JANET BUTEL

TitleDistinguished Service Professor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
Address
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    Collapse Biography 
    Collapse awards and honors
    1963 - 1966National Science Foundation Graduate Fellowships
    1966Sigma Xi Research Award for Excellence in Research
    1972 - 1976American Cancer Society Faculty Research Award
    1986Joseph L. Melnick Professor of Virology, Baylor College of Medicine
    1988Fellow, American Association for the Advancement of Science
    1995Distinguished Service Professor, Baylor College of Medicine
    1997Included in “Women Pioneers in Texas Medicine” (Silverthorne and Fulgham, Texas A&M Univ. Press)
    20022002 Distinguished Alumnus, Graduate School of Biomedical Sciences Award, Baylor College of Medicine
    2003Kansas State University Alumni Fellow
    2004Fellow, American Academy of Microbiology
    2007Recipient, Am. Assoc. Cancer Research–Women in Cancer Research–Charlotte Friend Memorial Lecture
    2013Kyle and Josephine Morrow Chair in Molecular Virology and Microbiology, Baylor College of Medicine
    2014Honoree, Hearts of Gold: Honoring Women in Health & Medical Science Gala, The Harris County Medical Society and The Health Museum

    Collapse Overview 
    Collapse overview
    Polyomavirus Pathogenesis of Infections and Disease

    The Butel laboratory studies the biology and molecular biology of the polyomaviruses, with a primary focus on polyomavirus SV40. Originally isolated from monkeys, SV40 is a small DNA virus that is able to transform cells in culture and induce tumors in hamsters. As a model tumor virus, SV40 has provided many fundamental insights into the molecular basis of carcinogenesis.

    The large tumor antigen (T-ag) of SV40 is the major transforming protein of the virus, responsible for tumor causation in hamsters and transformation of many cell types in culture. It is a complex protein that possesses multiple functions important for replicating the viral DNA and for dysregulating cell cycle control. Sequence analysis of viral isolates has revealed differences in the structure of the noncoding viral regulatory region as well as the existence of a variable region at the C-terminus of T-ag that can classify SV40 strains into genogroups. We have identified rare variants of polyomaviruses, recovered from immunosuppressed hosts, that have lost the ability to express viral microRNAs.

    We have developed the Syrian golden hamster small animal model to study SV40 pathogenesis of infection and disease. Recent results from the hamster model identified broad tissue tropism for SV40 and provided the first evidence of expression and function of SV40 microRNA in vivo. Viral microRNA reduced viral DNA levels in infected tissues and may contribute to the establishment of persistent infections. Other findings include the significant effect of the structure of the viral regulatory region on both oncogenic potential and vertical transmission in vivo. As there was no effect on transforming activity in vitro, strain-specific factors must affect virus–host interactions that are not detectable using cultured cells. Both viral genetic variation and route of inoculation influence host antibody responses to viral proteins.

    Authentic SV40 can cause human infections. Findings from our studies include the detection of SV40 neutralizing antibodies in various population groups; the fecal excretion of polyomaviruses by humans, indicating a probable fecal–oral route of transmission; the detection of SV40 in normal and malignant lymphoid-rich tissues, suggesting that lymphoid cells are important in the pathogenesis of SV40 infections; and the variable frequency of SV40-positive lymphomas in two urban populations, emphasizing that SV40 infection and disease likely reflect population differences. The interaction of SV40 with human lymphocytes is under study.

    Collapse Research 
    Collapse research activities and funding
    R01CA134524     (BUTEL, JANET S)Jul 1, 2009 - Aug 31, 2014
    NIH
    Hamster Model of SV40 Infection and Disease
    Role: Principal Investigator

    R01CA104818     (BUTEL, JANET S)May 20, 2004 - Apr 30, 2010
    NIH
    SV40 Pathogenesis of Human Infections
    Role: Principal Investigator

    R21CA096951     (BUTEL, JANET S)Sep 1, 2002 - Aug 31, 2005
    NIH
    Hamster Model for AIDS Lymphomas
    Role: Principal Investigator

