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Institute for Clinical and Translational Research

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WEEI-CHIN LIN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Hematology & Oncology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDuncan Cancer Center
    DivisionCancer Center


    Collapse ORNG Applications 
    Collapse Faculty Mentor
    Collapse Verify Publications

    Collapse Biography 
    Collapse awards and honors
    2014 - 2019BCM Oncology Scholars Training Program (T32), NIH/NCI
    2013Dan L. Duncan Cancer Center pilot project award, Baylor College of Medicine
    2012Breast SPORE Translational Research Award, Baylor College of Medicine
    2010Dan Duncan Professorship of Oncology, Baylor College of Medicine, Baylor College of Medicine
    2007 - 2014America’s Top Doctors (Hematology), Castle Connolly Medical Ltd.
    2007 - 2011America’s Top Doctors for Cancer, Castle Connolly Medical Ltd.
    2006 - 2011Leukemia & Lymphoma Society Scholar, University of Alabama at Birmingham
    2002 - 2005General Motors Cancer Research Scholar, University of Alabama at Birmingham
    2001 - 2004Breast SPORE Career Development Award, UAB, University of Alabama at Birmingham
    2001 - 2004Howard Hughes Medical Institute Junior Faculty Development Award, University of Alabama at Birmingham
    1998 - 2001Physician Scientist Award, Damon Runyon-Walter Winchell Foundation , Duke University
    1998American Society of Hematology Fellow Scholar Award
    1993the Martin and Carol Macht Research Prize, Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine
    1979 - 1986Book Coupon Awards, National Taiwan University College of Medicine, National Taiwan University

