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JENNIFER SPINLER

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address6621 FANNIN
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Horvath TD, Haidacher SJ, Engevik MA, Luck B, Ruan W, Ihekweazu F, Bajaj M, Hoch KM, Oezguen N, Spinler JK, Versalovic J, Haag AM. Interrogation of the mammalian gut-brain axis using LC-MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic mouse models. Nat Protoc. 2023 02; 18(2):490-529. PMID: 36352124.
      Citations: 4     Fields:    Translation:AnimalsCells
    2. Norsigian CJ, Danhof HA, Brand CK, Midani FS, Broddrick JT, Savidge TC, Britton RA, Palsson BO, Spinler JK, Monk JM. Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2119396119. PMID: 35476524; PMCID: PMC9170149.
      Citations:    Fields:    Translation:HumansCells
    3. Horvath TD, Ihekweazu FD, Haidacher SJ, Ruan W, Engevik KA, Fultz R, Hoch KM, Luna RA, Oezguen N, Spinler JK, Haag AM, Versalovic J, Engevik MA. Bacteroides ovatus colonization influences the abundance of intestinal short chain fatty acids and neurotransmitters. iScience. 2022 May 20; 25(5):104158. PMID: 35494230; PMCID: PMC9038548.
      Citations:    
    4. Kellermayer R, Wu Q, Nagy-Szakal D, Queliza K, Ihekweazu FD, Bocchini CE, Magee AR, Oezguen N, Spinler JK, Hollister EB, Shulman RJ, Versalovic J, Luna RA, Savidge TC. Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities. J Pediatr Gastroenterol Nutr. 2022 02 01; 74(2):227-235. PMID: 34724447; PMCID: PMC8799498.
      Citations:    Fields:    Translation:HumansCells
    5. Fultz R, Ticer T, Ihekweazu FD, Horvath TD, Haidacher SJ, Hoch KM, Bajaj M, Spinler JK, Haag AM, Buffington SA, Engevik MA. Unraveling the Metabolic Requirements of the Gut Commensal Bacteroides ovatus. Front Microbiol. 2021; 12:745469. PMID: 34899632; PMCID: PMC8656163.
      Citations: 1     
    6. Spinler JK, Raza S, Thapa S, Venkatachalam A, Scott T, Runge JK, Dunn J, Versalovic J, Luna RA. Comparison of Whole Genome Sequencing and Repetitive Element PCR for Multidrug-Resistant Pseudomonas aeruginosa Strain Typing. J Mol Diagn. 2022 02; 24(2):158-166. PMID: 34775029.
      Citations: 1     Fields:    Translation:HumansCells
    7. Engevik M, Ruan W, Visuthranukul C, Shi Z, Engevik KA, Engevik AC, Fultz R, Schady DA, Spinler JK, Versalovic J. Limosilactobacillus reuteri ATCC 6475 metabolites upregulate the serotonin transporter in the intestinal epithelium. Benef Microbes. 2021 Nov 16; 12(6):583-599. PMID: 34550056; PMCID: PMC10977654.
      Citations:    Fields:    Translation:AnimalsCells
    8. Luck B, Horvath TD, Engevik KA, Ruan W, Haidacher SJ, Hoch KM, Oezguen N, Spinler JK, Haag AM, Versalovic J, Engevik MA. Neurotransmitter Profiles Are Altered in the Gut and Brain of Mice Mono-Associated with Bifidobacterium dentium. Biomolecules. 2021 07 23; 11(8). PMID: 34439760; PMCID: PMC8392031.
      Citations: 4     Fields:    Translation:AnimalsCells
    9. Gonzales-Luna AJ, Spinler JK, Oezguen N, Khan MAW, Danhof HA, Endres BT, Alam MJ, Begum K, Lancaster C, Costa GP, Savidge TC, Hurdle JG, Britton R, Garey KW. Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe. 2021 Aug; 70:102387. PMID: 34044101; PMCID: PMC8384661.
      Citations: 3     Fields:    Translation:HumansCells
    10. Engevik MA, Danhof HA, Hall A, Engevik KA, Horvath TD, Haidacher SJ, Hoch KM, Endres BT, Bajaj M, Garey KW, Britton RA, Spinler JK, Haag AM, Versalovic J. The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal. BMC Microbiol. 2021 05 24; 21(1):154. PMID: 34030655; PMCID: PMC8145834.