    T32AI007483     (BUTEL, JANET S)Aug 1, 1994 - Apr 30, 2000
    NIH
    TRAINING IN BASIC RESEARCH ON HIV AND AIDS
    Role: Principal Investigator

    P30AI036211     (RICE, ANDREW P)Apr 1, 1994 - Jul 31, 2017
    NIH
    Baylor-UT Houston Center for AIDS Research
    Role: Principal Investigator

    U01AI030243     (BUTEL, JANET S)Jul 1, 1990 - Jun 30, 1995
    NIH
    GENE THERAPY FOR AIDS
    Role: Principal Investigator

    R01CA037257     (BUTEL, JANET S)Jun 1, 1984 - May 31, 1989
    NIH
    HEPATITIS B VIRUS AND HUMAN LIVER CANCER
    Role: Principal Investigator

    R01CA033369     (BUTEL, JANET S)Sep 1, 1982 - Dec 31, 1998
    NIH
    CARCINOGEN/VIRAL ONCOGENE INTERACTIONS IN MAMMARY CANCER
    Role: Principal Investigator

    T32CA009197     (MARRIOTT, SUSAN J)Sep 15, 1979 - Jul 31, 2005
    NIH
    RESEARCH TRAINING PROGRAM IN VIRAL ONCOLOGY
    Role: Co-Principal Investigator

    R01CA025215     (BUTEL, JANET S)May 1, 1979 - Jul 31, 2005
    NIH
    SUPPRESSOR GENES AND BREAST CANCER
    Role: Principal Investigator

    N01CP081006     (BUTEL, JANET S)Jan 13, 1978
    NIH/NCI
    EFFECT OF ENVIRONMENTAL FACTORS ON MMTV EXPRESSION
    Role: Principal Investigator

