InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    R01DK121348     (WU, HUAIZHU)Jan 27, 2020 - Dec 31, 2023
    Regulation of Type 1 Inflammation in Diet-induced Obesity
    Role: Principal Investigator

    R01HL098839     (WU, HUAIZHU)Dec 1, 2009 - Mar 31, 2020
    Monocyte Activation and the Role of CD11c in obesity-linked metabolic syndrome
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang Q, Su X, He Y, Wang M, Yang D, Zhang R, Wei J, Ma Q, Zhai W, Pang A, Huang Y, Feng S, Ballantyne CM, Wu H, Pei X, Feng X, Han M, Jiang E. CD11c participates in triggering acute graft-versus-host disease during bone marrow transplantation. Immunology. 2021 09; 164(1):148-160. PMID: 33934334; PMCID: PMC8358721.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X. Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nat Commun. 2021 03 26; 12(1):1927. PMID: 33772019; PMCID: PMC7997910.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    3. Antony A, Lian Z, Perrard XD, Perrard J, Liu H, Cox AR, Saha P, Hennighausen L, Hartig SM, Ballantyne CM, Wu H. Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet. Diabetes. 2021 03; 70(3):720-732. PMID: 33323395; PMCID: PMC7897343.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    4. Hernandez AA, Foster GA, Soderberg SR, Fernandez A, Reynolds MB, Orser MK, Bailey KA, Rogers JH, Singh GD, Wu H, Passerini AG, Simon SI. An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes. J Immunol. 2020 11 15; 205(10):2806-2820. PMID: 33055281; PMCID: PMC7653512.
      Citations: 2     Fields:    Translation:HumansCells
    5. Cox AR, Chernis N, Bader DA, Saha PK, Masschelin PM, Felix JB, Sharp R, Lian Z, Putluri V, Rajapakshe K, Kim KH, Villareal DT, Armamento-Villareal R, Wu H, Coarfa C, Putluri N, Hartig SM. STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity. Diabetes. 2020 12; 69(12):2630-2641. PMID: 32994273; PMCID: PMC7679774.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. Lian Z, Saeed A, Peng X, Perrard XD, Jia X, Hussain A, Ballantyne CM, Wu H. Monocyte phenotyping and management of lipoprotein X syndrome. J Clin Lipidol. 2020 Nov - Dec; 14(6):850-858. PMID: 33011137; PMCID: PMC7736232.
      Citations: 1     Fields:    Translation:HumansCells
    7. Peng X, WU H, Wang M, Zhu H. . Chin J. Arterioscler. Hyperlipidemia, monocyte subtypes and atherosclerosis. 2020; 28(9):815-822.
    8. Wu H, Ballantyne CM. Metabolic Inflammation and Insulin Resistance in Obesity. Circ Res. 2020 05 22; 126(11):1549-1564. PMID: 32437299; PMCID: PMC7250139.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    9. Wu H, Xu L, Ballantyne CM. Dietary and Pharmacological Fatty Acids and Cardiovascular Health. J Clin Endocrinol Metab. 2020 04 01; 105(4). PMID: 31678992; PMCID: PMC7174038.
      Citations: 4     Fields:    Translation:Humans
    10. Dong B, Zhou Y, Wang W, Scott J, Kim K, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig SM, York RB, Yang F, Moore DD. Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice. Hepatology. 2020 05; 71(5):1559-1574. PMID: 31506976.
      Citations: 30     Fields:    Translation:AnimalsCells
    11. Lian Z, Perrard XD, Peng X, Raya JL, Hernandez AA, Johnson CG, Lagor WR, Pownall HJ, Hoogeveen RC, Simon SI, Sacks FM, Ballantyne CM, Wu H. Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice. Arterioscler Thromb Vasc Biol. 2020 01; 40(1):72-85. PMID: 31619061; PMCID: PMC6991890.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Lewis DE, Lysaght J, Wu H. Editorial: T Cell Alterations in Adipose Tissue During Obesity, HIV, and Cancer. Front Immunol. 2019; 10:1190. PMID: 31191549; PMCID: PMC6546799.
      Citations: 2     Fields:    Translation:HumansCells
    13. Wu H, Ballantyne CM. Letter by Wu and Ballantyne Regarding Article, "Protein Kinase C? via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6Chi Cells Contributes to Atherosclerosis". Circulation. 2019 04 23; 139(17):2077-2078. PMID: 31013133; PMCID: PMC6481314.
      Citations:    Fields:    Translation:HumansCells
    14. Kalathookunnel Antony A, Lian Z, Wu H. T Cells in Adipose Tissue in Aging. Front Immunol. 2018; 9:2945. PMID: 30619305; PMCID: PMC6299975.