      Citations: 5     Fields:    Translation:HumansCells
    11. Marquez L, Koy T, Spinler JK, Luna RA, Tocco L, Fasciano L, Dunn J, Campbell JR. Reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 variant in an immunocompromised adolescent. Infect Control Hosp Epidemiol. 2022 08; 43(8):1088-1090. PMID: 33934744; PMCID: PMC8144827.
      Citations: 5     Fields:    
    12. Engevik MA, Danhof HA, Ruan W, Engevik AC, Chang-Graham AL, Engevik KA, Shi Z, Zhao Y, Brand CK, Krystofiak ES, Venable S, Liu X, Hirschi KD, Hyser JM, Spinler JK, Britton RA, Versalovic J. Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation. mBio. 2021 03 02; 12(2). PMID: 33653893; PMCID: PMC8092269.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    13. Ihekweazu FD, Engevik MA, Ruan W, Shi Z, Fultz R, Engevik KA, Chang-Graham AL, Freeborn J, Park ES, Venable S, Horvath TD, Haidacher SJ, Haag AM, Goodwin A, Schady DA, Hyser JM, Spinler JK, Liu Y, Versalovic J. Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid-Driven Colonic Inflammation. Am J Pathol. 2021 04; 191(4):704-719. PMID: 33516788; PMCID: PMC8027925.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Engevik MA, Herrmann B, Ruan W, Engevik AC, Engevik KA, Ihekweazu F, Shi Z, Luck B, Chang-Graham AL, Esparza M, Venable S, Horvath TD, Haidacher SJ, Hoch KM, Haag AM, Schady DA, Hyser JM, Spinler JK, Versalovic J. Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation. Gut Microbes. 2021 Jan-Dec; 13(1):1-21. PMID: 33985416; PMCID: PMC8128206.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    15. Engevik MA, Engevik AC, Engevik KA, Auchtung JM, Chang-Graham AL, Ruan W, Luna RA, Hyser JM, Spinler JK, Versalovic J. Mucin-Degrading Microbes Release Monosaccharides That Chemoattract Clostridioides difficile and Facilitate Colonization of the Human Intestinal Mucus Layer. ACS Infect Dis. 2021 05 14; 7(5):1126-1142. PMID: 33176423; PMCID: PMC8110611.
      Citations: 6     Fields:    Translation:HumansCells
    16. Engevik MA, Danhof HA, Shrestha R, Chang-Graham AL, Hyser JM, Haag AM, Mohammad MA, Britton RA, Versalovic J, Sorg JA, Spinler JK. Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation. Gut Microbes. 2020 11 09; 12(1):1788898. PMID: 32804011; PMCID: PMC7524292.
      Citations: 7     Fields:    Translation:HumansCells
    17. Norsigian CJ, Danhof HA, Brand CK, Oezguen N, Midani FS, Palsson BO, Savidge TC, Britton RA, Spinler JK, Monk JM. Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence. NPJ Syst Biol Appl. 2020 10 20; 6(1):31. PMID: 33082337; PMCID: PMC7576604.
      Citations: 8     Fields:    Translation:Cells
    18. Spinler JK, Oezguen N, Runge JK, Luna RA, Karri V, Yang J, Hirschi KD. Dietary impact of a plant-derived microRNA on the gut microbiome. ExRNA. 2020; 2. PMID: 33542959; PMCID: PMC7856875.
      Citations: 3     
    19. Engevik MA, Danhof HA, Chang-Graham AL, Spinler JK, Engevik KA, Herrmann B, Endres BT, Garey KW, Hyser JM, Britton RA, Versalovic J. Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis. Am J Physiol Gastrointest Liver Physiol. 2020 05 01; 318(5):G870-G888. PMID: 32223302; PMCID: PMC7272722.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Ruan W, Engevik MA, Spinler JK, Versalovic J. Healthy Human Gastrointestinal Microbiome: Composition and Function After a Decade of Exploration. Dig Dis Sci. 2020 03; 65(3):695-705. PMID: 32067143.
      Citations: 24     Fields:    Translation:Humans
    21. Spinler JK, Raza S, Runge JK, Luna RA. Complete Genome Sequence of the Multidrug-Resistant Pseudomonas aeruginosa Endemic Houston-1 Strain, Isolated from a Pediatric Patient with Cystic Fibrosis and Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiol Resour Announc. 2019 Oct 24; 8(43). PMID: 31649076; PMCID: PMC6813388.