    R01CA022555     (BUTEL, JANET S)Jan 1, 1978 - Jun 30, 1995
    NIH
    BIOLOGICAL PROPERTIES OF SV40 EARLY PROTEINS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Carbone M, Gazdar A, Butel JS, Carbone M, Gazdar A, Butel JS. SV40 and human mesothelioma. Transl Lung Cancer Res. 2020 Feb; 9(Suppl 1):S47-S59. PMID: 32206570; PMCID: PMC7082262.
      Citations: 7     
    2. Wong C, Zhang S, Adam E, Paszat L, Butel JS, Wong C, Zhang S, Adam E, Paszat L, Butel JS. SV40 seroprevalence in two Latin American countries involved in field trials of candidate oral poliovaccines. J Infect. 2019 06; 78(6):476-483. PMID: 30965068; PMCID: PMC6544904.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    3. McNees AL, Harrigal LJ, Kelly A, Minard CG, Wong C, Butel JS, McNees AL, Harrigal LJ, Kelly A, Minard CG, Wong C, Butel JS. Viral microRNA effects on persistent infection of human lymphoid cells by polyomavirus SV40. PLoS One. 2018; 13(2):e0192799. PMID: 29432481; PMCID: PMC5809058.
      Citations: 2     Fields:    Translation:HumansCells
    4. Tognon M, Corallini A, Manfrini M, Taronna A, Butel JS, Pietrobon S, Trevisiol L, Bononi I, Vaccher E, Barbanti-Brodano G, Martini F, Mazzoni E, Tognon M, Corallini A, Manfrini M, Taronna A, Butel JS, Pietrobon S, Trevisiol L, Bononi I, Vaccher E, Barbanti-Brodano G, Martini F, Mazzoni E. Specific Antibodies Reacting with SV40 Large T Antigen Mimotopes in Serum Samples of Healthy Subjects. PLoS One. 2016; 11(1):e0145720. PMID: 26731525; PMCID: PMC4701414.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    5. Comar M, Wong C, Tognon M, Butel JS, Comar M, Wong C, Tognon M, Butel JS. Neutralizing and IgG antibodies against simian virus 40 in healthy pregnant women in Italy. PLoS One. 2014; 9(10):e110700. PMID: 25335106; PMCID: PMC4205009.
      Citations: 6     Fields:    Translation:HumansCells
    6. Vanchiere JA, Carillo B, Morrow AL, Jiang X, Ruiz-Palacios GM, Butel JS, Vanchiere JA, Carillo B, Morrow AL, Jiang X, Ruiz-Palacios GM, Butel JS. Fecal Polyomavirus Excretion in Infancy. J Pediatric Infect Dis Soc. 2016 Jun; 5(2):210-3. PMID: 27199472; PMCID: PMC5407132.
      Citations: 4     Fields:    Translation:HumansCells
    7. Lednicky JA, Butel JS, Luetke MC, Loeb JC, Lednicky JA, Butel JS, Luetke MC, Loeb JC. Complete genomic sequence of a new Human polyomavirus 9 strain with an altered noncoding control region. Virus Genes. 2014 Dec; 49(3):490-2. PMID: 25260554.
      Citations: 7     Fields:    Translation:HumansCells
    8. Chen CJ, Burke JM, Kincaid RP, Azarm KD, Mireles N, Butel JS, Sullivan CS, Chen CJ, Burke JM, Kincaid RP, Azarm KD, Mireles N, Butel JS, Sullivan CS. Naturally arising strains of polyomaviruses with severely attenuated microRNA expression. J Virol. 2014 Nov; 88(21):12683-93. PMID: 25142594; PMCID: PMC4248899.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    9. Zhang S, Sroller V, Zanwar P, Chen CJ, Halvorson SJ, Ajami NJ, Hecksel CW, Swain JL, Wong C, Sullivan CS, Butel JS, Zhang S, Sroller V, Zanwar P, Chen CJ, Halvorson SJ, Ajami NJ, Hecksel CW, Swain JL, Wong C, Sullivan CS, Butel JS. Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters. PLoS Pathog. 2014 Feb; 10(2):e1003912. PMID: 24516384; PMCID: PMC3916418.
      Citations: 13     Fields:    Translation:AnimalsCells
