TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee S, Roh SH, Lee J, Sung N, Liu J, Tsai FTF. Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation. Cell Rep. 2019 01 02; 26(1):29-36.e3. PMID: 30605683; PMCID: PMC6347426.
      Citations: 13     Fields:    Translation:HumansCells
    2. Lee J, Kim JH, Biter AB, Sielaff B, Lee S, Tsai FT. Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8513-8. PMID: 23650362; PMCID: PMC3666692.
      Citations: 60     Fields:    Translation:AnimalsCells
    3. Biter AB, Lee S, Sung N, Tsai FT. Structural basis for intersubunit signaling in a protein disaggregating machine. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12515-20. PMID: 22802670; PMCID: PMC3411974.
      Citations: 27     Fields:    Translation:Cells
    4. Biter AB, Lee J, Sung N, Tsai FT, Lee S. Functional analysis of conserved cis- and trans-elements in the Hsp104 protein disaggregating machine. J Struct Biol. 2012 Aug; 179(2):172-80. PMID: 22634726; PMCID: PMC3411918.
      Citations: 14     Fields:    Translation:HumansCells
    5. Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, Tsai FT. Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease. J Biol Chem. 2011 Feb 11; 286(6):4404-11. PMID: 21147776; PMCID: PMC3039362.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    6. Lee S, Sielaff B, Lee J, Tsai FT. CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8135-40. PMID: 20404203; PMCID: PMC2889573.
      Citations: 61     Fields:    Translation:AnimalsCells
    7. Lee S, Tsai FT. Crystallization and preliminary X-ray crystallographic analysis of a 40 kDa N-terminal fragment of the yeast prion-remodeling factor Hsp104. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 01; 63(Pt 9):784-6. PMID: 17768355; PMCID: PMC2376311.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Lee S, Choi JM, Tsai FT. Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB. Mol Cell. 2007 Jan 26; 25(2):261-71. PMID: 17244533; PMCID: PMC1855157.
      Citations: 69     Fields:    Translation:Cells
    9. Weibezahn J, Zahn R, Lee S, Tsai FT, Bukau B, Mogk A, Haslberger T. M domains couple the ClpB threading motor with the DnaK chaperone activity. Mol Cell. 2007 Jan 26; 25(2):247-60. PMID: 17244532.
      Citations: 77     Fields:    Translation:Cells
    10. Rees I, Lee S, Kim H, Tsai FT. The E3 ubiquitin ligase CHIP binds the androgen receptor in a phosphorylation-dependent manner. Biochim Biophys Acta. 2006 Jun; 1764(6):1073-9. PMID: 16725394.
      Citations: 28     Fields:    Translation:HumansCells
    11. Lee S, Tsai FT. Molecular chaperones in protein quality control. J Biochem Mol Biol. 2005 May 31; 38(3):259-65. PMID: 15943899.
      Citations: 14     Fields:    Translation:Cells
    12. Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B, Weibezahn J. Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Cell. 2004 Nov 24; 119(5):653-65. PMID: 15550247.
      Citations: 220     Fields:    Translation:Cells
    13. Lee S, Sowa ME, Choi JM, Tsai FT. The ClpB/Hsp104 molecular chaperone-a protein disaggregating machine. J Struct Biol. 2004 Apr-May; 146(1-2):99-105. PMID: 15037241.
      Citations: 29     Fields:    Translation:Cells
    14. Lee S, Hisayoshi M, Yoshida M, Tsai FT. Crystallization and preliminary X-ray crystallographic analysis of the Hsp100 chaperone ClpB from Thermus thermophilus. Acta Crystallogr D Biol Crystallogr. 2003 Dec; 59(Pt 12):2334-6. PMID: 14646112.
      Citations: 3     Fields:    Translation:Cells
    15. Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT. The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell. 2003 Oct 17; 115(2):229-40. PMID: 14567920.
      Citations: 193     Fields:    Translation:Cells
    16. Lee S, Kuhn RJ, Rossmann MG. Probing the potential glycoprotein binding site of sindbis virus capsid protein with dioxane and model building. Proteins. 1998 Nov 01; 33(2):311-7. PMID: 9779796.
      Citations: 9     Fields:    Translation:Cells
    17. Kovari LC, Momany CA, Miyagi F, Lee S, Campbell S, Vuong B, Vogt VM, Rossmann MG. Crystals of Rous sarcoma virus capsid protein show a helical arrangement of protein subunits. Virology. 1997 Nov 10; 238(1):79-84. PMID: 9375011.
      Citations: 4     Fields:    Translation:Cells
    18. Hwang KY, Song HK, Chang C, Lee J, Lee SY, Kim KK, Choe S, Sweet RM, Suh SW. Crystal structure of thermostable alpha-amylase from Bacillus licheniformis refined at 1.7 A resolution. Mol Cells. 1997 Apr 30; 7(2):251-8. PMID: 9163741.
      Citations: 10     Fields:    Translation:Cells
    19. Choi HK, Lu G, Lee S, Wengler G, Rossmann MG. Structure of Semliki Forest virus core protein. Proteins. 1997 Mar; 27(3):345-59. PMID: 9094737.
      Citations: 37     Fields:    Translation:Cells
    20. Choi HK, Lee S, Zhang YP, McKinney BR, Wengler G, Rossmann MG, Kuhn RJ. Structural analysis of Sindbis virus capsid mutants involving assembly and catalysis. J Mol Biol. 1996 Sep 20; 262(2):151-67. PMID: 8831786.
      Citations: 23     Fields:    Translation:Cells
    21. Lee S, Owen KE, Choi HK, Lee H, Lu G, Wengler G, Brown DT, Rossmann MG, Kuhn RJ. Identification of a protein binding site on the surface of the alphavirus nucleocapsid and its implication in virus assembly. Structure. 1996 May 15; 4(5):531-41. PMID: 8736552.
      Citations: 81     Fields:    Translation:Cells
    22. Lee SY, Kim S, Sweet RM, Suh SW. Crystallization and a preliminary X-ray crystallographic study of alpha-amylase from Bacillus licheniformis. Arch Biochem Biophys. 1991 Dec; 291(2):255-7. PMID: 1952938.
      Citations: 4     Fields:    Translation:Cells
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