      Citations:    
    22. Spinler JK, Gonzales-Luna AJ, Raza S, Runge JK, Luna RA, Savidge TC, Garey KW. Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiol Resour Announc. 2019 Oct 17; 8(42). PMID: 31624167; PMCID: PMC6797532.
      Citations: 3     
    23. Engevik MA, Morra CN, Engevik K, Spinler JK, Devaraj S, Crawford SE, Estes MK, Kalkum M, Versalovic J, R?th D. Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors. Front Microbiol. 2019; 10:2305. PMID: 31649646; PMCID: PMC6795088.
      Citations: 31     
    24. Spinler JK, Karri V, Hirschi KD. Planting the Microbiome. Trends Microbiol. 2019 02; 27(2):90-93. PMID: 30600139.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Peniche AG, Spinler JK, Boonma P, Savidge TC, Dann SM. Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity. Anaerobe. 2018 Dec; 54:83-91. PMID: 30099125; PMCID: PMC6291369.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Spinler JK, Auchtung J, Brown A, Boonma P, Oezguen N, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TC, Ross CL. Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis. Infect Immun. 2017 10; 85(10). PMID: 28760934; PMCID: PMC5607411.
      Citations: 25     Fields:    Translation:HumansCells
    27. Panpetch W, Spinler JK, Versalovic J, Tumwasorn S. Characterization of Lactobacillus salivarius strains B37 and B60 capable of inhibiting IL-8 production in Helicobacter pylori-stimulated gastric epithelial cells. BMC Microbiol. 2016 10 18; 16(1):242. PMID: 27756217; PMCID: PMC5070129.
      Citations: 11     Fields:    Translation:HumansCells
    28. Thomas CM, Saulnier DM, Spinler JK, Hemarajata P, Gao C, Jones SE, Grimm A, Balderas MA, Burstein MD, Morra C, Roeth D, Kalkum M, Versalovic J. FolC2-mediated folate metabolism contributes to suppression of inflammation by probiotic Lactobacillus reuteri. Microbiologyopen. 2016 Oct; 5(5):802-818. PMID: 27353144; PMCID: PMC5061717.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. Spinler JK, Savidge TC, Ross CL. Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for? Anaerobe. 2016 Oct; 41:51-57. PMID: 27180657; PMCID: PMC5050073.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    30. Spinler JK, Savidge TC, Ross CL. Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection. Anaerobe. 2016 Oct; 41:37-43. PMID: 27180006; PMCID: PMC5050078.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    31. Spinler JK, Brown A, Boonma P, Conner ME, Savidge TC, Ross CL. Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease. Anaerobe. 2016 Aug; 40:54-7. PMID: 27180007; PMCID: PMC4969211.
      Citations: 7     Fields:    Translation:AnimalsCells
    32. Boonma P, Spinler JK, Venable SF, Versalovic J, Tumwasorn S. Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells. BMC Microbiol. 2014 Jul 02; 14:177. PMID: 24989059; PMCID: PMC4094603.
      Citations: 32     Fields:    Translation:HumansCells
    33. Finocchario-Kessler S, Gautney BJ, Khamadi S, Okoth V, Goggin K, Spinler JK, Mwangi A, Kimanga D, Clark KF, Olungae HD, Preidis GA, HITSystem Team. If you text them, they will come: using the HIV infant tracking system to improve early infant diagnosis quality and retention in Kenya. AIDS. 2014 Jul; 28 Suppl 3:S313-21. PMID: 24991904; PMCID: PMC4226133.
      Citations: 45     Fields:    Translation:HumansPHPublic Health
    34. Spinler JK, Sontakke A, Hollister EB, Venable SF, Oh PL, Balderas MA, Saulnier DM, Mistretta TA, Devaraj S, Walter J, Versalovic J, Highlander SK. From prediction to function using evolutionary genomics: human-specific ecotypes of Lactobacillus reuteri have diverse probiotic functions. Genome Biol Evol. 2014 Jun 19; 6(7):1772-89. PMID: 24951561; PMCID: PMC4122935.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    35. Boonma P, Spinler JK, Qin X, Jittaprasatsin C, Muzny DM, Doddapaneni H, Gibbs R, Petrosino J, Tumwasorn S, Versalovic J. Draft genome sequences and description of Lactobacillus rhamnosus strains L31, L34, and L35. Stand Genomic Sci. 2014 Jun 15; 9(3):744-54. PMID: 25197459; PMCID: PMC4148986.