    10. Jasani B, Butel JS, Jasani B, Butel JS. Can SV40 infect and immortalize human B-lymphocytes and mesothelial cells as a natural pathogen? Leuk Res. 2013 Jun; 37(6):607-8. PMID: 23601746.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Swain JL, Sroller V, Wong C, Zhang S, Halvorson SJ, Herron AJ, Kozinetz CA, Butel JS, Swain JL, Sroller V, Wong C, Zhang S, Halvorson SJ, Herron AJ, Kozinetz CA, Butel JS. Effects of route of inoculation and viral genetic variation on antibody responses to polyomavirus SV40 in Syrian golden hamsters. Comp Med. 2012 Oct; 62(5):400-8. PMID: 23114044; PMCID: PMC3472605.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Wong C, Vilchez RA, Quiroz J, Adam E, Butel JS, Wong C, Vilchez RA, Quiroz J, Adam E, Butel JS. Ethnic differences in polyomavirus simian virus 40 seroprevalence among women in Houston, Texas. J Infect. 2013 Jan; 66(1):67-74. PMID: 22940252; PMCID: PMC3518614.
      Citations: 6     Fields:    Translation:HumansCells
    13. Butel JS, Fan H, Butel JS, Fan H. The diversity of human cancer viruses. Curr Opin Virol. 2012 Aug; 2(4):449-52. PMID: 22819022.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Kusne S, Vilchez RA, Zanwar P, Quiroz J, Mazur MJ, Heilman RL, Mulligan D, Butel JS, Kusne S, Vilchez RA, Zanwar P, Quiroz J, Mazur MJ, Heilman RL, Mulligan D, Butel JS. Polyomavirus JC urinary shedding in kidney and liver transplant recipients associated with reduced creatinine clearance. J Infect Dis. 2012 Sep 15; 206(6):875-80. PMID: 22802433; PMCID: PMC3501156.
      Citations: 7     Fields:    Translation:HumansCells
    15. Butel JS, Butel JS. Patterns of polyomavirus SV40 infections and associated cancers in humans: a model. Curr Opin Virol. 2012 Aug; 2(4):508-14. PMID: 22771310; PMCID: PMC3422415.
      Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    16. Toracchio S, Foyle A, Sroller V, Reed JA, Wu J, Kozinetz CA, Butel JS, Toracchio S, Foyle A, Sroller V, Reed JA, Wu J, Kozinetz CA, Butel JS. Lymphotropism of Merkel cell polyomavirus infection, Nova Scotia, Canada. Emerg Infect Dis. 2010 Nov; 16(11):1702-9. PMID: 21029527; PMCID: PMC3294524.
      Citations: 15     Fields:    Translation:HumansCells
    17. Broekema NM, Abend JR, Bennett SM, Butel JS, Vanchiere JA, Imperiale MJ, Broekema NM, Abend JR, Bennett SM, Butel JS, Vanchiere JA, Imperiale MJ. A system for the analysis of BKV non-coding control regions: application to clinical isolates from an HIV/AIDS patient. Virology. 2010 Nov 25; 407(2):368-73. PMID: 20869740; PMCID: PMC2957895.
      Citations: 13     Fields:    Translation:HumansCells
    18. Thomas LD, Milstone AP, Vilchez RA, Zanwar P, Butel JS, Dummer JS, Thomas LD, Milstone AP, Vilchez RA, Zanwar P, Butel JS, Dummer JS. Polyomavirus infection and its impact on renal function and long-term outcomes after lung transplantation. Transplantation. 2009 Aug 15; 88(3):360-6. PMID: 19667938; PMCID: PMC2752200.
      Citations: 10     Fields:    Translation:HumansCells
    19. Toracchio S, Kozinetz CA, Killen DE, Sheehan AM, Banez EI, Ittmann MM, Sroller V, Butel JS, Toracchio S, Kozinetz CA, Killen DE, Sheehan AM, Banez EI, Ittmann MM, Sroller V, Butel JS. Variable frequency of polyomavirus SV40 and herpesvirus EBV in lymphomas from two different urban population groups in Houston, TX. J Clin Virol. 2009 Oct; 46(2):154-60. PMID: 19631582; PMCID: PMC2739273.
      Citations: 8     Fields:    Translation:HumansCells
    20. Vanchiere JA, Abudayyeh S, Copeland CM, Lu LB, Graham DY, Butel JS, Vanchiere JA, Abudayyeh S, Copeland CM, Lu LB, Graham DY, Butel JS. Polyomavirus shedding in the stool of healthy adults. J Clin Microbiol. 2009 Aug; 47(8):2388-91. PMID: 19494079; PMCID: PMC2725650.
      Citations: 31     Fields:    Translation:HumansCells