    Collapse Research 
    Collapse research activities and funding
    R01CA100857     (LIN, WEEI-CHIN)Apr 1, 2003 - Mar 31, 2009
    NIH/NCI
    The ATM/E2F1 Pathway in DNA Damage and Growth Control
    Role: Principal Investigator
    R01CA138641     (LIN, WEEI-CHIN)Apr 1, 2010 - Jan 31, 2015
    NIH/NCI
    Therapeutic Targeting of Oncogenic Stress in Cancer Treatment
    Role: Principal Investigator
    T32CA174647     (LIN, WEEI-CHIN)Aug 5, 2014 - Jul 31, 2019
    NIH/NCI
    BCM Oncology Scholars Training Program
    Role: Principal Investigator
    R21CA198041     (LIN, WEEI-CHIN)Jun 1, 2016 - May 31, 2018
    NIH/NCI
    New mechanisms of breast cancer metastasis and loss of estrogen receptor driven by 14-3-3
    Role: Principal Investigator
    R01CA203824     (LIN, WEEI-CHIN)Dec 15, 2016 - Nov 30, 2021
    NIH/NCI
    Novel therapeutics for targeting checkpoint dysfunction in cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Liu K, Graves JD, Lee YJ, Lin FT, Lin WC. Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt. Mol Cell Biol. 2020 Mar 30; 40(8). PMID: 31964753.
      View in: PubMed
    2. Lee YJ, Ho SR, Graves JD, Xiao Y, Huang S, Lin WC. CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res. 2019 12 04; 21(1):134. PMID: 31801577.
      View in: PubMed
    3. Ho SR, Lin WC. RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation. J Biol Chem. 2018 10 19; 293(42):16307-16323. PMID: 30171075.
      View in: PubMed
    4. Liu K, Lin FT, Graves JD, Lee YJ, Lin WC. Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):E3766-E3775. PMID: 28439015.
      View in: PubMed
    5. Lin FT, Lin VY, Lin VT, Lin WC. TRIP6 antagonizes the recruitment of A20 and CYLD to TRAF6 to promote the LPA2 receptor-mediated TRAF6 activation. Cell Discov. 2016; 2. PMID: 27134758.
      View in: PubMed
    6. Mahanic CS, Budhavarapu V, Graves JD, Li G, Lin WC. Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37. J Biol Chem. 2015 Oct 30; 290(44):26508-22. PMID: 26396186.
      View in: PubMed
    7. Ho SR, Lee YJ, Lin WC. Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain. J Biol Chem. 2015 Sep 18; 290(38):23026-38. PMID: 26216882.
      View in: PubMed
    8. Chowdhury P, Lin GE, Liu K, Song Y, Lin FT, Lin WC. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014 Nov 17; 5:5476. PMID: 25400145.
      View in: PubMed
    9. Xiao Y, Lin VY, Ke S, Lin GE, Lin FT, Lin WC. 14-3-3t promotes breast cancer invasion and metastasis by inhibiting RhoGDIa. Mol Cell Biol. 2014 Jul; 34(14):2635-49. PMID: 24820414.
      View in: PubMed
    10. Ho SR, Mahanic CS, Lee YJ, Lin WC. RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):E2646-55. PMID: 24979766.
      View in: PubMed
    11. Liu K, Graves JD, Scott JD, Li R, Lin WC. Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization. Mol Cell Biol. 2013 Dec; 33(23):4685-700. PMID: 24081328.
      View in: PubMed
    12. Lin VT, Lin VY, Lai YJ, Chen CS, Liu K, Lin WC, Lin FT. TRIP6 regulates p27 KIP1 to promote tumorigenesis. Mol Cell Biol. 2013 Apr; 33(7):1394-409. PMID: 23339869.
      View in: PubMed
    13. Budhavarapu VN, White ED, Mahanic CS, Chen L, Lin FT, Lin WC. Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012 May 15; 11(10):2030-8. PMID: 22580462.
      View in: PubMed
    14. Liu K, Ling S, Lin WC. TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73. Mol Cell Biol. 2011 Nov; 31(22):4464-81. PMID: 21930790.
      View in: PubMed
    15. Ling S, Lin WC. EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem. 2011 Apr 29; 286(17):14972-82. PMID: 21383020.
      View in: PubMed
    16. Bhonde MR, Hanski ML, Stehr J, Jebautzke B, Peiró-Jordán R, Fechner H, Yokoyama KK, Lin WC, Zeitz M, Hanski C. Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38. Int J Cancer. 2010 Jun 15; 126(12):2813-25. PMID: 19739070.
      View in: PubMed
    17. Wang B, Ling S, Lin WC. 14-3-3Tau regulates Beclin 1 and is required for autophagy. PLoS One. 2010 Apr 29; 5(4):e10409. PMID: 20454448.
      View in: PubMed
    18. Wang B, Liu K, Lin HY, Bellam N, Ling S, Lin WC. 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol. 2010 Mar; 30(6):1508-27. PMID: 20086099.
      View in: PubMed
    19. Paik JC, Wang B, Liu K, Lue JK, Lin WC. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J Biol Chem. 2010 Feb 26; 285(9):6348-63. PMID: 20040599.
      View in: PubMed
    20. Liu K, Bellam N, Lin HY, Wang B, Stockard CR, Grizzle WE, Lin WC. Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol. 2009 May; 29(10):2673-93. PMID: 19289498.
      View in: PubMed
    21. Yang SZ, Lin FT, Lin WC. MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep. 2008 Sep; 9(9):907-15. PMID: 18660752.
      View in: PubMed
    22. Lin FT, Lai YJ, Makarova N, Tigyi G, Lin WC. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. J Biol Chem. 2007 Dec 28; 282(52):37759-69. PMID: 17965021.
      View in: PubMed
    23. Lai YJ, Lin WC, Lin FT. PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration. J Biol Chem. 2007 Aug 17; 282(33):24381-7. PMID: 17591779.
      View in: PubMed
    24. Liu K, Paik JC, Wang B, Lin FT, Lin WC. Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J. 2006 Oct 18; 25(20):4795-807. PMID: 17006541.
      View in: PubMed
    25. Lai YJ, Chen CS, Lin WC, Lin FT. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol Cell Biol. 2005 Jul; 25(14):5859-68. PMID: 15988003.
      View in: PubMed
    26. Wang B, Liu K, Lin FT, Lin WC. A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 2004 Dec 24; 279(52):54140-52. PMID: 15494392.
      View in: PubMed
    27. Luo Y, Lin FT, Lin WC. ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol. 2004 Jul; 24(14):6430-44. PMID: 15226443.
      View in: PubMed
    28. Liu K, Luo Y, Lin FT, Lin WC. TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev. 2004 Mar 15; 18(6):673-86. PMID: 15075294.
      View in: PubMed
    29. Xu J, Lai YJ, Lin WC, Lin FT. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12; 279(11):10459-68. PMID: 14688263.
      View in: PubMed
    30. Liu K, Lin FT, Ruppert JM, Lin WC. Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol. 2003 May; 23(9):3287-304. PMID: 12697828.
      View in: PubMed
    31. Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15; 15(14):1833-44. PMID: 11459832.
      View in: PubMed
    32. Lin WC, Telen MJ. Cardiac metastasis from a transitional cell carcinoma: a case report. Med Oncol. 2000 May; 17(2):147-50. PMID: 10871822.
      View in: PubMed
    33. Lin WC, Moore JO, Mann KP, Traweek ST, Smith C. Post transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection. Leuk Lymphoma. 1999 Apr; 33(3-4):377-84. PMID: 10221519.
      View in: PubMed
    34. Desiderio S, Lin WC, Li Z. The cell cycle and V(D)J recombination. Curr Top Microbiol Immunol. 1996; 217:45-59. PMID: 8787617.
      View in: PubMed
    35. Lin WC, Desiderio S. V(D)J recombination and the cell cycle. Immunol Today. 1995 Jun; 16(6):279-89. PMID: 7662097.
      View in: PubMed
    36. Lin WC, Desiderio S. Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2733-7. PMID: 8146183.
      View in: PubMed
    37. Oltz EM, Alt FW, Lin WC, Chen J, Taccioli G, Desiderio S, Rathbun G. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol Cell Biol. 1993 Oct; 13(10):6223-30. PMID: 8413222.
      View in: PubMed
    38. Lin WC, Desiderio S. Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation. Science. 1993 May 14; 260(5110):953-9. PMID: 8493533.
      View in: PubMed
    39. Lin LY, Lin WC, Huang PC. Pigeon metallothionein consists of two species. Biochim Biophys Acta. 1990 Feb 09; 1037(2):248-55. PMID: 2407296.
      View in: PubMed
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