      Citations: 3     
    36. Hemarajata P, Spinler JK, Balderas MA, Versalovic J. Identification of a proton-chloride antiporter (EriC) by Himar1 transposon mutagenesis in Lactobacillus reuteri and its role in histamine production. Antonie Van Leeuwenhoek. 2014 Mar; 105(3):579-92. PMID: 24488273; PMCID: PMC4011013.
      Citations: 5     Fields:    Translation:Cells
    37. Thiraworawong T, Spinler JK, Werawatganon D, Klaikeaw N, Venable SF, Versalovic J, Tumwasorn S. Anti-inflammatory properties of gastric-derived Lactobacillus plantarum XB7 in the context of Helicobacter pylori infection. Helicobacter. 2014 Apr; 19(2):144-55. PMID: 24387083.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    38. Hemarajata P, Gao C, Pflughoeft KJ, Thomas CM, Saulnier DM, Spinler JK, Versalovic J. Lactobacillus reuteri-specific immunoregulatory gene rsiR modulates histamine production and immunomodulation by Lactobacillus reuteri. J Bacteriol. 2013 Dec; 195(24):5567-76. PMID: 24123819; PMCID: PMC3889603.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    39. Olson D, Preidis GA, Milazi R, Spinler JK, Lufesi N, Mwansambo C, Hosseinipour MC, McCollum ED. Task shifting an inpatient triage, assessment and treatment programme improves the quality of care for hospitalised Malawian children. Trop Med Int Health. 2013 Jul; 18(7):879-86. PMID: 23600592; PMCID: PMC3683117.
      Citations: 22     Fields:    Translation:Humans
    40. Santos F, Spinler JK, Saulnier DM, Molenaar D, Teusink B, de Vos WM, Versalovic J, Hugenholtz J. Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis. Microb Cell Fact. 2011 Jul 21; 10:55. PMID: 21777454; PMCID: PMC3162504.
      Citations: 15     Fields:    Translation:Cells
    41. Saulnier DM, Santos F, Roos S, Mistretta TA, Spinler JK, Molenaar D, Teusink B, Versalovic J. Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features. PLoS One. 2011 Apr 29; 6(4):e18783. PMID: 21559529; PMCID: PMC3084715.
      Citations: 65     Fields:    Translation:HumansCells
    42. Saulnier DM, Spinler JK, Gibson GR, Versalovic J. Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol. 2009 Apr; 20(2):135-41. PMID: 19243931; PMCID: PMC2713183.
      Citations: 48     Fields:    Translation:HumansCells
    43. Taweechotipatr M, Iyer C, Spinler JK, Versalovic J, Tumwasorn S. Lactobacillus saerimneri and Lactobacillus ruminis: novel human-derived probiotic strains with immunomodulatory activities. FEMS Microbiol Lett. 2009 Apr; 293(1):65-72. PMID: 19222575; PMCID: PMC4105522.
      Citations: 22     Fields:    Translation:HumansCells
    44. Spinler JK, Zajdowicz SL, Haller JC, Oram DM, Gill RE, Holmes RK. Development and use of a selectable, broad-host-range reporter transposon for identifying environmentally regulated promoters in bacteria. FEMS Microbiol Lett. 2009 Feb; 291(2):143-50. PMID: 19146571; PMCID: PMC2772819.
      Citations: 1     Fields:    Translation:Cells
    45. Spinler JK, Taweechotipatr M, Rognerud CL, Ou CN, Tumwasorn S, Versalovic J. Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens. Anaerobe. 2008 Jun; 14(3):166-71. PMID: 18396068; PMCID: PMC2494590.
      Citations: 99     Fields:    Translation:HumansCells
    46. Oram DM, Must LM, Spinler JK, Twiddy EM, Holmes RK. Analysis of truncated variants of the iron dependent transcriptional regulators from Corynebacterium diphtheriae and Mycobacterium tuberculosis. FEMS Microbiol Lett. 2005 Feb 01; 243(1):1-8. PMID: 15667993.
      Citations: 3     Fields:    Translation:Cells
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