    21. Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G, Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G. Immune responses in adult female volunteers during the bed-rest model of spaceflight: antibodies and cytokines. J Allergy Clin Immunol. 2009 Apr; 123(4):900-5. PMID: 19232702.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    22. Patel NC, Halvorson SJ, Sroller V, Arrington AS, Wong C, Smith EO, Vilchez RA, Butel JS, Patel NC, Halvorson SJ, Sroller V, Arrington AS, Wong C, Smith EO, Vilchez RA, Butel JS. Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters. Virology. 2009 Mar 30; 386(1):94-101. PMID: 19181358; PMCID: PMC2668977.
      Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    23. McNees AL, Vilchez RA, Heard TC, Sroller V, Wong C, Herron AJ, Hamilton MJ, Davis WC, Butel JS, McNees AL, Vilchez RA, Heard TC, Sroller V, Wong C, Herron AJ, Hamilton MJ, Davis WC, Butel JS. SV40 lymphomagenesis in Syrian golden hamsters. Virology. 2009 Feb 05; 384(1):114-24. PMID: 19038412; PMCID: PMC3648995.
      Citations: 10     Fields:    Translation:AnimalsCells
    24. Javier RT, Butel JS, Javier RT, Butel JS. The history of tumor virology. Cancer Res. 2008 Oct 01; 68(19):7693-706. PMID: 18829521; PMCID: PMC3501656.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    25. Patel NC, Vilchez RA, Killen DE, Zanwar P, Sroller V, Eldin KW, López-Terrada D, Butel JS, Patel NC, Vilchez RA, Killen DE, Zanwar P, Sroller V, Eldin KW, López-Terrada D, Butel JS. Detection of polyomavirus SV40 in tonsils from immunocompetent children. J Clin Virol. 2008 Sep; 43(1):66-72. PMID: 18539521; PMCID: PMC2584969.
      Citations: 18     Fields:    Translation:HumansCells
    26. Westfall LW, Shearer MH, Jumper CA, White GL, Papin JF, Eberle R, Butel JS, Bright RK, Kennedy RC, Westfall LW, Shearer MH, Jumper CA, White GL, Papin JF, Eberle R, Butel JS, Bright RK, Kennedy RC. Evidence of simian virus 40 exposure in a colony of captive baboons. Virology. 2008 Jul 20; 377(1):54-62. PMID: 18485439; PMCID: PMC2527742.
      Citations: 2     Fields:    Translation:AnimalsCells
    27. Sroller V, Vilchez RA, Stewart AR, Wong C, Butel JS, Sroller V, Vilchez RA, Stewart AR, Wong C, Butel JS. Influence of the viral regulatory region on tumor induction by simian virus 40 in hamsters. J Virol. 2008 Jan; 82(2):871-9. PMID: 17977966; PMCID: PMC2224577.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Comar M, Rizzardi C, de Zotti R, Melato M, Bovenzi M, Butel JS, Campello C, Comar M, Rizzardi C, de Zotti R, Melato M, Bovenzi M, Butel JS, Campello C. SV40 multiple tissue infection and asbestos exposure in a hyperendemic area for malignant mesothelioma. Cancer Res. 2007 Sep 15; 67(18):8456-9. PMID: 17875683.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    29. Vilchez RA, Butel JS, Vilchez RA, Butel JS. Polyomavirus SV40 and AIDS-related systemic non-Hodgkin's lymphoma. Cancer Treat Res. 2007; 133:215-40. PMID: 17672043.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Thomas LD, Vilchez RA, White ZS, Zanwar P, Milstone AP, Butel JS, Dummer S, Thomas LD, Vilchez RA, White ZS, Zanwar P, Milstone AP, Butel JS, Dummer S. A prospective longitudinal study of polyomavirus shedding in lung-transplant recipients. J Infect Dis. 2007 Feb 01; 195(3):442-9. PMID: 17205484.
      Citations: 12     Fields:    Translation:HumansCells
    31. Meneses A, Lopez-Terrada D, Zanwar P, Killen DE, Monterroso V, Butel JS, Vilchez RA, Meneses A, Lopez-Terrada D, Zanwar P, Killen DE, Monterroso V, Butel JS, Vilchez RA. Lymphoproliferative disorders in Costa Rica and simian virus 40. Haematologica. 2005 Dec; 90(12):1635-42. PMID: 16330436.
      Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