      Citations: 13     Fields:    Translation:HumansCells
    15. Wang Q, Wu H. T Cells in Adipose Tissue: Critical Players in Immunometabolism. Front Immunol. 2018; 9:2509. PMID: 30459770; PMCID: PMC6232870.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    16. Wu J, Wu H, An J, Ballantyne CM, Cyster JG. Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6786-6791. PMID: 29891680; PMCID: PMC6042080.
      Citations: 20     Fields:    Translation:AnimalsCells
    17. Dai Perrard XY, Lian Z, Bobotas G, Dicklin MR, Maki KC, Wu H. Effects of n-3 fatty acid treatment on monocyte phenotypes in humans with hypertriglyceridemia. J Clin Lipidol. 2017 Nov - Dec; 11(6):1361-1371. PMID: 28942094; PMCID: PMC5698114.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    18. Aziz MH, Cui K, Das M, Brown KE, Ardell CL, Febbraio M, Pluskota E, Han J, Wu H, Ballantyne CM, Smith JD, Cathcart MK, Yakubenko VP. The Upregulation of Integrin aD?2 (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis. J Immunol. 2017 06 15; 198(12):4855-4867. PMID: 28500072; PMCID: PMC5553324.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    19. Wu H, Ballantyne CM. Dyslipidaemia: PCSK9 inhibitors and foamy monocytes in familial hypercholesterolaemia. Nat Rev Cardiol. 2017 07; 14(7):385-386. PMID: 28492287; PMCID: PMC5808934.
      Citations: 8     Fields:    Translation:HumansCells
    20. Wu H, Ballantyne CM. Skeletal muscle inflammation and insulin resistance in obesity. J Clin Invest. 2017 01 03; 127(1):43-54. PMID: 28045398; PMCID: PMC5199705.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    21. Khan IM, Pokharel Y, Dadu RT, Lewis DE, Hoogeveen RC, Wu H, Ballantyne CM. Postprandial Monocyte Activation in Individuals With Metabolic Syndrome. J Clin Endocrinol Metab. 2016 11; 101(11):4195-4204. PMID: 27575945; PMCID: PMC5095236.
      Citations: 21     Fields:    Translation:HumansCells
    22. Zhou H, Ran Y, Da Q, Shaw TS, Shang D, Reddy AK, Ballantyne CM, Ware J, Wu H, Peng Y, L?pez JA. Defective Association of the Platelet Glycoprotein Ib-IX Complex with the Glycosphingolipid-Enriched Membrane Domain Inhibits Murine Thrombus and Atheroma Formation. J Immunol. 2016 07 01; 197(1):288-95. PMID: 27206768; PMCID: PMC4929148.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Lin L, Lee JH, Buras ED, Yu K, Wang R, Smith CW, Wu H, Sheikh-Hamad D, Sun Y. Ghrelin receptor regulates adipose tissue inflammation in aging. Aging (Albany NY). 2016 Jan; 8(1):178-91. PMID: 26837433; PMCID: PMC4761721.
      Citations: 29     Fields:    Translation:AnimalsCells
    24. Foster GA, Xu L, Chidambaram AA, Soderberg SR, Armstrong EJ, Wu H, Simon SI. CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia. J Immunol. 2015 Dec 01; 195(11):5380-92. PMID: 26519532; PMCID: PMC4655135.
      Citations: 19     Fields:    Translation:AnimalsCells
    25. Xu L, Dai Perrard X, Perrard JL, Yang D, Xiao X, Teng BB, Simon SI, Ballantyne CM, Wu H. Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8):1787-97. PMID: 26112011; PMCID: PMC4514542.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    26. Khan IM, Perrard XY, Brunner G, Lui H, Sparks LM, Smith SR, Wang X, Shi ZZ, Lewis DE, Wu H, Ballantyne CM. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. Int J Obes (Lond). 2015 Nov; 39(11):1607-18. PMID: 26041698; PMCID: PMC5007876.
      Citations: 65     Fields:    Translation:AnimalsCells
    27. Wu H, Ballantyne CM. Inflammation versus host defense in obesity. Cell Metab. 2014 Nov 04; 20(5):708-709. PMID: 25440053; PMCID: PMC4755485.
      Citations: 6     Fields:    Translation:Animals
    28. Wooten JS, Wu H, Raya J, Perrard XD, Gaubatz J, Hoogeveen RC. The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice. Cholesterol. 2014; 2014:843468. PMID: 24672716; PMCID: PMC3941159.
      Citations: 11     
    29. Khan IM, Dai Perrard XY, Perrard JL, Mansoori A, Wayne Smith C, Wu H, Ballantyne CM. Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. Atherosclerosis. 2014 Apr; 233(2):419-428. PMID: 24530773; PMCID: PMC4094239.
