-182.
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