    32. Zhang S, McNees AL, Butel JS, Zhang S, McNees AL, Butel JS. Quantification of vertical transmission of Murine polyoma virus by real-time quantitative PCR. J Gen Virol. 2005 Oct; 86(Pt 10):2721-2729. PMID: 16186225.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    33. McNees AL, White ZS, Zanwar P, Vilchez RA, Butel JS, McNees AL, White ZS, Zanwar P, Vilchez RA, Butel JS. Specific and quantitative detection of human polyomaviruses BKV, JCV, and SV40 by real time PCR. J Clin Virol. 2005 Sep; 34(1):52-62. PMID: 16087125.
      Citations: 47     Fields:    Translation:HumansCells
    34. Vilchez RA, Lopez-Terrada D, Middleton JR, Finch CJ, Killen DE, Zanwar P, Jorgensen JL, Butel JS, Vilchez RA, Lopez-Terrada D, Middleton JR, Finch CJ, Killen DE, Zanwar P, Jorgensen JL, Butel JS. Simian virus 40 tumor antigen expression and immunophenotypic profile of AIDS-related non-Hodgkin's lymphoma. Virology. 2005 Nov 10; 342(1):38-46. PMID: 16122775.
      Citations: 9     Fields:    Translation:HumansCells
    35. Vanchiere JA, Nicome RK, Greer JM, Demmler GJ, Butel JS, Vanchiere JA, Nicome RK, Greer JM, Demmler GJ, Butel JS. Frequent detection of polyomaviruses in stool samples from hospitalized children. J Infect Dis. 2005 Aug 15; 192(4):658-64. PMID: 16028135; PMCID: PMC4010313.
      Citations: 37     Fields:    Translation:HumansCells
    36. Shearer WT, Zhang S, Reuben JM, Lee BN, Butel JS, Shearer WT, Zhang S, Reuben JM, Lee BN, Butel JS. Effects of radiation and latent virus on immune responses in a space flight model. J Allergy Clin Immunol. 2005 Jun; 115(6):1297-303. PMID: 15940150.
      Citations: 11     Fields:    Translation:AnimalsCells
    37. Vanchiere JA, White ZS, Butel JS, Vanchiere JA, White ZS, Butel JS. Detection of BK virus and simian virus 40 in the urine of healthy children. J Med Virol. 2005 Mar; 75(3):447-54. PMID: 15648074.
      Citations: 23     Fields:    Translation:HumansCells
    38. Nurgalieva ZZ, Wong C, Zhangabylov AK, Omarbekova ZE, Graham DY, Vilchez RA, Butel JS, Nurgalieva ZZ, Wong C, Zhangabylov AK, Omarbekova ZE, Graham DY, Vilchez RA, Butel JS. Polyomavirus SV40 infections in Kazakhstan. J Infect. 2005 Feb; 50(2):142-8. PMID: 15667916.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    39. Vilchez RA, Brayton CF, Wong C, Zanwar P, Killen DE, Jorgensen JL, Butel JS, Vilchez RA, Brayton CF, Wong C, Zanwar P, Killen DE, Jorgensen JL, Butel JS. Differential ability of two simian virus 40 strains to induce malignancies in weanling hamsters. Virology. 2004 Dec 05; 330(1):168-77. PMID: 15527843.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    40. Forsman ZH, Lednicky JA, Fox GE, Willson RC, White ZS, Halvorson SJ, Wong C, Lewis AM, Butel JS, Forsman ZH, Lednicky JA, Fox GE, Willson RC, White ZS, Halvorson SJ, Wong C, Lewis AM, Butel JS. Phylogenetic analysis of polyomavirus simian virus 40 from monkeys and humans reveals genetic variation. J Virol. 2004 Sep; 78(17):9306-16. PMID: 15308725; PMCID: PMC506915.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    41. Vilchez RA, Butel JS, Vilchez RA, Butel JS. Emergent human pathogen simian virus 40 and its role in cancer. Clin Microbiol Rev. 2004 Jul; 17(3):495-508, table of contents. PMID: 15258090; PMCID: PMC452549.
      Citations: 34     Fields:    Translation:HumansCells
    42. Vilchez RA, Butel JS, Vilchez RA, Butel JS. Re: Lack of serologic evidence for prevalent simian virus 40 infection in humans. J Natl Cancer Inst. 2004 Apr 21; 96(8):633; author reply 633-4. PMID: 15100343.
      Citations: 1     Fields:    Translation:HumansCells
    43. Milstone A, Vilchez RA, Geiger X, Fogo AB, Butel JS, Dummer S, Milstone A, Vilchez RA, Geiger X, Fogo AB, Butel JS, Dummer S. Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipient. Transplantation. 2004 Apr 15; 77(7):1019-24. PMID: 15087764.