      Citations: 41     Fields:    Translation:AnimalsCells
    30. Lim H, Kim YU, Sun H, Lee JH, Reynolds JM, Hanabuchi S, Wu H, Teng BB, Chung Y. Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo. Immunity. 2014 Jan 16; 40(1):153-65. PMID: 24412615; PMCID: PMC3955722.
      Citations: 52     Fields:    Translation:AnimalsCells
    31. Ma X, Lin L, Yue J, Pradhan G, Qin G, Minze LJ, Wu H, Sheikh-Hamad D, Smith CW, Sun Y. Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance. Nutr Diabetes. 2013 Dec 23; 3:e99. PMID: 24366371; PMCID: PMC3877431.
      Citations: 12     Fields:    
    32. Xu L, Ping F, Yin J, Xiao X, Xiang H, Ballantyne CM, Wu H, Li M. Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus. PLoS One. 2013; 8(12):e81615. PMID: 24349098; PMCID: PMC3857203.
      Citations: 21     Fields:    Translation:Humans
    33. Jiang E, Perrard XD, Yang D, Khan IM, Perrard JL, Smith CW, Ballantyne CM, Wu H. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol. 2014 Jan; 34(1):34-43. PMID: 24158516; PMCID: PMC4060534.
      Citations: 30     Fields:    Translation:AnimalsCells
    34. Wang J, Perrard XD, Perrard JL, Mukherjee A, Rosales C, Chen Y, Smith CW, Pownall HJ, Ballantyne CM, Wu H. ApoE and the role of very low density lipoproteins in adipose tissue inflammation. Atherosclerosis. 2012 Aug; 223(2):342-9. PMID: 22770993; PMCID: PMC3411924.
      Citations: 15     Fields:    Translation:Animals
    35. Liu MY, Zhou Z, Ma R, Tao Z, Choi H, Bergeron AL, Wu H, Dong JF. Gender-dependent up-regulation of ADAMTS-13 in mice with obesity and hypercholesterolemia. Thromb Res. 2012 Apr; 129(4):536-9. PMID: 22192156.
      Citations: 3     Fields:    Translation:AnimalsCells
    36. Wang Q, Perrard XD, Perrard JL, Mansoori A, Raya JL, Hoogeveen R, Smith CW, Ballantyne CM, Wu H. Differential effect of weight loss with low-fat diet or high-fat diet restriction on inflammation in the liver and adipose tissue of mice with diet-induced obesity. Atherosclerosis. 2011 Nov; 219(1):100-8. PMID: 21824616; PMCID: PMC3206136.
      Citations: 17     Fields:    Translation:AnimalsCells
    37. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton AA, Simon SI. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):160-6. PMID: 21030716; PMCID: PMC3038249.
      Citations: 72     Fields:    Translation:HumansCells
    38. Wang Q, Perrard XD, Perrard JL, Mansoori A, Smith CW, Ballantyne CM, Wu H. Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity. Obesity (Silver Spring). 2011 Mar; 19(3):505-13. PMID: 20885384; PMCID: PMC3272877.
      Citations: 11     Fields:    Translation:Animals
    39. Wu H, Perrard XD, Wang Q, Perrard JL, Polsani VR, Jones PH, Smith CW, Ballantyne CM. CD11c expression in adipose tissue and blood and its role in diet-induced obesity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):186-92. PMID: 19910635; PMCID: PMC2830649.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    40. Wu H, Ballantyne CM. Inflammation, adipose tissue, and T cells: what is the "straight skinny" on lean versus fat mice? Circ Res. 2009 Jul 17; 105(2):e3-4; author reply e5. PMID: 19608985; PMCID: PMC2740980.
      Citations:    Fields:    Translation:HumansAnimalsCells
    41. Wu H, Gower RM, Wang H, Perrard XY, Ma R, Bullard DC, Burns AR, Paul A, Smith CW, Simon SI, Ballantyne CM. Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation. 2009 May 26; 119(20):2708-17. PMID: 19433759; PMCID: PMC2716173.
      Citations: 125     Fields:    Translation:AnimalsCells
    42. Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, Ballantyne CM. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation. 2007 Feb 27; 115(8):1029-38. PMID: 17296858.
      Citations: 311     Fields:    Translation:HumansAnimalsCells
    43. Vasudevan AR, Wu H, Xydakis AM, Jones PH, Smith EO, Sweeney JF, Corry DB, Ballantyne CM. Eotaxin and obesity. J Clin Endocrinol Metab. 2006 Jan; 91(1):256-61. PMID: 16263831.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    44. Wu H, Rodgers JR, Perrard XY, Perrard JL, Prince JE, Abe Y, Davis BK, Dietsch G, Smith CW, Ballantyne CM. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 01; 173(1):297-306. PMID: 15210787.