      Citations: 14     Fields:    Translation:HumansCells
    44. Arrington AS, Moore MS, Butel JS, Arrington AS, Moore MS, Butel JS. SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus. Oncogene. 2004 Mar 18; 23(12):2231-5. PMID: 14676832.
      Citations: 10     Fields:    Translation:HumansCells
    45. Vilchez RA, Butel JS, Vilchez RA, Butel JS. Polyomavirus SV40 infection and lymphomas in Spain. Int J Cancer. 2003 Nov 10; 107(3):505-6; author reply 507-8. PMID: 14506754.
      Citations:    Fields:    Translation:HumansCells
    46. Ling PD, Vilchez RA, Keitel WA, Poston DG, Peng RS, White ZS, Visnegarwala F, Lewis DE, Butel JS, Ling PD, Vilchez RA, Keitel WA, Poston DG, Peng RS, White ZS, Visnegarwala F, Lewis DE, Butel JS. Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapy. Clin Infect Dis. 2003 Nov 01; 37(9):1244-9. PMID: 14557970.
      Citations: 23     Fields:    Translation:HumansCells
    47. Vilchez RA, Butel JS, Vilchez RA, Butel JS. Simian virus 40 and its association with human lymphomas. Curr Oncol Rep. 2003 Sep; 5(5):372-9. PMID: 12895387.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    48. Vilchez RA, Arrington AS, Butel JS, Vilchez RA, Arrington AS, Butel JS. Re: Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40. J Natl Cancer Inst. 2003 Aug 20; 95(16):1249; author reply 1250. PMID: 12928352.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    49. Vilchez RA, Butel JS, Vilchez RA, Butel JS. SV40 in human brain cancers and non-Hodgkin's lymphoma. Oncogene. 2003 Aug 11; 22(33):5164-72. PMID: 12910253.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    50. Vilchez RA, Kozinetz CA, Arrington AS, Madden CR, Butel JS, Vilchez RA, Kozinetz CA, Arrington AS, Madden CR, Butel JS. Simian virus 40 in human cancers. Am J Med. 2003 Jun 01; 114(8):675-84. PMID: 12798456.
      Citations: 16     Fields:    Translation:HumansCells
    51. Vilchez RA, Butel JS, Vilchez RA, Butel JS. Re: Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccines. J Natl Cancer Inst. 2003 May 07; 95(9):687; author reply 689. PMID: 12734326.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    52. Vilchez RA, Butel JS, Vilchez RA, Butel JS. Simian virus 40 infection in lymphoproliferative disorders. Lancet. 2003 May 03; 361(9368):1565; author reply 1565-6. PMID: 12737902.
      Citations: 1     Fields:    Translation:HumansCells
    53. Ling PD, Lednicky JA, Keitel WA, Poston DG, White ZS, Peng R, Liu Z, Mehta SK, Pierson DL, Rooney CM, Vilchez RA, Smith EO, Butel JS, Ling PD, Lednicky JA, Keitel WA, Poston DG, White ZS, Peng R, Liu Z, Mehta SK, Pierson DL, Rooney CM, Vilchez RA, Smith EO, Butel JS. The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study. J Infect Dis. 2003 May 15; 187(10):1571-80. PMID: 12721937.
      Citations: 57     Fields:    Translation:HumansCells
    54. Lednicky JA, Vilchez RA, Keitel WA, Visnegarwala F, White ZS, Kozinetz CA, Lewis DE, Butel JS, Lednicky JA, Vilchez RA, Keitel WA, Visnegarwala F, White ZS, Kozinetz CA, Lewis DE, Butel JS. Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy. AIDS. 2003 Apr 11; 17(6):801-7. PMID: 12660526.
      Citations: 9     Fields:    Translation:HumansCells
    55. Vilchez RA, Finch CJ, Jorgensen JL, Butel JS, Vilchez RA, Finch CJ, Jorgensen JL, Butel JS. The clinical epidemiology of Hodgkin lymphoma in HIV-infected patients in the highly active antiretroviral therapy (HAART) era. Medicine (Baltimore). 2003 Mar; 82(2):77-81. PMID: 12640183.
      Citations: 4     Fields:    Translation:HumansCells
    56. Vilchez RA, Kozinetz CA, Butel JS, Vilchez RA, Kozinetz CA, Butel JS. Conventional epidemiology and the link between SV40 and human cancers. Lancet Oncol. 2003 Mar; 4(3):188-91. PMID: 12623365.
      Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
    57. Vilchez RA, Butel JS, Vilchez RA, Butel JS. An overview of the biology and viral pathogenesis of lymphoproliferative disorders in HIV-infected patients. Res Initiat Treat Action. 2003; 9(1):14-8. PMID: 14971361.
      Citations:    Fields:    Translation:Humans
    58. Sonnenfeld G, Butel JS, Shearer WT, Sonnenfeld G, Butel JS, Shearer WT. Effects of the space flight environment on the immune system. Rev Environ Health. 2003 Jan-Mar; 18(1):1-17. PMID: 12875508.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    59. Butel JS, Vilchez RA, Jorgensen JL, Kozinetz CA, Butel JS, Vilchez RA, Jorgensen JL, Kozinetz CA. Association between SV40 and non-Hodgkin's lymphoma. Leuk Lymphoma. 2003; 44 Suppl 3:S33-9. PMID: 15202523.
      Citations:    Fields:    Translation:HumansCells
    60. Gazdar AF, Butel JS, Carbone M, Gazdar AF, Butel JS, Carbone M. SV40 and human tumours: myth, association or causality? Nat Rev Cancer. 2002 Dec; 2(12):957-64. PMID: 12459734.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    61. Kwak EJ, Vilchez RA, Randhawa P, Shapiro R, Butel JS, Kusne S, Kwak EJ, Vilchez RA, Randhawa P, Shapiro R, Butel JS, Kusne S. Pathogenesis and management of polyomavirus infection in transplant recipients. Clin Infect Dis. 2002 Nov 01; 35(9):1081-7. PMID: 12384842.
      Citations: 20     Fields:    Translation:Humans
    62. Vilchez RA, Butel JS, Kusne S, Vilchez RA, Butel JS, Kusne S. Polyomaviruses in solid-organ transplant recipients. Transplantation. 2002 Aug 27; 74(4):579-80; author reply 580-1. PMID: 12352925.
      Citations: 1     Fields:    Translation:HumansCells
    63. Vilchez RA, Arrington AS, Butel JS, Vilchez RA, Arrington AS, Butel JS. Polyomaviruses in kidney transplant recipients. Am J Transplant. 2002 May; 2(5):481. PMID: 12123217.
      Citations:    Fields:    Translation:HumansCells
    64. Vilchez RA, Madden CR, Kozinetz CA, Halvorson SJ, White ZS, Jorgensen JL, Finch CJ, Butel JS, Vilchez RA, Madden CR, Kozinetz CA, Halvorson SJ, White ZS, Jorgensen JL, Finch CJ, Butel JS. Association between simian virus 40 and non-Hodgkin lymphoma. Lancet. 2002 Mar 09; 359(9309):817-23. PMID: 11897278.
      Citations: 36     Fields:    Translation:HumansCells
    65. Lednicky JA, Halvorson SJ, Butel JS, Lednicky JA, Halvorson SJ, Butel JS. PCR detection and DNA sequence analysis of the regulatory region of lymphotropic papovavirus in peripheral blood mononuclear cells of an immunocompromised rhesus macaque. J Clin Microbiol. 2002 Mar; 40(3):1056-9. PMID: 11880438; PMCID: PMC120229.
      Citations: 5     Fields:    Translation:AnimalsCells
    66. Vilchez RA, Kozinetz CA, Jorgensen JL, Kroll MH, Butel JS, Vilchez RA, Kozinetz CA, Jorgensen JL, Kroll MH, Butel JS. AIDS-related systemic non-Hodgkin's lymphoma at a large community program. AIDS Res Hum Retroviruses. 2002 Mar 01; 18(4):237-42. PMID: 11860669.
      Citations: 4     Fields:    Translation:HumansCells
    67. Vilchez RA, Lednicky JA, Halvorson SJ, White ZS, Kozinetz CA, Butel JS, Vilchez RA, Lednicky JA, Halvorson SJ, White ZS, Kozinetz CA, Butel JS. Detection of polyomavirus simian virus 40 tumor antigen DNA in AIDS-related systemic non-Hodgkin lymphoma. J Acquir Immune Defic Syndr. 2002 Feb 01; 29(2):109-16. PMID: 11832678.
      Citations: 9     Fields:    Translation:HumansCells
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