      Citations: 37     Fields:    Translation:AnimalsCells
    45. Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 2003 Oct; 71(10):5986-93. PMID: 14500519; PMCID: PMC201099.
      Citations: 6     Fields:    Translation:AnimalsCells
    46. Wu H, Li J, Peng L, Liu H, Wu W, Zhou Y, Hou Q, Kong D. Anti-human platelet tetraspanin (CD9) monoclonal antibodies induce platelet integrin alpha IIb beta 3 activation in a Fc receptor-independent fashion. Chin Med J (Engl). 2001 Jan; 114(1):14-8. PMID: 11779428.
      Citations:    Fields:    Translation:Humans
    47. An X, Han Z, Wang P, WU H, Zhou Y. . Study on the relationship between plasmingen activator inhibitor-1 (PAI-1) and acute myocardial infarction. Chin J Cardiovasc Med. 2001; 6(2):71-74.
    48. An X, Han Z, Zhou Y, WU H, Wang P, You H. . Role of plasmingen activator inhibitor-1 in acute myocardial infarction. Chin J Hematol. 2001; 22(9):489-491.
    49. Peng L, Li J, Wu H. [Study on conformational changes of GP IIb/IIIa complex during platelet activation]. Zhonghua Xue Ye Xue Za Zhi. 1999 Sep; 20(9):459-61. PMID: 11721407.
      Citations:    Fields:    Translation:HumansCells
    50. Wu H, Li J, Peng L. [Characteristics of human platelet fibrinogen receptors regulated by anti-CD9 monoclonal antibodies]. Zhonghua Xue Ye Xue Za Zhi. 1999 Sep; 20(9):456-8. PMID: 11721406.
      Citations:    Fields:    Translation:HumansCells
    51. Wu H, Peng L, Li J, Wu W, Hou Q, Liu H, Wang M. Reversible exposure of human platelet fibrinogen receptors by antiplatelet tetraspanin monoclonal antibodies via induction of a conformational change in membrane glycoprotein IIb/IIIa complex. Thromb Res. 1999 Sep 01; 95(5):245-53. PMID: 10515289.
      Citations:    Fields:    Translation:HumansCells
    52. Sun C, Jin B, Sun K, Li J, WU H, Liu X, Yang K, Dong B. . Expression and localization of PTA1 molecule on human platelets and HEL cell line. Chinese journal of cellular and molecular immunology. 1998; 14(3):195-198.
    53. Yuan H, Lin H, Zhu X, Zhang Y, Zhang X, Zhu L, Lei Z, Zhao M, WU H. Study on the in vitro and in vivo Thrombolytic Efficacy of Bispecific Antifibrin-Antiurokinase Monoclonal Antibodies. ACTA ACADEMIAE MEDICINAE SINICAE. 1998; 20(5):357-360.
    54. Peng L, Li JZ, Wu HZ, Wang MJ. The activation of human platelets mediated by two monoclonal antibodies raised against CD9. Thromb Res. 1997 Jul 01; 87(1):65-73. PMID: 9253801.
      Citations: 1     Fields:    Translation:Humans
    55. Wu H, Li J, Peng L, Teng B, Zhai Z. Effect of 764-3 on aggregation and calcium movements in aequorin-loaded human platelets. Chin Med Sci J. 1996 Mar; 11(1):49-52. PMID: 9206120.
      Citations:    Fields:    Translation:HumansCells
    56. WU H, Li J, Peng L, Teng B, Liu F, Liu H. Clot lysis in vivo targeted by a bispecific monoclonal antibody directed against urokinase and human fibrin. J Exp Hematol. 1996; 4(2):183-187.
    57. Peng L, Li J, Wu H, Teng B. [Characterization of platelet activation induced by CD9 McAbs]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1995 Oct; 17(5):365-70. PMID: 8706172.
      Citations:    Fields:    Translation:HumansCells
    58. WU H, Li J. The study of blood coagulation mechanisms. Chin J Thromb Hemost. 1995; 2(1):27-30.
    59. WU H, Li J. . The anti-platelet effects of calcium channel blockers. Chin J Hematol. 1995; 16(3):157-159.
    60. WU H, Li J, Bao C. . In vitro inhibition by 764-3 of human platelet aggregation and release reaction. Chin J Hematol. 1994; 15(9):458-460.
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    62. Wu HZ, Li JZ. [Development of the high effective thrombolytic agents with molecular biological technique]. Zhonghua Nei Ke Za Zhi. 1993 Jan; 32(1):11-3. PMID: 8404311.
      Citations:    Fields:    Translation:Animals
    63. WU H. . Modification of thrombolytic agents. Foreign Medicine: Section of Pharmacology. 1992; 19(6):341-3435.
    64. WU H, Li J. The study of antibody-targeted thrombolysis. Basic Medical Science and Clinics. 1992; 12(4):213-216.
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